Hub : Genes

SRP19

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0840 0.0260 1.9e-07 0.058 0.064 0.064 0.062 0.067 1.3e-07 3.2e-08 2.7e-08 4.5e-08 1.3e-08
2 YFS Blood 0.0169 0.0081 4.0e-03 0.006 0.002 0.002 0.003 0.001 4.0e-03 5.7e-02 5.8e-02 2.9e-02 1.6e-01
3 TCGA Brain Lower Grade Glioma 0.0529 0.0327 3.5e-05 0.038 0.034 0.029 NA 0.038 3.3e-05 8.4e-05 2.6e-04 NA 3.7e-05
4 TCGA Liver Hepatocellular Carcinoma 0.1010 0.0690 9.6e-03 0.015 0.015 0.000 NA 0.005 6.3e-02 6.2e-02 3.2e-01 NA 1.8e-01
5 TCGA Prostate Adenocarcinoma 0.0516 0.0292 2.8e-04 0.053 0.036 0.047 NA 0.051 3.0e-06 1.1e-04 1.1e-05 NA 4.6e-06
6 TCGA Soft Tissue Sarcoma 0.0720 0.0490 8.5e-03 0.033 0.010 0.008 NA 0.020 4.5e-03 7.9e-02 1.1e-01 NA 2.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.0 0.1 0.3 -0.1 -0.6 0.4 0.0 0.0 -0.0
Bipolar Disorder or Schizophrenia 0.8 1.8 3.3 1.6 -1.3 1.8 0.9 1.2 1.1
Depressed Affect (Nagel 2018) 3.5 7.3 9.4 -2.1 2.8 -2.0 -3.0 -3.0 -3.1
Depression (Nagel 2018) 0.2 0.3 0.7 0.5 0.9 0.4 -0.4 -0.4 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.4 -1.1 -1.2 -1.1 0.4 -0.1 -0.1
Neuroticism (Nagel 2018) 0.2 0.4 1.1 0.9 -0.4 1.1 0.2 0.5 0.4
Schizophrenia (2018) 1.3 2.7 4.4 2.1 -1.3 2.0 1.2 1.5 1.5
Schizophrenia vs Biploar Disorder 1.4 1.9 4.0 2.0 0.5 1.6 1.3 1.1 1.1
Worry (Nagel 2018) 2.7 5.7 8.3 2.8 -1.6 2.9 2.0 2.4 2.4
Alzheimer’s Disease (in mother) 0.5 0.6 1.3 1.2 -0.1 1.1 0.7 0.5 0.5
Alzheimer’s Disease (in father) 1.1 1.2 1.9 1.4 -1.2 1.0 0.7 1.1 1.1
Alzheimer’s Disease (including proxy) 1.8 2.6 3.8 1.9 -1.5 1.7 1.3 1.6 1.6
Crohns Disease (2017) 1.4 3.1 6.3 -1.3 1.0 -1.4 -2.5 -2.0 -2.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.9 -0.3 -0.2 -0.3 -1.4 -0.7 -0.7
Ulcerative Colitis (UC) 0.4 0.8 1.3 0.9 -1.1 1.0 0.4 0.9 0.9
Major Depression (MDD) 0.6 0.7 1.5 -0.8 -0.7 -0.5 1.2 0.8 0.8
Reaction Time 16.1 30.6 33.4 -5.5 5.7 -5.5 -4.9 -5.8 -5.7
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.8 -0.3 -1.7 -0.1 1.5 1.1 1.1
Breast Cancer 0.0 0.1 0.2 0.2 -0.1 0.4 0.1 0.2 0.2
Ovarian Cancer 1.9 2.5 6.1 -2.5 0.6 -2.4 -0.8 -1.1 -1.0
Prostate Cancer 0.7 1.0 2.3 1.5 0.6 1.4 0.9 0.4 0.4
Age at First Birth 0.7 1.0 3.8 1.1 -1.9 0.9 0.1 0.4 0.4
Bipolar Disorder (2011) 0.2 0.2 0.5 -0.2 -0.2 -0.1 -0.7 -0.5 -0.5
Body Mass Index (BMI) (2010) 0.8 1.2 2.5 -1.6 1.1 -1.4 -0.4 -0.7 -0.7
Coronary Artery Disease (CAD) 0.2 0.2 0.7 -0.0 0.8 0.3 -0.7 0.1 0.1
Crohns Disease (2012) 0.4 0.6 1.7 -0.6 0.3 -0.6 -1.3 -0.7 -0.7
Mean Putamen Volume 0.5 0.6 1.7 1.2 -0.1 1.3 0.1 0.3 0.2
Fasting Glucose 0.1 0.1 0.4 -0.3 0.3 -0.7 0.1 -0.1 -0.0
HbA1C 1.6 1.8 5.2 -0.3 2.3 -0.5 -0.8 -1.4 -1.5
HDL Cholesterol 0.1 0.2 0.4 0.5 0.5 0.4 -0.3 -0.6 -0.6
LDL Cholesterol 0.8 1.2 3.0 -0.5 0.6 -0.7 -1.7 -1.3 -1.3
Lupus 1.0 1.5 2.2 0.8 -1.3 1.0 1.0 1.5 1.5
Neuroticism (2016) 0.3 0.4 0.8 0.2 0.9 0.5 0.0 -0.8 -0.8
Primary Biliary Cirrhosis 0.4 0.6 2.0 0.7 1.4 1.0 -0.4 0.3 0.3
Rheumatoid Arthritis 0.6 0.8 1.3 -1.0 0.0 -0.7 -1.2 -1.0 -1.0
Schizophrenia (2014) 0.6 1.2 2.5 1.6 -0.8 1.4 0.8 1.0 0.9
