Hub : Genes

SYNE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.073	0.0250	7.3e-04	0.014	0.030	0.036	0.032	0.042	0.0067	1.4e-04	3.2e-05	8.0e-05	5.9e-06
2	GTEx	Artery Aorta	0.160	0.0630	5.5e-03	0.038	NA	0.004	NA	0.017	0.0038	NA	1.9e-01	NA	4.0e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.121	0.0337	1.1e-05	0.010	0.048	0.035	0.048	0.024	0.0150	6.9e-07	2.4e-05	8.5e-07	3.5e-04
4	TCGA	Liver Hepatocellular Carcinoma	0.144	0.0640	8.9e-03	0.014	0.010	0.037	NA	0.031	0.0720	1.0e-01	7.2e-03	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	5.3	0.4	2.3	1.4	1.2
Bipolar Disorder or Schizophrenia	0.8	2.1	7.3	-0.7	2.7	0.7	-0.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.6	1.6	-0.4	0.9	-1.2
Depression (Nagel 2018)	0.2	0.3	0.7	0.3	0.8	-0.0	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	1.5	-0.1	0.1	0.2
Neuroticism (Nagel 2018)	0.5	1.1	2.6	1.6	-0.4	-0.1	-1.2
Schizophrenia (2018)	0.7	1.4	2.6	-1.2	1.6	-0.3	-1.3
Schizophrenia vs Biploar Disorder	2.6	3.4	5.9	-0.9	-2.2	-2.4	-1.5
Worry (Nagel 2018)	0.5	1.1	2.5	0.7	-0.7	-1.6	-0.9
Alzheimer’s Disease (in mother)	0.9	1.1	3.1	-0.5	-0.9	-1.8	0.1
Alzheimer’s Disease (in father)	1.6	1.7	2.6	-1.6	1.4	-1.4	0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	4.7	-1.7	0.5	-2.2	-0.2
Crohns Disease (2017)	0.1	0.2	0.5	-0.1	0.3	-0.5	0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.4	-0.1	0.0	0.8
Ulcerative Colitis (UC)	0.4	0.7	1.0	0.9	-0.6	0.7	1.0
Major Depression (MDD)	0.9	1.1	2.3	1.5	1.0	0.6	0.9
Reaction Time	0.5	0.9	1.7	0.9	1.3	0.5	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.5	-0.1	-0.3	0.7
Breast Cancer	2.4	5.7	10.4	-1.4	-1.7	3.2	2.8
Ovarian Cancer	1.4	1.9	4.7	-0.7	0.1	-2.2	-1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.5	1.4	-0.4	0.6	0.5	1.2
Bipolar Disorder (2011)	3.8	3.7	8.5	0.6	2.3	0.6	2.9
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	-0.1	0.4	1.3	-1.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.3	-0.5	0.3	-0.1
Crohns Disease (2012)	0.7	1.1	3.4	-0.1	-0.8	-0.5	1.8
Mean Putamen Volume	0.5	0.6	1.4	-0.1	-1.0	-0.2	1.2
Fasting Glucose	2.4	2.9	5.2	0.9	1.1	2.1	-2.3
HbA1C	1.4	1.6	3.8	1.9	0.8	1.3	0.6
HDL Cholesterol	0.9	1.6	5.0	-0.8	-0.0	-2.2	0.8
LDL Cholesterol	0.2	0.3	0.5	-0.3	-0.7	-0.5	0.7
Lupus	0.3	0.5	1.1	-0.4	1.1	0.7	-0.6
Neuroticism (2016)	0.9	1.3	2.4	1.1	1.6	-0.9	-0.8
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.1	0.3	0.2	0.6
Rheumatoid Arthritis	0.7	1.0	2.3	-1.1	0.7	0.4	-1.5
Schizophrenia (2014)	0.4	0.9	2.0	-1.2	1.4	0.2	-0.4
Triglycerides	0.2	0.4	0.6	0.6	0.1	0.7	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	-0.5	-1.6	0.0	-0.0
