TWAS hub - UGDH-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.123	0.0510	4.2e-03	0.022	NA	0.060	NA	0.052	2.1e-02	NA	0.00031	NA	7.8e-04
2	GTEx	Brain Nucleus accumbens basal ganglia	0.261	0.0980	7.0e-03	0.010	NA	-0.005	NA	0.008	1.7e-01	NA	0.45000	NA	1.9e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.213	0.0820	8.8e-03	0.020	NA	0.068	NA	0.006	7.3e-02	NA	0.00300	NA	2.0e-01
4	GTEx	Cells Transformed fibroblasts	0.168	0.0550	9.4e-05	0.093	NA	0.018	NA	0.063	1.7e-07	NA	0.01500	NA	1.7e-05
5	GTEx	Lung	0.121	0.0384	1.1e-04	-0.001	NA	0.019	NA	0.001	4.0e-01	NA	0.01300	NA	2.7e-01
6	GTEx	Small Intestine Terminal Ileum	0.219	0.0910	4.6e-03	0.092	NA	0.170	NA	0.119	4.6e-03	NA	0.00013	NA	1.3e-03
7	GTEx	Stomach	0.081	0.0380	3.6e-03	0.012	NA	0.019	NA	0.020	8.6e-02	NA	0.03900	NA	3.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Alcohol intake frequency.	6.1	14.2	35.2	3.2	0.2	2.7	5.2	2.3	5.9	3.8
Angina	5.7	7.5	13.0	-3.3	2.5	-1.4	-3.6	-1.9	-3.4	-2.4
Angina (self-reported)	5.0	6.6	12.3	-3.0	2.3	-1.2	-3.5	-1.5	-3.1	-2.4
Average weekly beer plus cider intake	3.3	4.8	14.1	-2.2	0.3	-1.6	-2.5	-0.5	-3.8	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	11.6	-0.1	0.6	-2.1	-1.8	-1.5	-3.4	-2.1
Bipolar Disorder (2018)	2.9	4.6	7.8	0.6	-1.5	2.8	2.8	2.3	2.0	2.3
Prospective memory result	2.9	3.5	14.6	-1.0	1.7	-3.8	-1.5	-1.3	0.1	1.5
Hair/balding pattern: Pattern 4	2.7	6.6	16.7	3.2	-1.2	3.2	4.1	1.4	2.2	0.8
Noisy workplace	2.6	3.2	5.3	-1.9	2.0	-2.3	-2.1	-0.2	-1.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	7.7	-2.5	1.1	-1.9	-1.5	-0.3	-2.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	8.8	2.0	-1.4	2.0	1.6	0.0	3.0	2.3
Medication: Atenolol	2.4	3.0	7.7	-1.9	-0.3	-0.3	-2.1	-0.5	-2.8	-2.2
Illnesses of siblings	2.4	3.3	11.6	1.4	-1.4	0.1	0.0	-1.2	2.6	3.4
Glaucoma (self-reported)	2.3	2.7	7.8	1.7	0.5	0.4	0.9	-0.1	2.6	2.8
Verbal and Numeric Reasoning (VNR)	2.2	5.3	12.0	3.4	-0.4	3.5	2.3	1.5	2.2	1.0
Hair/balding pattern: Pattern 3	2.2	3.3	9.5	-2.4	1.2	-1.6	-3.1	-1.1	-0.2	-1.6
Ever highly irritable/argumentative for 2 days	2.2	2.7	9.8	-1.4	0.5	0.3	-0.0	1.6	-2.0	-3.1
Trunk predicted mass	2.1	12.0	28.7	3.2	-2.1	1.1	4.8	0.6	4.0	5.4
Gout (self-reported)	2.1	2.9	5.6	-2.4	1.2	-2.1	-2.2	-1.0	-1.4	-1.0
Comparative height size at age 10	2.1	11.6	18.6	4.3	-1.8	3.4	4.1	-0.1	3.9	4.1
Bipolar Disorder (2011)	2.0	1.9	3.2	1.1	-1.6	1.8	0.0	1.4	1.6	1.3
Smoking Status	2.0	4.9	16.4	-2.6	1.6	-4.0	-2.2	-0.8	-0.7	1.6
Average weekly spirits intake	2.0	2.4	7.3	-0.2	1.0	1.9	0.5	0.5	2.1	2.7
Trunk fat-free mass	2.0	11.7	27.4	3.2	-2.1	1.1	4.7	0.5	3.9	5.2
High blood pressure (siblings)	2.0	2.9	9.4	-1.2	0.0	-0.3	0.6	1.3	-2.6	-3.1
Whole body fat-free mass	2.0	11.3	26.5	2.9	-2.1	1.1	4.7	1.1	4.0	5.2
Leg fat-free mass (right)	2.0	10.6	22.0	2.4	-2.2	1.2	4.6	2.0	3.9	4.7
Alcohol intake versus 10 years previously	1.9	2.8	6.2	1.0	-0.6	2.5	1.9	1.5	2.5	0.6
Whole body water mass	1.9	11.0	26.8	2.7	-2.0	1.1	4.5	1.1	4.0	5.2
Leg predicted mass (right)	1.9	10.4	21.4	2.4	-2.1	1.1	4.5	2.1	3.8	4.6
Leg predicted mass (left)	1.8	9.4	18.9	2.3	-1.9	1.1	4.3	1.9	3.8	4.3
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	9.0	1.8	0.1	1.8	1.0	0.7	-1.8	-3.0
Arm fat-free mass (right)	1.8	9.2	23.8	2.5	-2.2	0.8	3.9	0.8	3.5	4.9
