TWAS hub - EFCAB4A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1090	0.0460	9.1e-03	0.012	NA	0.042	NA	0.040	7.3e-02	NA	3.1e-03	NA	3.9e-03
2	GTEx	Artery Tibial	0.1164	0.0456	1.6e-03	0.003	NA	0.002	NA	0.001	1.7e-01	NA	2.2e-01	NA	2.8e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.2120	0.0870	3.9e-03	0.036	NA	0.047	NA	0.036	2.5e-02	NA	1.2e-02	NA	2.5e-02
4	GTEx	Heart Left Ventricle	0.1240	0.0485	3.8e-03	-0.003	NA	0.002	NA	-0.004	5.5e-01	NA	2.4e-01	NA	6.2e-01
5	GTEx	Pancreas	0.2330	0.0620	5.0e-05	0.187	NA	0.156	NA	0.154	2.5e-08	NA	4.1e-07	NA	4.9e-07
6	YFS	Blood	0.3201	0.0455	0.0e+00	0.053	0.127	0.137	0.147	0.114	5.3e-17	2.0e-39	1.7e-42	1.1e-45	2.1e-35
7	TCGA	Breast Invasive Carcinoma	0.0235	0.0186	6.5e-03	0.009	0.008	0.004	NA	0.005	5.1e-03	7.3e-03	4.1e-02	NA	3.1e-02
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0396	0.0186	3.5e-05	0.047	0.041	0.046	NA	0.045	4.8e-06	2.0e-05	6.1e-06	NA	8.0e-06
9	TCGA	Lung Adenocarcinoma	0.0396	0.0228	6.1e-04	0.018	0.029	0.035	NA	0.037	3.1e-03	2.4e-04	5.7e-05	NA	3.0e-05
10	TCGA	Lung Squamous Cell Carcinoma	0.0419	0.0293	5.8e-03	0.020	0.019	0.015	NA	0.019	2.2e-03	3.0e-03	6.1e-03	NA	2.5e-03
11	TCGA	Thyroid Carcinoma	0.0790	0.0470	2.5e-03	0.035	0.028	0.016	NA	0.020	2.4e-04	9.1e-04	8.7e-03	NA	4.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Medication: Lisinopril	6.1	7.9	14.0	1.1	1.7	2.4	2.3	3.6	2.5	3.5	3.7	3.1	2.7	3.2
Breast Cancer	5.6	13.4	37.8	-2.0	0.2	-4.3	-3.1	-5.9	-1.6	-2.4	-2.9	-6.2	-5.0	-1.1
Pulse wave Arterial Stiffness index	5.2	6.1	12.2	0.2	2.1	-2.7	-1.8	-2.6	-1.2	-3.5	-3.4	-2.3	-2.1	-3.2
Waist Hip Ratio (WHR)	4.9	22.0	67.7	-3.4	1.8	-5.5	-5.4	-8.2	-5.7	-3.1	-2.9	-5.9	-3.9	-0.0
Impedance of leg (left)	4.7	23.1	54.3	1.5	1.3	-4.2	-4.4	-7.4	-2.4	-6.2	-6.3	-5.4	-4.7	-4.7
Pulse wave peak to peak time	4.5	5.3	12.2	-0.7	-1.8	2.5	1.3	2.4	0.8	3.4	3.5	2.1	1.9	3.1
Eye problems/disorders: None of the above	4.2	4.8	12.5	1.5	0.6	2.1	2.7	2.1	1.6	3.0	2.5	1.3	1.6	3.5
Impedance of leg (right)	3.9	19.1	48.6	1.2	1.0	-3.7	-4.2	-7.0	-2.5	-5.3	-5.3	-5.4	-4.6	-3.7
Medication: Co-codamol	3.6	4.2	14.4	-0.2	1.9	0.2	1.4	2.0	1.4	3.5	2.5	0.3	0.9	3.8
High blood pressure (mother)	3.0	4.3	8.3	1.3	2.2	2.1	1.1	2.9	1.9	2.4	2.3	2.0	1.8	2.1
Pulse wave reflection index	3.0	3.6	10.7	1.1	1.5	-1.0	-1.0	-1.9	0.3	-3.1	-3.3	-0.9	-0.5	-3.1
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	10.2	-3.2	0.5	-2.8	-1.9	-1.5	-1.5	-0.3	-0.4	-2.3	-2.6	-0.3
Impedance of whole body	3.0	15.3	48.5	1.8	1.1	-2.6	-3.6	-7.0	-2.7	-4.3	-4.0	-5.3	-4.5	-2.5
Leg fat-free mass (left)	2.9	15.5	31.2	-2.9	-0.2	3.2	1.9	5.5	0.9	5.4	5.6	3.9	3.8	5.1
Leg predicted mass (left)	2.9	15.3	30.6	-3.0	-0.1	3.1	1.8	5.5	0.8	5.3	5.5	4.0	3.8	5.1
Ulcerative Colitis (UC)	2.8	5.2	13.4	0.7	-0.3	2.6	2.4	3.7	1.1	1.5	1.9	3.5	3.3	0.7
BMI	2.8	16.0	42.9	-1.8	-0.1	2.5	2.5	6.5	1.9	5.2	4.7	5.2	4.7	4.1
Hip circumference	2.6	11.2	33.6	0.1	1.1	2.5	2.9	5.8	1.7	3.8	3.6	4.3	3.8	3.4
Leg fat-free mass (right)	2.6	13.8	29.7	-3.0	-0.2	2.9	1.8	5.5	0.9	5.0	5.2	3.9	3.7	4.5
Leg predicted mass (right)	2.6	13.7	29.4	-3.0	-0.3	2.9	1.7	5.4	1.0	5.0	5.1	3.9	3.7	4.5
Ever depressed for a whole week	2.6	3.2	8.5	-1.8	-0.3	-1.8	-2.9	-2.5	-1.0	-1.4	-1.6	-1.9	-1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	6.2	2.5	0.5	2.1	2.0	1.9	2.2	1.1	1.1	1.8	1.7	0.2
Gout (self-reported)	2.5	3.5	8.1	1.5	1.4	1.8	2.9	2.2	0.9	1.5	1.5	1.8	2.4	1.9
Body mass index (BMI)	2.4	10.0	29.5	-1.0	0.2	1.8	2.7	5.4	1.9	4.0	3.3	4.0	3.4	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	5.3	0.8	2.3	-2.0	-1.5	-2.2	-1.0	-1.5	-2.2	-1.6	-1.7	-0.8
Breast cancer (self-reported)	2.4	2.8	10.6	0.6	-0.4	1.1	1.6	3.3	1.0	1.1	1.3	2.8	2.1	0.3
Medication: Paracetamol	2.3	3.7	12.3	1.9	-1.1	1.1	3.5	2.4	0.8	2.1	1.5	0.7	0.8	2.9
Mean Putamen Volume	2.2	2.5	5.8	1.6	2.4	1.8	0.5	0.8	2.4	1.4	1.1	0.7	1.1	2.1
Lupus	2.1	3.2	16.5	-2.4	2.3	-2.0	-4.1	-0.1	-0.8	-1.0	-1.0	-0.1	-0.7	-0.9
Neuroticism (2016)	2.1	3.0	8.6	2.7	0.3	1.3	2.7	0.8	0.0	-0.7	-0.1	2.4	2.9	-0.9