Ulcerative Colitis	0.3	0.5	1.0	1.0	-0.5	0.8	0.4
Blood Eosinophil Count	0.1	0.9	2.1	-1.5	0.4	0.4	-1.1
Blood Platelet Count	0.2	2.7	6.7	-0.1	0.2	-2.6	2.0
Blood Red Count	0.5	4.9	6.9	2.6	2.2	2.2	1.8
Blood White Count	0.1	0.6	0.8	-0.9	0.7	-0.8	-0.8
Heel T-Score	1.0	7.9	17.1	-4.1	3.8	-0.2	-0.5
BMI	2.4	14.0	29.7	2.7	3.8	5.5	-2.1
Height	0.6	11.3	40.3	-0.2	-2.0	6.3	-0.9
Waist Hip Ratio (WHR)	0.1	0.6	1.4	1.2	-0.2	1.0	0.2
Systolic Blood Pressure	1.2	5.9	19.3	1.2	4.4	-1.1	1.3
Smoking Status	0.7	1.6	5.8	0.4	-0.6	0.3	2.4
Allergy or Eczema	0.7	1.8	4.8	-1.3	-0.8	-2.2	-0.4
Cardiovascular Disease	1.2	4.1	8.6	2.3	2.9	-0.3	-1.5
Hypothyroidism (self reported)	0.2	0.4	0.9	0.2	0.8	0.9	-0.4
Respiratory disease	1.7	3.7	7.0	-2.3	-1.6	-2.6	0.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.6	1.3	0.9	2.4	-0.9
Lung FEV1/FVC ratio	0.1	0.6	1.3	0.8	0.6	1.1	0.2
Lung FVC	0.6	3.1	7.2	-0.2	-2.3	-0.1	2.7
Neuroticism	0.6	1.6	5.6	2.4	-0.2	0.0	-0.8
Chronotype (morning person)	1.6	3.8	5.0	1.9	2.2	-1.9	-1.7
Hair Pigment	0.1	3.5	9.3	-1.1	1.9	-0.1	3.0
Tanning	0.1	1.5	2.5	0.7	-1.6	-0.7	1.6
Hand grip strength (left)	0.8	2.1	7.2	-0.1	-0.7	0.9	-2.7
Number of treatments/medications taken	0.2	0.4	0.6	-0.0	0.7	0.8	0.6
Average weekly spirits intake	1.5	1.8	3.4	-1.2	-1.2	-1.8	-1.1
Sensitivity / hurt feelings	1.1	1.9	7.3	2.7	0.6	0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	1.3	0.8	-0.1	0.9
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.6	-0.9	0.7	-0.5
Relative age of first facial hair	0.3	0.6	1.6	-0.2	-0.9	-1.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	-1.5	0.8	0.4	0.8
Ever used hormone-replacement therapy (HRT)	2.0	2.5	7.0	0.6	-2.7	-1.0	1.3
Ever had hysterectomy (womb removed)	1.3	1.5	4.3	0.0	0.2	-1.3	2.1
Systolic blood pressure, automated reading	0.7	2.0	7.1	-0.1	2.7	0.2	0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.6	-0.3	-1.3	-0.6	-1.6
Angina	1.9	2.5	4.9	1.0	1.9	2.2	0.4
Medication for hormone replacement therapy	0.3	0.3	0.9	0.5	-1.0	-0.3	-0.2
Vitamin and mineral supplements	0.6	0.8	1.6	-1.1	1.3	0.0	0.5
Supplements: Zinc	0.6	0.7	1.2	0.1	-0.7	-1.0	-1.1
Medication: Co-codamol	0.5	0.6	1.5	1.2	-0.6	-0.6	0.0
Medication: Metformin	1.6	2.3	7.0	1.3	-0.5	2.6	0.4
Diabetes (father)	1.0	1.2	2.9	0.6	-0.2	1.7	1.2
Diabetes (mother)	0.6	0.7	1.8	0.3	-0.8	0.5	-1.3
Severe depression (siblings)	1.3	1.5	5.6	0.1	0.4	0.3	2.4
Pack years adult smoking proportion	0.3	0.5	0.9	-0.3	0.4	0.9	-0.9
Impedance of leg (right)	1.4	6.7	10.4	0.0	-3.2	-2.8	2.9
Leg fat-free mass (left)	1.8	9.4	25.7	0.8	2.6	5.1	-2.1
Trunk fat percentage	1.7	7.0	20.1	2.5	1.2	4.5	0.1
