TWAS hub - SRP19

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0260	1.9e-07	0.058	0.064	0.064	0.062	0.067	1.3e-07	3.2e-08	2.7e-08	4.5e-08	1.3e-08
2	YFS	Blood	0.0169	0.0081	4.0e-03	0.006	0.002	0.002	0.003	0.001	4.0e-03	5.7e-02	5.8e-02	2.9e-02	1.6e-01
3	TCGA	Brain Lower Grade Glioma	0.0529	0.0327	3.5e-05	0.038	0.034	0.029	NA	0.038	3.3e-05	8.4e-05	2.6e-04	NA	3.7e-05
4	TCGA	Liver Hepatocellular Carcinoma	0.1010	0.0690	9.6e-03	0.015	0.015	0.000	NA	0.005	6.3e-02	6.2e-02	3.2e-01	NA	1.8e-01
5	TCGA	Prostate Adenocarcinoma	0.0516	0.0292	2.8e-04	0.053	0.036	0.047	NA	0.051	3.0e-06	1.1e-04	1.1e-05	NA	4.6e-06
6	TCGA	Soft Tissue Sarcoma	0.0720	0.0490	8.5e-03	0.033	0.010	0.008	NA	0.020	4.5e-03	7.9e-02	1.1e-01	NA	2.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Reaction Time	16.1	30.6	33.4	-5.5	5.7	-5.5	-4.9	-5.8	-5.7
Mean time to correctly identify matches	14.2	27.1	30.8	-5.4	4.9	-5.6	-4.3	-5.5	-5.5
Number of treatments/medications taken	5.7	10.2	12.3	-2.8	3.3	-2.6	-3.5	-3.4	-3.4
Knee pain experienced in last month	5.5	8.5	9.5	-2.7	3.1	-2.9	-2.9	-2.9	-2.9
Osteoporosis (self-reported)	5.5	6.8	7.5	2.5	-2.6	2.4	2.7	2.7	2.7
Hair/balding pattern: Pattern 2	5.4	6.9	8.8	-2.3	2.5	-2.4	-3.0	-2.8	-2.8
Pulse wave Arterial Stiffness index	5.4	6.3	13.0	-3.1	1.4	-3.6	-1.5	-2.4	-2.3
Guilty feelings	5.4	8.2	11.0	3.3	-1.9	3.2	3.0	2.8	2.7
Peak expiratory flow (PEF)	5.3	12.4	15.4	2.9	-3.6	2.9	3.7	3.9	3.9
Chest pain or discomfort	5.2	7.5	10.0	-2.7	1.8	-2.6	-2.7	-3.2	-3.2
Ever used hormone-replacement therapy (HRT)	4.9	6.2	9.2	-1.4	3.0	-1.7	-2.8	-2.7	-2.7
Heel T-Score	4.7	37.7	42.5	-6.5	5.7	-6.4	-5.2	-6.5	-6.4
Other serious medical condition/disability diagnosed by doctor	4.7	6.1	7.6	-2.2	1.8	-2.4	-2.8	-2.7	-2.7
Medication for pain relief, constipation, heartburn	4.6	7.8	10.4	3.1	-3.2	2.9	2.4	2.6	2.5
Leg pain on walking	4.6	5.8	12.1	-1.5	3.5	-1.3	-2.5	-2.4	-2.5
Number of self-reported non-cancer illnesses	4.5	7.8	11.5	-2.3	2.6	-2.3	-3.4	-3.0	-3.0
Pulse wave peak to peak time	4.2	5.0	10.9	2.8	-1.2	3.3	1.2	2.1	2.0
Arm fat-free mass (left)	4.1	21.0	31.8	-5.6	4.1	-5.6	-3.9	-4.0	-3.9
Arm predicted mass (left)	4.0	20.4	30.9	-5.6	4.2	-5.5	-3.8	-3.8	-3.8
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	6.0	-2.5	2.2	-2.2	-1.8	-2.3	-2.2
Arm fat-free mass (right)	3.9	20.0	31.5	-5.5	3.9	-5.6	-3.6	-3.9	-3.8
Medication: Ibuprofen	3.9	4.7	5.3	-2.1	2.0	-2.1	-2.2	-2.3	-2.3
Hearing aid user	3.9	4.4	7.4	-2.7	2.1	-2.5	-1.7	-1.6	-1.6
Trunk fat-free mass	3.7	21.2	31.8	-5.6	4.1	-5.6	-3.9	-4.0	-4.0
Trunk predicted mass	3.7	21.1	31.9	-5.7	4.0	-5.6	-3.9	-4.0	-4.0
Arm predicted mass (right)	3.7	19.0	29.9	-5.4	3.7	-5.5	-3.5	-3.9	-3.8
Whole body water mass	3.6	20.6	32.3	-5.7	4.2	-5.6	-3.6	-3.9	-3.7
Miserableness	3.6	6.2	12.9	-1.9	3.6	-1.6	-2.4	-2.5	-2.5
Depressed Affect (Nagel 2018)	3.5	7.3	9.4	-2.1	2.8	-2.0	-3.0	-3.0	-3.1
Whole body fat-free mass	3.5	20.1	32.5	-5.7	4.1	-5.7	-3.5	-3.7	-3.6
Basal metabolic rate	3.5	19.6	32.0	-5.7	4.2	-5.6	-3.3	-3.6	-3.5
Glaucoma (self-reported)	3.4	4.0	8.0	1.2	-2.8	1.2	2.5	1.9	1.9
