Hub : Genes

CALN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.049	0.0200	1.3e-03	0.021	0.008	0.010	0.008	0.012	1.2e-03	2.9e-02	1.9e-02	2.8e-02	1.0e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.114	0.0313	2.5e-09	0.078	0.073	0.073	0.074	0.071	3.1e-10	1.2e-09	1.2e-09	9.5e-10	1.9e-09
3	TCGA	Skin Cutaneous Melanoma	0.374	0.1100	2.2e-03	0.044	0.092	0.246	NA	0.172	2.6e-02	1.9e-03	3.1e-07	NA	2.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.6	0.0	-0.8	0.4
Bipolar Disorder or Schizophrenia	2.3	5.6	9.4	3.1	1.8	-2.0
Depressed Affect (Nagel 2018)	1.0	2.2	3.0	1.7	0.7	1.7
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	0.7	-0.2
Intelligence (Savage-Jansen 2018)	10.6	32.6	58.2	7.6	6.2	-1.2
Neuroticism (Nagel 2018)	1.5	3.4	7.4	2.7	1.6	0.3
Schizophrenia (2018)	5.3	11.1	15.6	3.9	3.0	-3.0
Schizophrenia vs Biploar Disorder	5.5	7.3	8.4	2.7	2.9	-2.4
Worry (Nagel 2018)	1.9	3.9	6.8	2.2	2.6	-0.5
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.2	1.3	0.3
Alzheimer’s Disease (in father)	1.0	1.1	2.8	1.7	0.6	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	1.1	1.0	-0.5
Crohns Disease (2017)	2.0	4.4	6.2	-2.5	-2.5	0.9
Irritable Bowel Disease (IBD)	1.8	4.3	6.8	-2.6	-2.5	0.1
Ulcerative Colitis (UC)	1.0	1.8	2.9	-1.5	-1.7	-0.5
Major Depression (MDD)	0.3	0.3	0.5	-0.7	-0.7	-0.1
Reaction Time	0.4	0.7	1.1	0.6	-0.8	-1.1
Verbal and Numeric Reasoning (VNR)	7.1	16.9	27.3	5.2	4.8	-0.7
Breast Cancer	1.5	3.6	7.1	-2.7	-1.7	-1.0
Ovarian Cancer	0.8	1.1	1.8	1.2	1.3	-0.2
Prostate Cancer	0.4	0.5	1.0	-0.8	-0.1	-1.0
Age at First Birth	0.8	1.2	2.7	0.7	0.6	-1.6
Bipolar Disorder (2011)	2.0	2.0	5.8	0.3	0.2	-2.4
Body Mass Index (BMI) (2010)	3.8	5.3	9.1	-2.1	-3.0	1.5
Coronary Artery Disease (CAD)	2.0	2.4	6.2	-0.7	-0.8	-2.5
Crohns Disease (2012)	2.0	3.2	7.4	-1.2	-2.7	0.8
Mean Putamen Volume	0.7	0.8	1.8	0.8	1.3	-0.1
Fasting Glucose	0.9	1.1	1.4	-0.9	-1.1	1.2
HbA1C	1.1	1.3	3.2	0.2	-0.7	-1.8
HDL Cholesterol	0.7	1.2	2.7	1.6	0.9	-0.2
LDL Cholesterol	0.9	1.4	1.7	1.3	1.2	-1.1
Lupus	0.2	0.3	0.8	0.1	0.9	0.4
Neuroticism (2016)	2.5	3.6	6.7	2.6	1.5	1.4
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.1	-0.4	0.1
Rheumatoid Arthritis	1.8	2.5	7.2	-0.1	-0.4	-2.7
Schizophrenia (2014)	4.4	9.7	15.6	3.9	2.6	-2.6
Triglycerides	0.9	1.4	1.9	-1.1	-1.1	1.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.1	-1.4	-1.3	1.0
Ulcerative Colitis	1.0	1.5	2.3	-1.5	-1.5	-0.3
Blood Eosinophil Count	0.0	0.2	0.5	0.7	0.4	-0.0
Blood Platelet Count	0.0	0.4	0.9	-1.0	-0.4	-0.2
Blood Red Count	0.0	0.4	0.6	-0.8	0.4	-0.7
Blood White Count	0.3	2.5	3.3	-1.1	-1.7	1.8
Heel T-Score	0.0	0.2	0.3	0.4	0.3	0.5
BMI	2.6	15.1	33.9	-2.0	-2.7	5.8
Height	0.1	2.0	4.4	-0.3	-1.3	2.1
Waist Hip Ratio (WHR)	0.2	0.9	2.0	1.4	0.4	-0.6