Shortness of breath walking on level ground	1.8	2.1	4.1	-1.7	0.2	-1.7	-0.9	-1.5	-2.0	-1.4
Medication: Allopurinol	1.8	2.4	6.8	-1.0	1.6	-2.6	-1.6	-1.2	-1.3	-0.9
Smoking status: Current	1.8	2.8	13.5	-1.2	1.2	-3.7	-0.7	-1.0	-1.0	1.0
Basal metabolic rate	1.8	10.0	23.6	2.7	-1.9	1.0	4.4	1.1	3.8	4.9
Arm predicted mass (left)	1.8	9.3	23.3	2.5	-1.8	0.8	4.1	0.7	3.7	4.8
Leg fat-free mass (left)	1.7	9.2	18.7	2.3	-1.8	1.2	4.3	1.8	3.7	4.3
Current tobacco smoking	1.7	2.8	12.4	-1.4	1.5	-3.5	-0.9	-0.9	-0.8	1.0
Average weekly fortified wine intake	1.7	2.0	5.1	1.9	-0.3	2.1	2.3	0.2	0.8	0.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	5.6	-1.3	1.4	-2.4	-0.7	-1.6	0.0	0.6
Arm fat-free mass (left)	1.7	8.5	21.4	2.4	-1.9	0.6	4.0	0.7	3.4	4.6
Bipolar Disorder or Schizophrenia	1.6	3.9	7.6	-0.0	-1.8	1.8	2.5	1.2	2.4	2.8
Blood Red Count	1.6	15.4	51.8	2.8	1.7	-0.5	1.8	-2.0	6.1	7.2
Supplements: Glucosamine	1.6	2.1	3.7	1.5	1.1	0.4	-0.2	1.9	1.9	1.9
Father’s age at death	1.6	2.1	4.8	1.8	-0.4	1.2	1.0	-0.6	2.2	2.0
Medication: Amlodipine	1.6	2.2	8.0	0.0	-1.4	2.8	0.8	1.1	-1.2	-1.5
Illnesses of siblings: Diabetes	1.6	2.0	5.4	-1.7	0.4	-0.2	-0.3	0.9	-2.0	-2.3
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.8	0.9	-1.3	2.4	1.5	1.6	1.2	1.8
Intelligence (Savage-Jansen 2018)	1.5	4.7	8.5	2.7	-0.1	2.9	2.3	1.0	2.8	1.6
Prostate Cancer	1.5	2.2	5.6	0.3	-2.4	-0.0	1.3	0.0	2.1	1.9
Height	1.5	29.5	65.9	6.5	-2.0	4.6	4.7	-2.2	6.9	8.1
Standing height	1.5	14.9	35.8	4.9	-0.7	2.3	4.3	-0.9	4.5	6.0
Arm predicted mass (right)	1.5	7.9	20.2	2.2	-2.0	1.0	3.7	0.9	3.2	4.5
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.9	-2.2	-1.1	-1.0	0.0	-0.2	-1.5	-1.6
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.7	0.6	-0.6	1.6	1.9	1.9	0.4	0.8
Chronotype (morning person)	1.4	3.3	11.4	1.9	-1.6	1.0	0.8	-0.6	1.9	3.4
Past tobacco smoking	1.4	2.6	7.6	2.7	-1.2	1.8	1.9	-0.4	1.3	0.8
Time employed in main current job	1.4	1.6	3.7	0.9	1.3	1.9	1.1	1.9	0.2	-0.4
Qualifications: A levels/AS levels or equivalent	1.4	3.2	9.3	3.0	-0.2	2.1	2.2	0.4	1.4	1.2
Schizophrenia vs Biploar Disorder	1.3	1.7	5.1	-0.7	0.8	-2.3	-0.4	-2.1	-0.6	-0.6
Neuroticism	1.3	3.2	5.7	1.3	-2.2	1.7	2.4	2.2	1.4	0.7
Impedance of leg (right)	1.3	6.5	16.2	-0.1	1.9	-0.4	-4.0	-3.4	-2.7	-2.6
Impedance of leg (left)	1.3	6.4	15.7	-0.3	1.7	-0.7	-4.0	-3.5	-2.7	-2.4
Loud music exposure frequency	1.3	1.4	2.4	1.6	-0.5	1.5	0.6	1.6	1.3	0.5
Age at last live birth	1.3	1.9	3.2	1.8	-1.1	1.3	0.7	1.2	1.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.6	2.0	-1.6	-0.2	1.0	-1.6	1.6	2.4
Eye problems/disorders: Cataract	1.3	1.5	5.7	-0.9	2.4	-1.8	-0.2	0.9	-0.2	-0.4
Ever taken oral contraceptive pill	1.3	1.4	4.6	-2.1	0.4	-1.1	-1.3	-0.5	-1.4	-0.4
Ever smoked	1.3	2.2	5.5	-2.4	1.6	-1.7	-1.4	0.6	-1.3	-0.7
Unable to work because of sickness or disability	1.3	1.7	5.2	-2.1	-2.3	-0.8	-0.6	-0.7	-0.6	-0.1
Heart disease (siblings)	1.3	1.6	5.4	-1.5	-0.2	-0.3	-0.4	0.6	-1.6	-2.3
Alzheimer’s Disease (including proxy)	1.2	1.7	6.0	-0.9	1.0	-0.1	-2.5	0.4	-1.6	-1.1
Crohns Disease (2017)	1.2	2.7	9.9	-0.2	1.4	-0.4	-3.1	-2.6	0.1	0.4
Irritable Bowel Disease (IBD)	1.2	2.9	11.0	-0.1	1.7	-0.5	-3.3	-2.4	-0.3	-0.1
Ovarian Cancer	1.2	1.6	3.8	0.7	0.2	1.9	-1.6	-1.2	-1.4	-0.9
