Best TWAS P=4.84e-09 · Best GWAS P=6.87e-09 conditioned to 0.00288
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POLR2L | 0.09 | 0.09 | enet | 16 | 0.10 | 4.6e-12 | -3.9 | -5.4 | 6.9e-08 | 0.85 | 0.10 | 0.89 | FALSE |
| 2 | GTEx | Heart Left Ventricle | CD151 | 0.27 | 0.10 | enet | 47 | 0.10 | 5.5e-06 | -4.4 | 5.2 | 1.5e-07 | -0.49 | 0.34 | 0.61 | FALSE |
| 3 | GTEx | Pancreas | EFCAB4A | 0.23 | 0.19 | enet | 8 | 0.16 | 4.1e-07 | -5.2 | 5.2 | 1.9e-07 | -0.51 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Testis | POLR2L | 0.16 | 0.03 | enet | 10 | 0.03 | 1.9e-02 | -5.8 | -5.8 | 7.6e-09 | 0.85 | 0.00 | 0.99 | FALSE |
| 5 | METSIM | Adipose | POLR2L | 0.03 | 0.02 | bslmm | 413 | 0.01 | 5.0e-03 | -3.7 | -5.8 | 4.8e-09 | 0.57 | 0.24 | 0.10 | TRUE |
| 6 | YFS | Blood | POLR2L | 0.26 | 0.19 | bslmm | 383 | 0.30 | 2.4e-98 | -3.9 | 5.4 | 6.1e-08 | -0.78 | 0.45 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PNPLA2 | 0.07 | 0.00 | blup | 51 | 0.03 | 1.4e-04 | -3.9 | 5.5 | 3.8e-08 | -0.61 | 0.01 | 0.50 | FALSE |