Systolic Blood Pressure	1.7	8.7	10.4	-3.2	-3.1	2.5
Smoking Status	0.8	1.8	5.1	2.2	-0.2	0.6
Allergy or Eczema	0.9	2.4	3.0	1.6	1.4	1.7
Cardiovascular Disease	3.0	9.9	13.1	-2.9	-2.9	3.6
Hypothyroidism (self reported)	0.0	0.1	0.2	0.1	-0.2	-0.5
Respiratory disease	0.7	1.6	3.2	0.3	1.3	1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	2.8	-1.0	-1.5	1.7
Lung FEV1/FVC ratio	1.1	5.5	10.4	3.2	1.9	-1.5
Lung FVC	0.7	3.3	7.3	-2.7	-1.3	-1.0
Neuroticism	1.4	3.5	6.3	2.5	1.8	-0.9
Chronotype (morning person)	5.2	12.0	16.9	-4.1	-3.5	2.7
Hair Pigment	0.0	0.6	0.9	-0.5	-1.0	0.7
Tanning	0.2	1.9	4.6	-0.9	-0.7	-2.1
Hand grip strength (left)	5.0	13.2	21.1	-4.6	-3.7	2.2
Number of treatments/medications taken	4.2	7.5	12.2	-3.5	-1.9	2.6
Average weekly spirits intake	0.8	1.0	1.4	-1.0	-1.2	0.8
Sensitivity / hurt feelings	0.7	1.2	2.8	1.7	0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	0.7	1.2	0.0
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.5	0.9	-0.6
Relative age of first facial hair	0.1	0.3	0.5	0.5	-0.7	0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.3	0.9	1.4	-1.8
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.0	0.2	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.0	-1.0	0.4	0.7
Systolic blood pressure, automated reading	1.7	4.8	5.3	-2.1	-2.3	2.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	-0.6	-0.1	0.9
Angina	0.2	0.2	0.5	-0.3	-0.7	0.4
Medication for hormone replacement therapy	0.8	0.9	2.5	0.5	1.6	0.2
Vitamin and mineral supplements	0.6	0.8	2.0	1.4	0.2	0.6
Supplements: Zinc	0.2	0.2	0.5	-0.1	-0.3	0.7
Medication: Co-codamol	1.1	1.3	1.9	-1.3	-1.4	0.6
Medication: Metformin	3.1	4.4	7.6	-2.8	-2.0	1.2
Diabetes (father)	2.2	2.7	3.8	-0.6	-1.9	1.9
Diabetes (mother)	1.1	1.4	2.5	1.0	-0.9	1.6
Severe depression (siblings)	0.9	1.0	1.6	0.9	1.3	0.7
Pack years adult smoking proportion	1.2	1.8	2.8	1.7	1.3	1.0
Impedance of leg (right)	1.1	5.1	13.7	0.9	1.0	-3.7
Leg fat-free mass (left)	2.1	10.9	24.3	-1.6	-2.4	4.9
Trunk fat percentage	1.2	4.7	12.6	-0.4	-1.2	3.5
Hand grip strength (right)	2.5	6.7	7.2	-2.7	-2.4	2.7
Townsend deprivation index at recruitment	0.9	1.3	3.3	0.7	-0.4	1.8
Current tobacco smoking	0.6	1.0	1.8	1.4	-0.7	0.8
Average weekly fortified wine intake	0.2	0.2	0.2	-0.5	0.3	-0.5
Maternal smoking around birth	0.7	1.0	1.8	1.3	0.0	1.1
Fed-up feelings	1.7	3.1	5.5	1.9	0.3	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.3	0.9	1.1	0.2
Relative age voice broke	0.4	0.7	1.4	0.8	0.2	1.2
Taking other prescription medications	0.6	0.9	1.6	-1.0	0.4	1.3
Age when periods started (menarche)	0.3	0.7	0.9	-0.7	1.0	-0.8
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	8.7	-1.0	-0.3	2.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	1.4	0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.1	0.3	0.8	1.8