Triglycerides 1.0 1.6 2.2 -1.2 1.1 -1.0 -1.3 -1.5 -1.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.1 -0.7 0.7 -0.8 -1.4 -0.8 -0.8
Ulcerative Colitis 1.2 1.8 3.4 1.2 -1.8 1.1 0.8 1.4 1.4
Blood Eosinophil Count 0.3 2.4 4.6 -1.4 2.1 -1.3 -1.5 -1.3 -1.3
Blood Platelet Count 0.0 0.2 0.4 0.2 -0.0 0.0 -0.4 -0.6 -0.6
Blood Red Count 0.0 0.2 0.3 0.5 0.1 0.3 0.1 0.6 0.6
Blood White Count 0.7 5.5 7.2 -1.9 2.7 -1.4 -2.6 -2.6 -2.6
Heel T-Score 4.7 37.7 42.5 -6.5 5.7 -6.4 -5.2 -6.5 -6.4
BMI 2.5 14.6 28.6 -5.2 3.2 -5.3 -2.6 -2.8 -2.7
Height 2.2 42.9 53.2 -7.2 7.3 -7.0 -4.7 -6.4 -6.3
Waist Hip Ratio (WHR) 0.6 2.9 6.2 -0.9 2.5 -1.2 -1.7 -1.8 -1.8
Systolic Blood Pressure 0.7 3.4 7.2 -1.3 2.7 -1.2 -1.9 -1.8 -1.8
Smoking Status 2.5 5.9 7.0 -2.6 2.5 -2.5 -1.6 -2.6 -2.6
Allergy or Eczema 0.1 0.2 0.8 -0.4 0.9 -0.4 0.5 -0.2 -0.2
Cardiovascular Disease 3.1 10.3 12.0 -3.1 2.7 -3.1 -3.5 -3.4 -3.4
Hypothyroidism (self reported) 1.8 4.1 5.6 -2.4 0.7 -2.2 -2.3 -2.1 -2.1
Respiratory disease 2.5 5.5 9.3 -3.1 0.2 -2.7 -2.5 -2.2 -2.2
Type 2 Diabetes (T2D) (2018) 1.0 1.8 7.0 -0.8 2.7 -0.9 -1.0 -0.9 -0.9
Lung FEV1/FVC ratio 1.5 7.5 10.8 2.5 -2.3 2.4 3.3 2.9 2.9
Lung FVC 0.5 2.7 6.9 0.4 -2.6 0.4 1.7 1.7 1.7
Neuroticism 0.1 0.2 0.8 0.6 0.0 0.9 -0.4 -0.2 -0.3
Chronotype (morning person) 0.5 1.2 2.8 0.3 1.7 -0.1 -1.2 -1.2 -1.3
Hair Pigment 0.0 0.6 1.2 -0.6 0.5 -0.6 -0.7 -1.1 -1.1
Tanning 0.2 2.4 3.5 -1.9 0.7 -1.8 -1.6 -1.6 -1.5
Hand grip strength (left) 0.2 0.5 0.9 0.7 0.4 0.7 1.0 0.7 0.7
Number of treatments/medications taken 5.7 10.2 12.3 -2.8 3.3 -2.6 -3.5 -3.4 -3.4
Average weekly spirits intake 0.3 0.4 0.9 -0.7 1.0 -0.5 -0.0 -0.5 -0.5
Sensitivity / hurt feelings 1.1 1.9 3.6 1.9 -0.0 1.9 0.8 1.4 1.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.6 -0.0 1.6 0.0 -1.0 -0.7 -0.7
Hearing difficulty/problems: Yes 0.6 0.9 1.6 -1.0 1.3 -1.0 -0.7 -0.9 -0.9
Relative age of first facial hair 0.9 1.8 5.3 -0.1 2.3 0.1 -1.7 -1.1 -1.1
Other serious medical condition/disability diagnosed by doctor 4.7 6.1 7.6 -2.2 1.8 -2.4 -2.8 -2.7 -2.7
Ever used hormone-replacement therapy (HRT) 4.9 6.2 9.2 -1.4 3.0 -1.7 -2.8 -2.7 -2.7
Ever had hysterectomy (womb removed) 2.7 3.0 4.5 -1.9 2.0 -2.1 -0.8 -1.6 -1.6
Systolic blood pressure, automated reading 2.0 5.8 8.3 -2.2 2.9 -2.2 -2.5 -2.3 -2.3
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 5.4 2.3 -0.9 2.3 0.7 1.2 1.2
Angina 0.5 0.6 2.8 0.3 -1.7 0.3 0.6 0.3 0.3
Medication for hormone replacement therapy 0.0 0.1 0.1 -0.3 0.1 -0.3 0.2 -0.2 -0.2
Vitamin and mineral supplements 1.5 2.0 4.5 2.1 -0.6 2.1 0.9 1.0 1.0
Supplements: Zinc 1.1 1.2 1.6 -1.0 0.8 -1.2 -0.9 -1.3 -1.2
Medication: Co-codamol 2.1 2.4 3.3 -1.6 1.4 -1.5 -1.1 -1.8 -1.8
Medication: Metformin 0.2 0.2 0.6 -0.4 0.8 -0.6 -0.3 -0.3 -0.3
Diabetes (father) 3.0 3.7 5.0 -2.2 1.2 -2.1 -1.9 -2.0 -2.0
Diabetes (mother) 1.3 1.7 4.0 -0.6 2.0 -0.7 -1.4 -1.3 -1.3
Severe depression (siblings) 2.6 2.9 5.0 -1.4 1.9 -1.5 -2.2 -1.5 -1.5
Pack years adult smoking proportion 0.7 1.0 4.2 -0.6 2.0 -0.2 -0.8 -0.6 -0.7
Impedance of leg (right) 0.4 2.1 5.8 2.4 -0.7 2.4 0.1 0.7 0.6