Mean Putamen Volume	1.2	1.3	5.5	0.1	-2.4	0.1	1.3	1.0	-0.1	-1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.4	1.0	-1.2	0.1	1.8	-0.2	1.8	1.2
Medication for hormone replacement therapy	1.2	1.3	2.6	-1.6	1.6	0.1	-1.3	0.5	-0.6	-1.3
Weight	1.2	5.9	15.1	2.0	-1.0	0.7	3.2	1.1	3.1	3.9
Happiness	1.2	1.4	3.8	0.8	-0.2	1.1	1.8	1.2	1.9	0.0
Worry too long after embarrassment	1.2	1.9	5.9	0.2	-1.6	0.5	1.4	0.6	2.4	1.6
Average weekly champagne plus white wine intake	1.2	1.6	7.1	-0.1	0.0	1.1	0.3	2.7	-1.0	-1.5
Basal cell carcinoma (self-reported)	1.2	1.4	3.1	-0.8	-0.5	0.8	0.3	1.6	1.7	1.8
Coronary Artery Disease (CAD)	1.1	1.3	5.1	-0.7	-1.2	0.0	-1.2	-2.3	-0.3	-0.4
Rheumatoid Arthritis	1.1	1.5	3.9	-0.8	1.5	1.2	-1.1	2.0	-0.5	-0.9
Diabetes (mother)	1.1	1.4	5.7	0.1	1.7	-0.7	0.5	-0.2	0.7	2.4
Maternal smoking around birth	1.1	1.6	4.6	-1.7	0.9	0.8	-2.1	0.1	-1.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.6	-1.4	-1.4	-0.2	0.2	1.6	1.1	1.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.4	-1.8	-0.5	-1.3	-0.9	-1.3	-0.9	0.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.9	1.4	-1.0	1.0	2.2	0.5	0.4	-0.4
Financial difficulties in last 2 years	1.1	1.5	4.9	-2.2	-1.3	-1.8	0.3	-0.2	-0.4	-0.6
Medication: Simvastatin	1.1	1.6	5.3	-2.3	-1.5	0.3	-1.1	-0.2	-0.7	-1.4
Fluid intelligence score	1.1	2.4	6.1	2.5	0.3	2.4	1.1	-0.1	1.8	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.1	1.4	-1.2	-0.8	1.6	0.9	1.8	1.4
Mouth/teeth dental problems: Dentures	1.1	1.8	6.4	-0.6	1.7	-0.7	-2.5	-1.2	-1.2	-0.4
Breastfed as a baby	1.1	1.3	4.4	1.0	2.1	1.6	0.7	0.4	0.7	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.9	-1.0	2.0	0.6	-1.0	0.7	-1.5	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.3	-0.1	-1.8	0.5	1.8	1.1	1.0	0.5
Smoking status: Previous	1.1	1.7	5.4	-2.3	0.7	-1.0	-2.0	-0.5	-0.6	-0.5
Qualifications: nursing, teaching	1.1	1.7	3.7	0.1	-1.0	1.9	1.8	1.6	-0.4	-1.2
Eye problems/disorders: Glaucoma	1.1	1.4	3.7	1.3	-0.0	-0.1	0.8	-0.1	1.9	1.9
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.9	1.7	0.2	1.5	2.0	1.0	0.3	-0.2
Cholesterol lowering medication	1.1	1.6	4.2	-2.0	-1.8	-1.4	-0.8	-0.5	-1.1	-0.1
Heart attack/myocardial infarction (self-reported)	1.1	1.4	7.7	-0.3	-0.3	-0.1	0.1	0.2	-1.4	-2.8
HbA1C	1.0	1.1	4.9	1.1	1.2	-0.1	-0.5	-2.2	-0.0	0.3
Blood Eosinophil Count	1.0	7.4	41.6	0.9	1.1	0.2	1.6	6.5	2.1	0.7
Sitting height	1.0	7.2	19.1	3.3	-0.4	2.6	2.3	-0.0	2.8	4.4
Number of incorrect matches in round	1.0	1.6	3.2	-1.8	0.1	-1.0	-1.1	-1.7	-1.2	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	9.2	2.2	-3.0	-0.5	1.1	-0.7	0.6	-0.1
Heart attack	1.0	1.2	6.7	-0.1	-0.4	-0.2	0.3	0.3	-1.3	-2.6
Number of full brothers	1.0	1.2	4.3	-1.0	0.2	0.4	-0.1	1.2	-1.2	-2.1
Qualifications: College or University degree	1.0	3.0	5.5	2.1	-0.1	1.9	1.6	0.8	2.2	2.3
Medication: Ibuprofen	1.0	1.1	3.5	0.4	0.6	1.1	1.2	0.2	1.1	1.9
Had major operations	1.0	1.1	2.3	0.4	0.5	-1.5	-0.3	-1.1	1.2	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.6	-0.3	0.0	0.2	-0.5	-1.6	-1.6	-1.6
Vitamin and mineral supplements	0.9	1.2	2.5	-0.8	-0.8	-1.5	-0.3	-0.7	-1.6	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	3.0	1.0	-1.7	1.1	-0.1	0.7	-0.6	-1.5
