TWAS hub - CALN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.049	0.0200	1.3e-03	0.021	0.008	0.010	0.008	0.012	1.2e-03	2.9e-02	1.9e-02	2.8e-02	1.0e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.114	0.0313	2.5e-09	0.078	0.073	0.073	0.074	0.071	3.1e-10	1.2e-09	1.2e-09	9.5e-10	1.9e-09
3	TCGA	Skin Cutaneous Melanoma	0.374	0.1100	2.2e-03	0.044	0.092	0.246	NA	0.172	2.6e-02	1.9e-03	3.1e-07	NA	2.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Intelligence (Savage-Jansen 2018)	10.6	32.6	58.2	7.6	6.2	-1.2
Qualifications: College or University degree	7.5	23.5	41.1	6.4	5.2	-1.4
Verbal and Numeric Reasoning (VNR)	7.1	16.9	27.3	5.2	4.8	-0.7
Fluid intelligence score	6.3	13.1	22.1	4.7	4.0	-0.9
Qualifications: A levels/AS levels or equivalent	5.6	12.4	19.8	4.0	4.5	-1.2
Schizophrenia vs Biploar Disorder	5.5	7.3	8.4	2.7	2.9	-2.4
Schizophrenia (2018)	5.3	11.1	15.6	3.9	3.0	-3.0
Commuting to job workplace: Public transport	5.3	6.3	10.2	2.6	3.2	-1.3
Chronotype (morning person)	5.2	12.0	16.9	-4.1	-3.5	2.7
Qualifications: None of the above	5.2	11.1	17.6	-4.2	-3.9	0.7
Age started oral contraceptive pill	5.1	6.4	15.5	-0.0	1.9	-3.9
Hand grip strength (left)	5.0	13.2	21.1	-4.6	-3.7	2.2
Medication for cholesterol, blood pressure or diabetes	5.0	8.3	13.0	3.6	3.0	-1.7
Commuting to job workplace: Car/motor vehicle	4.8	5.5	6.8	-2.1	-2.3	2.6
Schizophrenia (2014)	4.4	9.7	15.6	3.9	2.6	-2.6
Medication: Gliclazide	4.3	4.9	10.7	-1.6	-1.3	3.3
Number of treatments/medications taken	4.2	7.5	12.2	-3.5	-1.9	2.6
Family relationship satisfaction	4.1	5.0	7.2	2.7	1.2	-2.5
Miserableness	3.9	6.8	11.0	2.9	3.3	1.1
Body Mass Index (BMI) (2010)	3.8	5.3	9.1	-2.1	-3.0	1.5
Medication: Ramipril	3.8	4.8	6.2	-2.1	-2.5	1.9
Vascular/heart problems diagnosed by doctor	3.7	10.0	14.1	2.8	2.8	-3.8
Lung cancer (father)	3.6	4.2	4.8	-2.2	-2.0	-1.9
Qualifications: nursing, teaching	3.6	5.6	8.1	2.8	2.0	-2.1
Falls in the last year	3.5	4.7	10.0	-0.9	-1.8	3.2
Noisy workplace	3.4	4.2	6.1	-2.5	-2.1	-1.4
Arm predicted mass (left)	3.4	17.1	27.4	-3.2	-3.7	5.2
Arm fat-free mass (left)	3.3	17.0	27.7	-3.1	-3.7	5.3
Worrier / anxious feelings	3.2	6.1	13.4	3.7	2.2	0.2
Medication: Metformin	3.1	4.4	7.6	-2.8	-2.0	1.2
Guilty feelings	3.1	4.7	8.8	3.0	2.3	-0.1
Cardiovascular Disease	3.0	9.9	13.1	-2.9	-2.9	3.6
Medication: Cholesterol lowering	3.0	4.7	9.0	-3.0	-2.0	1.0
Arm fat-free mass (right)	3.0	15.4	26.9	-2.9	-3.2	5.2
High blood pressure	2.9	8.2	10.4	-2.8	-2.5	3.2
Hip circumference	2.9	12.5	22.0	-2.4	-3.1	4.7
Arm predicted mass (right)	2.9	14.8	27.2	-2.6	-3.2	5.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	8.0	2.8	1.5	0.4
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	8.7	-1.0	-0.3	2.9
Alcohol intake versus 10 years previously	2.7	4.1	8.3	-2.9	-1.7	1.1