Hand grip strength (right)	0.9	2.3	8.4	0.1	-0.4	0.9	-2.9
Townsend deprivation index at recruitment	1.1	1.5	4.1	-0.6	2.0	-1.2	-0.5
Current tobacco smoking	0.3	0.5	1.1	-0.3	-1.1	-0.6	-0.7
Average weekly fortified wine intake	0.8	1.0	1.8	0.2	-1.3	0.7	-1.2
Maternal smoking around birth	0.1	0.2	0.6	0.4	0.2	-0.1	-0.7
Fed-up feelings	0.4	0.8	2.4	1.5	0.4	0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.6	1.2	0.3	-0.4
Relative age voice broke	0.5	0.8	2.3	-1.0	-0.3	-1.5	-0.3
Taking other prescription medications	0.2	0.3	1.0	0.4	1.0	0.4	0.1
Age when periods started (menarche)	0.6	1.3	2.0	-1.1	-1.4	-1.4	-0.4
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	5.3	1.0	0.3	-0.4	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.0	-2.2	1.7	0.4	-0.6
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	7.5	2.7	2.2	-0.8	0.0
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.6	0.2	-0.7	0.4
Serious illness, injury or assault to yourself	1.0	1.2	1.9	-1.4	-1.0	-0.5	1.3
High blood pressure	1.2	3.3	6.6	2.6	2.3	0.5	-1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.8	0.3	-0.4	-2.0	-1.0
Multivitamins +/- minerals	1.3	1.7	4.3	1.4	-0.1	0.7	-2.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.0	-0.3	0.4	0.2
Supplements: Glucosamine	0.7	0.9	3.7	0.1	-1.9	-0.0	0.1
Diverticular disease/diverticulitis (self-reported)	4.2	5.0	9.2	-2.6	-1.0	-3.0	1.7
Medication: Atenolol	0.8	1.0	3.8	1.9	0.2	0.4	0.1
Medication: Levothyroxine sodium	0.5	0.8	2.5	-0.0	1.6	0.8	0.4
Sitting height	0.6	4.1	15.9	0.4	-0.0	4.0	-0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	2.6	-0.6	-0.1	1.6	0.4
High blood pressure (mother)	1.1	1.5	4.0	1.1	0.2	-2.0	-0.9
Body mass index (BMI)	1.9	7.9	15.9	2.2	2.7	4.0	-1.9
Impedance of leg (left)	1.3	6.1	12.2	0.4	-3.5	-2.1	2.7
Leg predicted mass (left)	1.8	9.5	25.7	0.8	2.6	5.1	-2.2
Trunk fat mass	2.2	9.6	28.7	2.5	1.7	5.4	-0.5
Waist circumference	2.1	7.6	21.3	2.0	1.9	4.6	-1.2
Number of incorrect matches in round	2.9	4.8	8.8	-3.0	-2.2	-2.0	1.2
Past tobacco smoking	1.3	2.5	8.0	1.2	0.1	-0.7	-2.8
Alcohol usually taken with meals	1.2	1.9	4.2	1.6	0.6	2.0	0.5
Nervous feelings	0.4	0.8	2.5	0.4	-0.8	-1.6	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.5	1.4	-0.0	1.6	0.4
Hearing difficulty/problems with background noise	0.6	0.9	1.9	0.3	-1.0	0.8	-1.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.1	0.7	0.1	-0.3
Had menopause	0.6	0.8	1.7	-0.6	-1.3	0.2	1.0
Had other major operations	0.5	0.6	2.1	-1.4	-0.4	-0.3	0.0
