Hub : Genes

RGS17

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0690 0.0260 2.6e-03 0.006 0.024 0.030 0.028 0.024 4.9e-02 5.1e-04 1.2e-04 1.9e-04 5.6e-04
2 GTEx Adipose Subcutaneous 0.0970 0.0320 4.1e-04 0.043 NA 0.051 NA 0.059 1.8e-04 NA 5.3e-05 NA 1.3e-05
3 GTEx Cells Transformed fibroblasts 0.1350 0.0500 1.2e-03 0.015 NA 0.002 NA 0.015 2.5e-02 NA 2.2e-01 NA 2.6e-02
4 GTEx Esophagus Mucosa 0.2160 0.0500 5.5e-08 0.147 NA 0.148 NA 0.178 4.8e-10 NA 4.1e-10 NA 5.5e-12
5 GTEx Thyroid 0.2540 0.0610 4.3e-06 0.042 NA 0.086 NA 0.089 3.3e-04 NA 3.9e-07 NA 2.5e-07
6 YFS Blood 0.0958 0.0175 0.0e+00 0.107 0.072 0.106 0.097 0.100 3.1e-33 1.4e-22 6.3e-33 5.0e-30 6.2e-31
7 TCGA Breast Invasive Carcinoma 0.0187 0.0093 7.1e-04 0.023 0.014 0.017 NA 0.014 1.1e-05 6.6e-04 1.8e-04 NA 5.0e-04
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0430 0.0184 1.6e-05 0.039 0.053 0.039 NA 0.045 3.3e-05 1.2e-06 3.1e-05 NA 8.4e-06
9 TCGA Prostate Adenocarcinoma 0.3362 0.0633 0.0e+00 0.293 0.270 0.270 NA 0.294 5.8e-31 3.0e-28 3.3e-28 NA 5.7e-31
10 TCGA Rectum Adenocarcinoma 0.1800 0.0820 4.4e-03 -0.009 0.000 -0.007 NA -0.010 5.8e-01 3.2e-01 5.0e-01 NA 6.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.4 2.2 8.5 1.2 1.3 1.0 1.7 -1.2 -0.8 1.0 0.9 1.7 2.9
Bipolar Disorder or Schizophrenia 2.7 6.6 12.6 2.8 2.6 2.0 2.4 -2.0 -2.2 2.7 2.8 2.4 3.5
Depressed Affect (Nagel 2018) 0.2 0.3 1.5 0.0 -0.3 0.5 -0.4 0.6 0.5 -0.2 0.5 -0.5 -1.2
Depression (Nagel 2018) 0.5 0.8 1.6 1.0 0.6 1.3 0.9 -1.0 -0.6 0.9 1.1 0.7 0.7
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.9 -0.8 1.0 1.7 1.5 -0.1 -0.5 0.6 1.2 1.4 1.0
Neuroticism (Nagel 2018) 0.7 1.7 3.4 1.7 1.2 1.9 1.4 -0.7 -0.4 1.2 1.8 1.6 0.0
Schizophrenia (2018) 2.3 4.8 8.0 2.6 2.4 1.8 1.7 -1.6 -2.1 2.7 2.8 1.7 2.2
Schizophrenia vs Biploar Disorder 0.3 0.4 1.4 0.1 -0.7 -0.7 -0.3 -0.6 0.5 -0.5 0.1 -0.7 -1.2
Worry (Nagel 2018) 4.0 8.4 13.9 3.2 3.0 2.7 3.4 -2.7 -1.3 2.8 3.5 3.7 1.7
Alzheimer’s Disease (in mother) 0.3 0.3 1.4 0.8 0.4 -0.6 0.5 -1.2 0.3 0.3 0.2 0.5 0.2
Alzheimer’s Disease (in father) 0.9 1.0 3.8 1.3 0.6 1.1 0.5 -2.0 -0.3 0.5 0.6 0.9 1.0
Alzheimer’s Disease (including proxy) 0.9 1.3 6.5 2.5 -0.0 -1.1 0.3 -1.9 0.7 0.1 0.7 0.4 0.5
Crohns Disease (2017) 0.1 0.3 1.2 -0.2 -0.5 -0.4 0.5 0.4 1.1 -0.8 -0.3 0.1 -0.5
Irritable Bowel Disease (IBD) 0.6 1.4 3.2 -0.9 -1.5 -0.5 0.1 1.5 1.5 -1.5 -0.8 -0.6 -1.8
Ulcerative Colitis (UC) 0.6 1.1 2.6 -0.9 -1.3 0.2 -0.1 1.5 0.8 -1.0 -0.9 -0.7 -1.6
Major Depression (MDD) 0.4 0.5 1.7 0.2 0.4 1.3 0.9 -0.3 -0.0 0.2 0.7 0.7 1.2
Reaction Time 2.0 3.7 7.4 1.6 2.3 1.0 2.3 -0.4 -1.5 2.3 1.9 2.1 2.7
Verbal and Numeric Reasoning (VNR) 0.4 1.1 1.8 -0.5 1.3 1.2 1.2 -0.8 -0.8 0.9 1.4 1.2 0.7
Breast Cancer 0.6 1.5 4.8 -0.5 -1.3 -0.9 0.1 0.3 2.2 -1.8 -0.6 -0.0 -1.9
Ovarian Cancer 0.6 0.8 3.4 0.4 -0.6 -0.8 0.8 0.2 0.8 -0.7 0.9 0.5 -1.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.1 3.0 7.6 2.8 0.9 -0.9 2.1 -2.5 0.2 0.7 2.1 2.1 0.8
Bipolar Disorder (2011) 4.7 4.5 10.2 3.2 1.4 2.8 2.0 0.0 -1.4 1.9 2.3 1.8 2.7
Body Mass Index (BMI) (2010) 2.3 3.2 8.0 -1.1 -1.4 -2.1 -2.8 0.9 0.6 -1.3 -1.9 -2.3 -2.1
Coronary Artery Disease (CAD) 0.9 1.1 4.4 0.0 1.3 0.6 -0.1 -2.1 -1.0 1.1 0.6 0.7 1.4
Crohns Disease (2012) 0.3 0.5 1.7 0.6 0.5 0.4 1.3 -1.0 0.2 0.1 1.0 0.9 0.2
Mean Putamen Volume 0.4 0.5 1.6 0.3 -0.9 -0.3 -0.7 -0.4 0.5 -0.7 -0.8 -1.2 -0.4
Fasting Glucose 9.2 11.0 23.9 -2.5 -3.5 -3.4 -4.9 2.6 1.7 -2.9 -4.1 -4.5 -1.0
HbA1C 1.7 1.9 4.1 -0.5 -1.9 -1.7 -0.9 0.2 1.6 -2.0 -1.0 -1.0 -1.8
HDL Cholesterol 3.1 5.1 11.2 1.0 2.6 3.4 2.5 -0.9 -2.2 2.5 2.3 2.7 1.5
LDL Cholesterol 0.2 0.3 1.8 1.3 0.2 -0.1 0.1 -0.3 0.0 0.2 0.5 0.5 0.4
Lupus 0.3 0.4 0.7 0.6 0.7 0.6 0.8 -0.2 -0.2 0.8 0.8 0.7 -0.6
Neuroticism (2016) 2.9 4.2 7.8 0.6 2.7 2.2 0.7 -1.6 -2.6 2.8 1.7 1.3 2.8
Primary Biliary Cirrhosis 0.9 1.3 4.0 -0.9 -1.2 -0.9 -1.0 1.3 0.8 -1.0 -2.0 -1.1 0.3