Impedance of arm (left)	2.7	12.4	15.3	3.2	3.4	-3.9
Medication: Blood pressure	2.7	4.7	6.4	-2.5	-2.2	1.7
Medication: Omeprazole	2.7	3.2	5.0	-1.8	-2.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	4.4	-1.4	-1.9	2.1
Supplements: Vitamin C	2.7	3.2	6.6	-2.6	-1.8	-0.1
Basal metabolic rate	2.7	15.2	29.2	-2.5	-3.2	5.4
BMI	2.6	15.1	33.9	-2.0	-2.7	5.8
Weight	2.6	12.7	27.0	-1.8	-2.8	5.2
Hypertension (Self-reported)	2.6	7.3	9.8	-2.4	-2.5	3.1
Whole body water mass	2.6	14.7	27.1	-2.6	-3.2	5.2
Medication: Bendroflumethiazide	2.6	3.9	10.4	-0.5	-1.0	3.2
Leg fat mass (left)	2.6	10.3	18.2	-2.1	-2.9	4.3
Neuroticism (2016)	2.5	3.6	6.7	2.6	1.5	1.4
Hand grip strength (right)	2.5	6.7	7.2	-2.7	-2.4	2.7
Qualifications: CSEs or equivalent	2.5	3.2	5.5	-2.3	-1.5	1.4
Impedance of arm (right)	2.5	11.7	19.1	2.7	2.9	-4.4
Trunk fat-free mass	2.5	14.2	23.2	-2.9	-3.3	4.8
Father’s age at death	2.5	3.4	7.5	-0.3	1.6	-2.7
Whole body fat-free mass	2.5	14.2	26.4	-2.6	-3.1	5.1
Body mass index (BMI)	2.4	10.1	23.6	-1.2	-2.3	4.9
Trunk predicted mass	2.4	13.9	22.8	-2.9	-3.2	4.8
Leg fat mass (right)	2.4	9.3	16.7	-2.0	-2.7	4.1
Average weekly champagne plus white wine intake	2.4	3.2	4.7	2.2	1.9	-1.2
Bipolar Disorder or Schizophrenia	2.3	5.6	9.4	3.1	1.8	-2.0
High blood pressure (mother)	2.3	3.2	6.3	-0.8	-1.6	2.5
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	5.5	2.4	1.8	-0.3
Medication: Amlodipine	2.3	3.3	6.2	-2.5	-1.7	-0.8
Age at last live birth	2.3	3.4	5.4	2.1	2.3	0.5
Friendships satisfaction	2.3	2.8	3.5	1.8	1.3	-1.9
Diabetes (father)	2.2	2.7	3.8	-0.6	-1.9	1.9
Arm fat mass (right)	2.2	9.2	20.5	-1.5	-2.2	4.5
Leg fat-free mass (right)	2.2	11.8	25.3	-1.8	-2.7	5.0
Leg predicted mass (right)	2.2	11.7	25.6	-1.7	-2.6	5.1
Arm fat mass (left)	2.2	9.1	21.2	-1.2	-2.1	4.6
Leg fat-free mass (left)	2.1	10.9	24.3	-1.6	-2.4	4.9
Leg predicted mass (left)	2.1	11.3	25.3	-1.6	-2.5	5.0
Hair/balding pattern: Pattern 3	2.1	3.2	6.7	1.7	2.6	-0.1
Worry too long after embarrassment	2.1	3.6	8.8	3.0	1.4	-0.1
Crohns Disease (2017)	2.0	4.4	6.2	-2.5	-2.5	0.9
Bipolar Disorder (2011)	2.0	2.0	5.8	0.3	0.2	-2.4
Coronary Artery Disease (CAD)	2.0	2.4	6.2	-0.7	-0.8	-2.5
Crohns Disease (2012)	2.0	3.2	7.4	-1.2	-2.7	0.8
Number of incorrect matches in round	2.0	3.4	8.4	-2.9	-1.3	-0.4
Whole body fat mass	2.0	8.5	18.8	-1.4	-2.1	4.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.0	-1.5	-2.0	1.0
Worry (Nagel 2018)	1.9	3.9	6.8	2.2	2.6	-0.5
Number of live births	1.9	2.7	5.8	2.4	1.1	1.1
Depression (self-reported)	1.9	2.3	4.0	0.0	1.7	-2.0
Heart disease (mother)	1.9	2.3	4.1	1.1	2.0	1.3
Medication: Atorvastatin	1.9	2.3	4.5	-2.1	-1.1	1.1
Leg fat percentage (left)	1.9	6.9	12.8	-1.4	-2.4	3.6
Irritable Bowel Disease (IBD)	1.8	4.3	6.8	-2.6	-2.5	0.1