Leg fat-free mass (left) 2.8 14.8 25.4 -5.0 3.8 -5.0 -2.7 -2.9 -2.8
Trunk fat percentage 0.8 3.0 6.8 -2.0 2.6 -2.1 -1.0 -1.0 -0.9
Hand grip strength (right) 0.1 0.3 1.6 -0.2 1.3 -0.1 0.5 0.2 0.2
Townsend deprivation index at recruitment 1.0 1.3 2.4 -0.7 1.6 -0.8 -1.2 -1.2 -1.2
Current tobacco smoking 1.0 1.7 3.1 -1.0 1.8 -1.0 -0.7 -1.5 -1.5
Average weekly fortified wine intake 0.5 0.6 1.1 -0.4 1.0 -0.6 -0.4 -1.0 -1.0
Maternal smoking around birth 0.8 1.2 2.5 -1.1 1.6 -1.0 -1.2 -0.8 -0.7
Fed-up feelings 2.1 3.8 6.1 -1.5 2.5 -1.6 -1.9 -2.0 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.7 -0.3 1.9 -0.3 -1.7 -1.3 -1.4
Relative age voice broke 0.6 0.9 3.4 0.0 1.8 0.3 -0.9 -0.8 -0.8
Taking other prescription medications 1.5 2.4 3.0 -1.1 1.7 -1.1 -1.7 -1.7 -1.7
Age when periods started (menarche) 1.1 2.5 4.5 -1.0 0.7 -0.7 -2.0 -2.1 -2.1
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.6 -0.8 2.1 -1.2 -0.2 -0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 4.0 -1.9 1.0 -1.9 -1.8 -2.0 -2.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 0.7 -1.0 0.5 0.2 0.0 0.0
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.5 0.2 -0.3 -0.6 0.3 0.3
Serious illness, injury or assault to yourself 0.3 0.4 0.9 -0.2 -0.0 -0.5 -1.0 -0.8 -0.8
High blood pressure 2.3 6.4 8.6 -2.6 2.9 -2.6 -2.2 -2.4 -2.4
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.1 -0.4 0.2 -0.4 1.0 0.4 0.4
Multivitamins +/- minerals 1.7 2.1 4.5 -2.1 1.0 -2.1 -0.8 -1.1 -1.0
Stomach or abdominal pain in last month 2.0 2.5 4.0 -1.2 1.0 -0.9 -1.9 -2.0 -2.0
Supplements: Glucosamine 3.3 4.3 5.2 -2.3 1.6 -2.2 -1.7 -2.3 -2.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 -0.5 -1.0 -0.8 -0.5 -0.3 -0.3
Medication: Atenolol 0.1 0.2 0.2 -0.2 -0.5 -0.4 -0.5 -0.5 -0.5
Medication: Levothyroxine sodium 0.9 1.6 2.9 -1.4 -0.2 -1.4 -1.7 -1.2 -1.2
Sitting height 2.9 20.6 28.6 -5.1 5.3 -4.7 -3.7 -4.1 -4.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 0.9 -0.2 0.7 0.7 0.4 0.4
High blood pressure (mother) 1.7 2.4 4.1 -1.1 2.0 -1.3 -1.5 -1.6 -1.6
Body mass index (BMI) 1.1 4.8 11.0 -3.2 1.9 -3.3 -1.3 -1.1 -1.1
Impedance of leg (left) 0.9 4.1 9.7 3.1 -1.3 3.1 1.1 1.2 1.2
Leg predicted mass (left) 2.8 14.7 25.5 -5.0 3.8 -5.0 -2.7 -2.9 -2.8
Trunk fat mass 1.6 7.0 11.0 -3.2 3.3 -3.3 -1.8 -1.9 -1.8
Waist circumference 2.0 7.4 13.3 -3.5 3.1 -3.7 -1.8 -1.7 -1.6
Number of incorrect matches in round 1.7 2.8 4.5 2.1 -0.2 2.1 1.6 1.6 1.6
Past tobacco smoking 0.6 1.1 1.5 0.9 -1.2 0.8 0.7 1.2 1.2
Alcohol usually taken with meals 0.1 0.1 0.3 -0.5 0.5 -0.5 0.2 -0.0 0.0
Nervous feelings 2.9 5.3 6.2 2.4 -2.0 2.5 2.4 2.3 2.3
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 6.6 -1.0 2.6 -1.1 -2.2 -2.0 -2.0
Hearing difficulty/problems with background noise 0.1 0.2 0.3 -0.6 0.2 -0.5 -0.4 -0.5 -0.5
Hair/balding pattern: Pattern 2 5.4 6.9 8.8 -2.3 2.5 -2.4 -3.0 -2.8 -2.8
Had menopause 0.2 0.2 1.1 -0.1 -1.1 -0.1 0.1 0.0 0.0
Had other major operations 0.5 0.7 1.5 -0.8 0.3 -1.2 -0.6 -0.9 -0.8