Stomach or abdominal pain in last month	0.9	1.1	2.0	-1.4	-0.6	0.7	-0.8	1.2	-1.4	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	3.9	1.2	0.0	-0.5	0.0	-1.5	-2.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	0.9	1.1	1.4	0.3	0.6	1.0	1.6
Medication: Seretide 50 evohaler	0.9	1.0	2.1	-1.4	0.7	-0.2	-1.5	0.1	-1.4	-0.6
Mean time to correctly identify matches	0.9	1.7	5.4	-0.7	1.5	-1.0	0.0	0.0	-1.6	-2.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.5	-0.2	2.1	0.5	-0.4	1.2	0.7	1.1
Supplements: Vitamin C	0.9	1.0	2.6	1.3	1.5	1.6	-0.1	-0.6	0.4	0.3
Loneliness, isolation	0.9	1.2	3.4	-1.3	0.9	-1.9	-1.2	0.5	-0.8	0.6
Alcohol drinker status: Never	0.9	1.1	3.8	1.1	-0.9	-0.5	2.0	0.5	0.5	1.0
Reaction Time	0.8	1.5	3.7	-0.5	1.3	-1.3	-0.4	-0.1	-1.7	-1.9
Age at First Birth	0.8	1.1	2.7	1.4	1.0	1.7	0.9	0.1	1.0	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	1.6	0.0	1.1	0.7	-1.5	-0.2	-0.5
Blood White Count	0.8	6.2	21.9	-4.7	0.8	-2.6	-2.5	0.2	-2.5	-1.1
Sensitivity / hurt feelings	0.8	1.4	5.6	1.1	-0.8	1.3	0.7	0.7	2.4	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.6	1.1	-0.9	0.3	1.0	0.7	-0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	7.6	1.8	-2.8	-0.5	1.1	-0.1	0.4	-0.0
Serious illness, injury or assault to yourself	0.8	1.0	4.5	0.5	-0.3	-0.9	-0.3	-0.3	-2.1	-1.1
High blood pressure	0.8	2.1	6.8	0.1	-2.3	2.6	1.2	1.2	0.4	-0.1
Alcohol usually taken with meals	0.8	1.3	2.3	1.3	1.5	0.9	0.2	0.6	-1.2	-1.5
Qualifications: None of the above	0.8	1.7	4.3	-2.1	1.4	-1.8	-1.4	-0.2	-0.5	-0.4
Neuroticism score	0.8	1.6	3.2	0.2	-0.9	0.3	1.7	1.7	1.8	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.0	0.3	-0.4	1.7	1.3	0.5	1.0	0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.1	-0.5	0.1	-0.2	-1.4	-1.3	-1.5	-0.6
Eye problems/disorders: None of the above	0.8	0.9	1.7	-0.5	-0.9	1.3	-0.9	-0.1	-1.1	-1.2
Neck or shoulder pain in last month	0.8	1.1	4.3	-0.7	0.4	-0.0	0.2	0.2	-2.1	-1.6
Migraine (self-reported)	0.8	1.0	3.7	1.9	-0.1	0.6	-0.2	0.8	-0.7	-1.3
Leg pain on walking	0.8	1.0	4.0	-0.1	0.0	0.3	0.9	1.0	1.1	2.0
Hypertension (Self-reported)	0.8	2.1	7.0	-0.2	-2.4	2.6	0.8	1.0	-0.0	-0.1
Illnesses of father: Heart disease	0.8	1.1	3.3	-0.5	-1.3	1.8	-0.9	-1.1	-0.4	0.7
Ever had bowel cancer screening	0.8	0.9	3.2	-0.1	-0.2	-0.2	0.7	-0.7	1.8	1.4
Commuting to job workplace: Public transport	0.8	0.9	3.2	1.8	-0.4	1.3	0.0	-0.8	0.1	-0.9
Illnesses of father: High blood pressure	0.8	0.9	3.0	0.5	-1.7	0.6	0.1	0.5	0.9	1.4
Irritability	0.8	1.4	4.7	0.2	-0.9	2.2	0.7	1.7	0.7	-0.7
Impedance of whole body	0.8	4.1	11.9	-0.1	2.2	-0.2	-3.4	-2.5	-1.5	-1.8
Depression (Nagel 2018)	0.7	1.0	2.2	0.2	-1.1	-0.1	1.1	1.4	1.5	0.4
Alzheimer’s Disease (in mother)	0.7	0.8	3.6	-0.4	0.6	-0.4	-1.9	-0.4	-1.1	-0.6
Breast Cancer	0.7	1.7	3.4	-1.6	1.3	-0.7	-0.2	-0.9	-1.8	-1.7
Crohns Disease (2012)	0.7	1.2	3.4	-0.1	0.1	-0.1	-1.7	-1.8	-1.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-1.2	1.0	0.7	-1.2	-0.4	-0.5	-1.0
Medication: Levothyroxine sodium	0.7	1.2	4.7	0.1	-0.5	-0.1	0.8	2.2	1.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.7	-0.1	1.9	0.0	-1.4	0.5	-0.3	-0.6
Hip circumference	0.7	2.9	11.8	0.3	-0.4	0.5	1.8	0.4	2.1	3.4
Depression (self-reported)	0.7	0.8	2.5	-1.0	-1.1	0.3	1.6	0.7	0.2	0.5
Lung cancer (father)	0.7	0.9	2.2	0.2	0.3	0.9	0.5	1.4	1.5	0.8