Rheumatoid Arthritis	1.8	2.5	7.2	-0.1	-0.4	-2.7
Trunk fat mass	1.8	7.8	18.4	-1.1	-1.9	4.3
Waist circumference	1.8	6.6	13.9	-1.2	-2.1	3.7
Nervous feelings	1.8	3.3	5.9	2.4	2.0	0.1
Hearing difficulty/problems with background noise	1.8	2.9	6.6	2.6	1.4	-0.1
Medication: Lansoprazole	1.8	2.0	3.3	-1.8	-1.3	1.0
Length of working week for main job	1.8	2.0	4.8	-0.8	0.8	2.2
Systolic Blood Pressure	1.7	8.7	10.4	-3.2	-3.1	2.5
Systolic blood pressure, automated reading	1.7	4.8	5.3	-2.1	-2.3	2.1
Fed-up feelings	1.7	3.1	5.5	1.9	0.3	2.3
Impedance of whole body	1.7	8.5	15.8	2.0	2.3	-4.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.3	0.9	1.4	-1.8
Neuroticism score	1.6	3.3	6.9	2.6	1.6	0.7
Blood clot in the leg (DVT)	1.6	2.1	3.2	-0.9	-1.8	-1.5
Emphysema/chronic bronchitis	1.6	1.7	2.9	0.4	-1.5	1.7
Neuroticism (Nagel 2018)	1.5	3.4	7.4	2.7	1.6	0.3
Breast Cancer	1.5	3.6	7.1	-2.7	-1.7	-1.0
Leg fat percentage (right)	1.5	5.6	10.3	-1.3	-2.2	3.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.2	1.8	1.2	0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.1	-1.4	-1.3	1.0
Neuroticism	1.4	3.5	6.3	2.5	1.8	-0.9
Medication: Atenolol	1.4	1.8	4.2	-0.2	-1.0	2.0
Pain all over the body in last month	1.4	1.5	2.8	-1.2	-0.4	1.7
Breastfed as a baby	1.4	1.7	2.9	-1.7	-0.7	-1.3
Peak expiratory flow (PEF)	1.4	3.2	5.0	-2.2	-1.2	1.7
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.3	-0.9	-1.5	-1.5
Osteoarthritis (self-reported)	1.3	1.7	3.1	-1.8	-0.6	-1.2
Pack years adult smoking proportion	1.2	1.8	2.8	1.7	1.3	1.0
Trunk fat percentage	1.2	4.7	12.6	-0.4	-1.2	3.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.1	0.3	0.8	1.8
Had menopause	1.2	1.5	2.2	-1.3	-0.9	-1.5
Arm fat percentage (right)	1.2	4.7	13.0	-0.3	-1.0	3.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.1	0.8	1.4	-1.8
Body fat percentage	1.2	4.7	12.1	-0.6	-1.3	3.5
Health satisfaction	1.2	1.6	3.5	0.9	0.6	-1.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.8	0.0	-0.7	2.0
Pulse rate, automated reading	1.2	3.8	10.1	-0.3	-1.1	3.2
Arm fat percentage (left)	1.2	4.7	13.7	0.0	-0.7	3.7
Medication for cholesterol	1.2	1.9	4.9	0.9	0.2	-2.2
High cholesterol (Self-reported)	1.2	2.1	4.7	-2.2	-0.8	1.0
HbA1C	1.1	1.3	3.2	0.2	-0.7	-1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	2.8	-1.0	-1.5	1.7
Lung FEV1/FVC ratio	1.1	5.5	10.4	3.2	1.9	-1.5
Medication: Co-codamol	1.1	1.3	1.9	-1.3	-1.4	0.6
Diabetes (mother)	1.1	1.4	2.5	1.0	-0.9	1.6
Impedance of leg (right)	1.1	5.1	13.7	0.9	1.0	-3.7
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.3	1.3	1.5	-1.1
Illnesses of mother	1.1	1.3	2.9	-0.9	0.5	-1.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.8	1.2	2.0	-0.5
High blood pressure (siblings)	1.1	1.6	1.9	-1.0	-1.4	-1.3
