Best TWAS P=8.26e-11 · Best GWAS P=8.57e-10 conditioned to 0.689
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | AL137059.1 | 0.11 | 0.01 | lasso | 6 | 0.02 | 5.0e-03 | -2.2 | -5.1 | 3.1e-07 | 0.34 | 0.14 | 0.26 | TRUE |
| 2 | GTEx | Muscle Skeletal | MTIF3 | 0.12 | 0.03 | lasso | 5 | 0.03 | 1.2e-03 | -4.7 | -5.5 | 3.8e-08 | 0.74 | 0.24 | 0.62 | FALSE |
| 3 | GTEx | Nerve Tibial | AL137059.1 | 0.10 | 0.02 | lasso | 3 | 0.03 | 2.9e-03 | 5.5 | -6.3 | 2.2e-10 | 0.71 | 0.02 | 0.94 | FALSE |
| 4 | GTEx | Testis | MTIF3 | 0.45 | 0.28 | lasso | 11 | 0.25 | 1.8e-11 | 5.5 | -6.1 | 1.3e-09 | 0.49 | 0.12 | 0.88 | FALSE |
| 5 | YFS | Blood | GTF3A | 0.17 | 0.15 | lasso | 5 | 0.19 | 1.1e-58 | 4.2 | -5.7 | 1.6e-08 | 0.44 | 0.85 | 0.15 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GTF3A | 0.03 | 0.00 | enet | 8 | 0.01 | 2.3e-02 | 2.6 | 6.5 | 8.3e-11 | -0.63 | 0.01 | 0.82 | TRUE |