Forced vital capacity (FVC)	0.6	2.2	3.5	-0.8	-1.2	1.9	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	6.2	-2.5	1.5	0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.9	1.0	0.8	0.9	-2.0
Qualifications: None of the above	0.1	0.3	0.5	-0.4	-0.4	-0.7	0.6
Financial difficulties in last 2 years	0.8	1.1	2.5	0.3	1.1	-1.6	-0.8
Mouth/teeth dental problems	0.2	0.3	0.7	0.7	-0.9	0.1	0.2
Heart attack	1.5	2.0	3.1	1.8	1.5	1.3	1.0
Allergy	0.6	1.3	3.8	0.6	-0.1	1.9	1.1
Pain all over the body in last month	0.5	0.5	1.9	-0.4	1.4	-0.2	-0.2
Diabetes (self-reported)	0.2	0.3	1.0	0.4	-0.5	0.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	-0.2	-0.0	-1.5	1.1
Medication: Ramipril	2.1	2.7	9.3	1.1	3.0	-0.0	0.6
Medication: Simvastatin	0.2	0.3	1.2	-0.2	-0.3	0.0	-1.1
Fluid intelligence score	0.1	0.2	0.5	0.7	-0.1	0.5	0.0
Illnesses of siblings	0.9	1.3	4.5	0.7	-0.1	2.1	0.3
Neuroticism score	0.7	1.5	4.3	2.1	0.2	-0.4	-1.2
Weight	2.4	11.7	35.0	2.0	2.3	5.9	-1.5
Impedance of arm (right)	1.4	6.5	13.0	-1.2	-2.2	-2.6	3.6
Arm fat percentage (right)	1.2	4.6	11.0	1.8	2.1	3.3	-0.1
Trunk fat-free mass	1.5	8.8	26.0	0.6	2.3	5.1	-1.9
Hip circumference	1.9	8.0	22.8	1.3	2.4	4.8	-1.2
Time employed in main current job	0.4	0.4	0.9	0.1	-0.9	0.3	-0.8
Alcohol intake versus 10 years previously	2.3	3.4	7.7	2.3	2.8	-0.0	0.7
Father’s age at death	1.1	1.5	4.4	1.2	-0.6	2.1	-0.1
Worrier / anxious feelings	0.7	1.4	2.8	0.7	-1.4	-1.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	0.4	1.5	0.9	0.1
Falls in the last year	0.2	0.3	1.2	-0.1	0.1	-0.4	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	1.1	1.2	-0.7	-0.1
Number of live births	1.6	2.2	5.7	-2.4	0.7	-1.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.3	-0.0	-0.6	1.8	1.2
Pulse rate	1.7	2.8	3.6	-1.6	-1.9	-1.8	1.3
Happiness	0.6	0.8	2.8	0.1	1.7	0.4	0.3
Noisy workplace	0.7	0.8	1.7	-0.4	0.7	-1.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.8	0.2	-1.7	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	4.9	1.2	2.2	2.2	0.3
Mouth/teeth dental problems: Dentures	0.9	1.6	2.4	1.1	0.9	1.4	-1.6
Asthma	1.1	2.1	4.9	-1.7	-0.8	-2.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	5.2	-0.2	2.3	0.2	2.2
Medication: Cholesterol lowering	0.4	0.6	1.6	-0.0	1.3	0.9	-0.4
Depression (self-reported)	1.9	2.2	4.2	2.0	1.4	1.5	-0.8
Medication: Lansoprazole	1.1	1.3	3.3	0.6	-0.3	1.1	1.8
Prospective memory result	0.4	0.5	1.1	-0.6	-0.6	0.2	1.1
Lung cancer (father)	1.6	1.9	5.5	-1.4	0.1	-2.3	-0.4
Illnesses of mother	0.1	0.1	0.2	-0.5	0.2	0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	7.5	-0.7	0.2	1.9	2.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.7	-1.2	-0.2	0.5
Impedance of arm (left)	1.1	5.3	11.2	-0.6	-2.5	-1.8	3.3