Qualifications: CSEs or equivalent	2.5	3.2	5.5	-2.3	-1.5	1.4
Serious illness, injury or assault to yourself	0.7	0.8	1.9	0.7	0.1	-1.4
High blood pressure	2.9	8.2	10.4	-2.8	-2.5	3.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.3	-0.1	0.6
Multivitamins +/- minerals	0.4	0.6	1.4	-0.4	0.4	-1.2
Stomach or abdominal pain in last month	0.6	0.7	1.5	-0.7	-1.2	0.2
Supplements: Glucosamine	0.2	0.3	0.8	-0.9	0.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.2	0.1	-1.8	0.3
Medication: Atenolol	1.4	1.8	4.2	-0.2	-1.0	2.0
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.1	-0.1	-0.3
Sitting height	0.6	4.3	6.6	-1.5	-2.0	2.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.0	-0.5	-0.6
High blood pressure (mother)	2.3	3.2	6.3	-0.8	-1.6	2.5
Body mass index (BMI)	2.4	10.1	23.6	-1.2	-2.3	4.9
Impedance of leg (left)	0.7	3.6	10.5	0.4	0.5	-3.2
Leg predicted mass (left)	2.1	11.3	25.3	-1.6	-2.5	5.0
Trunk fat mass	1.8	7.8	18.4	-1.1	-1.9	4.3
Waist circumference	1.8	6.6	13.9	-1.2	-2.1	3.7
Number of incorrect matches in round	2.0	3.4	8.4	-2.9	-1.3	-0.4
Past tobacco smoking	0.3	0.5	0.8	-0.9	-0.8	0.4
Alcohol usually taken with meals	0.1	0.2	0.5	0.0	-0.2	0.7
Nervous feelings	1.8	3.3	5.9	2.4	2.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.3	1.3	1.5	-1.1
Hearing difficulty/problems with background noise	1.8	2.9	6.6	2.6	1.4	-0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.1	-0.7	-0.0
Had menopause	1.2	1.5	2.2	-1.3	-0.9	-1.5
Had other major operations	0.2	0.3	0.4	0.2	0.6	-0.6
Forced vital capacity (FVC)	0.8	3.0	5.1	-2.2	-1.7	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.9	-0.1	0.1
Qualifications: None of the above	5.2	11.1	17.6	-4.2	-3.9	0.7
Financial difficulties in last 2 years	0.9	1.2	3.1	0.8	-0.0	1.7
Mouth/teeth dental problems	0.9	1.4	4.0	-0.3	-0.0	-2.0
Heart attack	0.7	0.9	2.2	-0.4	-0.5	1.5
Allergy	0.1	0.2	0.4	0.1	0.6	-0.3
Pain all over the body in last month	1.4	1.5	2.8	-1.2	-0.4	1.7
Diabetes (self-reported)	0.8	1.3	2.2	-1.1	-1.5	0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	0.7	1.6	-0.9
Medication: Ramipril	3.8	4.8	6.2	-2.1	-2.5	1.9
Medication: Simvastatin	0.9	1.3	2.4	-1.6	-1.2	0.3
Fluid intelligence score	6.3	13.1	22.1	4.7	4.0	-0.9
Illnesses of siblings	0.6	0.8	1.5	1.0	1.2	-0.3
Neuroticism score	1.6	3.3	6.9	2.6	1.6	0.7
Weight	2.6	12.7	27.0	-1.8	-2.8	5.2
Impedance of arm (right)	2.5	11.7	19.1	2.7	2.9	-4.4
Arm fat percentage (right)	1.2	4.7	13.0	-0.3	-1.0	3.6
Trunk fat-free mass	2.5	14.2	23.2	-2.9	-3.3	4.8
Hip circumference	2.9	12.5	22.0	-2.4	-3.1	4.7
Time employed in main current job	0.0	0.0	0.1	-0.3	-0.0	0.0
Alcohol intake versus 10 years previously	2.7	4.1	8.3	-2.9	-1.7	1.1
