Best TWAS P=2.15e-09 · Best GWAS P=6.37e-08 conditioned to 0.007
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WDR19 | 0.05 | 0.01 | lasso | 5 | 0.00 | 1.3e-01 | -5.0 | 5.1 | 2.7e-07 | 0.89 | 0.04 | 0.91 | FALSE |
2 | GTEx | Adrenal Gland | RP11-360F5.3 | 0.09 | 0.01 | enet | 12 | 0.02 | 6.2e-02 | 5.4 | 5.2 | 2.2e-07 | 0.88 | 0.04 | 0.88 | FALSE |
3 | GTEx | Stomach | UGDH-AS1 | 0.08 | 0.01 | lasso | 7 | 0.02 | 3.8e-02 | -5.0 | 5.2 | 2.3e-07 | 0.80 | 0.05 | 0.73 | FALSE |
4 | GTEx | Testis | WDR19 | 0.28 | 0.29 | lasso | 5 | 0.27 | 1.6e-12 | -5.0 | 5.3 | 8.7e-08 | 0.87 | 0.05 | 0.95 | FALSE |
5 | GTEx | Vagina | AC021860.1 | 0.42 | 0.04 | lasso | 12 | 0.07 | 1.2e-02 | 3.9 | 5.3 | 1.2e-07 | 0.01 | 0.02 | 0.08 | TRUE |
6 | METSIM | Adipose | UGDH | 0.12 | 0.06 | blup | 366 | 0.07 | 2.6e-10 | -3.2 | 5.4 | 5.4e-08 | 0.45 | 0.95 | 0.03 | FALSE |
7 | METSIM | Adipose | WDR19 | 0.04 | 0.01 | enet | 20 | 0.02 | 7.7e-04 | -5.2 | 6.0 | 2.1e-09 | 0.51 | 0.04 | 0.94 | TRUE |
8 | ROSMAP | Brain Pre-frontal Cortex | WDR19 | 0.02 | 0.02 | enet | 9 | 0.02 | 2.8e-03 | 5.4 | 5.6 | 2.3e-08 | 0.99 | 0.03 | 0.92 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WDR19 | 0.03 | 0.04 | blup | 61 | 0.02 | 3.6e-03 | -5.1 | 5.1 | 2.7e-07 | 0.89 | 0.03 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | WDR19 | 0.08 | 0.00 | blup | 61 | 0.03 | 1.9e-02 | -5.2 | 5.2 | 2.0e-07 | 0.86 | 0.02 | 0.60 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR19 | 0.04 | 0.01 | blup | 61 | 0.02 | 2.4e-03 | 5.4 | 5.2 | 2.5e-07 | 0.90 | 0.02 | 0.96 | FALSE |