Forced vital capacity (FVC) 0.0 0.1 0.2 -0.4 0.1 -0.4 -0.0 -0.0 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 4.7 -2.0 0.5 -2.2 -1.0 -1.2 -1.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.0 -0.2 1.4 -0.2 -1.4 -0.8 -0.9
Qualifications: None of the above 1.9 4.0 6.0 -1.3 2.2 -1.2 -2.1 -2.4 -2.5
Financial difficulties in last 2 years 2.0 2.7 5.5 -1.0 2.4 -0.6 -1.9 -1.7 -1.7
Mouth/teeth dental problems 0.4 0.6 1.6 0.2 -1.0 0.1 1.2 0.7 0.8
Heart attack 0.2 0.3 1.1 0.4 -1.0 0.4 0.1 0.4 0.4
Allergy 0.4 0.8 2.5 1.6 -0.2 1.6 -0.3 -0.1 -0.1
Pain all over the body in last month 2.5 2.7 3.9 -1.6 0.9 -1.6 -2.0 -1.7 -1.7
Diabetes (self-reported) 0.1 0.2 1.0 0.3 1.0 -0.1 0.1 0.2 0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.8 0.2 -0.6 0.3 0.2 0.2
Medication: Ramipril 0.1 0.2 0.8 -0.1 -0.9 0.0 0.3 0.1 0.2
Medication: Simvastatin 1.0 1.4 3.0 0.1 0.9 0.0 -1.7 -1.6 -1.6
Fluid intelligence score 0.7 1.6 3.2 0.7 -1.8 0.9 1.2 1.3 1.3
Illnesses of siblings 3.2 4.4 5.9 1.6 -2.2 1.6 2.2 2.4 2.4
Neuroticism score 0.2 0.3 1.0 0.8 0.4 1.0 -0.1 0.1 0.1
Weight 2.6 13.0 21.2 -4.6 4.0 -4.6 -2.5 -2.7 -2.6
Impedance of arm (right) 1.9 9.0 16.7 4.0 -1.0 4.1 2.4 2.7 2.6
Arm fat percentage (right) 0.9 3.4 6.9 -2.6 2.2 -2.6 -1.0 -0.8 -0.8
Trunk fat-free mass 3.7 21.2 31.8 -5.6 4.1 -5.6 -3.9 -4.0 -4.0
Hip circumference 1.4 5.9 12.2 -3.5 2.4 -3.3 -1.5 -1.4 -1.4
Time employed in main current job 1.0 1.2 3.4 1.0 -1.8 0.8 0.8 0.8 0.8
Alcohol intake versus 10 years previously 2.3 3.4 5.3 -2.0 0.8 -2.1 -2.3 -1.8 -1.8
Father’s age at death 0.2 0.3 0.7 0.7 -0.5 0.8 0.7 0.2 0.2
Worrier / anxious feelings 2.6 5.0 7.1 2.5 -1.7 2.7 1.8 2.3 2.3
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 6.3 -1.5 2.2 -1.4 -2.2 -2.5 -2.5
Falls in the last year 1.3 1.7 4.0 -1.3 0.1 -1.1 -2.0 -1.3 -1.3
Hair/balding pattern: Pattern 3 1.1 1.6 2.2 1.4 -0.5 1.5 1.1 1.4 1.4
Number of live births 0.4 0.6 1.0 -1.0 -0.1 -1.0 -0.9 -0.7 -0.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 2.6 0.9 -1.2 0.8 1.6 1.5 1.5
Pulse rate 1.6 2.6 6.2 -2.4 0.6 -2.5 -0.3 -1.4 -1.3
Happiness 0.5 0.6 1.6 1.3 0.2 1.0 0.3 0.6 0.6
Noisy workplace 0.9 1.1 2.1 -1.5 1.2 -1.4 -0.5 -0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.0 -0.2 -1.4 -0.2 0.9 1.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.6 1.2 -0.6 1.3 1.0 1.1 1.1
Mouth/teeth dental problems: Dentures 2.2 3.7 5.1 -1.5 2.1 -1.2 -2.3 -2.1 -2.1
Asthma 0.6 1.2 3.2 -1.8 -0.9 -1.5 -0.8 -0.3 -0.3
Medication: Ibuprofen (e.g. Nurofen) 3.9 4.9 6.0 -2.5 2.2 -2.2 -1.8 -2.3 -2.2
Medication: Cholesterol lowering 1.6 2.6 4.3 -0.4 1.5 -0.4 -2.1 -2.1 -2.1
Depression (self-reported) 0.8 1.0 2.9 -1.0 1.7 -0.9 -0.9 -0.4 -0.5
Medication: Lansoprazole 1.0 1.1 2.1 -0.8 0.7 -0.5 -1.0 -1.4 -1.4
Prospective memory result 0.8 1.0 1.4 -0.7 1.0 -1.2 -1.0 -1.1 -1.1
Lung cancer (father) 0.1 0.1 0.4 0.5 0.6 0.4 -0.1 -0.0 -0.0
Illnesses of mother 3.1 3.9 5.9 2.0 -2.4 1.9 1.4 2.0 2.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 1.8 0.7 -1.3 0.6 1.2 1.4 1.4
Pulse wave Arterial Stiffness index 5.4 6.3 13.0 -3.1 1.4 -3.6 -1.5 -2.4 -2.3