Illnesses of mother	0.7	0.9	1.7	1.3	-0.2	0.8	1.2	1.0	1.0	0.1
Wheeze or whistling in the chest in last year	0.7	1.2	4.5	-0.7	2.1	-0.4	-0.4	1.0	-1.1	-0.8
Age at first live birth	0.7	1.3	2.9	1.7	0.7	1.3	0.5	1.6	1.0	-0.1
Pulse wave peak to peak time	0.7	0.8	1.7	0.2	-0.8	1.2	1.0	0.5	1.3	0.7
Health satisfaction	0.7	0.9	3.0	-0.7	-0.2	-1.6	0.3	-0.5	-1.7	-0.5
Overall health rating	0.7	1.6	3.7	-1.6	0.0	-1.9	0.1	0.3	-1.8	-1.2
Family relationship satisfaction	0.7	0.8	1.6	0.3	0.2	-1.2	1.3	1.0	1.0	-0.8
Breast cancer (self-reported)	0.7	0.8	1.9	0.4	0.5	1.2	-1.4	-1.3	0.0	-0.5
Wears glasses or contact lenses	0.7	0.8	2.5	-0.5	0.9	0.6	-0.2	-0.4	1.6	1.4
Hearing aid user	0.7	0.8	2.9	0.5	1.2	-0.7	-0.1	-0.4	0.6	1.7
Medication: Lisinopril	0.7	0.9	3.4	1.2	-1.8	0.8	0.7	0.3	-0.6	-0.4
Age started oral contraceptive pill	0.7	0.8	3.0	0.7	1.7	-0.4	-0.9	-1.0	0.4	0.3
Alcohol drinker status: Previous	0.7	0.8	1.4	1.2	1.2	1.1	1.0	-0.0	-0.5	-0.8
Neuroticism (Nagel 2018)	0.6	1.3	2.4	0.9	-1.5	0.9	1.4	0.9	1.5	0.3
Schizophrenia (2018)	0.6	1.2	2.9	-0.9	-1.1	0.1	0.9	-0.0	1.5	1.7
Ulcerative Colitis (UC)	0.6	1.1	4.1	-0.1	1.1	-0.5	-2.0	-1.3	-0.5	0.1
LDL Cholesterol	0.6	0.9	2.7	-0.7	-0.2	-0.2	-1.7	-1.1	-0.9	-1.0
Ulcerative Colitis	0.6	0.9	2.8	-0.2	0.9	-0.7	-1.5	-0.2	-1.7	-0.1
Heel T-Score	0.6	4.4	15.7	4.0	-0.7	1.8	2.5	2.2	0.9	-0.2
Allergy or Eczema	0.6	1.5	6.8	1.3	2.6	0.3	-0.8	0.3	0.5	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	-0.2	-1.4	-0.5	1.1	1.0	1.1	0.2
Hand grip strength (right)	0.6	1.6	5.8	0.8	-0.8	0.3	0.9	2.4	1.0	1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.9	-0.8	0.1	0.1	-0.5	0.5	-1.7	-0.8
Waist circumference	0.6	2.0	4.2	0.6	-0.4	0.8	2.0	1.4	1.7	2.1
Hearing difficulty/problems with background noise	0.6	0.9	2.6	-1.5	-0.3	-1.1	-0.3	-0.3	0.2	1.6
Number of live births	0.6	0.8	1.8	-1.3	-1.1	-0.8	-1.0	-0.2	-0.3	0.9
Length of working week for main job	0.6	0.7	1.1	-0.9	-0.7	-0.6	-1.0	-1.1	0.5	0.9
Exposure to tobacco smoke at home	0.6	0.7	1.8	0.2	0.2	1.0	-1.3	-0.5	-0.8	-1.0
Tense / ‘highly strung’	0.6	1.0	3.3	-0.5	0.1	-0.8	0.4	0.0	1.8	1.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.3	1.0	-0.9	-0.5	0.9	1.1	1.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	-0.2	0.3	0.8	-0.4	1.1	1.0	1.2
Average weekly red wine intake	0.6	0.8	2.1	0.1	0.1	1.0	0.1	-1.2	-1.5	-1.1
Long-standing illness, disability or infirmity	0.6	0.9	3.8	-0.1	-0.5	-0.2	1.3	1.9	-0.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.8	-0.0	0.6	-1.0	0.4	0.0	0.4	1.7
Friendships satisfaction	0.6	0.7	3.1	0.5	-0.7	-0.7	1.8	0.6	0.5	0.3
Mother’s age at death	0.6	0.8	1.8	-0.1	1.2	-1.2	0.4	-0.6	0.4	1.3
Supplements: Calcium	0.6	0.6	2.2	-0.9	-0.1	-0.0	0.3	0.7	-0.8	-1.5
Worry (Nagel 2018)	0.5	1.1	2.2	0.7	-0.8	0.2	1.5	0.5	1.5	1.3
Triglycerides	0.5	0.9	2.9	-0.9	-0.3	-0.6	-0.6	1.7	-0.9	-1.1
Lung FVC	0.5	2.4	4.8	-1.3	-0.9	-1.8	-1.2	-2.2	-2.0	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	0.9	0.0	1.3	0.4	-0.4	0.5	-1.0
Supplements: Zinc	0.5	0.5	2.1	-0.3	-0.0	-0.1	0.2	0.3	1.4	1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.6	0.9	-1.1	0.4	1.0	-0.2	0.6
Falls in the last year	0.5	0.7	1.6	-0.3	-1.2	-0.0	0.4	1.1	1.0	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	3.1	1.5	-1.4	0.6	1.2	-1.0	0.7	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	0.9	-1.1	0.9	0.0	0.3	1.1	0.2