Arm fat mass (right)	2.1	8.7	20.8	-1.3	0.5	1.8	2.0	4.6	1.4	3.9	3.3	3.4	3.2	4.0
Ever had hysterectomy (womb removed)	2.0	2.3	10.2	0.1	-0.2	0.8	0.8	1.1	-0.4	2.4	2.4	0.5	0.5	3.2
Comparative body size at age 10	2.0	5.6	14.4	-2.0	-0.1	0.9	1.1	3.2	0.8	2.9	3.8	3.1	1.9	3.0
Arm fat mass (left)	2.0	8.1	18.7	-1.1	0.8	1.8	2.0	4.3	1.2	3.8	3.1	3.3	3.2	3.9
Basal metabolic rate	2.0	10.8	27.1	-3.1	0.2	2.1	1.2	5.2	0.7	4.1	4.2	3.8	3.5	3.9
Osteoporosis (self-reported)	1.9	2.3	6.5	-1.5	-1.3	-0.1	-1.5	-2.5	-1.4	-1.6	-1.7	-2.0	-0.6	-1.2
Weight	1.8	8.8	22.2	-2.2	0.6	1.7	1.5	4.7	0.8	3.9	3.6	3.3	3.1	3.9
Whole body fat-free mass	1.8	10.3	25.9	-3.3	-0.0	2.1	1.2	5.1	0.5	3.9	4.1	3.7	3.5	3.6
Back pain experienced in last month	1.8	2.6	5.3	1.6	0.7	1.1	1.6	2.0	1.9	2.3	1.7	0.5	0.7	2.2
Whole body water mass	1.8	10.5	26.4	-3.4	-0.0	2.1	1.2	5.1	0.5	4.0	4.2	3.7	3.5	3.7
Mother’s age at death	1.8	2.3	8.7	0.1	-1.5	0.6	0.2	-0.8	-0.4	-3.0	-2.3	0.6	0.5	-2.6
Relative age of first facial hair	1.7	3.6	9.9	-0.5	-0.8	-1.4	-1.2	-3.1	-1.7	-3.0	-2.7	-1.4	-0.7	-1.9
Supplements: Zinc	1.7	1.9	4.5	0.9	0.6	2.0	0.9	1.2	1.9	2.1	1.9	0.4	0.3	1.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	8.2	-1.9	-1.7	-0.9	-2.9	-1.9	-1.1	-0.4	-0.2	-1.1	-0.9	-0.1
Arm fat percentage (right)	1.7	6.6	13.9	-0.5	0.8	1.9	2.0	3.5	1.2	3.5	3.0	2.8	2.7	3.7
Length of working week for main job	1.7	1.9	4.5	-1.2	-2.1	0.3	-0.1	1.4	1.8	2.1	1.7	0.7	0.4	1.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	6.1	1.7	2.5	1.5	1.7	1.9	2.3	-0.6	-0.5	1.7	1.7	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	10.6	-1.7	1.3	0.4	-0.7	1.1	-0.9	3.2	3.3	-0.6	-0.2	3.2
Mineral and other dietary supplements	1.7	2.3	6.7	1.7	0.7	-1.0	-0.3	-1.4	-1.4	-2.4	-2.3	0.1	-0.1	-2.6
Age started oral contraceptive pill	1.7	2.1	5.5	2.3	2.1	1.0	1.7	1.1	0.2	1.4	1.1	0.8	0.7	2.1
Heart disease (siblings)	1.7	2.1	5.5	-1.8	-1.2	-2.3	0.4	-1.5	-1.2	-0.2	-1.0	-2.1	-1.8	-0.1
Ulcerative Colitis	1.6	2.3	7.4	2.1	0.6	2.2	2.1	1.8	2.7	0.0	0.0	0.0	0.0	0.0
Chest pain or discomfort	1.6	2.3	6.0	-0.1	-0.1	-1.0	-1.1	-2.1	-2.5	-2.2	-2.0	-0.4	0.1	-1.7
Arm fat percentage (left)	1.6	6.6	14.1	0.0	0.9	2.0	2.4	3.4	1.1	3.5	2.8	2.8	2.9	3.8
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.2	0.1	-0.8	1.4	1.5	1.8	1.2	2.0	2.0	0.8	0.5	2.0
Chronic bronchitis/emphysema (father)	1.5	1.8	5.0	-1.9	0.1	-1.1	-2.2	-2.0	-0.5	-0.7	-0.2	-1.8	-1.2	0.6
Exposure to tobacco smoke outside home	1.5	2.0	5.4	0.1	-0.7	1.3	1.1	1.2	0.2	1.8	2.3	1.3	1.2	2.2
Medication for pain relief, constipation, heartburn	1.5	2.5	7.7	-1.0	-1.2	-1.0	-2.0	-1.8	0.5	-1.7	-1.4	-1.3	-1.7	-2.8
Medication: Allopurinol	1.5	2.1	4.0	1.1	0.5	1.2	1.6	1.3	1.7	1.5	1.3	1.3	2.0	1.7
Medication: Paracetamol	1.5	2.2	7.0	1.5	-1.1	1.2	2.6	2.3	0.4	1.3	1.0	0.9	0.9	1.7
Medication: Atorvastatin	1.5	1.9	5.2	-0.4	0.5	-1.6	-1.5	-2.3	-1.8	-0.7	-1.1	-2.1	-0.9	0.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.8	-1.8	-2.2	-0.9	-1.4	-2.0	-1.2	0.1	-0.1	-1.9	-1.2	0.4
Alcohol drinker status: Previous	1.5	1.8	4.4	0.9	-0.9	1.2	2.1	2.0	-0.3	1.3	1.5	1.5	1.2	0.7
Arm predicted mass (left)	1.5	7.7	24.5	-3.1	0.1	1.3	0.9	5.0	0.7	3.0	3.0	3.6	3.2	2.6
HbA1C	1.4	1.6	4.5	-2.1	-1.7	-0.5	-1.6	-1.7	-0.0	-1.5	-0.8	-0.3	0.5	-0.9
Blood Platelet Count	1.4	15.9	51.4	-3.0	-1.6	3.1	1.1	4.0	3.3	6.7	7.2	1.9	1.4	5.0
Hypothyroidism (self reported)	1.4	3.1	18.8	-3.1	0.3	0.1	-4.3	0.2	-1.0	-1.0	-0.4	0.8	0.2	-1.7
Average weekly spirits intake	1.4	1.7	7.5	-0.6	0.5	-1.5	-0.8	-0.4	-2.7	1.1	1.4	-1.1	-0.3	1.9
Falls in the last year	1.4	1.9	8.8	-0.7	0.6	-1.9	-1.0	-1.3	-3.0	-1.7	-1.2	-0.4	-0.3	-0.7
Lung cancer (father)	1.4	1.7	4.5	0.8	-0.1	-2.1	1.6	-1.1	-0.4	-1.1	-1.4	-1.7	-1.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	7.1	-0.0	-2.0	-0.1	-0.2	0.1	-0.6	-2.4	-1.8	1.5	1.1	-2.7
Blood clot in the leg (DVT)	1.4	1.7	7.1	-1.3	-2.7	1.2	0.1	0.5	0.1	1.8	1.4	-0.0	0.2	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	3.9	0.4	0.5	1.6	1.0	0.8	1.6	1.5	1.0	1.3	2.0	1.3
Eye problems/disorders: Cataract	1.4	1.6	5.9	-0.9	-2.4	-0.5	-0.5	-1.0	-0.8	-1.4	-1.3	-1.2	-0.9	-1.8