Medication: Ibuprofen	1.1	1.3	2.7	1.6	1.1	-0.4
Overall health rating	1.1	2.3	5.0	1.4	2.2	-0.0
Financial situation satisfaction	1.1	1.4	3.0	0.4	-1.7	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.3	0.6	1.5	1.1
Depressed Affect (Nagel 2018)	1.0	2.2	3.0	1.7	0.7	1.7
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.2	1.3	0.3
Alzheimer’s Disease (in father)	1.0	1.1	2.8	1.7	0.6	-0.4
Ulcerative Colitis (UC)	1.0	1.8	2.9	-1.5	-1.7	-0.5
Ulcerative Colitis	1.0	1.5	2.3	-1.5	-1.5	-0.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	0.7	1.6	-0.9
Mouth/teeth dental problems: Dentures	1.0	1.6	2.4	-1.0	-1.2	1.6
Hair/balding pattern: Pattern 4	1.0	2.4	3.0	-1.7	-1.2	-1.7
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-1.5	-0.9	0.5
Mean time to correctly identify matches	1.0	2.0	5.6	0.0	-0.5	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.8	-1.7	-0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.6	-0.1	-1.2	2.2
Osteoporosis (self-reported)	1.0	1.2	2.3	0.1	1.2	-1.5
Fasting Glucose	0.9	1.1	1.4	-0.9	-1.1	1.2
LDL Cholesterol	0.9	1.4	1.7	1.3	1.2	-1.1
Triglycerides	0.9	1.4	1.9	-1.1	-1.1	1.4
Allergy or Eczema	0.9	2.4	3.0	1.6	1.4	1.7
Severe depression (siblings)	0.9	1.0	1.6	0.9	1.3	0.7
Townsend deprivation index at recruitment	0.9	1.3	3.3	0.7	-0.4	1.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.2	0.1	-1.8	0.3
Financial difficulties in last 2 years	0.9	1.2	3.1	0.8	-0.0	1.7
Mouth/teeth dental problems	0.9	1.4	4.0	-0.3	-0.0	-2.0
Medication: Simvastatin	0.9	1.3	2.4	-1.6	-1.2	0.3
Happiness	0.9	1.1	2.5	1.6	-0.1	-0.8
Exposure to tobacco smoke at home	0.9	1.0	2.7	0.3	0.4	1.6
Comparative body size at age 10	0.9	2.4	4.8	2.2	1.6	0.2
Neck or shoulder pain in last month	0.9	1.3	2.1	-1.3	-1.4	-0.3
Mood swings	0.9	1.6	3.0	0.9	-1.1	1.7
Long-standing illness, disability or infirmity	0.9	1.4	2.1	-1.3	-0.6	1.5
Medication: Blood pressure	0.9	1.8	3.5	-1.0	-0.9	1.9
Diastolic blood pressure, automated reading	0.9	2.7	7.4	-0.3	-0.8	2.7
Ever depressed for a whole week	0.9	1.1	2.6	1.6	0.2	0.9
Ovarian Cancer	0.8	1.1	1.8	1.2	1.3	-0.2
Age at First Birth	0.8	1.2	2.7	0.7	0.6	-1.6
Smoking Status	0.8	1.8	5.1	2.2	-0.2	0.6
Average weekly spirits intake	0.8	1.0	1.4	-1.0	-1.2	0.8
Medication for hormone replacement therapy	0.8	0.9	2.5	0.5	1.6	0.2
Forced vital capacity (FVC)	0.8	3.0	5.1	-2.2	-1.7	1.0
Diabetes (self-reported)	0.8	1.3	2.2	-1.1	-1.5	0.7
Prospective memory result	0.8	1.0	1.8	-1.3	-0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.0	1.7	0.0	0.1
Number of full sisters	0.8	1.0	1.6	-0.9	-1.3	0.7
Medication: Aspirin	0.8	1.0	1.6	-1.3	-1.2	-0.3
Diabetes diagnosed by doctor	0.8	1.4	2.4	-1.3	-1.6	0.3
Medication: Aspirin	0.8	1.0	1.7	-1.3	-1.1	0.5
Medication: Lisinopril	0.8	1.0	2.4	-1.5	-0.8	-0.1