Rheumatoid Arthritis 0.8 1.1 1.9 0.0 -1.4 -1.0 -1.3 0.7 0.9 -1.2 -1.4 -1.2 -0.7
Schizophrenia (2014) 2.2 4.8 7.6 2.3 2.4 2.3 1.6 -1.4 -2.5 2.8 2.7 1.5 2.3
Triglycerides 1.8 3.0 4.4 -0.5 -2.0 -2.1 -2.0 1.7 1.5 -1.9 -2.1 -2.0 -0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.6 -0.7 -1.2 -0.4 -1.5 0.8 0.5 -0.9 -1.1 -1.6 -0.7
Ulcerative Colitis 0.9 1.3 4.2 -0.1 -1.7 0.2 -0.1 1.3 1.3 -1.3 -0.4 -0.9 -2.0
Blood Eosinophil Count 0.6 4.5 8.9 -2.1 -2.4 -1.0 -2.3 2.4 1.6 -2.3 -3.0 -2.6 -0.5
Blood Platelet Count 1.2 13.8 18.9 3.8 4.0 3.1 3.3 -4.3 -3.3 3.8 4.0 4.2 3.0
Blood Red Count 0.0 0.4 1.5 0.8 -0.5 -0.0 1.2 0.6 0.4 -0.1 0.4 0.5 0.5
Blood White Count 0.3 2.0 8.1 1.3 -0.9 -1.0 -1.5 2.0 0.2 -0.4 -1.2 -1.1 2.8
Heel T-Score 0.1 1.1 3.4 0.3 -0.2 -0.9 -1.8 0.1 -0.5 0.3 -1.2 -1.2 -1.8
BMI 4.7 27.4 40.1 -5.1 -5.4 -4.9 -5.1 5.9 4.1 -5.5 -6.3 -5.8 -3.7
Height 0.5 8.9 39.4 2.3 -0.3 0.2 6.3 -1.6 3.1 -1.6 2.5 4.7 -0.2
Waist Hip Ratio (WHR) 1.2 5.2 9.7 0.5 -2.9 -3.1 -1.4 2.2 3.0 -2.7 -1.1 -2.3 -2.2
Systolic Blood Pressure 1.9 9.7 28.0 3.9 2.9 0.8 3.1 -5.3 -1.4 2.5 2.9 3.9 1.7
Smoking Status 1.7 4.0 8.8 -0.5 -2.6 0.1 -2.1 3.0 1.5 -2.1 -2.0 -2.8 -1.2
Allergy or Eczema 0.8 2.1 6.3 0.4 1.9 1.2 -0.5 -1.4 -2.5 2.3 1.3 -0.0 0.8
Cardiovascular Disease 0.5 1.7 5.0 1.2 1.4 0.8 1.6 -1.6 0.1 1.0 1.0 2.2 0.7
Hypothyroidism (self reported) 0.8 1.8 3.3 -0.1 1.6 1.3 1.6 -1.6 -1.0 1.3 1.6 1.8 -0.1
Respiratory disease 0.4 0.9 3.6 -1.1 0.7 0.0 -0.3 1.1 -1.3 0.8 -0.3 -0.5 1.9
Type 2 Diabetes (T2D) (2018) 2.9 5.4 10.1 -1.4 -2.6 -2.6 -2.9 1.6 2.0 -2.2 -3.1 -3.2 -0.3
Lung FEV1/FVC ratio 0.5 2.6 7.1 0.3 -2.0 -2.7 -0.3 0.4 2.6 -2.2 -1.5 -0.8 -0.3
Lung FVC 1.2 6.2 12.4 2.2 1.5 2.3 3.3 -3.5 -0.6 1.5 2.5 3.1 2.7
Neuroticism 0.5 1.2 2.5 1.1 1.0 1.2 1.3 -0.9 0.0 0.9 1.6 1.4 0.6
Chronotype (morning person) 2.7 6.2 10.1 3.0 2.5 0.9 1.9 -2.5 -2.1 2.7 3.2 2.6 2.7
Hair Pigment 0.1 2.0 4.3 0.3 2.1 0.5 0.3 -2.0 -1.9 2.0 1.5 0.9 0.3
Tanning 0.1 1.1 4.0 1.0 0.6 2.0 0.8 -1.4 -1.0 0.8 0.7 0.5 0.9
Hand grip strength (left) 2.0 5.3 10.4 -2.4 -3.0 -1.8 -1.2 2.0 2.4 -2.9 -3.2 -2.3 -0.0
Number of treatments/medications taken 0.8 1.4 3.2 1.5 1.6 1.3 0.1 -0.6 -1.3 1.8 1.3 0.6 0.1
Average weekly spirits intake 1.4 1.8 4.0 -1.9 -0.8 -1.2 -2.0 1.2 0.2 -0.8 -1.7 -1.6 -0.7
Sensitivity / hurt feelings 0.4 0.6 1.6 -0.7 -0.5 -0.8 -1.0 1.0 0.5 -0.6 -1.3 -0.5 -0.6
Frequency of depressed mood in last 2 weeks 2.5 3.5 5.9 1.7 1.4 2.2 2.2 -2.4 -1.1 1.5 1.9 1.9 2.0
Hearing difficulty/problems: Yes 0.3 0.4 1.4 -1.2 0.5 0.1 0.4 0.8 -0.5 0.3 0.2 0.3 -1.0
Relative age of first facial hair 0.2 0.4 0.9 -0.8 0.6 -0.1 -0.3 0.3 -1.0 0.7 -0.5 -0.4 0.8
Other serious medical condition/disability diagnosed by doctor 2.9 3.7 6.1 1.8 2.0 1.6 2.4 -2.0 -1.4 1.9 2.3 2.5 0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 6.2 -0.3 -0.6 0.5 -0.9 0.1 0.3 -0.3 -0.3 -0.8 -2.5
Ever had hysterectomy (womb removed) 0.8 0.9 2.5 -0.7 0.6 1.3 -0.9 1.6 -1.1 0.9 -0.1 -0.4 -0.7
Systolic blood pressure, automated reading 0.1 0.3 1.0 1.0 0.1 -0.3 0.4 -0.9 0.1 0.1 0.3 0.4 -0.7
Eye problems/disorders: Diabetes related eye disease 3.7 4.1 7.8 -1.1 -2.8 -1.6 -1.3 2.4 2.3 -2.3 -2.1 -2.5 -0.4
Angina 0.2 0.3 0.9 -0.7 0.1 0.3 0.9 -0.5 0.2 -0.3 0.7 0.5 -0.0
Medication for hormone replacement therapy 0.6 0.7 2.1 -0.7 0.4 0.6 -0.9 1.4 -0.8 0.7 -0.5 -0.2 -1.2
Vitamin and mineral supplements 1.1 1.5 10.4 -3.2 -0.2 -0.6 -0.5 1.2 0.5 -0.6 -0.8 -0.5 -1.1
Supplements: Zinc 1.9 2.0 5.3 1.8 1.3 1.1 1.1 -1.2 -1.1 1.4 1.2 1.3 2.3
Medication: Co-codamol 0.3 0.3 0.8 -0.0 0.6 0.4 -0.6 -0.9 -0.7 0.7 0.2 -0.3 0.6
Medication: Metformin 2.0 2.9 5.0 -1.1 -2.0 -1.9 -1.8 1.0 1.8 -1.9 -2.2 -2.0 -0.4
Diabetes (father) 3.2 3.9 7.4 -1.6 -2.3 -2.7 -1.0 1.3 2.5 -2.7 -1.7 -1.5 -1.7
Diabetes (mother) 1.4 1.8 3.5 -1.4 -1.8 -0.4 -0.6 1.1 1.7 -1.9 -1.5 -1.1 -1.1