Medication: Paracetamol	0.5	0.8	3.1	-0.0	-0.0	-0.1	-0.1	-0.1	1.5	1.8
Exposure to tobacco smoke outside home	0.5	0.7	2.2	-0.6	0.1	1.2	-0.5	1.5	0.2	0.6
Medication: Omeprazole	0.5	0.6	1.9	-0.3	-0.7	-0.5	1.4	1.1	-0.1	0.1
Chest pain or discomfort	0.5	0.7	1.3	-1.1	1.0	-0.3	-0.3	0.9	-0.9	-1.1
Knee pain experienced in last month	0.5	0.8	2.5	0.3	0.0	-0.2	1.2	1.6	0.8	0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	1.0	-0.2	-0.9	0.5	-0.9	1.0	0.1
Medication for cholesterol	0.5	0.8	2.1	1.1	1.4	0.6	0.5	-0.2	0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.7	-0.5	-1.9	0.5	-0.5	-1.4	-0.4	-0.1
Guilty feelings	0.5	0.7	2.9	0.1	-1.0	-0.3	1.7	0.5	0.8	0.2
Medication: Paracetamol	0.5	0.8	2.5	0.6	0.3	0.6	-0.1	0.4	1.6	1.5
Fractured/broken bones in last 5 years	0.5	0.6	2.4	-0.6	-0.6	0.1	-0.1	-0.4	-1.6	-1.1
Ever depressed for a whole week	0.5	0.6	2.0	1.4	0.9	0.7	0.3	-0.8	0.0	0.0
Commuting to job workplace: Cycle	0.5	0.6	1.1	-0.4	0.4	-1.0	-1.0	-1.1	0.7	0.7
Myopia	0.5	0.7	2.9	0.1	-0.9	1.1	1.7	-0.5	-0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	3.5	0.8	1.7	-1.9	-0.4	-0.9	0.4	0.8
Pain experienced in last month	0.5	0.9	3.8	-0.8	0.9	0.3	-1.9	-0.5	0.1	0.7
Major Depression (MDD)	0.4	0.5	1.3	0.9	1.2	-0.0	0.2	-0.7	0.3	0.7
Fasting Glucose	0.4	0.5	1.0	1.0	0.5	0.7	0.4	-0.1	-0.9	-0.8
Schizophrenia (2014)	0.4	0.8	2.0	-0.7	-0.9	0.6	0.7	-0.4	1.4	1.1
Hypothyroidism (self reported)	0.4	1.0	2.1	1.4	-0.5	-0.7	1.1	1.4	1.1	0.2
Respiratory disease	0.4	0.9	2.7	-0.2	1.1	0.5	-0.8	1.1	-1.6	-0.7
Lung FEV1/FVC ratio	0.4	2.1	4.0	2.0	-1.0	1.4	1.6	0.8	1.6	1.5
Hearing difficulty/problems: Yes	0.4	0.6	1.4	-0.4	0.4	-1.0	-0.7	-0.9	0.2	1.2
Relative age of first facial hair	0.4	0.8	1.3	-1.1	0.9	-0.7	-1.1	-0.5	-0.2	1.1
Diabetes (father)	0.4	0.5	2.2	-0.4	1.5	-0.8	-0.8	-0.0	0.2	-0.4
Townsend deprivation index at recruitment	0.4	0.5	1.0	-0.6	-0.7	-0.9	-0.2	-0.1	-1.0	-0.9
Fed-up feelings	0.4	0.8	2.6	-0.4	0.3	-1.0	0.8	1.6	0.5	0.7
Relative age voice broke	0.4	0.6	1.7	-1.3	-0.2	0.5	-1.2	-0.8	0.3	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	1.1	1.2	0.8	-0.5	0.4	1.0	0.9
Multivitamins +/- minerals	0.4	0.6	1.3	0.9	1.0	0.8	0.3	-0.1	1.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-1.1	-1.0	-0.4	0.2	1.1	-0.3	0.3
Had menopause	0.4	0.5	2.2	-0.2	1.5	0.9	-0.5	-0.4	0.3	0.0
Diabetes (self-reported)	0.4	0.6	2.5	1.1	-1.6	0.3	0.6	0.1	0.4	0.0
Medication: Ramipril	0.4	0.5	1.5	0.2	-1.2	-0.1	1.1	-0.4	-0.3	-0.3
Impedance of arm (right)	0.4	2.1	5.9	0.1	2.4	0.4	-2.3	-1.4	-0.5	-0.9
Worrier / anxious feelings	0.4	0.8	2.4	0.6	-0.2	0.6	0.7	-0.5	1.5	1.2
Medication: Cholesterol lowering	0.4	0.6	1.6	-1.3	0.1	0.7	-1.1	0.0	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	1.9	1.4	-1.3	0.7	1.4	-1.2	0.8	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	0.2	0.7	-1.0	-0.7	-0.4	-0.9	-0.2
Impedance of arm (left)	0.4	1.9	6.0	0.2	2.3	0.2	-2.5	-1.2	-0.3	-0.8
Birth weight of first child	0.4	0.7	2.6	1.2	0.6	1.6	0.3	-0.1	0.5	-0.0
Peak expiratory flow (PEF)	0.4	0.9	1.6	0.9	-1.0	1.3	0.3	-0.2	1.1	1.3
Blood clot in the leg (DVT)	0.4	0.6	1.4	0.6	-0.5	-0.0	0.9	-0.8	-0.6	-1.2