Father’s age at death	2.5	3.4	7.5	-0.3	1.6	-2.7
Worrier / anxious feelings	3.2	6.1	13.4	3.7	2.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.1	0.8	1.4	-1.8
Falls in the last year	3.5	4.7	10.0	-0.9	-1.8	3.2
Hair/balding pattern: Pattern 3	2.1	3.2	6.7	1.7	2.6	-0.1
Number of live births	1.9	2.7	5.8	2.4	1.1	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.1	-1.4	-1.2	0.6
Pulse rate	0.4	0.7	1.9	-0.0	-0.2	1.4
Happiness	0.9	1.1	2.5	1.6	-0.1	-0.8
Noisy workplace	3.4	4.2	6.1	-2.5	-2.1	-1.4
Qualifications: A levels/AS levels or equivalent	5.6	12.4	19.8	4.0	4.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.2	0.3	-0.7
Mouth/teeth dental problems: Dentures	1.0	1.6	2.4	-1.0	-1.2	1.6
Asthma	0.2	0.4	0.8	-0.4	0.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	5.5	2.4	1.8	-0.3
Medication: Cholesterol lowering	3.0	4.7	9.0	-3.0	-2.0	1.0
Depression (self-reported)	1.9	2.3	4.0	0.0	1.7	-2.0
Medication: Lansoprazole	1.8	2.0	3.3	-1.8	-1.3	1.0
Prospective memory result	0.8	1.0	1.8	-1.3	-0.8	-0.7
Lung cancer (father)	3.6	4.2	4.8	-2.2	-2.0	-1.9
Illnesses of mother	1.1	1.3	2.9	-0.9	0.5	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.4	-0.5	0.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	1.3	0.4	-0.4
Impedance of arm (left)	2.7	12.4	15.3	3.2	3.4	-3.9
Arm fat mass (right)	2.2	9.2	20.5	-1.5	-2.2	4.5
Trunk predicted mass	2.4	13.9	22.8	-2.9	-3.2	4.8
Standing height	0.2	2.1	2.4	-1.5	-1.4	1.4
Length of working week for main job	1.8	2.0	4.8	-0.8	0.8	2.2
Exposure to tobacco smoke at home	0.9	1.0	2.7	0.3	0.4	1.6
Breastfed as a baby	1.4	1.7	2.9	-1.7	-0.7	-1.3
Tense / ‘highly strung’	0.3	0.5	1.2	-0.1	0.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.5	0.0	1.0
Hair/balding pattern: Pattern 4	1.0	2.4	3.0	-1.7	-1.2	-1.7
Birth weight of first child	0.1	0.2	0.6	-0.7	0.2	-0.4
Peak expiratory flow (PEF)	1.4	3.2	5.0	-2.2	-1.2	1.7
Pulse wave reflection index	0.4	0.5	1.2	1.1	-0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.0	1.7	0.0	0.1
Loud music exposure frequency	0.4	0.5	0.6	0.5	-0.8	0.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.8	1.2	2.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.5	-0.4	-0.1	1.2
Blood clot in the leg (DVT)	1.6	2.1	3.2	-0.9	-1.8	-1.5
Medication: Paracetamol	0.2	0.3	0.4	0.3	-0.5	0.6
Headache pain in last month	0.1	0.1	0.2	0.3	-0.3	-0.5
Medication for cholesterol, blood pressure or diabetes	5.0	8.3	13.0	3.6	3.0	-1.7
Glaucoma (self-reported)	0.6	0.7	1.7	1.3	0.3	0.4
Gout (self-reported)	0.3	0.4	0.8	-0.3	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.6	0.3	-0.9
Medication: Amlodipine	2.3	3.3	6.2	-2.5	-1.7	-0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.2	0.9	-0.1