Commuting to job workplace: Cycle	0.8	0.9	2.0	0.7	1.4	0.5
Pack years of smoking	0.8	1.2	1.5	1.2	1.2	0.9
Mean Putamen Volume	0.7	0.8	1.8	0.8	1.3	-0.1
HDL Cholesterol	0.7	1.2	2.7	1.6	0.9	-0.2
Respiratory disease	0.7	1.6	3.2	0.3	1.3	1.8
Lung FVC	0.7	3.3	7.3	-2.7	-1.3	-1.0
Sensitivity / hurt feelings	0.7	1.2	2.8	1.7	0.4	-0.8
Maternal smoking around birth	0.7	1.0	1.8	1.3	0.0	1.1
Serious illness, injury or assault to yourself	0.7	0.8	1.9	0.7	0.1	-1.4
Impedance of leg (left)	0.7	3.6	10.5	0.4	0.5	-3.2
Heart attack	0.7	0.9	2.2	-0.4	-0.5	1.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.5	0.8	0.6	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-1.2	-0.9	-0.3
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.8	-0.2	-1.3
Comparative height size at age 10	0.7	3.7	6.5	-2.1	-2.5	0.5
Leg pain on walking	0.7	0.9	2.1	1.5	-0.6	-0.5
Loneliness, isolation	0.7	0.9	1.4	1.0	0.4	1.2
Eye problems/disorders: Cataract	0.7	0.8	2.2	-0.1	-0.4	1.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.4	1.2	0.2	1.0
Mother’s age at death	0.7	0.9	1.7	0.8	1.3	-0.6
Illnesses of father: High blood pressure	0.7	0.9	1.4	-1.0	-0.5	1.2
Ever smoked	0.7	1.2	1.6	1.1	0.9	-1.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	1.1	1.0	-0.5
Vitamin and mineral supplements	0.6	0.8	2.0	1.4	0.2	0.6
Current tobacco smoking	0.6	1.0	1.8	1.4	-0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.3	0.9	1.1	0.2
Taking other prescription medications	0.6	0.9	1.6	-1.0	0.4	1.3
Stomach or abdominal pain in last month	0.6	0.7	1.5	-0.7	-1.2	0.2
Sitting height	0.6	4.3	6.6	-1.5	-2.0	2.6
Illnesses of siblings	0.6	0.8	1.5	1.0	1.2	-0.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	1.3	0.4	-0.4
Glaucoma (self-reported)	0.6	0.7	1.7	1.3	0.3	0.4
Number of children fathered	0.6	0.6	0.9	-0.9	-0.7	-0.7
Pulse wave peak to peak time	0.6	0.7	1.6	-1.3	-0.5	0.6
Migraine (self-reported)	0.6	0.7	1.5	0.3	1.2	0.7
Had major operations	0.6	0.7	1.5	0.8	-0.1	1.2
Average weekly red wine intake	0.6	0.9	2.4	0.1	0.5	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	1.3	1.0	0.6
Smoking status: Current	0.6	0.9	1.4	1.2	-0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-0.2	-0.4	1.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.0	-1.0	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	1.4	0.6	-1.0
Exposure to tobacco smoke outside home	0.5	0.6	0.8	-0.9	-0.6	0.9
Medication: Allopurinol	0.5	0.6	1.1	-0.9	-0.2	1.0
Chest pain or discomfort	0.5	0.7	1.5	0.3	-0.7	-1.2
Illnesses of father: Heart disease	0.5	0.7	1.1	-1.0	1.1	0.3
Mineral and other dietary supplements	0.5	0.7	1.4	1.2	-0.6	0.5
Wears glasses or contact lenses	0.5	0.6	1.8	0.1	1.3	-0.1