Impedance of arm (left) 2.1 9.9 17.6 4.2 -1.2 4.2 2.8 2.8 2.7
Arm fat mass (right) 2.4 9.9 17.0 -4.1 3.6 -4.1 -2.1 -2.1 -2.0
Trunk predicted mass 3.7 21.1 31.9 -5.7 4.0 -5.6 -3.9 -4.0 -4.0
Standing height 1.5 14.9 26.7 -3.6 5.2 -3.5 -3.1 -3.8 -3.7
Length of working week for main job 0.4 0.4 0.9 -0.9 -0.6 -0.9 0.7 0.2 0.2
Exposure to tobacco smoke at home 1.7 1.9 2.7 -1.7 0.7 -1.6 -1.0 -1.5 -1.5
Breastfed as a baby 2.9 3.6 4.4 -1.8 2.1 -2.0 -1.6 -1.9 -1.9
Tense / ‘highly strung’ 0.1 0.1 0.3 -0.4 0.1 -0.3 -0.6 -0.1 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.1 9.0 -1.6 3.0 -1.4 -2.1 -1.8 -1.9
Hair/balding pattern: Pattern 4 0.4 0.9 2.6 -1.6 0.3 -1.6 0.4 -0.4 -0.4
Birth weight of first child 0.0 0.0 0.1 -0.0 0.0 -0.3 0.2 -0.1 -0.1
Peak expiratory flow (PEF) 5.3 12.4 15.4 2.9 -3.6 2.9 3.7 3.9 3.9
Pulse wave reflection index 0.1 0.2 0.5 -0.4 -0.2 -0.5 -0.7 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 1.0 1.2 1.9 -0.8 1.2 -0.9 -1.4 -1.1 -1.1
Loud music exposure frequency 0.6 0.7 1.1 0.1 -1.0 -0.0 0.8 1.0 1.1
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.1 0.0 0.3 0.2 -0.1 -0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 0.1 -1.0 0.0 0.6 0.6 0.7
Blood clot in the leg (DVT) 0.4 0.6 1.2 -0.7 0.8 -1.1 -0.8 -0.4 -0.4
Medication: Paracetamol 1.1 1.8 5.6 -1.5 2.4 -1.2 -1.2 -0.3 -0.3
Headache pain in last month 0.5 0.9 2.3 -1.5 0.3 -1.5 -0.5 -0.6 -0.6
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 4.9 0.7 -1.8 0.7 2.2 2.0 2.0
Glaucoma (self-reported) 3.4 4.0 8.0 1.2 -2.8 1.2 2.5 1.9 1.9
Gout (self-reported) 1.1 1.5 3.1 -1.0 1.8 -0.8 -1.3 -1.1 -1.1
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.6 -1.2 -0.1 -1.1 -1.9 -1.2 -1.3
Medication: Amlodipine 0.7 1.0 1.6 -1.2 1.3 -1.3 -0.3 -0.7 -0.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 0.3 -0.3 0.6 0.2 0.7 0.7
Birth weight 0.5 1.1 1.4 -1.1 0.7 -1.1 -1.0 -1.2 -1.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.2 -0.3 1.1 -0.0 -0.9 -0.5 -0.5
High blood pressure (siblings) 2.4 3.4 5.8 -0.9 2.4 -1.1 -2.2 -2.0 -2.0
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 -0.5 -0.2 -0.5 0.0 0.1 0.1
Body fat percentage 0.8 3.1 5.1 -2.2 2.3 -2.3 -1.1 -1.0 -1.0
Leg fat percentage (right) 1.2 4.2 9.1 -2.9 1.5 -3.0 -1.5 -1.3 -1.2
Arm fat-free mass (right) 3.9 20.0 31.5 -5.5 3.9 -5.6 -3.6 -3.9 -3.8
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.4 -0.4 0.4 0.6 0.5 0.4
Comparative body size at age 10 0.0 0.1 0.1 -0.3 -0.0 -0.4 0.3 -0.2 -0.2
Number of full brothers 1.1 1.3 2.6 1.6 0.9 1.4 0.6 1.1 1.0
Worry too long after embarrassment 1.2 2.0 7.2 0.9 -2.7 1.0 0.8 1.0 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 4.2 -1.7 1.9 -2.0 -1.8 -1.7 -1.6
Wheeze or whistling in the chest in last year 0.8 1.5 2.4 -1.5 1.0 -1.3 -1.2 -1.1 -1.1
Number of children fathered 0.4 0.4 1.0 0.4 1.0 0.7 0.3 0.6 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.2 -0.3 -0.0 -0.0 0.2 0.3
Age at first live birth 0.1 0.1 0.3 0.6 0.1 0.4 0.0 0.2 0.2
Pulse wave peak to peak time 4.2 5.0 10.9 2.8 -1.2 3.3 1.2 2.1 2.0
