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chr5:111,499,732-112,950,045

Best TWAS P=2.72e-12 · Best GWAS P=5.2e-12 conditioned to 0.00249

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	NTR	Blood	REEP5	0.03	0.04	lasso	9	0.04	3.3e-12	6.6	7.0	2.7e-12	-0.66	0.01	0.99	TRUE
18	GTEx	Testis	REEP5	0.22	0.14	lasso	5	0.14	6.6e-07	5.7	6.2	6.1e-10	-0.59	0.08	0.91	FALSE
9	GTEx	Esophagus Mucosa	REEP5	0.19	0.10	lasso	5	0.09	1.5e-06	6.1	6.1	1.1e-09	-0.60	0.06	0.92	FALSE
4	GTEx	Artery Aorta	REEP5	0.17	0.07	lasso	13	0.10	4.2e-06	6.6	6.0	1.7e-09	-0.74	0.02	0.98	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	REEP5	0.11	0.10	lasso	7	0.10	6.3e-06	5.5	6.0	1.9e-09	-0.63	0.14	0.84	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	REEP5	0.18	0.03	lasso	3	0.03	3.7e-02	6.1	5.9	2.9e-09	-0.61	0.04	0.88	FALSE
3	GTEx	Adipose Visceral Omentum	REEP5	0.09	0.05	lasso	5	0.02	4.9e-02	5.9	5.9	3.5e-09	-0.60	0.04	0.90	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APC	0.03	0.02	blup	77	0.02	5.2e-03	6.0	5.9	4.0e-09	-0.45	0.02	0.51	FALSE
7	GTEx	Colon Transverse	REEP5	0.12	0.14	lasso	2	0.14	4.4e-07	5.7	5.8	5.8e-09	-0.58	0.18	0.81	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.5	0.17	0.07	lasso	6	0.06	7.7e-06	5.5	5.7	1.1e-08	-0.60	0.40	0.60	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.7	0.08	0.09	enet	7	0.10	3.9e-06	5.5	5.7	1.3e-08	-0.65	0.12	0.84	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	REEP5	0.03	0.02	blup	47	0.03	4.1e-03	5.8	5.7	1.3e-08	-0.67	0.05	0.35	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SRP19	0.08	0.06	lasso	5	0.07	1.3e-08	5.3	-5.7	1.5e-08	0.63	0.57	0.43	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRP19	0.05	0.04	lasso	3	0.04	3.7e-05	5.5	-5.6	1.7e-08	0.60	0.66	0.27	FALSE
2	GTEx	Adipose Subcutaneous	REEP5	0.10	0.09	lasso	2	0.05	2.8e-05	5.5	5.6	1.8e-08	-0.64	0.26	0.73	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.7	0.06	0.07	lasso	1	0.04	2.4e-04	5.5	5.5	3.1e-08	-0.52	0.06	0.92	FALSE
5	GTEx	Artery Tibial	REEP5	0.17	0.12	lasso	5	0.13	3.0e-10	5.2	5.5	3.3e-08	-0.58	0.56	0.44	FALSE
10	GTEx	Esophagus Muscularis	REEP5	0.18	0.09	lasso	4	0.14	5.9e-09	5.7	5.4	6.5e-08	-0.68	0.43	0.57	FALSE
15	GTEx	Skin Sun Exposed Lower leg	REEP5	0.08	0.05	lasso	4	0.03	1.9e-03	5.5	5.4	6.6e-08	-0.70	0.18	0.80	FALSE
11	GTEx	Nerve Tibial	REEP5	0.16	0.13	lasso	3	0.10	9.2e-08	5.2	5.4	7.5e-08	-0.59	0.86	0.13	FALSE
6	GTEx	Cells Transformed fibroblasts	CTC-487M23.5	0.07	0.03	lasso	3	0.03	2.9e-03	-4.0	-5.3	9.3e-08	0.66	0.03	0.90	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.5	0.10	0.06	lasso	3	0.05	6.7e-04	5.5	5.3	1.2e-07	-0.56	0.19	0.50	FALSE
19	METSIM	Adipose	REEP5	0.05	0.00	bslmm	475	0.01	6.8e-03	5.9	5.2	1.5e-07	-0.63	0.17	0.75	FALSE