Supplements: Glucosamine	3.3	4.3	5.2	-2.3	1.6	-2.2	-1.7	-2.3	-2.3
Illnesses of siblings	3.2	4.4	5.9	1.6	-2.2	1.6	2.2	2.4	2.4
Ever had bowel cancer screening	3.2	3.8	5.8	-1.7	1.5	-1.6	-1.8	-2.4	-2.4
Cardiovascular Disease	3.1	10.3	12.0	-3.1	2.7	-3.1	-3.5	-3.4	-3.4
Illnesses of mother	3.1	3.9	5.9	2.0	-2.4	1.9	1.4	2.0	2.0
Mood swings	3.1	5.6	10.5	-1.8	3.2	-1.6	-2.4	-2.4	-2.4
Financial situation satisfaction	3.1	3.9	8.7	-1.1	1.4	-1.2	-2.9	-2.2	-2.3
Diabetes (father)	3.0	3.7	5.0	-2.2	1.2	-2.1	-1.9	-2.0	-2.0
Sitting height	2.9	20.6	28.6	-5.1	5.3	-4.7	-3.7	-4.1	-4.0
Nervous feelings	2.9	5.3	6.2	2.4	-2.0	2.5	2.4	2.3	2.3
Breastfed as a baby	2.9	3.6	4.4	-1.8	2.1	-2.0	-1.6	-1.9	-1.9
Medication: Bendroflumethiazide	2.9	4.4	6.5	-2.3	2.0	-2.6	-1.6	-2.0	-2.0
Number of operations (self-reported)	2.9	4.2	5.7	-2.2	1.7	-2.4	-2.1	-1.9	-1.9
Leg fat-free mass (left)	2.8	14.8	25.4	-5.0	3.8	-5.0	-2.7	-2.9	-2.8
Leg predicted mass (left)	2.8	14.7	25.5	-5.0	3.8	-5.0	-2.7	-2.9	-2.8
Worry (Nagel 2018)	2.7	5.7	8.3	2.8	-1.6	2.9	2.0	2.4	2.4
Ever had hysterectomy (womb removed)	2.7	3.0	4.5	-1.9	2.0	-2.1	-0.8	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	6.3	-1.5	2.2	-1.4	-2.2	-2.5	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	9.0	-1.6	3.0	-1.4	-2.1	-1.8	-1.9
Severe depression (siblings)	2.6	2.9	5.0	-1.4	1.9	-1.5	-2.2	-1.5	-1.5
Weight	2.6	13.0	21.2	-4.6	4.0	-4.6	-2.5	-2.7	-2.6
Worrier / anxious feelings	2.6	5.0	7.1	2.5	-1.7	2.7	1.8	2.3	2.3
Hypertension (Self-reported)	2.6	7.3	10.3	-2.6	3.2	-2.7	-2.4	-2.6	-2.6
Diastolic blood pressure, automated reading	2.6	8.1	12.1	-3.0	3.5	-3.0	-2.7	-2.4	-2.4
BMI	2.5	14.6	28.6	-5.2	3.2	-5.3	-2.6	-2.8	-2.7
Smoking Status	2.5	5.9	7.0	-2.6	2.5	-2.5	-1.6	-2.6	-2.6
Respiratory disease	2.5	5.5	9.3	-3.1	0.2	-2.7	-2.5	-2.2	-2.2
Pain all over the body in last month	2.5	2.7	3.9	-1.6	0.9	-1.6	-2.0	-1.7	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	4.2	-1.7	1.9	-2.0	-1.8	-1.7	-1.6
Vascular/heart problems diagnosed by doctor	2.5	6.9	7.7	2.6	-2.6	2.5	2.6	2.8	2.7
Arm fat mass (right)	2.4	9.9	17.0	-4.1	3.6	-4.1	-2.1	-2.1	-2.0
High blood pressure (siblings)	2.4	3.4	5.8	-0.9	2.4	-1.1	-2.2	-2.0	-2.0
Osteoarthritis (self-reported)	2.4	3.1	5.1	-1.6	2.2	-1.8	-1.2	-1.8	-1.8
Risk taking	2.4	3.5	4.5	-2.1	1.0	-1.9	-2.0	-1.9	-2.0
Fractured/broken bones in last 5 years	2.4	3.1	5.3	1.4	-1.4	1.5	1.4	2.3	2.3
Pain experienced in last month	2.4	4.0	6.7	2.5	-1.5	2.6	1.5	1.9	1.8
High blood pressure	2.3	6.4	8.6	-2.6	2.9	-2.6	-2.2	-2.4	-2.4
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	6.6	-1.0	2.6	-1.1	-2.2	-2.0	-2.0
Alcohol intake versus 10 years previously	2.3	3.4	5.3	-2.0	0.8	-2.1	-2.3	-1.8	-1.8
Height	2.2	42.9	53.2	-7.2	7.3	-7.0	-4.7	-6.4	-6.3
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	5.4	2.3	-0.9	2.3	0.7	1.2	1.2
Mouth/teeth dental problems: Dentures	2.2	3.7	5.1	-1.5	2.1	-1.2	-2.3	-2.1	-2.1
Leg fat-free mass (right)	2.2	11.8	21.4	-4.6	3.5	-4.6	-2.1	-2.5	-2.4
Leg predicted mass (right)	2.2	11.9	21.6	-4.7	3.5	-4.6	-2.1	-2.5	-2.4