Headache pain in last month	0.4	0.6	1.8	0.8	0.1	-0.4	1.3	1.3	0.2	0.1
Comparative body size at age 10	0.4	1.0	3.0	-0.2	-1.7	-0.9	1.3	-0.8	0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.7	-0.2	1.3	0.2	0.9	0.1	0.6	1.0
Number of children fathered	0.4	0.4	0.8	-0.6	0.2	-0.7	0.4	0.8	-0.9	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-1.1	0.2	-0.2	1.1	0.8	-0.6	0.1
Emphysema/chronic bronchitis	0.4	0.5	1.1	-0.0	0.5	0.6	0.9	0.9	-1.0	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	2.2	0.5	0.2	-0.6	-0.4	0.1	-1.3	-1.5
Number of full sisters	0.4	0.5	1.9	-0.9	-0.4	-0.7	-0.0	-1.4	-0.2	0.2
Suffer from ‘nerves’	0.4	0.7	2.4	-1.6	-0.6	-0.6	-0.2	0.6	-0.1	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.5	0.6	0.5	0.8	1.3	-0.1	-0.0
Asthma (self-reported)	0.4	0.7	2.5	-0.6	-0.2	0.7	-0.8	0.4	-1.6	-1.0
Medication: Gliclazide	0.4	0.5	1.5	0.2	0.5	-0.7	0.1	1.2	-1.0	-0.3
Financial situation satisfaction	0.4	0.5	1.2	-0.5	0.0	-1.0	-0.1	-0.2	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.5	0.2	1.6	-0.0	-0.1	0.2	-0.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.4	-0.5	-0.0	0.7	-1.1	-0.5	-1.0
Pack years of smoking	0.4	0.6	1.4	-1.0	1.2	0.6	0.8	0.5	-0.4	-0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.2	-0.2	-0.1	0.2	-1.1	-0.0	0.7	0.5
HDL Cholesterol	0.3	0.5	2.0	1.0	1.4	-0.4	0.5	-0.1	-0.1	-0.3
Lupus	0.3	0.4	2.0	-0.4	-0.3	0.6	-0.2	1.4	-0.4	-0.5
Hand grip strength (left)	0.3	0.9	4.0	-0.4	-1.0	-0.4	0.5	2.0	0.2	1.0
Medication: Co-codamol	0.3	0.4	1.8	-0.6	-0.1	-1.4	-0.7	0.3	0.1	-0.0
Medication: Metformin	0.3	0.4	1.2	-0.2	-1.0	-0.0	0.2	1.1	-0.1	0.6
Pack years adult smoking proportion	0.3	0.5	1.0	-1.0	0.9	0.8	0.6	0.4	-0.5	-0.0
Body mass index (BMI)	0.3	1.1	2.6	-0.3	-0.6	-0.4	1.3	1.6	1.2	1.3
Trunk fat mass	0.3	1.2	4.4	0.5	0.4	-0.0	0.8	0.4	1.7	2.1
Nervous feelings	0.3	0.6	1.4	0.2	0.1	0.7	1.1	-0.2	1.0	1.2
Forced vital capacity (FVC)	0.3	1.1	2.7	1.0	-1.1	-0.2	0.8	-1.4	0.1	1.6
Mouth/teeth dental problems	0.3	0.5	1.7	-0.2	-1.3	-0.9	0.5	-0.6	0.2	-0.7
Pain all over the body in last month	0.3	0.3	1.0	0.2	-0.1	-0.4	1.0	0.1	0.1	0.8
Asthma	0.3	0.6	2.7	-0.4	-0.6	0.6	-0.4	0.6	-1.6	-0.7
Medication: Lansoprazole	0.3	0.3	0.9	-0.7	0.3	-0.1	-0.3	-0.9	-0.5	-0.5
Arm fat mass (right)	0.3	1.3	4.5	0.1	0.3	-0.2	1.3	0.8	1.5	2.1
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	1.0	-0.6	-0.1	0.6	-1.9	0.0	1.3
Medication: Blood pressure	0.3	0.6	1.3	-1.0	-0.3	1.1	-0.6	0.4	-1.0	-0.6
Commuting to job workplace: Walk	0.3	0.3	1.0	1.0	0.2	-0.8	0.3	-0.5	-0.1	0.0
Back pain experienced in last month	0.3	0.4	1.5	0.1	-0.6	-1.0	1.2	0.3	0.2	0.1
Osteoarthritis (self-reported)	0.3	0.3	1.0	-0.1	0.2	-1.0	0.5	0.3	-0.6	-0.8
Medication: Aspirin	0.3	0.4	1.1	0.1	0.1	0.7	-0.3	-0.7	1.0	0.7
Arm fat mass (left)	0.3	1.4	4.8	0.1	0.2	-0.2	1.2	0.8	1.7	2.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.8	-1.3	-0.5	-0.6	-0.3	0.7	-0.4	-0.6
Medication: Blood pressure	0.3	0.6	2.0	0.4	-1.4	-0.0	0.3	-0.3	-1.1	-0.9
High cholesterol (Self-reported)	0.3	0.5	2.8	-1.7	-0.8	0.1	0.1	0.2	0.0	0.3
Medication: Bendroflumethiazide	0.3	0.5	1.6	0.7	0.2	-0.1	-0.7	-1.3	-0.7	-0.3
Medication: Atorvastatin	0.3	0.4	0.8	-0.5	0.7	-0.6	-0.2	0.9	0.3	0.6