Severe depression (siblings) 4.4 4.9 8.4 1.5 2.1 2.2 2.9 -2.4 -1.4 2.0 2.7 2.4 2.0
Pack years adult smoking proportion 3.5 5.3 8.7 -2.5 -2.5 -0.7 -2.3 2.9 2.1 -2.6 -2.9 -2.5 -0.7
Impedance of leg (right) 3.2 15.6 23.8 3.4 4.3 3.7 4.1 -3.0 -3.4 4.6 4.9 4.0 3.7
Leg fat-free mass (left) 2.3 11.9 24.4 -2.4 -4.3 -3.8 -1.3 2.7 4.6 -4.9 -3.9 -2.2 -2.4
Trunk fat percentage 2.7 10.7 14.5 -3.1 -3.3 -2.4 -3.4 3.8 2.3 -3.4 -3.6 -3.8 -3.2
Hand grip strength (right) 2.1 5.8 10.9 -1.9 -3.2 -2.7 -1.2 1.6 2.6 -3.3 -3.1 -2.3 -0.4
Townsend deprivation index at recruitment 0.6 0.8 3.0 -0.9 0.5 1.7 -0.3 -0.8 -0.6 0.4 -0.4 -0.2 1.6
Current tobacco smoking 1.9 3.1 5.7 -1.9 -2.2 0.3 -1.6 2.2 1.4 -1.8 -1.6 -2.4 -1.5
Average weekly fortified wine intake 1.3 1.6 5.1 0.4 1.5 1.1 1.6 -1.3 -0.4 0.8 1.1 2.2 0.8
Maternal smoking around birth 3.3 4.7 10.3 -3.2 -1.9 -0.2 -2.7 2.4 0.4 -1.4 -3.0 -3.1 0.2
Fed-up feelings 0.6 1.0 2.3 0.4 -1.2 -0.6 -1.2 1.5 1.0 -0.9 -0.9 -1.4 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.5 0.7 0.7 1.1 0.7 -1.1 -0.8 1.0 0.7 0.6 1.2
Relative age voice broke 0.3 0.4 1.1 -0.6 -0.5 -0.6 -0.9 0.1 0.2 -0.2 -0.8 -1.0 0.6
Taking other prescription medications 1.1 1.6 4.3 0.2 2.1 1.4 0.1 -0.6 -1.7 2.0 1.4 1.0 -0.1
Age when periods started (menarche) 0.2 0.4 2.9 -0.1 -0.1 -0.0 0.7 -1.7 0.4 -0.6 -0.1 0.8 0.3
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.7 -0.5 1.0 0.6 -2.2 1.3 -1.8 1.4 -0.4 -1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.0 -0.1 0.1 -0.9 -1.0 0.3 -0.9 0.5 -0.9 -0.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.4 0.3 0.4 -0.2 1.5 -1.0 0.3 -0.2 1.0 1.5 -0.2
Qualifications: CSEs or equivalent 1.7 2.3 6.6 0.7 -1.6 -2.6 -0.5 1.5 1.9 -1.8 -1.7 -0.8 0.9
Serious illness, injury or assault to yourself 0.4 0.5 1.4 0.7 0.4 1.2 0.5 0.9 -0.4 0.8 1.1 0.0 -0.3
High blood pressure 0.4 1.1 2.0 0.5 1.4 0.8 0.9 -1.4 -0.8 1.2 1.0 1.4 -0.4
Hayfever, allergic rhinitis or eczema 1.0 2.2 5.9 0.3 1.7 1.6 -0.2 -1.2 -2.4 2.1 0.8 0.1 1.9
Multivitamins +/- minerals 1.1 1.4 9.3 3.0 -0.5 0.8 0.4 -1.6 -0.1 -0.1 0.2 0.3 1.0
Stomach or abdominal pain in last month 0.3 0.3 0.8 0.4 0.3 -0.3 -0.5 -0.3 -0.9 0.8 0.0 -0.5 0.8
Supplements: Glucosamine 4.2 5.4 9.0 0.0 -2.9 -1.8 -2.8 1.8 1.7 -2.4 -2.3 -2.9 -3.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 3.6 1.9 0.4 -0.9 0.6 -1.9 -0.2 0.5 0.7 0.7 1.2
Medication: Atenolol 0.3 0.3 0.9 -0.3 0.7 -0.6 1.0 -0.5 -0.2 0.6 0.7 0.3 0.1
Medication: Levothyroxine sodium 0.6 1.0 4.5 -0.0 1.1 1.2 0.7 -2.1 -0.8 1.0 0.7 0.9 -0.4
Sitting height 0.4 2.9 12.7 1.2 -0.8 -0.8 3.6 -0.4 2.2 -1.3 1.2 2.4 0.3
Chronic bronchitis/emphysema (father) 4.7 5.5 9.9 -0.6 -3.1 -1.0 -1.9 3.2 3.0 -2.9 -2.1 -2.7 -1.4
High blood pressure (mother) 0.4 0.6 2.4 -1.3 0.3 -0.4 0.0 -1.0 -0.4 0.4 -0.3 -0.0 1.6
Body mass index (BMI) 3.7 15.8 21.2 -3.6 -4.0 -3.5 -4.2 4.5 2.9 -4.0 -4.6 -4.5 -3.7
Impedance of leg (left) 2.4 11.7 17.7 3.3 3.6 3.1 3.5 -2.9 -3.0 3.9 4.2 3.4 3.2
Leg predicted mass (left) 2.3 11.9 24.8 -2.3 -4.4 -3.8 -1.2 2.6 4.7 -5.0 -3.8 -2.2 -2.4
Trunk fat mass 3.2 13.8 19.0 -3.2 -4.1 -3.1 -3.1 4.2 3.4 -4.4 -4.1 -3.8 -3.5
Waist circumference 5.0 18.2 26.3 -3.0 -4.9 -3.8 -3.3 4.7 4.5 -5.1 -4.6 -4.2 -4.1
Number of incorrect matches in round 0.6 1.0 1.9 1.4 1.1 0.4 0.9 -0.8 -1.1 1.2 1.2 1.0 0.6
Past tobacco smoking 1.1 2.1 3.8 0.6 1.8 0.6 1.0 -2.0 -1.7 1.9 1.2 1.3 1.6
Alcohol usually taken with meals 4.5 7.3 13.1 -2.8 -3.0 -2.1 -2.6 2.3 2.4 -2.8 -3.6 -2.7 -2.3
Nervous feelings 1.4 2.6 5.5 2.3 1.5 0.8 2.0 -1.5 -0.4 1.2 1.9 2.3 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.6 1.1 -0.1 1.3 1.1 -0.7 0.7 0.0 0.9 0.4 0.6
Hearing difficulty/problems with background noise 1.1 1.7 5.2 -1.3 -1.0 0.2 -1.1 2.1 0.4 -0.9 -0.9 -1.4 -2.3
Hair/balding pattern: Pattern 2 1.2 1.5 4.0 -0.7 1.4 2.0 0.6 -1.5 -1.1 1.4 0.5 1.0 1.2