Arm fat-free mass (left)	1.4	7.0	21.8	-3.3	0.4	0.8	0.7	4.7	0.3	2.8	2.8	3.4	3.0	2.5
Hair/balding pattern: Pattern 2	1.3	1.6	6.5	-0.8	-0.1	-1.1	0.1	0.8	0.7	-1.8	-2.5	0.0	-0.4	-2.1
Heart attack	1.3	1.7	4.4	-1.6	-2.1	-0.8	-1.4	-1.7	-0.9	0.3	0.1	-1.8	-1.1	0.6
Impedance of arm (left)	1.3	6.2	26.2	1.8	0.6	-0.4	-2.1	-5.1	-2.4	-1.6	-1.0	-3.9	-3.0	0.1
Trunk predicted mass	1.3	7.3	19.4	-3.6	0.2	1.4	0.5	4.4	0.0	2.9	3.2	3.2	3.0	2.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	14.5	-2.7	0.8	-0.7	-3.8	-0.0	-1.8	-0.8	-0.3	0.2	-0.5	-0.9
Arm fat-free mass (right)	1.3	6.5	19.1	-3.0	-0.0	1.2	0.9	4.4	0.4	2.8	2.6	3.2	3.0	2.5
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.5	-0.3	-1.9	0.9	1.3	0.7	1.1	1.7	1.5	0.2	0.8	1.6
Medication: Omeprazole	1.3	1.5	4.9	-0.7	1.4	-1.1	-1.7	-2.2	-1.3	-0.3	-0.5	-1.3	-1.2	0.2
Whole body fat mass	1.3	5.4	14.7	-1.2	0.8	1.3	1.2	3.2	0.5	3.2	2.6	2.3	2.5	3.8
Alcohol intake frequency.	1.3	2.9	7.1	-0.7	-1.8	1.8	1.8	2.2	0.5	2.4	2.7	1.2	0.5	1.5
Illnesses of father: Heart disease	1.3	1.8	6.2	0.5	-2.2	0.5	2.5	1.2	1.1	-0.5	-0.6	1.4	1.4	-0.9
Verbal and Numeric Reasoning (VNR)	1.2	3.0	9.1	-1.3	0.7	-2.0	-1.8	-1.4	-0.0	-2.6	-3.0	-1.1	-1.0	-1.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.3	0.9	0.9	0.9	0.3	0.2	-0.2	-1.7	-1.4	1.7	1.8	-1.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.3	2.3	1.7	-0.3	-0.1	-0.9	0.8	-1.5	-1.8	-0.2	0.1	-1.2
Vitamin and mineral supplements	1.2	1.7	3.7	0.8	-0.1	-1.6	-0.2	-1.7	-1.4	-1.8	-1.9	-1.3	-0.5	-1.3
Relative age voice broke	1.2	1.9	4.5	2.1	0.0	-1.2	1.0	-2.0	-0.6	-1.8	-2.1	-1.1	-0.5	-0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.5	-0.9	1.1	-0.3	-0.2	0.6	-1.3	1.7	2.1	-0.0	-0.1	1.9
Trunk fat-free mass	1.2	7.2	19.6	-3.5	0.2	1.4	0.5	4.4	0.0	2.9	3.2	3.2	3.0	2.7
Breastfed as a baby	1.2	1.5	3.1	-0.8	1.0	-1.0	-1.8	-0.8	-0.8	-1.4	-0.9	-1.6	-1.5	-1.2
Arm predicted mass (right)	1.2	6.3	17.7	-3.1	0.0	1.1	0.8	4.2	0.0	2.6	2.5	3.3	3.1	2.5
Loneliness, isolation	1.2	1.7	5.6	0.4	0.2	2.2	0.6	1.7	1.0	0.3	0.7	2.4	1.9	-0.0
Commuting to job workplace: Walk	1.2	1.3	2.4	-1.5	0.4	-1.6	-1.4	-1.1	-1.3	-0.0	-0.1	-1.5	-1.5	0.6
Medication for cholesterol	1.2	1.8	4.9	-1.7	-1.7	0.2	-0.7	-1.0	0.1	-2.2	-1.6	-0.5	-1.0	-2.0
Irritability	1.2	2.0	8.4	0.3	0.5	0.3	0.1	0.0	0.9	2.5	2.0	-1.2	-0.7	2.9
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	5.5	-0.3	2.1	-0.7	-1.3	-2.3	-1.2	-0.1	-0.5	-1.0	-0.4	1.1
Prostate Cancer	1.1	1.6	3.9	0.9	-0.0	1.6	1.7	1.0	2.0	1.2	0.7	0.9	1.3	1.3
Supplements: Glucosamine	1.1	1.4	4.0	-2.0	-0.1	0.6	-0.7	1.7	0.3	1.4	1.6	0.6	0.8	1.3
Trunk fat mass	1.1	4.9	14.4	-1.2	1.0	1.3	0.9	2.7	0.2	3.0	2.6	2.2	2.4	3.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.7	2.2	1.6	0.8	1.7	0.1	1.0	0.0	0.2	0.9	1.7	0.7
Fluid intelligence score	1.1	2.3	5.5	-1.5	0.9	-1.9	-1.9	-1.0	-0.3	-2.0	-2.3	-0.6	-0.7	-1.8
Impedance of arm (right)	1.1	5.2	21.8	1.4	0.6	-0.4	-2.3	-4.7	-2.0	-1.5	-0.6	-3.5	-2.9	-0.1
Depression (self-reported)	1.1	1.4	5.3	0.7	-2.2	0.1	-0.1	-0.7	-0.1	-1.6	-1.3	0.3	-0.1	-2.3
Medication: Lansoprazole	1.1	1.3	2.3	-1.5	0.3	-0.7	-0.5	1.4	-1.4	1.5	1.0	1.1	0.9	1.4
Health satisfaction	1.1	1.4	3.7	1.9	1.1	0.5	0.5	1.3	1.0	-0.4	-0.3	1.9	1.6	-0.7
Leg fat mass (right)	1.1	4.4	10.5	-1.5	0.7	1.0	1.2	3.2	0.5	2.8	2.1	2.1	2.3	3.2
Suffer from ‘nerves’	1.1	1.7	4.8	0.9	0.1	-1.1	-0.0	-0.3	0.7	-1.1	-2.2	-1.7	-1.8	-2.0
Medication: Aspirin	1.1	1.4	6.1	-0.6	1.8	-0.3	-1.1	-0.4	-1.1	1.0	1.3	-0.6	0.0	2.5
Supplements: Vitamin C	1.1	1.3	3.2	0.5	0.2	1.8	0.5	0.4	1.5	1.5	1.6	0.3	0.4	1.8
Medication: Bendroflumethiazide	1.1	1.7	5.0	-0.6	0.2	0.7	-0.7	0.6	1.6	2.2	2.1	0.1	0.0	2.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.5	-1.0	-2.4	1.2	-0.0	0.1	-0.0	1.6	1.2	-0.2	0.2	1.8
Leg fat mass (left)	1.1	4.2	11.1	-1.3	0.7	0.9	1.3	3.3	0.6	2.6	1.9	2.3	2.4	2.9
Intelligence (Savage-Jansen 2018)	1.0	3.2	6.6	-0.9	1.1	-1.3	-2.5	-2.2	-0.8	-2.4	-2.6	-1.3	-1.2	-2.0
Alzheimer’s Disease (in mother)	1.0	1.2	3.4	-0.6	1.8	-1.0	-0.9	-0.7	-0.0	-1.1	-1.7	-0.6	-0.7	-1.4