Birth weight	0.2	0.5	0.5	-0.7	-0.6	0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.5	0.8	0.6	-1.2
High blood pressure (siblings)	1.1	1.6	1.9	-1.0	-1.4	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.9	1.3	-1.1	-1.0	0.6
Body fat percentage	1.2	4.7	12.1	-0.6	-1.3	3.5
Leg fat percentage (right)	1.5	5.6	10.3	-1.3	-2.2	3.2
Arm fat-free mass (right)	3.0	15.4	26.9	-2.9	-3.2	5.2
Exposure to tobacco smoke outside home	0.5	0.6	0.8	-0.9	-0.6	0.9
Comparative body size at age 10	0.9	2.4	4.8	2.2	1.6	0.2
Number of full brothers	0.4	0.5	0.9	0.9	-0.2	0.7
Worry too long after embarrassment	2.1	3.6	8.8	3.0	1.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.9	0.8	-0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	0.6	0.3
Number of children fathered	0.6	0.6	0.9	-0.9	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-1.2	-0.9	-0.3
Age at first live birth	0.1	0.2	0.4	0.5	0.6	-0.1
Pulse wave peak to peak time	0.6	0.7	1.6	-1.3	-0.5	0.6
Health satisfaction	1.2	1.6	3.5	0.9	0.6	-1.9
Shortness of breath walking on level ground	0.2	0.2	0.4	0.7	0.3	0.2
Qualifications: College or University degree	7.5	23.5	41.1	6.4	5.2	-1.4
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.8	-0.2	-1.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.8	0.0	-0.7	2.0
Emphysema/chronic bronchitis	1.6	1.7	2.9	0.4	-1.5	1.7
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.2	0.5	-0.9
Neck or shoulder pain in last month	0.9	1.3	2.1	-1.3	-1.4	-0.3
Medication: Blood pressure	2.7	4.7	6.4	-2.5	-2.2	1.7
Angina (self-reported)	0.1	0.1	0.2	-0.1	-0.2	0.4
Migraine (self-reported)	0.6	0.7	1.5	0.3	1.2	0.7
Medication: Ibuprofen	1.1	1.3	2.7	1.6	1.1	-0.4
Medication: Allopurinol	0.5	0.6	1.1	-0.9	-0.2	1.0
Medication: Omeprazole	2.7	3.2	5.0	-1.8	-2.2	1.2
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-1.5	-0.9	0.5
Mean time to correctly identify matches	1.0	2.0	5.6	0.0	-0.5	-2.4
Heart disease (mother)	1.9	2.3	4.1	1.1	2.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.8	-1.7	-0.3	-0.9
Whole body fat mass	2.0	8.5	18.8	-1.4	-2.1	4.3
Leg fat mass (right)	2.4	9.3	16.7	-2.0	-2.7	4.1
Arm predicted mass (right)	2.9	14.8	27.2	-2.6	-3.2	5.2
Pulse rate, automated reading	1.2	3.8	10.1	-0.3	-1.1	3.2
Alcohol intake frequency.	0.3	0.6	1.1	-1.1	-0.3	0.8
Comparative height size at age 10	0.7	3.7	6.5	-2.1	-2.5	0.5
Number of full sisters	0.8	1.0	1.6	-0.9	-1.3	0.7
Suffer from ‘nerves’	0.4	0.7	1.6	0.5	1.3	-0.3
Overall health rating	1.1	2.3	5.0	1.4	2.2	-0.0
Chest pain or discomfort	0.5	0.7	1.5	0.3	-0.7	-1.2
Had major operations	0.6	0.7	1.5	0.8	-0.1	1.2
Age at last live birth	2.3	3.4	5.4	2.1	2.3	0.5
Family relationship satisfaction	4.1	5.0	7.2	2.7	1.2	-2.5
Leg pain on walking	0.7	0.9	2.1	1.5	-0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	4.4	-1.4	-1.9	2.1