Had menopause 0.4 0.5 3.6 0.1 -0.0 0.2 -0.7 0.3 -0.4 0.3 0.1 -0.7 -1.9
Had other major operations 0.4 0.5 1.1 -0.9 -0.7 -0.3 -0.3 0.5 0.7 -0.7 -0.7 -0.6 -1.1
Forced vital capacity (FVC) 1.4 5.2 14.9 2.1 0.3 1.1 3.9 -3.2 0.9 0.1 1.3 3.1 3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.6 -0.1 -0.5 -1.1 -1.2 0.2 -0.2 -0.1 -1.3 -0.9 -0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.3 -0.5 -0.1 0.3 -0.3 0.3 0.3 -0.4 0.2 -0.1 0.2
Qualifications: None of the above 0.5 1.0 2.7 -0.5 -0.6 1.7 -1.6 0.7 -0.1 -0.1 -0.8 -1.5 -1.0
Financial difficulties in last 2 years 0.7 0.9 2.6 0.5 0.4 1.6 1.4 0.3 -0.4 0.4 1.2 0.6 1.4
Mouth/teeth dental problems 0.7 1.1 2.9 0.2 -0.7 -0.3 1.7 -1.6 1.6 -1.2 0.3 1.2 0.3
Heart attack 0.9 1.1 3.7 1.0 0.7 0.8 1.3 -1.9 -0.2 0.6 0.8 1.0 1.4
Allergy 0.3 0.8 2.1 1.5 -0.3 -0.4 1.1 -0.4 1.1 -0.5 0.9 1.0 -0.8
Pain all over the body in last month 0.2 0.3 0.6 -0.3 -0.3 -0.2 -0.8 0.3 0.6 -0.5 -0.8 -0.5 0.4
Diabetes (self-reported) 3.5 5.4 10.4 -2.1 -2.5 -2.1 -3.1 1.4 1.5 -2.2 -3.1 -3.2 -0.6
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.8 -1.2 0.7 1.0 -1.3 0.7 -1.3 0.9 -0.5 -0.9 0.9
Medication: Ramipril 0.3 0.3 1.9 0.5 0.5 0.6 -0.3 -1.4 -0.2 0.6 -0.1 0.2 0.2
Medication: Simvastatin 0.1 0.2 0.6 0.7 -0.5 0.1 -0.0 -0.1 0.8 -0.4 -0.1 -0.1 -0.4
Fluid intelligence score 0.2 0.4 1.2 -0.0 -0.7 -0.1 0.5 -0.4 1.1 -1.1 0.1 0.3 0.5
Illnesses of siblings 0.4 0.6 2.0 1.4 -0.1 -0.4 0.9 -0.6 0.3 -0.2 0.4 0.8 1.4
Neuroticism score 0.7 1.5 3.4 1.3 1.2 1.3 1.5 -0.7 -0.3 1.1 1.9 1.7 0.2
Weight 2.9 14.1 23.9 -2.6 -4.5 -3.7 -2.2 3.8 4.3 -4.9 -4.1 -3.1 -3.4
Impedance of arm (right) 2.2 10.0 16.0 2.8 3.3 3.4 2.5 -3.1 -2.8 3.6 3.2 2.7 4.0
Arm fat percentage (right) 2.8 10.9 16.4 -3.1 -3.2 -2.5 -3.9 3.7 2.2 -3.2 -4.0 -4.0 -2.6
Trunk fat-free mass 1.8 10.4 25.2 -1.5 -4.3 -3.6 -0.1 2.1 5.0 -4.9 -3.1 -1.3 -2.3
Hip circumference 2.3 9.9 18.2 -2.7 -3.7 -2.6 -1.7 2.9 3.6 -4.3 -3.6 -2.2 -3.4
Time employed in main current job 1.4 1.7 4.6 0.2 -1.3 -2.1 -0.6 -0.3 1.9 -1.7 -1.0 -0.6 -1.5
Alcohol intake versus 10 years previously 1.5 2.2 4.2 1.5 1.6 1.8 0.9 -1.6 -1.2 1.6 2.0 1.3 1.1
Father’s age at death 2.6 3.5 12.5 -2.1 -1.3 -1.5 -2.3 0.3 0.6 -1.3 -1.2 -2.2 -3.5
Worrier / anxious feelings 3.6 6.8 12.3 2.9 2.7 2.2 3.3 -1.8 -1.4 2.6 3.2 3.5 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.9 -1.0 -0.7 -0.4 -0.4 1.7 0.4 -0.5 -0.3 -1.0 0.3
Falls in the last year 6.0 8.1 17.0 2.9 3.0 2.1 2.0 -4.1 -2.5 3.2 2.7 2.4 2.9
Hair/balding pattern: Pattern 3 0.2 0.3 1.2 0.8 0.2 0.7 0.6 0.4 0.0 0.3 1.1 0.4 0.3
Number of live births 2.3 3.3 6.2 -1.2 -1.9 -0.2 -2.1 2.3 1.1 -1.7 -1.6 -2.3 -2.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 10.3 2.0 -0.1 0.3 3.2 -2.5 1.2 -0.2 0.6 2.4 3.2
Pulse rate 1.9 3.2 5.8 2.3 1.2 -0.6 2.4 -1.9 -0.5 0.9 2.3 2.4 1.9
Happiness 0.2 0.3 1.3 0.5 -0.3 0.5 0.4 -1.2 0.1 -0.2 0.7 0.3 0.5
Noisy workplace 0.6 0.8 2.5 0.2 1.0 0.9 0.7 -1.6 -0.7 0.9 0.8 0.9 -0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.8 0.3 0.7 0.1 1.7 -1.1 -0.2 0.5 0.9 1.2 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 3.3 -0.3 -1.4 -1.3 0.4 0.5 1.8 -1.6 -0.2 -0.4 -1.5
Mouth/teeth dental problems: Dentures 0.9 1.4 4.7 -0.6 0.4 0.6 -1.5 2.2 -1.0 0.9 -0.2 -1.2 -1.8
Asthma 0.4 0.8 2.5 -1.3 0.6 0.1 -0.1 1.1 -1.2 0.6 0.1 -0.4 1.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 5.1 2.3 0.3 1.3 1.4 -1.0 0.5 0.4 1.4 1.3 -0.1
Medication: Cholesterol lowering 1.0 1.5 3.6 1.9 1.1 0.8 1.6 -1.0 -0.4 1.1 1.8 1.3 0.7
Depression (self-reported) 0.8 1.0 2.2 0.9 1.1 1.1 0.8 -1.5 -0.6 0.9 1.2 0.9 0.4
Medication: Lansoprazole 0.6 0.6 2.0 -0.2 0.8 0.2 -0.9 -0.6 -1.4 1.2 0.5 -0.6 0.8
Prospective memory result 0.1 0.1 0.5 0.6 -0.2 -0.0 0.3 0.7 0.4 -0.1 0.0 0.1 0.2
Lung cancer (father) 0.3 0.4 1.8 -0.3 -0.8 0.3 0.2 0.6 1.3 -0.7 -0.6 -0.5 0.1