Hearing difficulty/problems: Yes	1.0	1.5	3.5	-1.8	1.9	0.1	-0.5	1.6	0.1	1.5	1.3	1.1	0.9	0.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	5.8	-0.0	2.4	0.1	-0.4	-0.3	-1.0	0.4	1.2	0.8	1.2	1.1
Stomach or abdominal pain in last month	1.0	1.2	3.9	2.0	0.6	1.4	1.5	1.3	0.6	0.3	0.5	1.3	1.1	-0.1
Illnesses of mother	1.0	1.2	2.7	-1.4	-1.6	-0.4	-0.2	-1.1	-0.4	-1.4	-1.6	-1.0	-0.4	-1.2
Glaucoma (self-reported)	1.0	1.2	3.3	-0.6	0.4	-1.4	-1.2	-1.8	-0.3	-0.9	-0.7	-1.4	-1.6	-0.6
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.9	0.5	1.6	0.2	1.2	1.1	0.1	-0.4	0.1	2.0	1.4	-0.9
Number of children fathered	1.0	1.1	2.8	-1.5	0.1	-0.6	-1.3	0.1	-0.5	1.4	1.7	-0.5	-0.1	1.7
Angina (self-reported)	1.0	1.3	4.6	-0.6	-0.2	-0.8	-1.6	-2.1	-1.5	-0.3	-0.4	-1.4	-0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	5.0	0.5	-1.6	1.0	1.0	0.8	-0.4	-0.4	0.1	1.3	2.2	0.7
Age at last live birth	1.0	1.4	3.6	-1.5	-1.4	-0.5	-0.4	-1.9	-1.2	-1.1	-0.8	-1.1	-0.9	-1.4
Commuting to job workplace: Car/motor vehicle	1.0	1.2	4.9	0.7	-1.0	0.6	2.2	0.7	1.5	-0.8	-0.4	1.1	1.1	-0.5
Medication: Aspirin	1.0	1.3	5.4	-0.3	1.8	-0.3	-1.0	-0.5	-1.2	0.9	1.1	-0.8	-0.0	2.3
Irritable Bowel Disease (IBD)	0.9	2.2	6.7	0.2	0.6	1.4	0.5	2.6	0.8	0.8	1.1	2.6	2.3	0.0
Fasting Glucose	0.9	1.1	4.0	-2.0	-0.1	-0.1	-0.0	1.8	-0.2	0.8	0.7	1.6	0.9	0.0
Medication for hormone replacement therapy	0.9	1.0	2.6	0.6	1.6	0.8	1.1	0.9	0.0	0.8	-0.1	1.3	1.6	1.0
Townsend deprivation index at recruitment	0.9	1.2	6.1	0.4	-0.8	-1.4	0.3	-0.5	-2.5	1.1	1.1	-0.6	-0.9	0.7
Average weekly fortified wine intake	0.9	1.0	3.6	1.3	1.9	0.1	-1.0	-1.2	-1.0	0.0	0.3	-1.0	-1.0	-0.0
Age when periods started (menarche)	0.9	2.2	5.6	-0.5	-0.7	-1.3	-0.3	-1.3	-1.7	-1.9	-2.1	-1.1	-1.3	-2.4
Medication: Atenolol	0.9	1.1	3.3	-1.3	-0.7	-0.0	-0.4	0.9	0.4	1.6	1.8	-0.7	-0.5	1.6
Waist circumference	0.9	3.3	11.8	-1.1	1.5	-0.3	0.6	2.0	-0.7	2.6	2.3	1.4	1.5	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.3	-1.4	-1.8	0.0	-0.8	0.2	-0.9	-1.0	0.1	1.2	0.5	-1.7
Emphysema/chronic bronchitis	0.9	1.0	3.6	-0.1	0.0	-1.1	-0.0	-1.7	-1.9	-1.0	-1.0	-0.6	-0.1	-0.6
Diabetes diagnosed by doctor	0.9	1.5	3.9	0.1	0.2	-1.4	-1.2	-2.0	-1.7	-0.8	-0.7	-1.7	-1.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.6	-1.6	-1.3	-0.3	-0.6	1.1	-0.7	1.5	1.2	0.5	0.3	0.5
Medication: Gliclazide	0.9	1.1	4.0	0.1	-0.9	-1.1	-0.3	-0.1	0.1	-1.3	-1.3	-0.7	-1.3	-2.0
Medication: Blood pressure	0.9	1.6	4.3	1.6	1.4	-0.3	0.9	1.1	0.9	2.1	2.0	-0.1	0.1	1.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.4	1.8	-0.5	-0.5	1.2	-0.4	-0.4	-1.6	-1.6	-0.7	-0.2	-1.2
Average weekly beer plus cider intake	0.9	1.3	3.5	1.1	-0.4	0.1	1.8	0.9	0.8	1.9	1.3	0.3	-0.2	1.7
Risk taking	0.9	1.3	4.5	-0.7	-1.2	1.0	1.1	1.3	1.0	1.6	2.1	0.5	0.6	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	-1.4	0.5	0.6	-1.1	-0.5	-1.2	1.2	1.2	-0.4	0.6	1.5
Commuting to job workplace: Cycle	0.9	1.1	3.4	-0.6	0.6	-0.3	-1.1	-0.4	-1.6	-1.6	-1.2	0.2	-0.2	-1.8
Supplements: Calcium	0.9	1.0	2.6	0.3	-0.2	0.6	1.3	1.3	1.6	1.5	1.1	0.0	-0.9	0.8
Smoking Status	0.8	1.9	6.0	0.8	-1.4	-2.0	1.1	-1.2	0.5	-1.4	-2.4	-1.2	-1.2	-0.8
Number of treatments/medications taken	0.8	1.4	6.0	-0.9	0.3	-0.3	-1.0	-0.2	-1.2	1.6	1.8	0.1	0.7	2.5
Angina	0.8	1.0	3.3	-0.8	-0.7	-0.6	-1.5	-1.8	-1.4	0.0	-0.1	-1.2	-0.5	0.9
Pack years adult smoking proportion	0.8	1.3	4.2	1.1	-2.0	1.2	0.7	1.1	0.4	-0.7	0.2	1.5	1.2	-1.2
Multivitamins +/- minerals	0.8	1.0	3.0	-0.1	-0.1	1.4	0.4	1.5	1.7	0.9	0.7	1.4	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	4.7	0.1	1.1	-0.8	-1.1	-1.3	-2.2	-0.6	0.0	-0.7	0.2	0.4
Qualifications: None of the above	0.8	1.7	4.6	-1.4	-0.6	-2.0	-0.7	-0.3	-2.1	1.0	1.0	-0.7	-1.3	1.7
Allergy	0.8	1.9	5.2	-1.1	0.1	-1.0	-1.4	-0.9	0.4	-2.1	-1.9	-0.6	-1.2	-2.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	9.9	-0.9	-0.6	1.2	0.8	3.1	1.0	-0.1	-0.1	2.3	1.7	-2.4
Medication: Cholesterol lowering	0.8	1.2	5.8	0.8	-0.8	-0.8	-0.4	-2.4	-1.0	-0.2	-0.9	-1.4	-0.3	1.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.2	-0.0	-0.5	-0.5	-0.5	-1.1	-1.4	-1.7	-1.1	-0.7	-0.1	-1.8
