Best TWAS P=7.18e-09 · Best GWAS P=4.19e-24 conditioned to 8.84e-19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | SYNE1 | 0.12 | 0.01 | blup | 875 | 0.05 | 6.9e-07 | 1.1 | 5.6 | 2.8e-08 | 0.26 | 0.63 | 0.08 | TRUE |
| 2 | YFS | Blood | RMND1 | 0.06 | 0.06 | lasso | 12 | 0.05 | 6.5e-16 | 4.9 | -5.4 | 7.8e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS17 | 0.02 | 0.02 | enet | 5 | 0.02 | 1.8e-04 | 5.2 | -5.2 | 1.7e-07 | 0.02 | 0.01 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMND1 | 0.02 | 0.00 | blup | 57 | 0.01 | 3.1e-03 | 3.9 | -5.2 | 2.6e-07 | -0.02 | 0.00 | 0.61 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMND1 | 0.16 | 0.10 | lasso | 7 | 0.12 | 1.6e-06 | 4.9 | -5.6 | 2.1e-08 | -0.02 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RMND1 | 0.07 | 0.06 | blup | 58 | 0.09 | 1.4e-10 | 4.9 | -5.5 | 4.3e-08 | 0.01 | 0.19 | 0.81 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | RMND1 | 0.05 | 0.06 | lasso | 2 | 0.07 | 4.3e-08 | 6.1 | -5.8 | 7.2e-09 | -0.04 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RMND1 | 0.16 | 0.15 | enet | 7 | 0.09 | 2.7e-03 | 6.1 | -5.4 | 7.0e-08 | -0.04 | 0.00 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMND1 | 0.06 | 0.04 | blup | 57 | 0.06 | 4.9e-05 | 4.2 | -5.6 | 1.9e-08 | -0.03 | 0.03 | 0.88 | FALSE |