Illnesses of mother 0.4 0.5 1.6 1.3 0.5 -0.0 -1.0 0.5 -0.8 0.6 0.4 0.0 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 12.5 2.8 0.2 0.2 3.5 -3.2 0.9 0.0 1.0 3.0 3.0
Pulse wave Arterial Stiffness index 0.7 0.9 1.8 0.0 -1.3 -0.0 -1.2 0.8 0.9 -0.9 -0.7 -1.4 -0.9
Impedance of arm (left) 1.6 7.2 9.9 2.5 2.8 2.9 2.2 -2.6 -2.7 3.1 2.9 2.3 2.7
Arm fat mass (right) 3.7 15.1 19.6 -3.4 -4.2 -3.6 -3.5 4.0 3.5 -4.4 -4.4 -4.0 -3.6
Trunk predicted mass 1.8 10.1 24.6 -1.5 -4.2 -3.5 -0.1 2.1 5.0 -4.8 -3.1 -1.3 -2.3
Standing height 0.5 5.3 15.7 1.7 -2.0 -1.3 4.0 -0.8 3.9 -2.8 0.4 2.4 -0.2
Length of working week for main job 0.9 1.0 2.3 -1.0 -0.9 -1.5 -0.8 1.5 0.3 -0.8 -0.3 -1.3 -0.8
Exposure to tobacco smoke at home 0.2 0.2 0.8 0.2 -0.4 -0.9 -0.6 -0.2 0.4 -0.3 -0.4 -0.6 0.3
Breastfed as a baby 2.2 2.8 6.9 2.5 1.2 1.3 1.4 -2.6 -1.0 1.3 1.8 1.8 0.1
Tense / ‘highly strung’ 5.7 9.4 17.2 2.5 3.2 3.2 3.7 -2.6 -1.7 3.1 3.5 4.1 2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.7 8.1 1.7 2.3 2.6 2.7 -0.6 -1.2 2.1 2.9 2.4 2.2
Hair/balding pattern: Pattern 4 0.5 1.1 2.3 -0.6 -1.1 -1.2 -1.3 0.5 0.6 -0.8 -1.5 -1.4 -1.0
Birth weight of first child 0.5 1.0 1.9 1.0 -0.8 -0.5 1.4 0.7 1.2 -1.0 0.9 0.6 -1.3
Peak expiratory flow (PEF) 0.7 1.7 4.9 -0.6 -1.6 -1.2 0.9 0.9 2.2 -1.8 -1.4 -0.1 0.9
Pulse wave reflection index 0.7 0.9 2.5 -0.1 -0.9 0.5 -1.6 0.6 0.6 -0.6 -1.0 -1.5 -1.1
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.3 0.9 1.1 1.5 0.2 0.3 -0.8 1.2 0.8 0.4 0.9
Loud music exposure frequency 1.0 1.1 3.9 0.2 0.7 0.6 2.0 -1.2 -0.3 0.6 1.7 1.2 0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 4.7 0.1 -0.4 -2.2 -0.1 0.3 0.3 -0.3 0.5 -0.5 -0.0
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.2 1.4 1.2 0.3 0.0 -1.5 -1.2 1.2 0.6 0.9 1.3
Blood clot in the leg (DVT) 0.2 0.3 1.7 -1.3 0.2 0.4 -0.1 -0.6 -0.0 -0.1 -0.4 0.2 -0.6
Medication: Paracetamol 1.2 2.0 8.1 1.3 0.7 1.8 1.6 -1.1 0.1 0.8 0.4 1.1 2.8
Headache pain in last month 0.8 1.4 5.0 1.4 0.8 -0.3 2.2 -1.0 0.1 0.5 1.3 1.6 0.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.7 -1.3 -0.7 0.1 -1.3 1.3 -0.2 -0.5 -1.0 -1.3 -0.2
Glaucoma (self-reported) 0.1 0.1 0.6 -0.3 -0.0 0.0 -0.7 -0.1 0.3 -0.0 -0.2 -0.6 0.3
Gout (self-reported) 0.8 1.0 2.1 0.4 1.3 0.6 0.6 -1.4 -1.4 1.3 0.8 1.0 -0.6
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.9 0.4 1.7 1.5 1.0 -2.0 -1.5 1.6 1.4 1.2 -0.2
Medication: Amlodipine 0.6 0.9 3.0 0.5 1.1 0.9 1.2 -0.9 -0.4 0.7 0.7 1.7 0.1
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.2 -1.2 -0.9 -1.5 -1.0 1.1 0.7 -0.8 -1.2 -1.3 0.7
Birth weight 2.6 5.7 14.0 3.4 1.1 0.1 3.7 -2.7 0.4 0.5 3.1 3.7 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.6 -0.8 -0.6 1.3 -0.6 0.7 0.0 -0.3 -0.8 -0.7 -0.4
High blood pressure (siblings) 0.5 0.7 2.6 -0.6 -0.4 -0.5 -1.5 0.6 -0.4 0.1 -0.9 -1.6 -0.5
Forced vital capacity (FVC), Best measure 2.1 7.9 19.0 3.2 1.0 1.1 4.4 -4.0 0.2 0.8 2.0 3.8 3.5
Body fat percentage 2.5 9.7 15.1 -2.9 -3.0 -2.2 -3.4 3.9 2.0 -3.0 -3.5 -3.8 -3.0
Leg fat percentage (right) 1.6 5.7 14.0 -2.5 -1.9 -1.3 -2.7 3.7 1.1 -1.8 -2.4 -3.0 -2.2
Arm fat-free mass (right) 2.6 13.4 26.7 -2.3 -4.6 -3.8 -0.9 3.1 5.0 -5.2 -3.4 -2.1 -3.9
Exposure to tobacco smoke outside home 0.3 0.3 1.7 -0.2 -0.3 1.3 -0.9 0.3 -0.0 -0.0 -0.3 -0.8 -0.3
Comparative body size at age 10 1.3 3.6 6.4 -2.0 -1.6 -1.3 -2.0 2.5 1.1 -1.6 -2.0 -2.1 -2.2
Number of full brothers 0.8 1.0 7.2 -2.7 0.4 0.6 0.1 1.3 -0.5 -0.1 -0.7 0.0 0.2
Worry too long after embarrassment 0.3 0.6 1.7 0.4 0.8 0.4 0.9 0.1 -0.1 0.5 0.7 1.1 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.3 6.8 1.3 2.3 2.5 1.2 0.3 -1.8 2.6 2.3 1.2 1.2
Wheeze or whistling in the chest in last year 1.4 2.4 7.2 -2.7 -1.3 -0.6 -1.9 1.7 0.6 -1.3 -1.5 -2.1 -0.3
Number of children fathered 1.1 1.2 3.5 1.2 0.6 -0.6 1.5 -0.3 -0.5 0.6 1.3 1.3 1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 4.2 0.6 1.1 -0.1 -1.4 -1.7 -1.9 1.7 -0.1 -1.1 2.0