Medication: Seretide 50 evohaler	0.8	0.9	4.1	-0.2	0.2	-0.5	-0.1	0.2	0.3	-1.6	-1.5	0.6	0.3	-2.0
Wears glasses or contact lenses	0.8	1.0	3.6	-1.0	0.6	-0.8	-1.3	-0.3	-1.9	-0.7	-0.8	-0.8	-1.0	-0.7
Ever taken oral contraceptive pill	0.8	0.9	4.3	0.3	0.2	1.2	0.0	1.1	0.0	0.1	0.4	2.1	1.6	-0.0
Hearing aid user	0.8	0.9	1.9	0.8	0.8	0.6	0.3	1.0	-0.4	1.3	1.1	1.2	1.4	1.0
High cholesterol (Self-reported)	0.8	1.4	5.2	0.4	-1.0	-1.9	-0.7	-2.3	-1.2	-0.9	-1.4	-0.6	0.1	-0.3
Fractured/broken bones in last 5 years	0.8	1.0	4.8	-1.0	-2.2	-0.8	0.3	0.0	-1.1	0.4	0.1	-1.0	-1.4	0.5
Unable to work because of sickness or disability	0.8	1.0	3.4	-0.5	-1.8	-0.7	0.8	1.3	-0.5	1.5	1.2	0.5	0.1	0.6
Myopia	0.8	1.2	4.8	-0.0	-0.1	1.0	-0.1	0.1	1.2	1.7	1.7	0.1	0.2	2.2
Pain experienced in last month	0.8	1.3	3.6	-1.5	0.4	-0.8	-1.5	-1.8	0.3	0.1	-0.3	-1.9	-1.5	0.1
Pack years of smoking	0.8	1.2	2.6	0.9	-1.5	0.9	0.3	0.8	0.1	-1.2	-0.4	1.6	1.3	-1.5
Lung FEV1/FVC ratio	0.7	3.5	10.5	-0.1	-1.2	1.4	2.9	3.2	0.6	0.9	1.1	3.0	2.2	-0.2
Trunk fat percentage	0.7	3.0	11.2	-0.3	1.4	1.1	0.8	1.7	-0.0	2.4	1.9	1.5	1.8	3.3
Number of incorrect matches in round	0.7	1.1	4.2	-0.1	1.5	-0.7	-1.4	-2.0	-1.3	-0.1	-0.6	-0.9	-0.7	0.5
Hearing difficulty/problems with background noise	0.7	1.1	3.7	-0.6	0.5	0.4	0.7	1.7	-0.1	1.9	1.6	0.8	0.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.8	-0.6	-0.4	0.6	0.4	0.6	-1.0	1.5	1.9	1.0	1.0	1.1
Exposure to tobacco smoke at home	0.7	0.8	2.0	-0.9	-0.2	0.5	-0.1	0.6	-0.8	1.0	1.4	1.2	0.5	1.4
Peak expiratory flow (PEF)	0.7	1.6	4.2	-0.8	-1.4	1.0	0.3	1.6	0.8	-0.7	-0.1	2.1	2.0	-1.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.3	-0.0	-1.3	0.8	0.5	1.5	1.2	0.8	0.8	1.3	0.6	0.1
Body fat percentage	0.7	2.9	10.5	-0.3	1.2	0.9	1.0	1.9	0.2	2.3	1.6	1.5	1.8	3.2
Shortness of breath walking on level ground	0.7	0.8	2.2	1.2	1.2	0.3	0.4	1.5	1.2	0.2	0.4	1.1	0.8	-0.2
Knee pain experienced in last month	0.7	1.1	3.3	-0.0	-0.7	1.1	1.0	1.4	-1.1	0.1	0.6	1.8	1.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.8	0.4	2.0	-0.1	0.8	1.8	-0.4	-0.7	-1.1	1.3	0.9	-2.2
Miserableness	0.7	1.2	4.4	1.0	0.1	0.2	-0.6	-0.8	-0.6	-2.1	-1.4	0.6	0.9	-1.9
Financial situation satisfaction	0.7	0.8	2.5	-0.4	-1.5	0.4	-1.0	-0.3	-1.1	-0.4	0.5	1.6	1.1	-0.3
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	0.7	0.6	-0.7	-1.0	-1.4	-0.0	-0.6	-0.8	-1.5	-1.1	-0.2
Ever smoked	0.7	1.2	4.9	0.8	-1.2	-1.0	0.8	-1.7	0.2	-1.1	-2.2	-0.5	0.1	0.1
Number of operations (self-reported)	0.7	1.0	3.8	-0.1	-1.9	-1.1	0.1	-0.6	-1.5	-1.1	-1.2	-0.1	0.8	-0.2
Diastolic blood pressure, automated reading	0.7	2.3	7.0	1.4	0.9	-0.0	2.2	2.1	2.6	-0.4	-0.9	1.6	0.9	-1.2
Worry (Nagel 2018)	0.6	1.2	5.5	2.1	0.6	0.7	1.3	0.8	2.4	0.3	-0.4	-0.1	0.1	-0.0
Reaction Time	0.6	1.2	3.4	0.7	-1.4	1.9	1.1	0.3	1.2	0.6	0.6	1.1	1.2	1.0
Primary Biliary Cirrhosis	0.6	0.8	2.8	-1.7	1.0	0.2	-1.7	-0.0	0.5	-0.3	-0.3	1.0	0.8	0.2
Blood Red Count	0.6	5.3	11.0	-0.4	-2.8	2.5	1.8	3.3	2.5	2.8	2.7	1.9	1.2	2.1
Allergy or Eczema	0.6	1.6	6.2	2.5	1.4	0.2	1.9	0.6	-0.0	0.6	0.6	1.1	1.6	1.2
Respiratory disease	0.6	1.3	5.7	2.4	0.2	0.6	1.9	-0.1	0.2	-0.3	-0.4	1.0	1.9	0.3
Neuroticism	0.6	1.4	3.2	1.8	1.5	1.5	1.0	0.2	1.5	0.3	0.1	1.0	1.6	0.9
Hand grip strength (right)	0.6	1.6	8.4	-2.9	-0.6	-0.8	-2.0	0.6	-0.8	-0.7	-0.6	-0.1	-0.3	-1.5
Current tobacco smoking	0.6	0.9	3.9	1.5	-2.0	-0.8	0.9	-0.7	-0.8	-0.4	-0.5	-0.6	-1.0	-0.1
Taking other prescription medications	0.6	1.0	2.4	-0.1	1.4	-0.7	-0.2	0.8	-1.2	0.9	0.6	1.3	1.5	1.0
Serious illness, injury or assault to yourself	0.6	0.8	3.2	-0.8	0.3	0.3	0.1	1.8	-0.3	0.4	0.0	1.4	0.4	-1.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.8	1.9	1.0	0.5	1.4	0.8	0.0	1.2	1.2	0.3	0.8	1.5
Medication: Levothyroxine sodium	0.6	1.0	7.0	-1.3	1.2	-0.5	-2.6	0.5	-0.7	0.4	0.4	0.3	-0.1	0.3
Sitting height	0.6	4.0	13.9	-3.7	0.7	0.7	-3.1	1.2	-0.9	1.8	2.3	0.6	1.2	2.6
Past tobacco smoking	0.6	1.0	4.5	0.0	1.2	1.4	-0.3	1.3	-0.6	0.9	2.1	0.5	-0.1	0.0
Father’s age at death	0.6	0.8	2.0	1.1	1.3	0.7	0.7	0.4	-0.3	0.9	1.4	0.1	0.5	1.3