Commuting to job workplace: Car/motor vehicle	4.8	5.5	6.8	-2.1	-2.3	2.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.4	-0.6	-0.4
Medication: Aspirin	0.8	1.0	1.6	-1.3	-1.2	-0.3
Supplements: Vitamin C	2.7	3.2	6.6	-2.6	-1.8	-0.1
Knee pain experienced in last month	0.3	0.4	0.9	-0.5	-0.9	0.3
Hypertension (Self-reported)	2.6	7.3	9.8	-2.4	-2.5	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.3	-0.3	0.9
Illnesses of father: Heart disease	0.5	0.7	1.1	-1.0	1.1	0.3
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.4	0.1	0.7
Smoking status: Previous	0.0	0.1	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.6	-0.1	-1.2	2.2
Whole body fat-free mass	2.5	14.2	26.4	-2.6	-3.1	5.1
Leg fat-free mass (right)	2.2	11.8	25.3	-1.8	-2.7	5.0
Arm fat percentage (left)	1.2	4.7	13.7	0.0	-0.7	3.7
Average weekly red wine intake	0.6	0.9	2.4	0.1	0.5	1.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.1	-0.5	-0.7
Mood swings	0.9	1.6	3.0	0.9	-1.1	1.7
Loneliness, isolation	0.7	0.9	1.4	1.0	0.4	1.2
Long-standing illness, disability or infirmity	0.9	1.4	2.1	-1.3	-0.6	1.5
Ever had bowel cancer screening	0.4	0.4	0.9	0.7	0.9	-0.1
Diabetes diagnosed by doctor	0.8	1.4	2.4	-1.3	-1.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.2	1.8	1.2	0.4
Friendships satisfaction	2.3	2.8	3.5	1.8	1.3	-1.9
Qualifications: nursing, teaching	3.6	5.6	8.1	2.8	2.0	-2.1
Commuting to job workplace: Walk	0.2	0.2	0.6	0.8	0.0	0.2
Eye problems/disorders: Cataract	0.7	0.8	2.2	-0.1	-0.4	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	1.3	1.0	0.6
Medication for cholesterol	1.2	1.9	4.9	0.9	0.2	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	8.0	2.8	1.5	0.4
Back pain experienced in last month	0.2	0.3	0.8	-0.2	-0.4	-0.9
Mineral and other dietary supplements	0.5	0.7	1.4	1.2	-0.6	0.5
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.2	-0.3
Asthma (self-reported)	0.2	0.4	0.7	-0.5	0.4	0.8
Osteoporosis (self-reported)	1.0	1.2	2.3	0.1	1.2	-1.5
Osteoarthritis (self-reported)	1.3	1.7	3.1	-1.8	-0.6	-1.2
Medication: Aspirin	0.8	1.0	1.7	-1.3	-1.1	0.5
Medication: Gliclazide	4.3	4.9	10.7	-1.6	-1.3	3.3
Illnesses of father: None of the above (group 1)	0.7	0.8	1.4	1.2	0.2	1.0
Smoking status: Current	0.6	0.9	1.4	1.2	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.0	-0.5	-0.8	1.0
Whole body water mass	2.6	14.7	27.1	-2.6	-3.2	5.2
Leg predicted mass (right)	2.2	11.7	25.6	-1.7	-2.6	5.1
Arm fat mass (left)	2.2	9.1	21.2	-1.2	-2.1	4.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-1.3	-0.1	0.5
Average weekly champagne plus white wine intake	2.4	3.2	4.7	2.2	1.9	-1.2
Miserableness	3.9	6.8	11.0	2.9	3.3	1.1
Guilty feelings	3.1	4.7	8.8	3.0	2.3	-0.1