Age at first live birth 0.7 1.3 1.9 0.7 1.4 -0.3 1.3 -1.2 -1.2 1.4 1.2 1.1 1.2
Pulse wave peak to peak time 1.0 1.1 2.6 0.3 1.3 0.1 1.6 -1.0 -0.8 0.9 1.0 1.6 1.0
Health satisfaction 0.8 1.1 1.9 -0.7 -1.0 -0.7 -1.3 1.0 0.9 -1.0 -0.6 -1.3 -1.4
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.1 0.0 0.0 0.4 -0.3 0.3 -0.2 0.2 0.3 -0.6
Qualifications: College or University degree 0.5 1.7 3.9 0.9 1.3 0.6 1.9 -1.8 -1.0 1.1 1.2 2.0 0.6
Eye problems/disorders: None of the above 1.6 1.8 5.6 0.5 1.7 0.8 2.1 -0.2 -0.9 1.3 1.3 2.4 0.4
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.2 0.0 0.3 -0.3 0.3 -0.4 -0.1 0.5 -0.1 -0.5
Emphysema/chronic bronchitis 0.4 0.4 1.1 -0.3 -0.9 0.4 -0.6 1.0 0.6 -0.8 -0.4 -0.4 -0.5
Medication for pain relief, constipation, heartburn 1.5 2.6 8.0 -1.7 -1.1 -2.8 -1.7 0.7 1.0 -1.6 -1.7 -1.1 -1.5
Neck or shoulder pain in last month 0.3 0.5 3.0 0.5 -0.2 1.7 -0.3 0.9 -0.1 0.1 -0.2 -0.5 -0.6
Medication: Blood pressure 0.5 0.9 3.1 0.9 0.8 0.3 1.1 -1.7 -0.5 0.8 1.1 1.1 -0.6
Angina (self-reported) 0.2 0.3 0.9 -0.8 0.1 0.5 1.0 -0.4 0.2 -0.2 0.6 0.6 0.1
Migraine (self-reported) 3.1 3.8 8.9 1.5 1.8 1.6 2.8 -2.4 -0.2 1.1 2.5 3.0 -0.2
Medication: Ibuprofen 0.9 1.0 2.6 1.6 0.4 1.1 1.5 -0.5 0.4 0.3 1.2 1.4 -0.2
Medication: Allopurinol 0.2 0.3 0.7 -0.7 0.4 -0.3 -0.1 -0.8 -0.7 0.4 -0.5 0.0 -0.6
Medication: Omeprazole 0.8 1.0 5.1 0.1 -0.3 1.3 0.7 2.3 0.8 -0.4 0.4 0.4 -1.1
Medication: Seretide 50 evohaler 0.3 0.3 0.8 0.9 -0.0 0.7 0.7 -0.6 0.5 -0.1 0.2 0.8 0.4
Mean time to correctly identify matches 1.7 3.2 7.2 1.4 2.6 1.0 1.2 -0.6 -2.1 2.7 1.9 1.4 1.9
Heart disease (mother) 0.4 0.5 1.3 1.1 0.8 -0.1 0.5 -0.2 -0.9 0.9 0.6 0.4 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.5 6.5 10.4 -3.0 -2.7 -1.4 -2.1 3.2 2.5 -2.8 -3.0 -2.6 -1.7
Whole body fat mass 3.2 13.2 17.6 -3.0 -4.0 -3.1 -3.0 4.2 3.3 -4.2 -3.9 -3.7 -3.7
Leg fat mass (right) 2.5 9.8 15.3 -2.8 -3.3 -2.8 -2.6 3.9 2.8 -3.4 -3.4 -3.3 -2.9
Arm predicted mass (right) 2.7 13.8 28.0 -2.5 -4.7 -3.9 -1.1 3.0 5.0 -5.3 -3.7 -2.2 -3.6
Pulse rate, automated reading 2.2 7.2 14.4 2.6 2.2 1.4 3.8 -2.2 -1.3 1.9 3.5 3.6 2.9
Alcohol intake frequency. 0.2 0.4 1.6 -1.3 -0.3 -0.1 -0.8 -0.3 0.4 -0.6 -0.6 -0.2 -1.0
Comparative height size at age 10 0.4 2.1 7.0 -0.1 -2.1 -1.3 0.6 -0.1 2.6 -2.3 -1.5 0.1 -0.3
Number of full sisters 0.9 1.1 3.9 0.6 -0.5 0.0 2.0 -0.2 1.6 -1.0 0.4 1.4 -0.9
Suffer from ‘nerves’ 1.9 2.9 5.0 2.2 1.6 1.4 2.2 -1.6 -0.2 1.2 2.2 2.2 1.1
Overall health rating 1.0 2.2 5.0 -0.2 -1.6 -1.5 -0.6 2.2 2.0 -2.0 -0.7 -0.7 -1.7
Chest pain or discomfort 0.6 0.8 2.2 -0.8 0.9 1.3 0.8 0.3 -0.8 0.9 0.6 0.5 1.5
Had major operations 0.5 0.6 2.9 -0.3 -0.1 -0.5 0.5 1.7 -0.1 -0.4 0.9 0.1 -1.2
Age at last live birth 0.3 0.4 0.8 0.4 0.3 -0.0 0.8 -0.8 -0.4 0.3 0.9 0.6 -0.9
Family relationship satisfaction 0.2 0.3 0.7 -0.4 0.3 0.9 0.8 -0.4 -0.2 0.1 0.6 0.5 0.6
Leg pain on walking 0.3 0.3 0.9 -0.8 -0.4 0.3 -0.9 0.2 0.2 -0.5 -0.8 -0.7 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.7 0.1 -0.8 -1.3 -0.2 1.6 1.0 -0.8 -1.0 -0.4 -0.1
Commuting to job workplace: Car/motor vehicle 2.1 2.4 4.6 -0.9 -1.6 -1.1 -1.6 2.0 1.1 -1.5 -2.1 -2.0 -0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 2.7 -0.8 0.4 -0.4 -0.3 -1.6 -0.1 -0.0 -0.3 0.5 -0.4
Medication: Aspirin 0.3 0.4 1.4 1.0 0.1 1.2 0.7 -0.5 -0.2 0.3 0.9 0.3 -0.2
Supplements: Vitamin C 3.4 4.0 6.2 1.1 2.3 2.3 1.6 -2.1 -2.1 2.5 2.2 1.9 1.4
Knee pain experienced in last month 1.3 2.1 6.4 -0.3 -1.2 -1.4 -2.5 0.4 0.4 -0.9 -2.1 -2.3 -0.5
Hypertension (Self-reported) 0.6 1.6 2.8 0.6 1.7 1.2 1.2 -1.6 -1.0 1.5 1.2 1.7 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 4.7 0.3 1.1 1.1 -0.7 -0.0 -1.9 1.7 0.1 -0.6 2.2
Illnesses of father: Heart disease 0.4 0.5 1.5 -1.2 -0.2 0.1 -0.7 1.0 -0.5 0.1 -1.0 -1.0 -0.5