Risk taking	0.3	0.4	1.6	-0.5	-0.6	0.4	-1.3	-0.6	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	-0.5	-0.6	-0.8	0.9	0.4	-0.3	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	0.3	-0.6	-0.1	1.1	1.4	-0.1	-0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.6	0.7	-0.6	-0.1	0.2	-0.5	-0.6
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.0	0.7	-1.0	0.4	0.7	-0.2	-0.1
BMI	0.2	1.0	3.7	-0.8	0.1	-1.2	1.0	1.9	0.2	0.4
Waist Hip Ratio (WHR)	0.2	0.9	1.8	0.3	1.0	0.6	0.2	1.2	-1.1	-1.4
Cardiovascular Disease	0.2	0.8	1.5	-1.2	-0.8	0.5	-1.2	-0.0	-1.1	-0.7
Number of treatments/medications taken	0.2	0.4	1.3	0.2	1.1	0.8	-0.3	0.4	0.6	0.7
Systolic blood pressure, automated reading	0.2	0.6	3.0	0.3	0.2	0.5	0.3	1.7	0.7	-0.0
Severe depression (siblings)	0.2	0.3	1.1	0.8	0.0	0.1	1.0	-0.2	0.0	-0.1
Had other major operations	0.2	0.3	0.9	0.2	-0.2	0.6	0.2	1.0	-0.2	-0.8
Arm fat percentage (right)	0.2	0.6	1.2	-0.7	0.9	-0.5	-0.0	0.5	1.0	1.1
Pulse rate	0.2	0.4	1.2	0.5	-0.1	-0.8	0.3	1.1	0.2	0.9
Pulse wave reflection index	0.2	0.2	1.1	-0.4	-0.1	-0.5	-0.5	-1.0	0.3	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	1.1	-0.1	-0.6	0.3	-0.5	0.4	0.6
Birth weight	0.2	0.5	2.6	0.5	1.6	-0.2	0.8	-0.0	0.0	0.3
Leg fat percentage (right)	0.2	0.6	1.1	-0.8	0.7	-1.0	-0.6	-0.4	-0.7	-0.8
Whole body fat mass	0.2	0.9	2.9	0.3	0.2	-0.1	1.0	0.5	1.3	1.7
Pulse rate, automated reading	0.2	0.5	1.3	-0.4	-1.1	-0.5	-1.0	-0.6	-0.7	-0.0
Arm fat percentage (left)	0.2	0.6	1.3	-0.6	0.9	-0.4	-0.1	0.7	1.1	1.1
Mood swings	0.2	0.4	0.8	-0.2	-0.7	-0.1	0.4	0.9	0.9	0.5
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.2	-0.8	-0.1	0.2	0.9	0.0	-0.5
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.8	0.4	-0.5	-0.5	-0.3	-0.6	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.4	0.3	-0.8	-0.2	0.6	-0.1	-0.6
Miserableness	0.2	0.4	0.9	0.7	0.9	-0.1	0.9	0.7	0.3	0.1
Number of operations (self-reported)	0.2	0.3	1.5	0.1	-0.4	-1.2	0.1	0.0	0.7	0.1
Diastolic blood pressure, automated reading	0.2	0.6	2.2	1.5	-0.4	0.7	0.3	0.7	1.0	0.2
Neuroticism (2016)	0.1	0.1	0.2	-0.2	0.1	-0.3	0.1	0.2	-0.3	0.5
Blood Platelet Count	0.1	1.6	5.5	-1.6	-1.4	-0.8	-2.4	-0.6	0.1	0.3
Systolic Blood Pressure	0.1	0.4	1.4	-0.5	-0.2	-0.9	-1.2	0.5	-0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.1	-0.3	-0.4	0.6	0.5	-0.0	-0.6
Tanning	0.1	1.6	4.3	-0.8	-0.8	-1.0	-1.9	-0.0	-2.1	-1.1
Trunk fat percentage	0.1	0.5	1.4	-0.2	1.2	-0.3	-0.6	0.1	1.0	1.0
Taking other prescription medications	0.1	0.2	0.5	-0.3	0.7	0.3	0.5	0.4	0.4	0.3
Age when periods started (menarche)	0.1	0.2	0.4	-0.4	0.2	0.6	0.4	-0.5	-0.2	-0.2
High blood pressure (mother)	0.1	0.2	0.6	-0.5	-0.8	0.1	0.3	-0.5	-0.3	0.1
Allergy	0.1	0.2	0.7	-0.7	0.2	-0.4	0.3	-0.3	-0.2	-0.8
Body fat percentage	0.1	0.4	1.3	-0.5	1.2	-0.6	-0.7	-0.0	0.3	0.5
Heart disease (mother)	0.1	0.2	0.4	0.3	0.4	-0.3	0.5	-0.6	-0.1	-0.4
Leg fat mass (right)	0.1	0.2	0.5	-0.4	0.1	-0.5	0.7	0.5	0.4	0.7
Medication: Aspirin	0.1	0.2	0.3	-0.4	-0.1	0.5	-0.5	-0.6	0.5	0.2
Mineral and other dietary supplements	0.1	0.2	0.5	-0.5	-0.7	-0.0	0.1	-0.4	0.3	0.2
Leg fat percentage (left)	0.1	0.4	1.2	-0.7	0.2	-1.1	-0.3	-0.4	-0.7	-0.8
Leg fat mass (left)	0.1	0.3	0.7	-0.3	-0.2	-0.4	0.8	0.5	0.5	0.8
Hair Pigment	0.0	0.3	0.7	-0.9	0.6	-0.2	-0.0	0.7	-0.0	0.7

Hub : Genes

UGDH-AS1

Models

Trait associations