Arm fat mass (right)	1.7	7.1	19.4	1.8	2.2	4.4	-0.9
Trunk predicted mass	1.6	9.0	26.2	0.6	2.4	5.1	-1.9
Standing height	0.6	6.3	23.9	0.0	-0.6	4.9	0.9
Length of working week for main job	0.6	0.7	1.6	-0.6	-0.6	-0.6	1.3
Exposure to tobacco smoke at home	1.5	1.7	5.0	0.0	-1.2	-2.2	0.7
Breastfed as a baby	0.4	0.5	1.0	1.0	-0.3	0.3	-0.8
Tense / ‘highly strung’	0.8	1.3	2.0	1.0	-1.4	-1.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.2	1.2	-1.2	-0.5	-1.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.2	0.1	0.8	-0.2
Birth weight of first child	1.6	2.9	6.1	0.7	1.3	2.5	1.8
Peak expiratory flow (PEF)	0.5	1.1	2.5	1.4	-0.0	1.6	-0.4
Pulse wave reflection index	0.7	0.9	1.4	0.9	-1.2	-0.3	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.1	-0.9	-0.2	-0.8
Loud music exposure frequency	0.4	0.5	0.9	0.6	0.5	0.7	0.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	4.1	1.7	-2.0	1.2	1.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	6.1	-2.5	0.2	-1.9	0.4
Blood clot in the leg (DVT)	0.8	1.1	3.0	0.8	1.7	0.8	0.4
Medication: Paracetamol	0.4	0.6	1.8	0.0	1.3	-0.5	0.6
Headache pain in last month	0.3	0.6	1.4	-0.5	1.2	-0.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.8	-0.5	-2.2	-1.0	-0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.1
Gout (self-reported)	0.8	1.0	4.1	0.0	2.0	-0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.3	0.4	1.1	0.7	-0.2
Medication: Amlodipine	1.4	1.9	3.7	1.9	1.2	-0.3	-1.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.6	-1.2	0.7	-0.4
Birth weight	0.9	1.9	4.6	0.3	2.1	1.6	0.8
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.8	1.1	0.7	1.7	-1.5
High blood pressure (siblings)	1.4	2.0	4.2	0.2	0.3	-2.1	-1.9
Forced vital capacity (FVC), Best measure	1.1	3.8	10.0	-1.2	-0.2	2.0	3.2
Body fat percentage	1.6	6.3	16.9	2.6	1.3	4.1	-0.2
Leg fat percentage (right)	1.4	4.9	10.8	2.6	1.1	3.3	-0.9
Arm fat-free mass (right)	2.2	11.2	31.5	1.6	2.3	5.6	-2.3
Exposure to tobacco smoke outside home	1.7	2.3	4.6	1.5	1.2	2.2	-0.9
Comparative body size at age 10	1.7	4.6	11.8	2.5	-0.3	3.4	-0.3
Number of full brothers	0.7	0.9	2.6	0.6	1.6	-0.2	-0.8
Worry too long after embarrassment	0.5	0.9	2.6	1.0	-1.6	-0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.7	0.5	-0.7	0.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-1.1	-0.7	-0.7	-0.8
Number of children fathered	0.7	0.8	2.9	0.1	-1.7	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	6.1	-1.5	-1.4	-2.5	1.5
Age at first live birth	0.8	1.5	2.8	-1.7	-1.6	-0.1	0.7
Pulse wave peak to peak time	0.5	0.6	1.3	0.7	1.2	0.6	-0.5
Health satisfaction	0.8	1.0	3.0	-0.3	0.5	-0.8	-1.7