Medication: Co-codamol	2.1	2.4	3.3	-1.6	1.4	-1.5	-1.1	-1.8	-1.8
Fed-up feelings	2.1	3.8	6.1	-1.5	2.5	-1.6	-1.9	-2.0	-2.0
Impedance of arm (left)	2.1	9.9	17.6	4.2	-1.2	4.2	2.8	2.8	2.7
Eye problems/disorders: None of the above	2.1	2.5	5.1	-0.4	2.3	-0.4	-2.0	-1.6	-1.7
Systolic blood pressure, automated reading	2.0	5.8	8.3	-2.2	2.9	-2.2	-2.5	-2.3	-2.3
Stomach or abdominal pain in last month	2.0	2.5	4.0	-1.2	1.0	-0.9	-1.9	-2.0	-2.0
Waist circumference	2.0	7.4	13.3	-3.5	3.1	-3.7	-1.8	-1.7	-1.6
Financial difficulties in last 2 years	2.0	2.7	5.5	-1.0	2.4	-0.6	-1.9	-1.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	5.7	2.2	-2.4	2.2	2.0	1.8	1.8
Ovarian Cancer	1.9	2.5	6.1	-2.5	0.6	-2.4	-0.8	-1.1	-1.0
Qualifications: None of the above	1.9	4.0	6.0	-1.3	2.2	-1.2	-2.1	-2.4	-2.5
Impedance of arm (right)	1.9	9.0	16.7	4.0	-1.0	4.1	2.4	2.7	2.6
Leg fat mass (right)	1.9	7.4	14.3	-3.7	2.4	-3.8	-2.0	-1.9	-1.8
Comparative height size at age 10	1.9	10.7	12.1	-3.3	3.3	-3.4	-2.7	-3.5	-3.4
Medication: Aspirin	1.9	2.5	4.0	-1.0	1.4	-0.9	-1.7	-2.0	-2.0
Arm fat mass (left)	1.9	7.8	14.1	-3.7	3.1	-3.8	-1.8	-1.8	-1.7
Age started oral contraceptive pill	1.9	2.3	4.2	2.0	-1.6	1.8	0.8	1.3	1.3
Alzheimer’s Disease (including proxy)	1.8	2.6	3.8	1.9	-1.5	1.7	1.3	1.6	1.6
Hypothyroidism (self reported)	1.8	4.1	5.6	-2.4	0.7	-2.2	-2.3	-2.1	-2.1
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	4.9	0.7	-1.8	0.7	2.2	2.0	2.0
Whole body fat mass	1.8	7.6	13.1	-3.5	3.1	-3.6	-1.9	-1.8	-1.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.1	-1.8	0.8	-1.2	-1.5	-1.6	-1.6
Ever taken oral contraceptive pill	1.8	2.0	4.0	-2.0	0.1	-1.7	-0.8	-1.5	-1.5
Medication: Blood pressure	1.8	3.4	6.5	-2.3	0.7	-2.5	-1.3	-1.8	-1.8
Multivitamins +/- minerals	1.7	2.1	4.5	-2.1	1.0	-2.1	-0.8	-1.1	-1.0
High blood pressure (mother)	1.7	2.4	4.1	-1.1	2.0	-1.3	-1.5	-1.6	-1.6
Number of incorrect matches in round	1.7	2.8	4.5	2.1	-0.2	2.1	1.6	1.6	1.6
Exposure to tobacco smoke at home	1.7	1.9	2.7	-1.7	0.7	-1.6	-1.0	-1.5	-1.5
Health satisfaction	1.7	2.2	3.9	-1.3	0.9	-1.2	-2.0	-1.7	-1.7
Long-standing illness, disability or infirmity	1.7	2.6	3.5	-1.1	1.7	-1.2	-1.9	-1.8	-1.9
Medication: Gliclazide	1.7	1.9	6.0	-0.8	2.5	-0.9	-0.8	-1.3	-1.3
Leg fat mass (left)	1.7	6.6	12.5	-3.4	2.4	-3.5	-1.8	-1.8	-1.7
HbA1C	1.6	1.8	5.2	-0.3	2.3	-0.5	-0.8	-1.4	-1.5
Trunk fat mass	1.6	7.0	11.0	-3.2	3.3	-3.3	-1.8	-1.9	-1.8
Pulse rate	1.6	2.6	6.2	-2.4	0.6	-2.5	-0.3	-1.4	-1.3
Medication: Cholesterol lowering	1.6	2.6	4.3	-0.4	1.5	-0.4	-2.1	-2.1	-2.1
Age at last live birth	1.6	2.3	3.8	1.0	-1.9	1.0	1.3	1.8	1.8
Commuting to job workplace: Public transport	1.6	1.9	3.3	0.3	-1.5	0.0	1.8	1.6	1.7
Illnesses of father: High blood pressure	1.6	1.9	3.9	-2.0	0.5	-2.0	-1.1	-1.1	-1.1
Ever smoked	1.6	2.8	4.5	-1.4	1.6	-1.5	-1.2	-2.1	-2.1
Cholesterol lowering medication	1.6	2.3	4.4	-0.9	0.5	-0.9	-1.9	-2.1	-2.1
Lung FEV1/FVC ratio	1.5	7.5	10.8	2.5	-2.3	2.4	3.3	2.9	2.9
Vitamin and mineral supplements	1.5	2.0	4.5	2.1	-0.6	2.1	0.9	1.0	1.0
Taking other prescription medications	1.5	2.4	3.0	-1.1	1.7	-1.1	-1.7	-1.7	-1.7