Ever taken oral contraceptive pill	0.5	0.5	0.9	-0.5	-1.0	0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	-1.2	-0.1	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	1.0	0.3	0.7
Reaction Time	0.4	0.7	1.1	0.6	-0.8	-1.1
Prostate Cancer	0.4	0.5	1.0	-0.8	-0.1	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	0.7	1.2	0.0
Relative age voice broke	0.4	0.7	1.4	0.8	0.2	1.2
Multivitamins +/- minerals	0.4	0.6	1.4	-0.4	0.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.1	-1.4	-1.2	0.6
Pulse rate	0.4	0.7	1.9	-0.0	-0.2	1.4
Pulse wave reflection index	0.4	0.5	1.2	1.1	-0.2	-0.5
Loud music exposure frequency	0.4	0.5	0.6	0.5	-0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.5	-0.4	-0.1	1.2
Number of full brothers	0.4	0.5	0.9	0.9	-0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.9	0.8	-0.2
Suffer from ‘nerves’	0.4	0.7	1.6	0.5	1.3	-0.3
Ever had bowel cancer screening	0.4	0.4	0.9	0.7	0.9	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-1.3	-0.1	0.5
Hearing aid user	0.4	0.4	0.6	-0.7	0.8	0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.3	-0.0	-1.2
Number of operations (self-reported)	0.4	0.5	1.5	0.2	1.2	-0.2
Supplements: Calcium	0.4	0.5	0.9	-0.9	-0.4	-0.6
Major Depression (MDD)	0.3	0.3	0.5	-0.7	-0.7	-0.1
Blood White Count	0.3	2.5	3.3	-1.1	-1.7	1.8
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.5	0.9	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	-0.6	-0.1	0.9
Age when periods started (menarche)	0.3	0.7	0.9	-0.7	1.0	-0.8
Past tobacco smoking	0.3	0.5	0.8	-0.9	-0.8	0.4
Tense / ‘highly strung’	0.3	0.5	1.2	-0.1	0.6	-1.1
Gout (self-reported)	0.3	0.4	0.8	-0.3	0.5	0.9
Alcohol intake frequency.	0.3	0.6	1.1	-1.1	-0.3	0.8
Knee pain experienced in last month	0.3	0.4	0.9	-0.5	-0.9	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.3	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.0	-0.5	-0.8	1.0
Medication: Paracetamol	0.3	0.5	1.2	0.3	-0.4	1.1
Fractured/broken bones in last 5 years	0.3	0.3	0.8	-0.5	0.2	0.9
Cholesterol lowering medication	0.3	0.4	0.6	-0.7	-0.5	0.6
Heart disease (siblings)	0.3	0.3	0.8	0.5	0.1	0.9
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.8	-0.2	0.6
Bipolar Disorder (2018)	0.2	0.3	0.6	0.0	-0.8	0.4
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	0.7	-0.2
Lupus	0.2	0.3	0.8	0.1	0.9	0.4
Waist Hip Ratio (WHR)	0.2	0.9	2.0	1.4	0.4	-0.6
Tanning	0.2	1.9	4.6	-0.9	-0.7	-2.1
Angina	0.2	0.2	0.5	-0.3	-0.7	0.4
Supplements: Zinc	0.2	0.2	0.5	-0.1	-0.3	0.7
Average weekly fortified wine intake	0.2	0.2	0.2	-0.5	0.3	-0.5
Supplements: Glucosamine	0.2	0.3	0.8	-0.9	0.0	0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.0	-0.5	-0.6
Had other major operations	0.2	0.3	0.4	0.2	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.9	-0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.2	0.3	-0.7