Shortness of breath walking on level ground	1.0	1.2	2.9	-0.8	-1.1	-1.7	-0.3
Qualifications: College or University degree	0.2	0.6	2.0	-1.4	-0.4	0.3	0.4
Eye problems/disorders: None of the above	1.4	1.6	5.0	2.2	0.9	0.4	0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.4	3.4	-1.8	-0.2	1.4	-0.2
Emphysema/chronic bronchitis	0.8	0.9	2.2	-1.1	-1.5	-0.6	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	3.0	0.1	-1.7	-0.2	-1.7
Neck or shoulder pain in last month	0.3	0.4	1.6	-1.3	0.0	0.1	-0.1
Medication: Blood pressure	1.6	2.8	6.5	1.7	2.5	1.4	0.2
Angina (self-reported)	2.0	2.6	5.2	1.2	1.9	2.3	0.2
Migraine (self-reported)	1.5	1.8	3.0	-0.1	1.7	-1.7	1.1
Medication: Ibuprofen	2.3	2.7	6.9	-0.8	1.8	-0.2	2.6
Medication: Allopurinol	0.5	0.7	2.3	-0.5	1.5	-0.3	0.3
Medication: Omeprazole	1.9	2.3	7.4	1.0	-0.2	2.7	0.8
Medication: Seretide 50 evohaler	2.2	2.5	4.1	-2.0	-1.3	-2.0	-0.6
Mean time to correctly identify matches	0.5	1.0	4.0	-0.1	0.1	0.3	2.0
Heart disease (mother)	0.6	0.7	1.7	-0.0	0.4	1.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	6.8	-0.6	2.6	-0.7	-2.1
Whole body fat mass	2.2	9.2	26.8	2.4	1.9	5.2	-0.7
Leg fat mass (right)	2.1	8.1	21.3	2.5	1.8	4.6	-1.4
Arm predicted mass (right)	2.1	10.9	31.7	1.6	1.7	5.6	-2.5
Pulse rate, automated reading	1.3	4.3	8.2	-2.9	-1.2	-0.7	2.7
Alcohol intake frequency.	0.9	2.1	5.1	2.2	1.5	0.8	-0.8
Comparative height size at age 10	0.8	4.6	14.4	-0.1	2.0	3.8	-0.1
Number of full sisters	2.0	2.4	5.7	0.0	1.6	-1.2	-2.4
Suffer from ‘nerves’	0.2	0.3	0.8	0.5	-0.3	-0.9	0.0
Overall health rating	0.8	1.8	4.2	-0.9	2.1	0.1	-1.4
Chest pain or discomfort	0.3	0.4	0.9	-1.0	-0.8	0.1	0.3
Had major operations	0.3	0.3	0.5	-0.7	0.5	0.3	-0.6
Age at last live birth	0.3	0.4	1.2	-1.1	-0.7	0.2	0.3
Family relationship satisfaction	0.3	0.4	1.2	0.5	-0.1	-1.1	0.2
Leg pain on walking	0.2	0.2	0.4	-0.4	0.1	-0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.9	-0.2	1.4	-1.1	-0.5
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.7	0.0	-2.6	-2.0	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	0.2	-0.9	-0.2	-0.1
Medication: Aspirin	0.5	0.7	2.0	-0.4	1.4	0.0	0.7
Supplements: Vitamin C	1.7	2.0	5.2	1.2	-2.3	-1.0	0.7
Knee pain experienced in last month	0.5	0.8	2.0	0.5	-0.8	-0.5	-1.4
Hypertension (Self-reported)	1.2	3.2	5.8	2.4	2.4	0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	-0.3	-0.1	1.3	1.2
Illnesses of father: Heart disease	0.4	0.6	1.7	-0.6	-1.3	0.5	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.9	-0.6	0.6	1.4	-0.7
Smoking status: Previous	1.7	2.5	8.4	-1.2	-0.1	0.3	2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	-0.1	0.5	0.3	0.3