Standing height	1.5	14.9	26.7	-3.6	5.2	-3.5	-3.1	-3.8	-3.7
Neck or shoulder pain in last month	1.5	2.1	4.5	-2.1	1.1	-2.0	-0.3	-1.1	-1.1
Medication for cholesterol	1.5	2.3	3.1	1.6	-0.7	1.7	1.2	1.8	1.7
Medication: Aspirin	1.5	1.9	3.5	-0.6	1.2	-0.6	-1.6	-1.9	-1.9
Medication: Atorvastatin	1.5	1.9	2.8	-1.0	1.7	-1.0	-1.1	-1.6	-1.6
Irritability	1.5	2.6	4.4	-1.6	0.9	-1.2	-2.1	-1.8	-1.8
Impedance of whole body	1.5	7.6	15.4	3.9	-1.4	3.9	2.1	2.1	2.1
Schizophrenia vs Biploar Disorder	1.4	1.9	4.0	2.0	0.5	1.6	1.3	1.1	1.1
Crohns Disease (2017)	1.4	3.1	6.3	-1.3	1.0	-1.4	-2.5	-2.0	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	4.0	-1.9	1.0	-1.9	-1.8	-2.0	-2.0
Hip circumference	1.4	5.9	12.2	-3.5	2.4	-3.3	-1.5	-1.4	-1.4
Shortness of breath walking on level ground	1.4	1.7	3.0	-1.2	0.3	-1.0	-1.7	-1.5	-1.5
Schizophrenia (2018)	1.3	2.7	4.4	2.1	-1.3	2.0	1.2	1.5	1.5
Diabetes (mother)	1.3	1.7	4.0	-0.6	2.0	-0.7	-1.4	-1.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.7	-0.3	1.9	-0.3	-1.7	-1.3	-1.4
Falls in the last year	1.3	1.7	4.0	-1.3	0.1	-1.1	-2.0	-1.3	-1.3
Suffer from ‘nerves’	1.3	2.0	2.7	1.6	-0.7	1.4	1.3	1.6	1.6
High cholesterol (Self-reported)	1.3	2.3	4.5	-0.5	1.0	-0.6	-2.1	-2.0	-2.0
Ulcerative Colitis	1.2	1.8	3.4	1.2	-1.8	1.1	0.8	1.4	1.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.6	-0.8	2.1	-1.2	-0.2	-0.9	-0.8
Leg fat percentage (right)	1.2	4.2	9.1	-2.9	1.5	-3.0	-1.5	-1.3	-1.2
Worry too long after embarrassment	1.2	2.0	7.2	0.9	-2.7	1.0	0.8	1.0	1.0
Medication: Blood pressure	1.2	2.1	4.0	-0.6	2.0	-0.6	-1.7	-1.6	-1.6
Eye problems/disorders: Cataract	1.2	1.4	3.4	0.1	-1.3	0.2	1.8	1.3	1.3
Alzheimer’s Disease (in father)	1.1	1.2	1.9	1.4	-1.2	1.0	0.7	1.1	1.1
Sensitivity / hurt feelings	1.1	1.9	3.6	1.9	-0.0	1.9	0.8	1.4	1.3
Supplements: Zinc	1.1	1.2	1.6	-1.0	0.8	-1.2	-0.9	-1.3	-1.2
Age when periods started (menarche)	1.1	2.5	4.5	-1.0	0.7	-0.7	-2.0	-2.1	-2.1
Body mass index (BMI)	1.1	4.8	11.0	-3.2	1.9	-3.3	-1.3	-1.1	-1.1
Hair/balding pattern: Pattern 3	1.1	1.6	2.2	1.4	-0.5	1.5	1.1	1.4	1.4
Medication: Paracetamol	1.1	1.8	5.6	-1.5	2.4	-1.2	-1.2	-0.3	-0.3
Gout (self-reported)	1.1	1.5	3.1	-1.0	1.8	-0.8	-1.3	-1.1	-1.1
Number of full brothers	1.1	1.3	2.6	1.6	0.9	1.4	0.6	1.1	1.0
Eye problems/disorders: Glaucoma	1.1	1.3	2.0	0.9	-1.4	1.0	1.4	1.1	1.1
Lupus	1.0	1.5	2.2	0.8	-1.3	1.0	1.0	1.5	1.5
Triglycerides	1.0	1.6	2.2	-1.2	1.1	-1.0	-1.3	-1.5	-1.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	7.0	-0.8	2.7	-0.9	-1.0	-0.9	-0.9
Townsend deprivation index at recruitment	1.0	1.3	2.4	-0.7	1.6	-0.8	-1.2	-1.2	-1.2
Current tobacco smoking	1.0	1.7	3.1	-1.0	1.8	-1.0	-0.7	-1.5	-1.5
Medication: Simvastatin	1.0	1.4	3.0	0.1	0.9	0.0	-1.7	-1.6	-1.6
Time employed in main current job	1.0	1.2	3.4	1.0	-1.8	0.8	0.8	0.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.6	1.2	-0.6	1.3	1.0	1.1	1.1
Medication: Lansoprazole	1.0	1.1	2.1	-0.8	0.7	-0.5	-1.0	-1.4	-1.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.9	-0.8	1.2	-0.9	-1.4	-1.1	-1.1
