Best TWAS P=1.13e-12 · Best GWAS P=3.55e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | ROSMAP | Brain Pre-frontal Cortex | MPPED2 | 0.25 | 0.29 | lasso | 7 | 0.29 | 4.4e-37 | 7.1 | -7.1 | 1.1e-12 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Pituitary | ARL14EP | 0.30 | 0.28 | lasso | 4 | 0.22 | 3.0e-06 | 6.8 | -6.7 | 2.5e-11 | -0.84 | 0.07 | 0.85 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ARL14EP | 0.18 | 0.20 | lasso | 8 | 0.19 | 9.5e-12 | 6.0 | -6.5 | 8.7e-11 | -0.62 | 0.94 | 0.06 | FALSE |
| 1 | GTEx | Brain Cerebellum | ARL14EP | 0.33 | 0.25 | lasso | 10 | 0.26 | 3.7e-08 | 5.9 | -6.2 | 7.5e-10 | -0.68 | 0.73 | 0.25 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ARL14EP | 0.15 | 0.14 | lasso | 3 | 0.11 | 1.2e-04 | 5.9 | -6.0 | 2.7e-09 | -0.71 | 0.45 | 0.25 | FALSE |
| 4 | GTEx | Pancreas | ARL14EP | 0.16 | 0.08 | lasso | 6 | 0.07 | 1.0e-03 | 4.9 | -5.6 | 2.0e-08 | -0.61 | 0.29 | 0.12 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf46 | 0.12 | 0.08 | blup | 34 | 0.07 | 5.7e-05 | 6.0 | 5.3 | 1.2e-07 | 0.67 | 0.05 | 0.56 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPPED2 | 0.07 | 0.01 | blup | 149 | 0.03 | 7.0e-05 | 6.8 | -5.2 | 2.0e-07 | -0.75 | 0.02 | 0.96 | FALSE |