Asthma	0.2	0.4	0.8	-0.4	0.4	0.9
Standing height	0.2	2.1	2.4	-1.5	-1.4	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.5	0.0	1.0
Medication: Paracetamol	0.2	0.3	0.4	0.3	-0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.6	0.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.2	0.9	-0.1
Birth weight	0.2	0.5	0.5	-0.7	-0.6	0.7
Forced vital capacity (FVC), Best measure	0.2	0.9	1.3	-1.1	-1.0	0.6
Shortness of breath walking on level ground	0.2	0.2	0.4	0.7	0.3	0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.2	0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.4	-0.6	-0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.4	0.1	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.1	-0.5	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.6	0.8	0.0	0.2
Back pain experienced in last month	0.2	0.3	0.8	-0.2	-0.4	-0.9
Asthma (self-reported)	0.2	0.4	0.7	-0.5	0.4	0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.7	0.2	0.5
Alcohol drinker status: Never	0.2	0.3	0.5	0.7	0.5	0.3
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.6	-0.6	0.5
Irritability	0.2	0.3	0.7	0.6	-0.8	-0.1
Risk taking	0.2	0.3	0.8	-0.1	-0.3	0.9
Unable to work because of sickness or disability	0.2	0.2	0.6	0.2	-0.3	-0.8
Myopia	0.2	0.3	0.9	0.1	0.2	1.0
Height	0.1	2.0	4.4	-0.3	-1.3	2.1
Relative age of first facial hair	0.1	0.3	0.5	0.5	-0.7	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.3	-0.1	0.6
Alcohol usually taken with meals	0.1	0.2	0.5	0.0	-0.2	0.7
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.1	-0.7	-0.0
Allergy	0.1	0.2	0.4	0.1	0.6	-0.3
Birth weight of first child	0.1	0.2	0.6	-0.7	0.2	-0.4
Headache pain in last month	0.1	0.1	0.2	0.3	-0.3	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	0.6	0.3
Age at first live birth	0.1	0.2	0.4	0.5	0.6	-0.1
Angina (self-reported)	0.1	0.1	0.2	-0.1	-0.2	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	0.4	-0.2
Pain experienced in last month	0.1	0.1	0.3	-0.0	0.5	0.4
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.1	-0.4	0.1
Blood Eosinophil Count	0.0	0.2	0.5	0.7	0.4	-0.0
Blood Platelet Count	0.0	0.4	0.9	-1.0	-0.4	-0.2
Blood Red Count	0.0	0.4	0.6	-0.8	0.4	-0.7
Heel T-Score	0.0	0.2	0.3	0.4	0.3	0.5
Hypothyroidism (self reported)	0.0	0.1	0.2	0.1	-0.2	-0.5
Hair Pigment	0.0	0.6	0.9	-0.5	-1.0	0.7
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.0	0.2	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.1	-0.1	-0.3
Time employed in main current job	0.0	0.0	0.1	-0.3	-0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.4	-0.5	0.1
Smoking status: Previous	0.0	0.1	0.1	0.1	0.3	-0.3
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.2	-0.3

Hub : Genes

CALN1

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Trait associations