Emphysema/chronic bronchitis	1.0	1.1	1.6	-1.3	1.1	-1.1	-0.5	-1.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	1.7	1.2	-0.9	1.0	0.9	1.3	1.3
Loneliness, isolation	1.0	1.3	2.2	-0.1	1.3	0.2	-1.4	-1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.7	2.2	0.6	2.1	-0.3	0.4	0.4
Medication: Paracetamol	1.0	1.6	4.8	-0.9	2.2	-0.6	-1.7	-0.6	-0.7
Medication: Lisinopril	1.0	1.3	2.7	-1.5	0.9	-1.6	-0.7	-0.9	-0.9
Myopia	1.0	1.4	3.8	0.4	-1.9	0.4	1.3	1.1	1.2
Supplements: Calcium	1.0	1.1	2.4	0.3	-1.6	0.1	0.7	1.4	1.4
Relative age of first facial hair	0.9	1.8	5.3	-0.1	2.3	0.1	-1.7	-1.1	-1.1
Medication: Levothyroxine sodium	0.9	1.6	2.9	-1.4	-0.2	-1.4	-1.7	-1.2	-1.2
Impedance of leg (left)	0.9	4.1	9.7	3.1	-1.3	3.1	1.1	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.7	-2.0	0.5	-2.2	-1.0	-1.2	-1.1
Arm fat percentage (right)	0.9	3.4	6.9	-2.6	2.2	-2.6	-1.0	-0.8	-0.8
Noisy workplace	0.9	1.1	2.1	-1.5	1.2	-1.4	-0.5	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.9	0.3	-1.2	0.2	1.7	1.1	1.1
Smoking status: Current	0.9	1.4	3.8	-0.7	2.0	-0.7	-0.6	-1.3	-1.3
Average weekly beer plus cider intake	0.9	1.2	4.0	1.1	-2.0	1.3	-0.1	0.5	0.4
Bipolar Disorder or Schizophrenia	0.8	1.8	3.3	1.6	-1.3	1.8	0.9	1.2	1.1
Body Mass Index (BMI) (2010)	0.8	1.2	2.5	-1.6	1.1	-1.4	-0.4	-0.7	-0.7
LDL Cholesterol	0.8	1.2	3.0	-0.5	0.6	-0.7	-1.7	-1.3	-1.3
Trunk fat percentage	0.8	3.0	6.8	-2.0	2.6	-2.1	-1.0	-1.0	-0.9
Maternal smoking around birth	0.8	1.2	2.5	-1.1	1.6	-1.0	-1.2	-0.8	-0.7
Depression (self-reported)	0.8	1.0	2.9	-1.0	1.7	-0.9	-0.9	-0.4	-0.5
Prospective memory result	0.8	1.0	1.4	-0.7	1.0	-1.2	-1.0	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.6	-1.2	-0.1	-1.1	-1.9	-1.2	-1.3
Body fat percentage	0.8	3.1	5.1	-2.2	2.3	-2.3	-1.1	-1.0	-1.0
Wheeze or whistling in the chest in last year	0.8	1.5	2.4	-1.5	1.0	-1.3	-1.2	-1.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.2	-1.1	1.5	-1.1	0.0	-0.8	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.3	-1.0	0.2	-0.9	-1.5	-1.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-1.4	0.0	-1.5	-1.0	-0.5	-0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	1.4	0.3	1.4	-0.0	1.0	1.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	-1.6	-0.5	-1.5	-0.3	-0.5	-0.5
Prostate Cancer	0.7	1.0	2.3	1.5	0.6	1.4	0.9	0.4	0.4
Age at First Birth	0.7	1.0	3.8	1.1	-1.9	0.9	0.1	0.4	0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	-0.7	0.7	-0.8	-1.4	-0.8	-0.8
Blood White Count	0.7	5.5	7.2	-1.9	2.7	-1.4	-2.6	-2.6	-2.6
Systolic Blood Pressure	0.7	3.4	7.2	-1.3	2.7	-1.2	-1.9	-1.8	-1.8
Pack years adult smoking proportion	0.7	1.0	4.2	-0.6	2.0	-0.2	-0.8	-0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.0	-0.2	1.4	-0.2	-1.4	-0.8	-0.9
Fluid intelligence score	0.7	1.6	3.2	0.7	-1.8	0.9	1.2	1.3	1.3
Medication: Amlodipine	0.7	1.0	1.6	-1.2	1.3	-1.3	-0.3	-0.7	-0.7
Qualifications: College or University degree	0.7	2.1	5.0	-0.1	-2.2	-0.2	1.6	1.5	1.5
Medication: Allopurinol	0.7	0.9	2.5	1.4	0.8	1.6	-0.0	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.6	-1.1	1.6	-0.5	-1.6	-0.9	-1.0