Worrier / anxious feelings	0.6	1.0	3.3	1.8	-1.0	0.6	1.8	0.5	1.5	-0.3	-0.5	0.4	0.9	0.0
Noisy workplace	0.6	0.7	2.1	0.6	-1.1	0.2	1.0	0.8	0.8	1.0	0.5	1.5	0.8	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.7	-1.9	0.3	-0.4	-1.1	0.8	-0.6	-0.8	-0.4	0.7	0.8	-0.5
High blood pressure (siblings)	0.6	0.9	2.9	-0.5	1.1	-0.7	0.8	1.7	0.1	1.2	1.2	0.7	0.2	0.7
Number of full brothers	0.6	0.7	2.3	-0.5	1.0	-1.0	-0.7	-1.0	-0.7	0.1	0.1	-1.5	-1.3	0.3
Wheeze or whistling in the chest in last year	0.6	1.0	3.6	-0.3	-0.1	-1.2	-0.5	-1.9	-0.9	-1.2	-1.5	-0.9	-0.0	-0.3
Medication: Ibuprofen	0.6	0.7	2.2	-1.4	0.8	0.3	-1.5	0.2	-0.7	-1.0	-0.6	0.7	0.8	-0.5
Smoking status: Previous	0.6	1.0	4.2	0.3	-1.4	-1.0	0.6	-0.4	1.2	-0.8	-2.0	-0.2	0.4	-0.6
Mood swings	0.6	1.1	4.9	2.2	0.7	1.1	0.1	0.2	0.9	0.5	0.5	1.2	1.5	0.7
Long-standing illness, disability or infirmity	0.6	0.9	3.5	1.1	0.0	0.0	0.7	1.0	-0.1	-0.4	-0.3	1.9	1.7	-0.5
Number of self-reported non-cancer illnesses	0.6	1.0	4.5	2.1	0.6	-0.2	1.2	0.4	-1.2	0.5	0.5	0.4	0.8	1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	4.0	1.3	0.8	0.7	0.4	0.7	2.0	0.4	0.2	-0.0	-0.4	0.0
Cholesterol lowering medication	0.6	0.9	2.9	-0.2	0.0	-0.9	-0.8	-0.7	-1.2	1.7	1.0	-0.6	0.2	1.6
Alzheimer’s Disease (including proxy)	0.5	0.8	2.6	-0.2	1.4	-0.7	-0.2	-0.8	0.0	-0.9	-1.6	0.1	-0.3	-1.2
Ovarian Cancer	0.5	0.6	1.5	1.2	0.7	0.2	0.1	-0.4	-1.0	-1.1	-0.5	0.8	0.6	-1.1
Age at First Birth	0.5	0.7	5.0	0.7	0.3	1.0	1.1	2.2	-0.4	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.5	3.5	12.2	0.1	1.3	-1.4	-2.5	-3.5	-1.1	-2.4	-1.9	-1.6	-1.2	-1.5
Systolic Blood Pressure	0.5	2.8	9.1	2.5	0.5	0.1	1.4	0.9	1.0	2.7	3.0	0.3	-0.7	1.7
Systolic blood pressure, automated reading	0.5	1.5	4.3	0.6	0.2	0.3	0.6	1.8	0.8	2.1	2.1	1.0	0.3	1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.2	0.0	-0.2	-1.0	-1.2	-1.0	-0.4	0.3	-1.0	-1.0	0.4
Diabetes (mother)	0.5	0.7	1.8	1.0	0.9	-0.6	-1.2	-1.3	-1.2	-0.7	-0.6	-0.1	-0.1	-0.0
Maternal smoking around birth	0.5	0.7	2.7	1.6	1.7	-0.8	0.8	-0.3	-0.6	-0.5	-0.3	-0.0	0.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.4	-0.0	-0.2	-0.3	-0.1	-0.8	0.6	-2.1	-1.6	-0.4	-0.2	-2.0
Prospective memory result	0.5	0.6	1.8	1.3	-0.3	0.4	0.5	0.6	-0.9	0.5	1.2	0.8	0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	5.1	-0.7	-0.1	0.7	0.9	2.3	-0.1	-0.4	-0.3	1.8	1.0	-2.1
Hair/balding pattern: Pattern 4	0.5	1.1	5.3	-0.9	0.0	-1.3	-1.2	-0.3	-2.3	0.3	0.3	-0.9	-1.2	0.7
Birth weight of first child	0.5	0.8	4.4	-0.8	2.1	0.5	-1.2	0.3	-0.3	-0.4	-0.5	0.8	1.1	-0.1
Loud music exposure frequency	0.5	0.5	2.1	-1.0	0.9	-1.1	-1.4	-0.2	0.1	0.0	0.3	-0.3	-0.6	0.5
Medication: Amlodipine	0.5	0.7	1.5	0.2	0.3	-1.1	-0.7	-1.2	-0.7	-1.0	-1.1	-0.7	-0.6	-1.2
Birth weight	0.5	1.2	6.7	-2.6	-0.2	-0.5	-0.1	1.5	-1.8	-0.5	0.2	0.2	-0.2	0.1
Leg fat percentage (right)	0.5	1.8	5.0	-0.3	0.9	0.3	1.2	2.2	0.1	1.8	0.8	1.3	1.6	2.2
Medication: Blood pressure	0.5	0.9	3.4	0.1	-0.4	0.4	0.0	0.5	1.3	1.5	1.5	-0.1	0.2	1.8
Family relationship satisfaction	0.5	0.6	1.9	0.3	-0.2	1.0	1.4	0.4	-0.2	-0.4	0.5	1.2	1.1	0.3
Leg pain on walking	0.5	0.7	2.4	0.8	0.8	0.5	0.6	1.6	0.5	0.8	0.8	0.9	0.8	-0.2
Friendships satisfaction	0.5	0.6	2.0	-0.3	-0.7	0.5	0.1	0.9	1.0	-0.5	0.4	1.4	1.2	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-0.3	0.8	-0.5	-1.1	0.1	-0.8	-1.4	-1.0	0.7	0.3	-1.1
Commuting to job workplace: Public transport	0.5	0.6	1.4	0.9	1.2	-0.4	-0.8	-0.8	-0.8	-0.6	-1.0	-0.7	-0.3	-0.3
Leg fat percentage (left)	0.5	1.6	4.8	-0.2	1.0	0.1	1.1	2.2	0.3	1.4	0.3	1.6	1.8	1.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.9	-1.7	0.4	0.8	-1.4	-1.0	-1.0	-1.5	-1.2	0.7	0.9	-1.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.4	0.3	1.6	0.0	-0.4	-1.0	-0.1	0.2	0.5	-0.7	-0.5	1.2
Bipolar Disorder (2018)	0.4	0.7	3.6	-0.8	-0.6	0.1	-0.1	-1.3	-1.9	-0.9	-0.4	-0.5	-0.1	-0.2
Depression (Nagel 2018)	0.4	0.6	1.5	-0.9	1.2	0.4	-1.0	-1.0	-1.0	0.0	-0.3	-1.0	-0.5	0.0
Schizophrenia (2018)	0.4	0.7	1.9	1.3	1.4	-0.1	-1.0	-1.1	-0.5	-1.0	-0.8	0.0	0.0	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	1.3	0.2	-0.3	-0.5	0.2	-0.7	-1.2	-0.9	-1.0	-0.1	-0.6	-0.4
