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chr12:109,231,851-113,517,494

Best TWAS P=4e-15 · Best GWAS P=9.81e-20 conditioned to 0.394

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	3.4	-6.3	3.5e-10	0.66	0.06	0.84	FALSE
2	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	5.1	6.0	1.7e-09	-0.19	0.03	0.18	TRUE
3	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	5.7	5.7	9.7e-09	-0.07	0.01	0.94	FALSE
4	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-8.2	-7.9	4.0e-15	0.85	0.02	0.92	TRUE
5	GTEx	Brain Cerebellar Hemisphere	MMAB	0.31	0.27	lasso	3	0.24	6.6e-07	5.2	-5.2	2.2e-07	-0.06	0.03	0.96	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	MMAB	0.40	0.24	enet	16	0.28	2.5e-08	4.7	-5.2	2.5e-07	-0.01	0.12	0.70	FALSE
7	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-4.6	6.0	2.5e-09	-0.24	0.02	0.27	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ARPC3	0.13	0.09	lasso	4	0.04	2.0e-02	5.2	-5.2	1.7e-07	0.00	0.05	0.65	FALSE
9	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	5.7	5.4	6.7e-08	-0.03	0.01	0.99	FALSE
10	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	5.1	-5.8	5.4e-09	0.39	0.06	0.06	FALSE
11	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	5.7	5.6	2.6e-08	-0.04	0.01	0.99	FALSE
12	GTEx	Muscle Skeletal	IFT81	0.08	0.08	lasso	5	0.07	1.7e-07	5.2	5.3	9.7e-08	0.01	0.05	0.95	FALSE
13	GTEx	Muscle Skeletal	ANAPC7	0.08	0.01	lasso	3	0.00	1.1e-01	4.7	5.3	1.2e-07	-0.01	0.03	0.76	FALSE
14	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	5.9	-6.1	1.2e-09	0.48	0.22	0.46	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	5.2	5.7	1.2e-08	-0.01	0.04	0.64	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ARPC3	0.13	0.15	lasso	3	0.15	1.9e-12	5.1	-5.1	2.8e-07	0.00	0.08	0.92	FALSE
17	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	3.1	-6.1	1.0e-09	0.67	0.61	0.39	FALSE
18	GTEx	Testis	ARPC3	0.16	0.16	lasso	3	0.14	7.5e-07	5.1	-5.1	2.9e-07	0.00	0.07	0.92	FALSE
19	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	2.9	5.2	1.7e-07	-0.57	0.20	0.68	FALSE
20	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	5.1	5.7	1.3e-08	-0.06	0.02	0.84	FALSE
21	GTEx	Whole Blood	GPN3	0.19	0.20	lasso	4	0.19	1.9e-17	5.1	-5.2	2.5e-07	0.04	0.04	0.96	FALSE
22	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	4.4	6.1	1.1e-09	-0.60	0.55	0.45	FALSE
23	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	4.7	-5.7	1.2e-08	0.06	0.06	0.93	FALSE
24	NTR	Blood	UBE3B	0.09	0.05	lasso	8	0.08	1.0e-25	4.8	5.7	1.4e-08	0.02	0.05	0.95	TRUE
25	YFS	Blood	GLTP	0.05	0.01	enet	14	0.04	1.5e-13	4.0	5.4	7.7e-08	-0.04	0.08	0.91	FALSE
26	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	2.9	-5.6	1.7e-08	0.61	0.64	0.36	FALSE
27	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	-4.3	-5.4	5.6e-08	0.61	0.09	0.85	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KCTD10	0.06	0.00	lasso	3	0.00	1.4e-01	4.8	-5.4	5.4e-08	-0.05	0.00	0.47	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	5.1	5.4	5.1e-08	-0.01	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	3.0	-5.1	2.6e-07	0.48	0.02	0.85	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	5.8	5.8	8.2e-09	-0.59	0.01	0.89	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS29	0.06	0.06	enet	7	0.06	2.1e-07	5.2	5.3	9.7e-08	0.00	0.00	0.99	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	4.6	6.4	1.3e-10	-0.16	0.06	0.67	TRUE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-4.5	-5.5	4.3e-08	-0.03	0.38	0.60	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	RAD9B	0.10	0.06	enet	5	0.06	1.2e-06	5.1	5.1	3.0e-07	0.00	0.03	0.97	FALSE