Best TWAS P=3.17e-09 · Best GWAS P=5.4e-10 conditioned to 0.018
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | PRR13 | 0.23 | 0.28 | enet | 39 | 0.30 | 4.3e-17 | 4.2 | -5.2 | 2.2e-07 | 0.32 | 0.96 | 0.04 | FALSE |
2 | GTEx | Artery Coronary | SP1 | 0.17 | 0.12 | lasso | 4 | 0.12 | 8.6e-05 | 4.4 | 5.5 | 3.2e-08 | -0.31 | 0.16 | 0.62 | FALSE |
3 | GTEx | Breast Mammary Tissue | SP1 | 0.12 | 0.13 | lasso | 5 | 0.08 | 9.5e-05 | 4.3 | 5.3 | 1.2e-07 | -0.23 | 0.89 | 0.05 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | PRR13 | 0.22 | 0.16 | lasso | 4 | 0.18 | 3.2e-07 | 4.2 | -5.2 | 2.5e-07 | 0.29 | 0.28 | 0.06 | FALSE |
5 | METSIM | Adipose | SP7 | 0.03 | 0.02 | lasso | 2 | 0.01 | 6.1e-03 | 5.0 | -5.4 | 5.9e-08 | 0.15 | 0.23 | 0.08 | TRUE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | 4.3 | -5.7 | 1.1e-08 | 0.58 | 0.07 | 0.40 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRR13 | 0.05 | 0.03 | blup | 28 | 0.04 | 4.1e-03 | 4.2 | -5.3 | 1.3e-07 | 0.47 | 0.03 | 0.05 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | 4.2 | -5.9 | 3.2e-09 | 0.60 | 0.38 | 0.24 | TRUE |
9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PCBP2 | 0.25 | 0.04 | blup | 36 | 0.10 | 2.3e-03 | -6.2 | -5.4 | 8.7e-08 | 0.64 | 0.00 | 0.62 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | PCBP2 | 0.04 | 0.01 | enet | 6 | 0.02 | 4.8e-03 | 2.8 | -5.5 | 3.7e-08 | 0.63 | 0.01 | 0.41 | FALSE |