Best TWAS P=4.31e-13 · Best GWAS P=1.43e-12 conditioned to 0.426
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DNAJC30 | 0.13 | 0.07 | enet | 32 | 0.07 | 2.7e-09 | 5.408 | 6.0 | 1.5e-09 | 0.36 | 0.99 | 0.00 | TRUE |
2 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | 6.326 | 6.9 | 5.3e-12 | 0.70 | 0.04 | 0.96 | FALSE |
3 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | 6.238 | 6.8 | 1.2e-11 | 0.67 | 0.15 | 0.83 | FALSE |
4 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | 6.992 | 5.7 | 1.3e-08 | 0.48 | 0.02 | 0.73 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 6.901 | 7.2 | 6.4e-13 | 0.77 | 0.02 | 0.98 | FALSE |
6 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | -0.003 | 5.2 | 2.0e-07 | 0.38 | 0.09 | 0.54 | FALSE |
7 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | 6.326 | 5.2 | 1.7e-07 | 0.50 | 0.08 | 0.80 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | 6.901 | 6.8 | 1.0e-11 | 0.62 | 0.02 | 0.96 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | 6.876 | 7.0 | 3.1e-12 | 0.69 | 0.04 | 0.96 | FALSE |
10 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | 6.661 | -6.9 | 6.2e-12 | -0.88 | 0.02 | 0.63 | FALSE |
11 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | 4.691 | 6.3 | 2.2e-10 | 0.58 | 0.03 | 0.43 | FALSE |
12 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 6.326 | 7.2 | 4.5e-13 | 0.73 | 0.02 | 0.98 | FALSE |
13 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 7.007 | 7.2 | 4.3e-13 | 0.80 | 0.02 | 0.98 | TRUE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | 6.987 | 6.7 | 2.1e-11 | 0.77 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 6.987 | 7.0 | 2.8e-12 | 0.83 | 0.00 | 0.97 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 6.987 | 6.0 | 1.7e-09 | 0.70 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CALN1 | 0.37 | 0.04 | enet | 10 | 0.25 | 3.1e-07 | -6.357 | 5.4 | 6.8e-08 | 0.05 | 0.01 | 0.96 | TRUE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | 6.987 | -5.9 | 3.1e-09 | -0.93 | 0.00 | 0.63 | FALSE |