Illnesses of siblings: Diabetes 3.1 3.9 5.7 -2.3 -2.1 0.3 -1.6 2.1 2.0 -2.2 -2.4 -2.2 -1.5
Smoking status: Previous 0.2 0.3 0.7 0.8 -0.6 -0.1 0.2 0.8 0.6 -0.8 0.0 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 2.9 1.0 0.1 0.7 1.1 -0.8 0.1 0.0 0.1 1.0 1.7
Whole body fat-free mass 2.2 12.4 27.2 -2.0 -4.6 -3.9 -0.6 2.5 5.2 -5.2 -3.7 -1.8 -2.6
Leg fat-free mass (right) 2.3 12.5 26.0 -2.2 -4.5 -4.0 -1.4 2.4 4.7 -5.1 -4.0 -2.2 -2.5
Arm fat percentage (left) 3.2 12.6 18.6 -3.3 -3.5 -2.7 -4.0 4.0 2.2 -3.4 -4.1 -4.3 -3.3
Average weekly red wine intake 0.8 1.2 2.2 -1.2 1.5 1.2 0.9 -0.5 -1.1 1.2 0.2 1.2 1.1
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.5 0.9 0.7 1.6 1.4 -0.5 -0.3 0.8 1.3 1.2 1.5
Mood swings 0.7 1.2 4.1 2.0 0.5 0.9 1.4 -1.0 0.2 0.5 1.5 1.2 -0.3
Loneliness, isolation 1.0 1.4 5.4 -0.5 -1.3 -0.0 -0.6 1.4 1.4 -1.2 -0.3 -0.9 -2.3
Long-standing illness, disability or infirmity 2.7 4.2 9.0 1.1 3.0 2.1 0.8 -1.6 -2.7 3.0 2.3 1.7 0.5
Ever had bowel cancer screening 0.3 0.3 1.0 -0.8 0.7 0.4 -0.0 -0.3 -0.5 0.4 0.0 0.5 -1.0
Diabetes diagnosed by doctor 5.1 8.4 15.1 -2.7 -3.0 -2.7 -3.6 2.4 2.1 -2.8 -3.7 -3.9 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 4.2 -1.3 -1.6 -1.4 -1.4 1.7 1.1 -1.5 -0.9 -1.8 -2.0
Friendships satisfaction 0.3 0.4 1.2 0.8 -0.2 0.1 1.1 -0.3 0.7 -0.7 0.3 0.8 0.4
Qualifications: nursing, teaching 0.9 1.4 2.5 -0.1 -1.6 -1.5 -0.8 0.8 1.1 -1.6 -1.6 -1.1 0.9
Commuting to job workplace: Walk 1.0 1.1 4.9 0.1 -0.4 -2.2 -0.9 1.6 0.3 -0.1 -0.2 -1.0 -1.0
Eye problems/disorders: Cataract 0.4 0.5 0.9 0.5 -0.9 -0.7 -1.0 0.2 0.3 -0.7 0.3 -0.9 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.6 -1.3 -0.2 0.5 -1.0 0.5 -0.5 -0.1 -0.9 -1.2 0.8
Medication for cholesterol 0.9 1.4 5.0 0.3 0.7 0.8 2.2 -1.3 -0.1 0.5 1.2 1.4 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 3.7 0.2 1.9 1.7 1.6 -1.5 -1.6 1.5 1.8 1.7 1.3
Back pain experienced in last month 0.6 0.8 1.7 0.6 -1.3 0.3 -0.4 1.3 1.1 -0.8 -0.7 -0.9 -1.1
Mineral and other dietary supplements 2.2 3.0 5.8 -1.0 2.0 1.6 2.4 0.1 -1.2 1.7 1.7 1.8 2.4
Breast cancer (self-reported) 0.5 0.6 1.1 -0.9 1.0 0.9 -0.2 0.1 -1.1 0.9 -0.1 0.3 0.9
Asthma (self-reported) 0.4 0.9 3.7 -0.7 1.0 0.1 0.4 0.5 -1.3 1.0 0.5 0.2 1.9
Osteoporosis (self-reported) 2.0 2.5 6.2 2.5 1.8 1.0 1.0 -0.4 -1.5 2.0 2.3 1.3 0.8
Osteoarthritis (self-reported) 0.2 0.2 0.9 0.8 -0.1 -0.5 0.0 -0.9 0.3 -0.1 0.1 0.4 -0.5
Medication: Aspirin 0.3 0.3 1.1 0.9 -0.2 1.1 0.7 -0.3 0.3 -0.1 0.7 0.2 -0.4
Medication: Gliclazide 0.3 0.3 0.9 -0.6 -0.5 0.2 0.0 0.9 0.8 -0.7 -0.7 -0.0 -0.6
Illnesses of father: None of the above (group 1) 2.5 3.0 5.7 1.1 2.1 0.8 1.4 -2.4 -1.6 2.0 1.7 2.1 1.6
Smoking status: Current 2.1 3.3 6.2 -1.6 -2.4 0.1 -1.6 2.2 1.6 -1.9 -1.8 -2.5 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 12.1 1.3 0.9 0.5 1.6 -3.5 -0.4 1.0 1.2 1.4 1.6
Whole body water mass 2.3 12.9 27.7 -2.1 -4.7 -4.0 -0.8 2.5 5.2 -5.3 -3.8 -2.0 -2.6
Leg predicted mass (right) 2.4 12.7 26.5 -2.2 -4.6 -4.0 -1.4 2.4 4.8 -5.1 -4.1 -2.3 -2.5
Arm fat mass (left) 4.3 17.8 23.0 -3.4 -4.6 -4.0 -3.8 4.4 3.7 -4.8 -4.7 -4.4 -4.2
Number of self-reported non-cancer illnesses 0.5 0.9 2.0 0.2 1.1 1.3 0.8 -0.4 -0.5 0.9 1.4 1.1 -0.8
Average weekly champagne plus white wine intake 1.0 1.4 3.9 0.5 -1.5 -1.9 0.2 -0.4 2.0 -1.5 -0.9 -0.0 0.7
Miserableness 0.4 0.7 1.8 0.8 0.9 0.7 0.8 0.2 -0.5 0.8 1.4 0.8 0.9
Guilty feelings 0.6 1.0 3.6 1.9 -0.3 0.7 1.3 -0.9 0.8 -0.1 1.2 0.8 -0.2
Wears glasses or contact lenses 2.3 2.7 5.6 0.6 2.4 1.4 1.3 -1.1 -2.2 2.2 1.8 2.0 -0.0
Ever taken oral contraceptive pill 3.2 3.5 5.4 -1.1 -2.2 -2.2 -1.3 1.6 2.2 -2.3 -2.3 -1.9 -0.9
Hearing aid user 2.7 3.1 4.3 1.4 1.9 1.9 1.9 -2.1 -1.4 2.0 1.9 1.8 0.8
Mother’s age at death 0.6 0.8 3.9 -2.0 0.8 0.2 -0.6 0.7 -1.2 0.8 -0.1 -0.7 0.3
Financial situation satisfaction 0.2 0.3 0.8 0.4 0.4 0.4 0.5 -0.9 -0.7 0.4 0.8 0.2 0.4