Whole body fat-free mass	1.8	10.2	28.6	0.9	2.5	5.3	-2.2
Leg fat-free mass (right)	1.9	10.4	28.1	0.9	2.7	5.3	-2.4
Arm fat percentage (left)	1.4	5.8	13.7	2.3	2.0	3.7	-0.4
Average weekly red wine intake	0.2	0.3	0.9	0.9	-0.6	-0.0	0.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.8	0.2	0.9	-0.7	2.2
Mood swings	0.8	1.4	4.2	1.0	2.0	0.5	-0.5
Loneliness, isolation	0.6	0.8	1.5	1.2	0.0	0.6	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.6	-0.6	1.3	-1.0	0.2
Ever had bowel cancer screening	0.3	0.4	1.2	-0.3	0.2	-1.1	0.4
Diabetes diagnosed by doctor	0.6	1.0	2.7	0.9	0.0	1.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.9	-1.4	-1.7	-0.0	-0.9
Friendships satisfaction	0.5	0.7	1.0	-0.9	1.0	-0.8	-0.3
Qualifications: nursing, teaching	1.5	2.4	4.1	1.2	-2.0	1.5	-1.3
Commuting to job workplace: Walk	3.4	3.7	10.5	0.0	1.9	3.2	-0.8
Eye problems/disorders: Cataract	0.6	0.6	1.3	-1.0	-1.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	-0.2	1.1	-1.0	-0.5
Medication for cholesterol	0.9	1.4	4.8	-2.2	-0.4	-0.8	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.7	0.6	-1.3	0.3	0.0
Back pain experienced in last month	1.1	1.6	5.2	0.3	-2.3	0.4	-1.0
Mineral and other dietary supplements	0.8	1.1	3.1	-0.6	1.8	0.5	0.9
Breast cancer (self-reported)	0.4	0.5	1.4	0.2	0.6	0.1	-1.2
Asthma (self-reported)	1.2	2.3	5.1	-1.9	-0.7	-2.3	0.4
Osteoporosis (self-reported)	0.4	0.5	1.4	1.2	0.1	0.7	-0.4
Osteoarthritis (self-reported)	0.8	1.0	1.6	-0.8	-1.0	-0.9	-1.3
Medication: Aspirin	0.6	0.7	2.2	-0.4	1.5	0.7	0.4
Medication: Gliclazide	0.8	0.9	1.8	-1.3	-0.3	-1.1	0.8
Illnesses of father: None of the above (group 1)	1.2	1.4	4.5	-0.9	-0.4	-2.1	-0.4
Smoking status: Current	0.2	0.4	1.1	0.1	-1.1	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-0.4	-0.0	0.7	1.4
Whole body water mass	1.8	10.3	29.3	0.9	2.5	5.4	-2.2
Leg predicted mass (right)	1.9	10.3	27.8	0.9	2.6	5.3	-2.4
Arm fat mass (left)	2.1	8.7	24.4	2.2	2.1	4.9	-1.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.7	0.4	0.2	-0.6
Average weekly champagne plus white wine intake	0.9	1.3	3.4	0.2	-1.0	0.8	-1.8
Miserableness	0.6	1.1	4.1	2.0	0.3	-0.3	0.0
Guilty feelings	0.4	0.7	1.2	0.9	0.8	-1.1	-0.1
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	0.1	-0.3	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	0.1	-0.3	-0.8
Hearing aid user	0.4	0.5	1.1	0.0	0.6	-1.0	0.6
Mother’s age at death	1.6	2.0	4.6	0.6	-2.1	1.6	-0.7
Financial situation satisfaction	1.4	1.7	5.9	-0.5	2.4	-0.8	0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	0.7	-0.6	1.1	-1.1