Health satisfaction 1.7 2.2 3.9 -1.3 0.9 -1.2 -2.0 -1.7 -1.7
Shortness of breath walking on level ground 1.4 1.7 3.0 -1.2 0.3 -1.0 -1.7 -1.5 -1.5
Qualifications: College or University degree 0.7 2.1 5.0 -0.1 -2.2 -0.2 1.6 1.5 1.5
Eye problems/disorders: None of the above 2.1 2.5 5.1 -0.4 2.3 -0.4 -2.0 -1.6 -1.7
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.2 -1.1 1.5 -1.1 0.0 -0.8 -0.8
Emphysema/chronic bronchitis 1.0 1.1 1.6 -1.3 1.1 -1.1 -0.5 -1.1 -1.0
Medication for pain relief, constipation, heartburn 4.6 7.8 10.4 3.1 -3.2 2.9 2.4 2.6 2.5
Neck or shoulder pain in last month 1.5 2.1 4.5 -2.1 1.1 -2.0 -0.3 -1.1 -1.1
Medication: Blood pressure 1.2 2.1 4.0 -0.6 2.0 -0.6 -1.7 -1.6 -1.6
Angina (self-reported) 0.6 0.8 3.5 0.2 -1.9 0.2 0.8 0.4 0.4
Migraine (self-reported) 0.1 0.1 0.4 0.6 -0.0 0.2 0.4 0.2 0.3
Medication: Ibuprofen 3.9 4.7 5.3 -2.1 2.0 -2.1 -2.2 -2.3 -2.3
Medication: Allopurinol 0.7 0.9 2.5 1.4 0.8 1.6 -0.0 0.5 0.4
Medication: Omeprazole 0.1 0.1 0.3 -0.5 0.4 -0.6 -0.3 -0.1 -0.0
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.5 0.1 -0.3 -0.4 -0.5 -0.5
Mean time to correctly identify matches 14.2 27.1 30.8 -5.4 4.9 -5.6 -4.3 -5.5 -5.5
Heart disease (mother) 0.5 0.6 1.9 0.9 1.4 0.9 -0.3 -0.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.6 -0.7 0.6 -0.1 -0.1 -0.2
Whole body fat mass 1.8 7.6 13.1 -3.5 3.1 -3.6 -1.9 -1.8 -1.8
Leg fat mass (right) 1.9 7.4 14.3 -3.7 2.4 -3.8 -2.0 -1.9 -1.8
Arm predicted mass (right) 3.7 19.0 29.9 -5.4 3.7 -5.5 -3.5 -3.9 -3.8
Pulse rate, automated reading 0.4 1.4 3.2 -1.8 0.8 -1.8 -0.2 -0.9 -0.9
Alcohol intake frequency. 0.3 0.6 1.5 -0.7 1.2 -0.6 -1.1 -0.3 -0.3
Comparative height size at age 10 1.9 10.7 12.1 -3.3 3.3 -3.4 -2.7 -3.5 -3.4
Number of full sisters 0.0 0.1 0.2 0.2 0.4 0.1 0.1 -0.2 -0.2
Suffer from ‘nerves’ 1.3 2.0 2.7 1.6 -0.7 1.4 1.3 1.6 1.6
Overall health rating 0.4 0.9 1.2 -1.0 1.0 -1.1 -0.6 -1.0 -1.0
Chest pain or discomfort 5.2 7.5 10.0 -2.7 1.8 -2.6 -2.7 -3.2 -3.2
Had major operations 0.4 0.4 2.0 0.4 1.4 0.5 0.1 0.4 0.4
Age at last live birth 1.6 2.3 3.8 1.0 -1.9 1.0 1.3 1.8 1.8
Family relationship satisfaction 0.2 0.3 0.9 0.1 0.7 0.2 -1.0 -0.2 -0.3
Leg pain on walking 4.6 5.8 12.1 -1.5 3.5 -1.3 -2.5 -2.4 -2.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.3 1.7 1.2 -0.9 1.0 0.9 1.3 1.3
Commuting to job workplace: Car/motor vehicle 1.8 2.1 3.1 -1.8 0.8 -1.2 -1.5 -1.6 -1.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.9 0.3 -1.2 0.2 1.7 1.1 1.1
Medication: Aspirin 1.9 2.5 4.0 -1.0 1.4 -0.9 -1.7 -2.0 -2.0
Supplements: Vitamin C 0.1 0.1 0.5 -0.4 -0.3 -0.7 0.3 0.1 0.1
Knee pain experienced in last month 5.5 8.5 9.5 -2.7 3.1 -2.9 -2.9 -2.9 -2.9
Hypertension (Self-reported) 2.6 7.3 10.3 -2.6 3.2 -2.7 -2.4 -2.6 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.2 0.8 1.1 0.8 0.0 -0.1 -0.1
Illnesses of father: Heart disease 0.6 0.8 1.8 -0.8 -0.9 -0.6 1.3 0.8 0.8
Illnesses of siblings: Diabetes 0.0 0.0 0.1 -0.1 -0.1 0.0 -0.1 0.4 0.3