Asthma (self-reported)	0.7	1.5	3.8	-1.9	-0.5	-1.7	-1.1	-0.6	-0.6
Wears glasses or contact lenses	0.7	0.8	1.4	-1.2	-0.1	-1.0	-0.7	-0.9	-0.9
Leg fat percentage (left)	0.7	2.6	6.2	-2.3	1.2	-2.5	-0.8	-0.9	-0.8
Major Depression (MDD)	0.6	0.7	1.5	-0.8	-0.7	-0.5	1.2	0.8	0.8
Rheumatoid Arthritis	0.6	0.8	1.3	-1.0	0.0	-0.7	-1.2	-1.0	-1.0
Schizophrenia (2014)	0.6	1.2	2.5	1.6	-0.8	1.4	0.8	1.0	0.9
Waist Hip Ratio (WHR)	0.6	2.9	6.2	-0.9	2.5	-1.2	-1.7	-1.8	-1.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.6	-0.0	1.6	0.0	-1.0	-0.7	-0.7
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-1.0	1.3	-1.0	-0.7	-0.9	-0.9
Relative age voice broke	0.6	0.9	3.4	0.0	1.8	0.3	-0.9	-0.8	-0.8
Past tobacco smoking	0.6	1.1	1.5	0.9	-1.2	0.8	0.7	1.2	1.2
Asthma	0.6	1.2	3.2	-1.8	-0.9	-1.5	-0.8	-0.3	-0.3
Loud music exposure frequency	0.6	0.7	1.1	0.1	-1.0	-0.0	0.8	1.0	1.1
Angina (self-reported)	0.6	0.8	3.5	0.2	-1.9	0.2	0.8	0.4	0.4
Illnesses of father: Heart disease	0.6	0.8	1.8	-0.8	-0.9	-0.6	1.3	0.8	0.8
Arm fat percentage (left)	0.6	2.4	5.2	-2.2	1.9	-2.3	-0.6	-0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	4.2	0.4	-2.0	0.2	0.0	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	-1.0	0.9	-1.3	-0.9	-0.6	-0.6
Pack years of smoking	0.6	0.9	3.1	-0.7	1.8	-0.2	-0.9	-0.7	-0.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	1.2	-0.1	1.1	0.7	0.5	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.8	-0.3	-1.7	-0.1	1.5	1.1	1.1
Mean Putamen Volume	0.5	0.6	1.7	1.2	-0.1	1.3	0.1	0.3	0.2
Lung FVC	0.5	2.7	6.9	0.4	-2.6	0.4	1.7	1.7	1.7
Chronotype (morning person)	0.5	1.2	2.8	0.3	1.7	-0.1	-1.2	-1.2	-1.3
Angina	0.5	0.6	2.8	0.3	-1.7	0.3	0.6	0.3	0.3
Average weekly fortified wine intake	0.5	0.6	1.1	-0.4	1.0	-0.6	-0.4	-1.0	-1.0
Had other major operations	0.5	0.7	1.5	-0.8	0.3	-1.2	-0.6	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.6	0.9	-1.2	0.8	1.6	1.5	1.5
Happiness	0.5	0.6	1.6	1.3	0.2	1.0	0.3	0.6	0.6
Headache pain in last month	0.5	0.9	2.3	-1.5	0.3	-1.5	-0.5	-0.6	-0.6
Birth weight	0.5	1.1	1.4	-1.1	0.7	-1.1	-1.0	-1.2	-1.2
Heart disease (mother)	0.5	0.6	1.9	0.9	1.4	0.9	-0.3	-0.3	-0.3
Ulcerative Colitis (UC)	0.4	0.8	1.3	0.9	-1.1	1.0	0.4	0.9	0.9
Crohns Disease (2012)	0.4	0.6	1.7	-0.6	0.3	-0.6	-1.3	-0.7	-0.7
Primary Biliary Cirrhosis	0.4	0.6	2.0	0.7	1.4	1.0	-0.4	0.3	0.3
Impedance of leg (right)	0.4	2.1	5.8	2.4	-0.7	2.4	0.1	0.7	0.6
Mouth/teeth dental problems	0.4	0.6	1.6	0.2	-1.0	0.1	1.2	0.7	0.8
Allergy	0.4	0.8	2.5	1.6	-0.2	1.6	-0.3	-0.1	-0.1
Number of live births	0.4	0.6	1.0	-1.0	-0.1	-1.0	-0.9	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.0	-0.2	-1.4	-0.2	0.9	1.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.8	0.7	-1.3	0.6	1.2	1.4	1.4
Length of working week for main job	0.4	0.4	0.9	-0.9	-0.6	-0.9	0.7	0.2	0.2
Hair/balding pattern: Pattern 4	0.4	0.9	2.6	-1.6	0.3	-1.6	0.4	-0.4	-0.4
Blood clot in the leg (DVT)	0.4	0.6	1.2	-0.7	0.8	-1.1	-0.8	-0.4	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	-0.3	1.1	-0.0	-0.9	-0.5	-0.5
Number of children fathered	0.4	0.4	1.0	0.4	1.0	0.7	0.3	0.6	0.6