Rheumatoid Arthritis	0.4	0.5	2.2	-1.5	-1.2	0.6	-0.5	0.3	-0.7	0.4	0.7	0.0	0.0	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	0.5	-0.1	-1.1	-0.9	-1.0	-1.3	0.1	0.1	-1.4	-1.0	0.6
Lung FVC	0.4	2.0	12.1	-0.0	-0.6	-0.2	-0.5	1.1	0.2	-1.7	-2.3	0.3	-0.5	-3.5
Medication: Metformin	0.4	0.6	2.8	0.3	-0.6	-0.3	-0.8	-1.7	-0.6	-0.6	-0.6	-1.1	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.4	-0.5	0.4	-0.5	-0.9	-0.4	-1.5	-0.0	-0.0	-0.5	-1.3	-0.7
Alcohol usually taken with meals	0.4	0.6	2.7	-1.6	-0.5	1.4	-0.2	-0.1	-0.2	-0.4	-0.2	0.4	1.3	0.2
Had menopause	0.4	0.4	1.1	0.9	0.4	-1.0	0.7	0.2	-0.9	-0.7	-0.7	-0.1	-0.4	-0.5
Diabetes (self-reported)	0.4	0.6	1.2	0.6	-0.2	-0.9	-0.6	-1.1	-0.7	-0.6	-0.7	-1.0	-0.7	-0.5
Medication: Ramipril	0.4	0.5	3.0	0.9	0.2	-0.2	0.7	0.3	1.7	0.4	0.2	0.7	-0.0	-0.0
Medication: Simvastatin	0.4	0.6	2.3	0.4	0.5	-0.4	-0.7	-1.5	-0.6	0.9	0.1	-0.7	0.1	1.4
Time employed in main current job	0.4	0.5	3.1	0.0	0.4	-0.4	-0.6	0.1	0.2	0.5	0.0	-1.2	-1.8	0.0
Alcohol intake versus 10 years previously	0.4	0.6	2.8	0.5	-1.7	-0.2	1.3	-0.0	0.9	-0.1	-0.2	-0.3	0.0	-1.1
Hair/balding pattern: Pattern 3	0.4	0.7	2.6	1.2	-0.2	1.1	0.8	-0.2	1.6	-0.3	-0.2	0.4	0.4	-0.9
Asthma	0.4	0.8	3.0	1.6	0.5	0.4	1.7	0.5	0.3	0.6	0.4	0.7	1.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.9	-1.0	0.7	-0.6	-0.5	-0.3	-0.6	-1.1	-0.7	-0.3	-0.5	-1.7
Mean time to correctly identify matches	0.4	0.8	3.0	0.5	-1.0	1.7	0.9	-0.5	0.2	0.3	0.3	0.6	1.0	1.2
Heart disease (mother)	0.4	0.4	1.5	0.1	-0.1	-0.4	1.1	0.6	0.5	0.4	0.3	0.9	1.2	0.5
Pulse rate, automated reading	0.4	1.2	3.6	0.8	1.6	-1.9	-0.8	0.1	-0.5	-0.6	-0.6	-0.7	-1.8	-1.2
Had major operations	0.4	0.4	1.2	-0.7	-0.9	0.2	0.6	-0.2	-1.0	-0.2	0.0	0.2	1.1	0.9
Illnesses of siblings: Diabetes	0.4	0.4	2.8	-0.6	-0.3	-0.5	-0.3	-0.0	-1.7	-0.8	-0.3	0.4	0.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	0.0	-0.7	-0.1	0.5	-1.2	0.7	-1.1	-1.4	0.1	0.4	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.8	0.7	0.5	0.3	0.6	0.9	-0.5	0.2	-0.0	1.4	1.2	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	2.5	0.8	1.6	0.3	0.5	0.8	-0.8	0.1	0.6	0.4	0.2	0.0
Smoking status: Current	0.4	0.6	2.5	0.9	-1.6	-0.6	0.5	-0.7	-0.7	0.0	-0.1	-0.6	-1.0	0.5
Alcohol drinker status: Never	0.4	0.5	1.5	-1.2	0.9	0.8	-0.8	-0.5	0.0	-0.0	-0.0	-0.7	-0.9	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	2.2	0.6	0.8	-0.1	-0.8	-1.2	-1.5	-1.2	-0.8	0.0	0.0	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	3.6	0.5	0.5	1.5	-0.0	0.1	0.2	0.1	0.3	1.0	1.9	0.6
Neuroticism (Nagel 2018)	0.3	0.7	1.8	1.2	0.2	1.3	0.6	0.0	1.4	0.4	-0.1	0.0	1.2	1.0
Crohns Disease (2017)	0.3	0.6	1.4	-0.4	1.2	0.1	-1.1	0.8	-0.3	0.3	0.3	1.1	1.1	-0.4
LDL Cholesterol	0.3	0.5	5.5	0.0	0.0	0.0	0.0	0.0	-2.4	0.0	0.0	0.0	0.0	0.0
Height	0.3	5.5	16.5	-4.1	1.5	-1.5	-3.9	-2.1	-2.6	-0.5	0.7	-2.4	-1.8	1.7
Cardiovascular Disease	0.3	1.2	3.2	1.8	0.2	-1.1	1.1	0.6	0.4	1.6	1.2	0.2	0.3	1.6
Tanning	0.3	4.1	15.0	0.1	-0.9	-1.9	0.2	-1.1	-0.3	-3.6	-3.1	-0.6	-1.4	-3.9
Hand grip strength (left)	0.3	0.9	6.0	-2.4	-0.7	-0.2	-1.3	1.1	0.2	-0.1	-0.0	-0.2	-0.1	-0.4
Diabetes (father)	0.3	0.3	0.9	-1.0	-0.9	0.3	-0.3	0.6	0.9	0.4	-0.0	0.3	0.5	0.1
Severe depression (siblings)	0.3	0.4	2.0	0.1	0.4	0.1	0.2	-0.1	-1.4	-0.8	-0.7	0.4	0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	0.2	0.5	0.4	-1.8	-1.4	-0.0	-0.4	-0.3	-1.0	-0.6	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-0.6	0.7	0.3	-0.9	0.3	0.7	-0.1	-0.8	0.2	0.0	-1.0
High blood pressure	0.3	0.9	2.9	1.7	-0.1	-1.1	0.9	0.7	0.9	1.0	0.7	-0.8	-0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.9	-1.0	0.3	0.9	0.7	-0.1	0.8	0.5	0.6	0.2	0.2
Had other major operations	0.3	0.4	1.3	-0.5	-0.6	-0.4	-0.8	-0.4	-0.3	-0.7	-0.6	0.5	1.1	0.5
Forced vital capacity (FVC)	0.3	1.2	5.6	-1.1	-0.3	0.5	-0.6	1.4	0.1	-0.9	-0.8	1.1	0.9	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.5	0.2	0.8	0.2	-1.5	-1.0	-0.1	0.5	0.8	-0.9	-0.6	1.6
