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chr6:124,741,508-127,355,237

Best TWAS P=1.74e-34 · Best GWAS P=1.82e-35 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CENPW	0.04	0.06	lasso	10	0.06	2.4e-07	12.2	-12.2	1.7e-34	-0.99	0.02	0.98	TRUE
9	GTEx	Thyroid	HEY2	0.22	0.24	lasso	6	0.23	1.0e-17	-9.0	-9.2	4.2e-20	-0.08	0.00	1.00	TRUE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	CENPW	0.04	0.06	blup	35	0.05	9.2e-07	12.2	-12.1	1.1e-33	-0.98	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CENPW	0.04	0.05	lasso	5	0.05	2.6e-06	12.4	-11.9	8.4e-33	-0.98	0.02	0.98	FALSE
8	GTEx	Testis	HEY2	0.31	0.17	lasso	5	0.19	7.4e-09	-9.0	-9.1	1.4e-19	-0.08	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HEY2	0.15	0.20	lasso	10	0.21	6.7e-25	-9.1	-9.0	2.4e-19	-0.07	0.01	0.99	FALSE
13	METSIM	Adipose	NCOA7	0.05	0.05	enet	5	0.05	1.9e-07	6.8	8.8	1.7e-18	0.24	0.95	0.02	FALSE
11	METSIM	Adipose	CENPW	0.02	0.02	blup	189	0.01	8.3e-03	12.4	-8.6	8.0e-18	-0.74	0.02	0.78	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	HEY2	0.10	0.12	enet	15	0.13	9.8e-17	8.6	-8.2	1.8e-16	-0.06	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	HEY2	0.03	0.04	lasso	3	0.02	3.8e-03	8.0	-8.2	2.4e-16	-0.07	0.01	0.98	FALSE
4	GTEx	Esophagus Muscularis	HINT3	0.08	0.00	enet	14	0.00	2.9e-01	8.7	-7.3	2.4e-13	-0.11	0.07	0.04	FALSE
6	GTEx	Pancreas	HEY2	0.28	0.11	lasso	3	0.10	3.5e-05	-6.4	-7.2	5.2e-13	-0.05	0.09	0.91	FALSE
12	METSIM	Adipose	HEY2	0.02	0.04	lasso	1	0.02	1.6e-04	-6.5	-6.5	8.6e-11	-0.05	0.02	0.97	FALSE
3	GTEx	Artery Coronary	TPD52L1	0.31	-0.01	enet	19	0.05	7.0e-03	0.1	-6.3	2.4e-10	-0.15	0.03	0.54	FALSE
18	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEY2	0.09	0.06	lasso	8	0.06	2.3e-03	-6.4	-6.3	3.1e-10	-0.03	0.03	0.76	FALSE
10	GTEx	Vagina	CENPW	0.24	-0.01	lasso	8	-0.01	7.9e-01	5.4	6.2	5.4e-10	0.41	0.04	0.07	FALSE
5	GTEx	Heart Atrial Appendage	CENPW	0.17	0.01	enet	15	0.06	1.8e-03	12.4	-6.2	6.7e-10	-0.69	0.02	0.59	FALSE
7	GTEx	Skin Sun Exposed Lower leg	HINT3	0.08	0.01	lasso	4	0.03	2.0e-03	-3.8	-5.5	4.7e-08	-0.19	0.22	0.13	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEY2	0.05	0.05	blup	36	0.05	4.9e-06	-6.4	-5.4	8.3e-08	-0.03	0.19	0.80	FALSE