Pulse rate, automated reading	0.4	1.4	3.2	-1.8	0.8	-1.8	-0.2	-0.9	-0.9
Overall health rating	0.4	0.9	1.2	-1.0	1.0	-1.1	-0.6	-1.0	-1.0
Had major operations	0.4	0.4	2.0	0.4	1.4	0.5	0.1	0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	0.8	1.1	0.8	0.0	-0.1	-0.1
Average weekly red wine intake	0.4	0.6	1.6	-1.0	-0.5	-1.3	0.6	0.2	0.2
Diabetes diagnosed by doctor	0.4	0.7	3.6	-0.3	1.9	-0.6	-0.4	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.1	-0.3	1.4	-0.3	-0.2	-0.6	-0.6
Alcohol drinker status: Previous	0.4	0.5	1.4	-1.0	1.2	-0.7	0.2	-0.0	0.0
Neuroticism (2016)	0.3	0.4	0.8	0.2	0.9	0.5	0.0	-0.8	-0.8
Blood Eosinophil Count	0.3	2.4	4.6	-1.4	2.1	-1.3	-1.5	-1.3	-1.3
Average weekly spirits intake	0.3	0.4	0.9	-0.7	1.0	-0.5	-0.0	-0.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.7	-1.0	0.5	0.2	0.0	0.0
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.2	-0.0	-0.5	-1.0	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.5	-1.0	-0.8	-0.5	-0.3	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.9	-0.2	0.7	0.7	0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.1	-1.0	0.0	0.6	0.6	0.7
Alcohol intake frequency.	0.3	0.6	1.5	-0.7	1.2	-0.6	-1.1	-0.3	-0.3
Qualifications: nursing, teaching	0.3	0.5	1.2	-0.9	-1.1	-0.9	0.2	0.3	0.3
Mineral and other dietary supplements	0.3	0.4	0.8	0.9	-0.5	0.8	-0.1	0.6	0.6
Breast cancer (self-reported)	0.3	0.4	2.2	-0.2	-1.5	-0.2	-0.4	-0.0	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.9	0.7	-0.9	-0.3	-0.5	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.2	-0.3	1.1	-0.2	-0.2	-0.4	-0.4
Ever depressed for a whole week	0.3	0.3	1.8	0.2	1.3	0.3	-0.2	-0.1	-0.1
Unable to work because of sickness or disability	0.3	0.4	0.7	0.7	0.7	0.9	-0.6	-0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.7	0.6	-0.9	-0.3	-0.3	-0.3
Depression (Nagel 2018)	0.2	0.3	0.7	0.5	0.9	0.4	-0.4	-0.4	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.4	-1.1	-1.2	-1.1	0.4	-0.1	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	1.1	0.9	-0.4	1.1	0.2	0.5	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-0.3	-0.2	-0.3	-1.4	-0.7	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.2	-0.2	-0.1	-0.7	-0.5	-0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.0	0.8	0.3	-0.7	0.1	0.1
Tanning	0.2	2.4	3.5	-1.9	0.7	-1.8	-1.6	-1.6	-1.5
Hand grip strength (left)	0.2	0.5	0.9	0.7	0.4	0.7	1.0	0.7	0.7
Medication: Metformin	0.2	0.2	0.6	-0.4	0.8	-0.6	-0.3	-0.3	-0.3
Had menopause	0.2	0.2	1.1	-0.1	-1.1	-0.1	0.1	0.0	0.0
Heart attack	0.2	0.3	1.1	0.4	-1.0	0.4	0.1	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.8	0.2	-0.6	0.3	0.2	0.2
Neuroticism score	0.2	0.3	1.0	0.8	0.4	1.0	-0.1	0.1	0.1
Father’s age at death	0.2	0.3	0.7	0.7	-0.5	0.8	0.7	0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.3	-0.3	0.6	0.2	0.7	0.7
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.4	-0.4	0.4	0.6	0.5	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	0.1	-0.3	-0.4	-0.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.6	-0.7	0.6	-0.1	-0.1	-0.2