Smoking status: Previous 0.0 0.0 0.1 -0.2 0.1 -0.2 0.1 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.6 -1.1 1.6 -0.5 -1.6 -0.9 -1.0
Whole body fat-free mass 3.5 20.1 32.5 -5.7 4.1 -5.7 -3.5 -3.7 -3.6
Leg fat-free mass (right) 2.2 11.8 21.4 -4.6 3.5 -4.6 -2.1 -2.5 -2.4
Arm fat percentage (left) 0.6 2.4 5.2 -2.2 1.9 -2.3 -0.6 -0.6 -0.6
Average weekly red wine intake 0.4 0.6 1.6 -1.0 -0.5 -1.3 0.6 0.2 0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.3 -1.0 0.2 -0.9 -1.5 -1.0 -1.0
Mood swings 3.1 5.6 10.5 -1.8 3.2 -1.6 -2.4 -2.4 -2.4
Loneliness, isolation 1.0 1.3 2.2 -0.1 1.3 0.2 -1.4 -1.4 -1.5
Long-standing illness, disability or infirmity 1.7 2.6 3.5 -1.1 1.7 -1.2 -1.9 -1.8 -1.9
Ever had bowel cancer screening 3.2 3.8 5.8 -1.7 1.5 -1.6 -1.8 -2.4 -2.4
Diabetes diagnosed by doctor 0.4 0.7 3.6 -0.3 1.9 -0.6 -0.4 -0.2 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.2 -1.4 0.0 -1.5 -1.0 -0.5 -0.5
Friendships satisfaction 0.1 0.1 0.4 -0.6 -0.1 -0.6 -0.1 0.1 0.1
Qualifications: nursing, teaching 0.3 0.5 1.2 -0.9 -1.1 -0.9 0.2 0.3 0.3
Commuting to job workplace: Walk 0.2 0.2 0.5 0.7 0.5 0.4 -0.3 -0.0 -0.1
Eye problems/disorders: Cataract 1.2 1.4 3.4 0.1 -1.3 0.2 1.8 1.3 1.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.7 2.2 0.6 2.1 -0.3 0.4 0.4
Medication for cholesterol 1.5 2.3 3.1 1.6 -0.7 1.7 1.2 1.8 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 4.2 0.4 -2.0 0.2 0.0 0.2 0.2
Back pain experienced in last month 0.2 0.2 0.6 -0.6 0.8 -0.4 -0.2 -0.3 -0.3
Mineral and other dietary supplements 0.3 0.4 0.8 0.9 -0.5 0.8 -0.1 0.6 0.6
Breast cancer (self-reported) 0.3 0.4 2.2 -0.2 -1.5 -0.2 -0.4 -0.0 -0.0
Asthma (self-reported) 0.7 1.5 3.8 -1.9 -0.5 -1.7 -1.1 -0.6 -0.6
Osteoporosis (self-reported) 5.5 6.8 7.5 2.5 -2.6 2.4 2.7 2.7 2.7
Osteoarthritis (self-reported) 2.4 3.1 5.1 -1.6 2.2 -1.8 -1.2 -1.8 -1.8
Medication: Aspirin 1.5 1.9 3.5 -0.6 1.2 -0.6 -1.6 -1.9 -1.9
Medication: Gliclazide 1.7 1.9 6.0 -0.8 2.5 -0.9 -0.8 -1.3 -1.3
Illnesses of father: None of the above (group 1) 0.8 1.0 2.0 1.4 0.3 1.4 -0.0 1.0 1.0
Smoking status: Current 0.9 1.4 3.8 -0.7 2.0 -0.7 -0.6 -1.3 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.3 5.7 2.2 -2.4 2.2 2.0 1.8 1.8
Whole body water mass 3.6 20.6 32.3 -5.7 4.2 -5.6 -3.6 -3.9 -3.7
Leg predicted mass (right) 2.2 11.9 21.6 -4.7 3.5 -4.6 -2.1 -2.5 -2.4
Arm fat mass (left) 1.9 7.8 14.1 -3.7 3.1 -3.8 -1.8 -1.8 -1.7
Number of self-reported non-cancer illnesses 4.5 7.8 11.5 -2.3 2.6 -2.3 -3.4 -3.0 -3.0
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.9 0.7 -0.9 -0.3 -0.5 -0.5
Miserableness 3.6 6.2 12.9 -1.9 3.6 -1.6 -2.4 -2.5 -2.5
Guilty feelings 5.4 8.2 11.0 3.3 -1.9 3.2 3.0 2.8 2.7
Wears glasses or contact lenses 0.7 0.8 1.4 -1.2 -0.1 -1.0 -0.7 -0.9 -0.9
Ever taken oral contraceptive pill 1.8 2.0 4.0 -2.0 0.1 -1.7 -0.8 -1.5 -1.5
Hearing aid user 3.9 4.4 7.4 -2.7 2.1 -2.5 -1.7 -1.6 -1.6
Mother’s age at death 0.2 0.3 0.7 -0.2 -0.8 -0.1 0.1 -0.6 -0.6
Financial situation satisfaction 3.1 3.9 8.7 -1.1 1.4 -1.2 -2.9 -2.2 -2.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 -1.6 -0.5 -1.5 -0.3 -0.5 -0.5