Tinnitus: Yes, now most or all of the time 7.8 9.1 16.1 -1.7 -3.9 -2.4 -2.0 2.0 3.2 -3.9 -3.2 -2.7 -4.0
Commuting to job workplace: Public transport 0.4 0.5 1.2 0.4 0.9 0.3 0.4 -0.2 -0.9 1.1 0.8 0.7 0.3
Eye problems/disorders: Glaucoma 0.7 0.9 2.7 -0.8 -0.6 -0.1 -1.5 0.9 0.4 -0.4 -1.2 -1.6 0.3
Medication: Blood pressure 0.2 0.4 1.4 0.7 0.2 -0.7 -0.9 -0.5 0.2 -0.1 -0.1 -0.0 -1.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.4 -0.7 -1.1 0.3 -1.1 0.8 0.7 -1.0 -1.0 -1.0 -1.2
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.7 1.2 -1.0 -1.5 -1.6 -0.8 0.5 -0.8 -1.1 -0.9 -1.1
High cholesterol (Self-reported) 0.3 0.5 1.7 1.3 -0.8 -0.1 -0.5 0.5 0.8 -0.6 0.0 -0.5 -0.9
Medication: Bendroflumethiazide 0.3 0.5 2.3 -0.6 0.4 0.9 0.4 0.0 0.1 0.0 0.5 0.7 -1.5
Medication: Paracetamol 0.6 0.9 3.3 0.8 0.2 1.7 1.2 -0.0 0.4 0.3 0.3 0.6 1.8
Medication: Lisinopril 1.0 1.2 5.0 -1.4 -0.1 -1.8 -0.8 0.2 0.0 -0.5 -0.7 -0.9 -2.2
Medication: Atorvastatin 0.2 0.2 0.8 -0.4 0.2 -0.9 0.4 0.2 0.1 -0.2 0.2 0.4 0.7
Illnesses of father: High blood pressure 2.3 2.9 4.0 1.9 1.8 1.0 1.6 -1.6 -1.4 1.8 1.9 1.7 2.0
Alcohol drinker status: Never 2.8 3.4 9.4 1.6 1.9 0.3 1.7 -3.1 -1.4 1.9 1.9 1.9 1.6
Ever smoked 2.1 3.6 5.9 -1.7 -2.2 -0.4 -1.5 2.2 2.0 -2.3 -1.7 -1.9 -2.4
Basal metabolic rate 2.4 13.0 27.4 -2.2 -4.7 -4.0 -1.0 2.8 5.0 -5.2 -3.8 -2.1 -2.7
Leg fat percentage (left) 2.1 7.5 13.9 -2.8 -2.4 -1.7 -3.2 3.7 1.5 -2.3 -2.9 -3.4 -2.5
Arm fat-free mass (left) 2.6 13.1 27.8 -2.1 -4.7 -3.9 -0.9 2.7 5.1 -5.3 -3.5 -1.9 -3.3
Number of operations (self-reported) 0.4 0.5 2.4 0.1 -0.3 0.2 0.1 1.1 0.7 -0.6 0.9 0.1 -1.5
Average weekly beer plus cider intake 0.5 0.7 3.1 1.4 -0.3 -0.0 1.0 0.3 0.4 -0.1 0.1 0.4 1.8
Irritability 0.7 1.2 6.4 -1.7 0.1 2.5 -0.7 1.0 -0.3 0.2 -0.7 -0.5 0.3
Risk taking 4.6 6.7 14.2 0.8 2.5 3.2 3.8 -2.2 -1.5 2.1 2.5 3.3 2.7
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.9 0.9 -0.1 -0.6 1.7 -0.1 1.1 -0.7 1.1 1.5 -1.6
Fractured/broken bones in last 5 years 2.2 2.8 5.4 2.3 1.5 1.5 1.5 -2.1 -1.0 1.4 1.6 2.1 1.4
Age started oral contraceptive pill 0.8 1.0 2.0 -1.4 0.3 1.0 -1.4 0.6 -1.2 0.6 -0.4 -1.0 -1.1
Diastolic blood pressure, automated reading 0.3 1.0 2.4 0.9 0.9 -0.6 1.3 -1.3 -0.5 0.6 1.0 1.6 -0.6
Ever depressed for a whole week 0.3 0.4 0.9 -0.9 -0.6 0.4 -0.8 0.2 0.4 -0.7 -0.9 -0.7 0.4
Unable to work because of sickness or disability 1.9 2.5 5.0 1.0 1.6 2.2 1.6 -2.0 -1.0 1.4 1.4 1.6 1.5
Commuting to job workplace: Cycle 1.8 2.2 8.0 -0.4 1.2 2.1 1.4 -2.8 -0.7 0.9 0.9 1.7 1.2
Myopia 0.9 1.3 4.4 0.3 1.8 -0.4 -0.1 0.1 -2.1 2.0 0.8 0.3 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.6 -0.0 -1.0 -0.6 -0.7 1.3 0.3 -0.7 -0.8 -1.1 0.6
Cholesterol lowering medication 2.9 4.3 7.2 -1.7 -2.5 -1.2 -2.6 1.1 1.8 -2.6 -2.7 -2.5 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 4.0 0.7 0.7 2.0 0.6 1.2 -0.6 0.8 1.0 0.6 -0.4
Pain experienced in last month 0.4 0.7 1.8 0.3 0.9 -0.5 0.7 -1.0 -0.8 0.7 1.4 0.9 0.4
Supplements: Calcium 0.4 0.5 1.8 0.7 -0.1 0.5 -1.4 0.8 -0.1 0.3 0.2 -1.1 -0.2
Basal cell carcinoma (self-reported) 2.3 2.7 5.5 -1.9 -1.8 -1.1 -2.3 0.8 0.9 -1.7 -1.9 -2.2 -0.4
Heart attack/myocardial infarction (self-reported) 1.3 1.6 4.1 1.2 0.9 0.9 1.8 -2.0 -0.2 0.7 1.3 1.5 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 -1.0 0.5 0.7 0.0 -0.5 -0.4 0.2 -0.1 0.5 -0.4
Heart disease (siblings) 0.3 0.4 1.9 -1.4 -0.3 -0.2 -0.2 0.0 0.6 -0.6 -0.2 -0.2 -1.0
Alcohol drinker status: Previous 1.0 1.1 2.2 0.1 1.5 1.0 0.5 -1.1 -1.1 1.2 0.8 1.2 1.2
Pack years of smoking 4.1 6.0 9.9 -2.5 -2.6 -0.9 -2.6 3.2 2.1 -2.7 -2.9 -2.7 -1.5
Impedance of whole body 2.0 10.1 14.0 2.8 3.4 3.2 2.8 -2.8 -3.1 3.7 3.7 2.8 3.3
Leg fat mass (left) 2.8 10.8 14.8 -2.8 -3.5 -3.0 -2.8 3.9 2.9 -3.6 -3.6 -3.5 -3.1
Arm predicted mass (left) 2.6 13.0 26.8 -2.5 -4.6 -4.0 -1.1 2.7 5.0 -5.2 -3.8 -2.2 -2.8