Mouth/teeth dental problems	0.3	0.5	1.7	0.5	1.3	0.3	-0.1	0.6	0.9	0.9	0.5	-0.3	-0.8	0.8
Pain all over the body in last month	0.3	0.4	1.6	-0.5	0.8	-0.6	-0.4	-0.5	-1.2	-0.0	-0.1	-0.4	-0.6	0.5
Illnesses of siblings	0.3	0.4	1.4	1.2	0.9	1.0	-0.8	-0.5	0.2	-0.5	-0.4	-0.1	0.3	-0.2
Number of live births	0.3	0.5	1.7	0.0	-1.3	0.2	0.6	-0.2	0.3	0.9	0.8	-0.7	-0.5	1.0
Happiness	0.3	0.3	1.3	0.1	-0.2	-0.4	-0.0	0.3	-0.3	-0.9	-0.2	1.1	1.1	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	3.1	-0.8	-1.8	-0.6	0.1	0.5	-0.3	0.4	0.3	0.4	0.5	-0.2
Standing height	0.3	2.7	9.6	-3.1	0.9	-0.2	-2.8	-0.9	-2.4	0.2	1.1	-1.0	-0.2	1.7
Tense / ‘highly strung’	0.3	0.4	2.3	1.5	0.0	0.4	1.3	0.1	0.8	0.1	0.1	0.0	0.0	0.3
Worry too long after embarrassment	0.3	0.4	1.5	0.8	-0.1	-0.4	-0.6	0.0	0.4	-0.8	-1.2	0.6	0.6	-0.7
Neck or shoulder pain in last month	0.3	0.5	2.8	0.6	-0.8	0.4	1.7	0.4	-0.3	0.3	0.3	0.5	0.5	0.7
Migraine (self-reported)	0.3	0.4	1.4	-1.2	0.6	-0.0	-0.4	-0.5	-0.2	0.5	0.4	0.1	0.4	1.2
Overall health rating	0.3	0.7	1.3	0.9	-0.5	0.0	1.0	0.5	0.9	1.1	1.2	0.2	0.7	1.1
Hypertension (Self-reported)	0.3	0.8	2.2	1.5	-0.2	-0.8	0.8	0.6	0.9	1.3	0.8	-0.8	-0.8	1.0
Average weekly red wine intake	0.3	0.5	1.7	0.0	1.3	-0.3	0.3	-0.6	-0.5	0.1	-0.3	-1.1	-0.5	1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.1	-1.0	0.9	0.5	-0.9	0.5	-0.8	-0.5	-0.5	0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.1	-0.0	0.8	-0.7	0.5	0.0	0.9	0.8	0.3	0.4	0.6
Asthma (self-reported)	0.3	0.7	2.9	1.6	0.0	0.1	1.7	0.2	0.3	0.3	0.1	0.6	1.0	0.5
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.6	0.8	-0.5	-0.0	-0.7	0.5	0.4	0.2	-1.1	-1.0	0.2
Crohns Disease (2012)	0.2	0.3	1.4	-0.8	-0.5	-0.2	-1.2	0.2	-0.8	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.2	0.5	1.9	0.9	1.0	0.4	-0.7	-1.4	-0.9	0.0	0.0	0.0	0.0	0.0
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.9	-1.0	-0.3	0.2	-0.3	1.0	-0.6	-1.0	-0.1	0.2	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.7	0.6	0.3	1.3	-0.2	0.0	0.3	0.1	0.2	0.4	-0.0	-0.6
Nervous feelings	0.2	0.4	2.1	1.4	0.2	0.7	0.4	-0.8	0.9	0.0	-0.5	-0.5	0.1	0.3
Financial difficulties in last 2 years	0.2	0.3	1.5	0.6	-0.2	-0.6	0.4	-0.2	0.1	-0.6	-0.6	0.2	0.1	-1.2
Neuroticism score	0.2	0.4	2.2	1.5	0.6	0.8	-0.0	-0.1	1.0	-0.3	-0.3	0.4	0.5	0.0
Pulse rate	0.2	0.4	1.1	0.5	0.7	-0.8	0.4	0.8	0.0	0.5	1.1	0.2	-0.8	0.1
Headache pain in last month	0.2	0.3	1.2	0.7	0.9	0.4	-0.5	1.1	-0.4	-0.2	0.2	0.7	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.3	0.3	-0.7	-1.1	0.4	-0.4	0.1	-0.2	-0.2	-0.8	-0.4	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	4.2	-1.0	0.0	-0.1	-0.3	1.0	-0.5	-0.9	-0.8	0.7	0.1	-2.1
Comparative height size at age 10	0.2	1.0	5.9	-1.7	1.0	0.2	-2.4	-0.1	-0.8	-0.2	0.3	-0.1	0.3	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.5	0.7	0.3	-0.9	-0.7	0.1	0.2	0.1	-0.5	0.1	0.9
Ever had bowel cancer screening	0.2	0.2	1.1	0.1	-1.0	0.1	0.1	0.7	-0.5	-0.1	0.0	-0.1	-0.1	0.6
Qualifications: nursing, teaching	0.2	0.3	0.9	0.1	0.2	0.3	0.5	0.3	0.8	-0.8	-0.5	-0.1	0.2	-0.9
Body Mass Index (BMI) (2010)	0.1	0.1	1.3	0.0	0.0	0.0	0.0	0.0	1.1	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.1	0.2	2.1	0.0	0.0	0.0	0.0	0.0	-1.4	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.1	0.7	2.0	-1.4	-0.9	-0.2	0.0	0.5	1.1	1.3	0.9	0.7	-0.1	0.8
Chronotype (morning person)	0.1	0.3	1.4	-0.3	0.8	-0.2	-1.2	-0.4	-0.2	0.4	0.9	0.2	0.2	0.5
Fed-up feelings	0.1	0.2	0.5	0.7	0.2	-0.4	-0.1	-0.6	-0.5	0.0	0.2	-0.7	-0.5	0.3
Age at first live birth	0.1	0.2	0.8	-0.5	-0.4	0.0	0.0	-0.5	-0.2	-0.6	-0.2	-0.3	-0.2	-0.9
Qualifications: College or University degree	0.1	0.5	1.5	-0.2	0.2	0.6	-1.2	-0.3	1.1	-0.9	0.1	-0.6	-0.6	-0.8
Number of full sisters	0.1	0.2	0.4	0.2	-0.3	-0.6	0.3	-0.3	-0.5	0.4	0.5	-0.1	-0.4	0.5
Guilty feelings	0.1	0.1	0.4	-0.6	-0.6	-0.1	-0.3	-0.2	-0.4	-0.1	0.1	-0.2	0.2	0.7
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.7	-0.0	-0.8	0.4	-0.0	0.0	0.7	-0.2	-0.2	0.8	0.5	-0.7
Hair Pigment	0.0	0.5	1.3	1.1	0.2	-0.8	-0.3	0.8	0.0	-0.4	-1.0	0.8	0.5	-0.9

Hub : Genes

EFCAB4A

Models

Trait associations