Commuting to job workplace: Public transport 1.6 1.9 3.3 0.3 -1.5 0.0 1.8 1.6 1.7
Eye problems/disorders: Glaucoma 1.1 1.3 2.0 0.9 -1.4 1.0 1.4 1.1 1.1
Medication: Blood pressure 1.8 3.4 6.5 -2.3 0.7 -2.5 -1.3 -1.8 -1.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.1 -0.3 1.4 -0.3 -0.2 -0.6 -0.6
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.5 -0.3 0.3 -0.3 0.7 0.3 0.3
High cholesterol (Self-reported) 1.3 2.3 4.5 -0.5 1.0 -0.6 -2.1 -2.0 -2.0
Medication: Bendroflumethiazide 2.9 4.4 6.5 -2.3 2.0 -2.6 -1.6 -2.0 -2.0
Medication: Paracetamol 1.0 1.6 4.8 -0.9 2.2 -0.6 -1.7 -0.6 -0.7
Medication: Lisinopril 1.0 1.3 2.7 -1.5 0.9 -1.6 -0.7 -0.9 -0.9
Medication: Atorvastatin 1.5 1.9 2.8 -1.0 1.7 -1.0 -1.1 -1.6 -1.6
Illnesses of father: High blood pressure 1.6 1.9 3.9 -2.0 0.5 -2.0 -1.1 -1.1 -1.1
Alcohol drinker status: Never 0.1 0.2 0.5 -0.0 0.0 -0.1 0.7 0.4 0.5
Ever smoked 1.6 2.8 4.5 -1.4 1.6 -1.5 -1.2 -2.1 -2.1
Basal metabolic rate 3.5 19.6 32.0 -5.7 4.2 -5.6 -3.3 -3.6 -3.5
Leg fat percentage (left) 0.7 2.6 6.2 -2.3 1.2 -2.5 -0.8 -0.9 -0.8
Arm fat-free mass (left) 4.1 21.0 31.8 -5.6 4.1 -5.6 -3.9 -4.0 -3.9
Number of operations (self-reported) 2.9 4.2 5.7 -2.2 1.7 -2.4 -2.1 -1.9 -1.9
Average weekly beer plus cider intake 0.9 1.2 4.0 1.1 -2.0 1.3 -0.1 0.5 0.4
Irritability 1.5 2.6 4.4 -1.6 0.9 -1.2 -2.1 -1.8 -1.8
Risk taking 2.4 3.5 4.5 -2.1 1.0 -1.9 -2.0 -1.9 -2.0
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.2 -0.3 1.1 -0.2 -0.2 -0.4 -0.4
Fractured/broken bones in last 5 years 2.4 3.1 5.3 1.4 -1.4 1.5 1.4 2.3 2.3
Age started oral contraceptive pill 1.9 2.3 4.2 2.0 -1.6 1.8 0.8 1.3 1.3
Diastolic blood pressure, automated reading 2.6 8.1 12.1 -3.0 3.5 -3.0 -2.7 -2.4 -2.4
Ever depressed for a whole week 0.3 0.3 1.8 0.2 1.3 0.3 -0.2 -0.1 -0.1
Unable to work because of sickness or disability 0.3 0.4 0.7 0.7 0.7 0.9 -0.6 -0.2 -0.3
Commuting to job workplace: Cycle 0.2 0.3 0.5 0.1 -0.3 -0.1 0.7 0.7 0.7
Myopia 1.0 1.4 3.8 0.4 -1.9 0.4 1.3 1.1 1.2
Vascular/heart problems diagnosed by doctor 2.5 6.9 7.7 2.6 -2.6 2.5 2.6 2.8 2.7
Cholesterol lowering medication 1.6 2.3 4.4 -0.9 0.5 -0.9 -1.9 -2.1 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 -0.7 0.6 -0.9 -0.3 -0.3 -0.3
Pain experienced in last month 2.4 4.0 6.7 2.5 -1.5 2.6 1.5 1.9 1.8
Supplements: Calcium 1.0 1.1 2.4 0.3 -1.6 0.1 0.7 1.4 1.4
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 -0.2 -0.5 0.1 -0.5 -0.7 -0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.7 0.2 -0.9 0.2 -0.1 0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.8 -1.0 0.9 -1.3 -0.9 -0.6 -0.6
Heart disease (siblings) 0.1 0.2 0.4 0.1 -0.2 -0.2 -0.5 -0.6 -0.6
Alcohol drinker status: Previous 0.4 0.5 1.4 -1.0 1.2 -0.7 0.2 -0.0 0.0
Pack years of smoking 0.6 0.9 3.1 -0.7 1.8 -0.2 -0.9 -0.7 -0.8
Impedance of whole body 1.5 7.6 15.4 3.9 -1.4 3.9 2.1 2.1 2.1
Leg fat mass (left) 1.7 6.6 12.5 -3.4 2.4 -3.5 -1.8 -1.8 -1.7
Arm predicted mass (left) 4.0 20.4 30.9 -5.6 4.2 -5.5 -3.8 -3.8 -3.8