Commuting to job workplace: Public transport	1.6	1.9	3.9	0.9	1.7	2.0	0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.4	0.1	0.0	-0.1
Medication: Blood pressure	1.4	2.7	6.5	2.6	1.9	0.8	-0.2
Pain type(s) experienced in last month: Hip pain	1.8	2.3	3.0	1.7	-1.6	0.7	-1.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.4	0.6	-1.8	-0.9	-0.8
High cholesterol (Self-reported)	0.1	0.2	0.6	0.6	0.1	0.0	-0.8
Medication: Bendroflumethiazide	0.7	1.0	1.6	1.0	1.3	-1.1	0.6
Medication: Paracetamol	0.4	0.6	1.6	-0.4	1.2	-0.5	0.8
Medication: Lisinopril	0.2	0.2	0.4	-0.0	0.6	0.4	0.6
Medication: Atorvastatin	0.8	1.0	2.8	0.3	1.7	0.4	-1.0
Illnesses of father: High blood pressure	1.4	1.7	4.7	2.2	1.2	-0.7	-0.4
Alcohol drinker status: Never	0.2	0.3	0.7	-0.4	0.9	-0.3	-0.4
Ever smoked	0.7	1.3	4.3	-0.7	-0.5	0.3	2.1
Basal metabolic rate	1.9	10.8	30.9	1.2	2.5	5.6	-2.1
Leg fat percentage (left)	1.7	6.1	14.4	2.9	1.0	3.8	-0.9
Arm fat-free mass (left)	1.8	8.9	28.2	1.1	1.8	5.3	-1.8
Number of operations (self-reported)	0.2	0.3	1.0	0.0	-0.5	-1.0	-0.2
Average weekly beer plus cider intake	0.2	0.3	0.9	-0.3	0.1	-0.0	1.0
Irritability	0.7	1.2	3.1	0.2	0.0	1.8	-1.3
Risk taking	0.9	1.3	2.6	-0.9	-1.2	-1.6	-0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.1	0.3	-0.0	1.5	0.6
Fractured/broken bones in last 5 years	1.2	1.5	5.4	0.2	-2.3	-0.4	0.7
Age started oral contraceptive pill	0.5	0.7	1.8	-0.7	-1.3	0.6	-0.1
Diastolic blood pressure, automated reading	1.8	5.7	9.3	-1.4	3.0	-1.7	3.0
Ever depressed for a whole week	2.2	2.7	4.9	1.8	1.2	2.2	-1.1
Unable to work because of sickness or disability	1.2	1.6	4.6	-0.5	-0.7	-2.2	0.9
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.9	-0.6	-0.5	-0.3
Myopia	0.2	0.2	0.8	-0.3	0.9	0.0	0.1
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.4	-2.7	-2.4	-0.7	0.5
Cholesterol lowering medication	0.6	0.9	1.5	1.1	-1.2	0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	5.8	1.2	-0.5	2.4	0.4
Pain experienced in last month	1.3	2.2	7.1	0.8	0.1	0.9	2.7
Supplements: Calcium	1.3	1.4	2.2	1.4	-0.7	1.5	-1.1
Basal cell carcinoma (self-reported)	1.6	1.9	5.0	-0.8	-1.3	-2.2	0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.3	1.8	1.8	1.3	0.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.6	0.9	1.6	0.7	0.6
Heart disease (siblings)	0.3	0.3	0.6	-0.6	0.8	-0.0	-0.6
Alcohol drinker status: Previous	1.6	1.8	5.5	2.4	0.3	0.3	-1.2
Pack years of smoking	0.6	0.9	2.0	-0.1	0.7	1.4	-1.0
Impedance of whole body	1.3	6.4	10.3	-0.1	-3.2	-2.4	3.1
Leg fat mass (left)	2.2	8.6	23.1	2.6	1.5	4.8	-1.4
Arm predicted mass (left)	1.9	9.6	28.9	1.2	2.0	5.4	-2.1