Family relationship satisfaction	0.2	0.3	0.9	0.1	0.7	0.2	-1.0	-0.2	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.5	0.7	0.5	0.4	-0.3	-0.0	-0.1
Back pain experienced in last month	0.2	0.2	0.6	-0.6	0.8	-0.4	-0.2	-0.3	-0.3
Mother’s age at death	0.2	0.3	0.7	-0.2	-0.8	-0.1	0.1	-0.6	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.1	-0.3	-0.1	0.7	0.7	0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.2	-0.5	0.1	-0.5	-0.7	-0.7
Fasting Glucose	0.1	0.1	0.4	-0.3	0.3	-0.7	0.1	-0.1	-0.0
HDL Cholesterol	0.1	0.2	0.4	0.5	0.5	0.4	-0.3	-0.6	-0.6
Allergy or Eczema	0.1	0.2	0.8	-0.4	0.9	-0.4	0.5	-0.2	-0.2
Neuroticism	0.1	0.2	0.8	0.6	0.0	0.9	-0.4	-0.2	-0.3
Hand grip strength (right)	0.1	0.3	1.6	-0.2	1.3	-0.1	0.5	0.2	0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.6	0.3	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	-0.4	0.2	-0.4	1.0	0.4	0.4
Medication: Atenolol	0.1	0.2	0.2	-0.2	-0.5	-0.4	-0.5	-0.5	-0.5
Alcohol usually taken with meals	0.1	0.1	0.3	-0.5	0.5	-0.5	0.2	-0.0	0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	0.2	-0.5	-0.4	-0.5	-0.5
Diabetes (self-reported)	0.1	0.2	1.0	0.3	1.0	-0.1	0.1	0.2	0.2
Medication: Ramipril	0.1	0.2	0.8	-0.1	-0.9	0.0	0.3	0.1	0.2
Lung cancer (father)	0.1	0.1	0.4	0.5	0.6	0.4	-0.1	-0.0	-0.0
Tense / ‘highly strung’	0.1	0.1	0.3	-0.4	0.1	-0.3	-0.6	-0.1	-0.1
Pulse wave reflection index	0.1	0.2	0.5	-0.4	-0.2	-0.5	-0.7	-0.2	-0.2
Age at first live birth	0.1	0.1	0.3	0.6	0.1	0.4	0.0	0.2	0.2
Migraine (self-reported)	0.1	0.1	0.4	0.6	-0.0	0.2	0.4	0.2	0.3
Medication: Omeprazole	0.1	0.1	0.3	-0.5	0.4	-0.6	-0.3	-0.1	-0.0
Supplements: Vitamin C	0.1	0.1	0.5	-0.4	-0.3	-0.7	0.3	0.1	0.1
Friendships satisfaction	0.1	0.1	0.4	-0.6	-0.1	-0.6	-0.1	0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	-0.3	0.3	-0.3	0.7	0.3	0.3
Alcohol drinker status: Never	0.1	0.2	0.5	-0.0	0.0	-0.1	0.7	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.7	0.2	-0.9	0.2	-0.1	0.1	0.2
Heart disease (siblings)	0.1	0.2	0.4	0.1	-0.2	-0.2	-0.5	-0.6	-0.6
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.1	-0.6	0.4	0.0	0.0	-0.0
Breast Cancer	0.0	0.1	0.2	0.2	-0.1	0.4	0.1	0.2	0.2
Blood Platelet Count	0.0	0.2	0.4	0.2	-0.0	0.0	-0.4	-0.6	-0.6
Blood Red Count	0.0	0.2	0.3	0.5	0.1	0.3	0.1	0.6	0.6
Hair Pigment	0.0	0.6	1.2	-0.6	0.5	-0.6	-0.7	-1.1	-1.1
Medication for hormone replacement therapy	0.0	0.1	0.1	-0.3	0.1	-0.3	0.2	-0.2	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.4	0.1	-0.4	-0.0	-0.0	-0.0
Birth weight of first child	0.0	0.0	0.1	-0.0	0.0	-0.3	0.2	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.1	0.0	0.3	0.2	-0.1	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	-0.5	-0.2	-0.5	0.0	0.1	0.1
Comparative body size at age 10	0.0	0.1	0.1	-0.3	-0.0	-0.4	0.3	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.2	-0.3	-0.0	-0.0	0.2	0.3
Number of full sisters	0.0	0.1	0.2	0.2	0.4	0.1	0.1	-0.2	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.1	0.4	0.3
Smoking status: Previous	0.0	0.0	0.1	-0.2	0.1	-0.2	0.1	-0.3	-0.3

Hub : Genes

SRP19

Models

Trait associations