Wears glasses or contact lenses	0.5	0.6	1.8	0.1	1.3	-0.1
Ever taken oral contraceptive pill	0.5	0.5	0.9	-0.5	-1.0	0.6
Hearing aid user	0.4	0.4	0.6	-0.7	0.8	0.2
Mother’s age at death	0.7	0.9	1.7	0.8	1.3	-0.6
Financial situation satisfaction	1.1	1.4	3.0	0.4	-1.7	1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.3	-0.0	-1.2
Commuting to job workplace: Public transport	5.3	6.3	10.2	2.6	3.2	-1.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	0.4	-0.2
Medication: Blood pressure	0.9	1.8	3.5	-1.0	-0.9	1.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.7	0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	-1.2	-0.1	-0.8
High cholesterol (Self-reported)	1.2	2.1	4.7	-2.2	-0.8	1.0
Medication: Bendroflumethiazide	2.6	3.9	10.4	-0.5	-1.0	3.2
Medication: Paracetamol	0.3	0.5	1.2	0.3	-0.4	1.1
Medication: Lisinopril	0.8	1.0	2.4	-1.5	-0.8	-0.1
Medication: Atorvastatin	1.9	2.3	4.5	-2.1	-1.1	1.1
Illnesses of father: High blood pressure	0.7	0.9	1.4	-1.0	-0.5	1.2
Alcohol drinker status: Never	0.2	0.3	0.5	0.7	0.5	0.3
Ever smoked	0.7	1.2	1.6	1.1	0.9	-1.3
Basal metabolic rate	2.7	15.2	29.2	-2.5	-3.2	5.4
Leg fat percentage (left)	1.9	6.9	12.8	-1.4	-2.4	3.6
Arm fat-free mass (left)	3.3	17.0	27.7	-3.1	-3.7	5.3
Number of operations (self-reported)	0.4	0.5	1.5	0.2	1.2	-0.2
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.6	-0.6	0.5
Irritability	0.2	0.3	0.7	0.6	-0.8	-0.1
Risk taking	0.2	0.3	0.8	-0.1	-0.3	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	1.0	0.3	0.7
Fractured/broken bones in last 5 years	0.3	0.3	0.8	-0.5	0.2	0.9
Age started oral contraceptive pill	5.1	6.4	15.5	-0.0	1.9	-3.9
Diastolic blood pressure, automated reading	0.9	2.7	7.4	-0.3	-0.8	2.7
Ever depressed for a whole week	0.9	1.1	2.6	1.6	0.2	0.9
Unable to work because of sickness or disability	0.2	0.2	0.6	0.2	-0.3	-0.8
Commuting to job workplace: Cycle	0.8	0.9	2.0	0.7	1.4	0.5
Myopia	0.2	0.3	0.9	0.1	0.2	1.0
Vascular/heart problems diagnosed by doctor	3.7	10.0	14.1	2.8	2.8	-3.8
Cholesterol lowering medication	0.3	0.4	0.6	-0.7	-0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.0	-1.5	-2.0	1.0
Pain experienced in last month	0.1	0.1	0.3	-0.0	0.5	0.4
Supplements: Calcium	0.4	0.5	0.9	-0.9	-0.4	-0.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.3	0.6	1.5	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-0.2	-0.4	1.4
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.3	-0.9	-1.5	-1.5
Heart disease (siblings)	0.3	0.3	0.8	0.5	0.1	0.9
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.8	-0.2	0.6
Pack years of smoking	0.8	1.2	1.5	1.2	1.2	0.9
Impedance of whole body	1.7	8.5	15.8	2.0	2.3	-4.0
Leg fat mass (left)	2.6	10.3	18.2	-2.1	-2.9	4.3
Arm predicted mass (left)	3.4	17.1	27.4	-3.2	-3.7	5.2