TWAS hub - MTIF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0240	9.3e-05	0.017	0.027	0.026	0.026	0.012	3.3e-03	2.7e-04	3.0e-04	3.6e-04	1.2e-02
2	GTEx	Adipose Subcutaneous	0.2930	0.0510	4.9e-12	0.155	NA	0.188	NA	0.189	1.1e-12	NA	2.9e-15	NA	2.4e-15
3	GTEx	Adipose Visceral Omentum	0.1590	0.0550	1.0e-03	0.114	NA	0.084	NA	0.110	1.7e-06	NA	3.9e-05	NA	2.5e-06
4	GTEx	Artery Tibial	0.2040	0.0471	1.6e-06	0.054	NA	0.026	NA	0.058	4.7e-05	NA	3.6e-03	NA	2.4e-05
5	GTEx	Breast Mammary Tissue (Female)	0.1221	0.1247	2.1e-01	0.022	NA	0.047	NA	0.031	7.4e-02	NA	1.6e-02	NA	4.1e-02
6	GTEx	Cells EBV-transformed lymphocytes	0.2120	0.0780	8.9e-03	-0.008	NA	0.006	NA	-0.002	7.8e-01	NA	2.0e-01	NA	3.8e-01
7	GTEx	Muscle Skeletal	0.1165	0.0392	9.4e-04	0.027	NA	0.007	NA	0.026	1.1e-03	NA	6.3e-02	NA	1.2e-03
8	GTEx	Skin Not Sun Exposed Suprapubic	0.2000	0.0700	8.1e-03	0.023	NA	0.000	NA	0.002	1.9e-02	NA	3.3e-01	NA	2.5e-01
9	GTEx	Testis	0.4500	0.0800	9.1e-08	0.275	NA	0.219	NA	0.250	1.2e-12	NA	4.6e-10	NA	1.8e-11
10	GTEx	Thyroid	0.1320	0.0430	6.5e-04	0.100	NA	0.063	NA	0.078	4.2e-08	NA	1.3e-05	NA	1.4e-06
11	YFS	Blood	0.0673	0.0138	1.3e-14	0.055	0.054	0.059	0.057	0.058	2.2e-17	4.0e-17	1.6e-18	3.5e-18	3.1e-18
12	TCGA	Brain Lower Grade Glioma	0.0356	0.0186	4.6e-03	0.007	0.014	0.005	NA	0.005	4.4e-02	8.3e-03	8.2e-02	NA	7.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	7	8	9	10	11	12
Body Mass Index (BMI) (2010)	5.4	7.3	27.9	1.7	-0.1	1.6	3.3	2.0	-2.6	1.8	-5.3	3.2	-1.3	4.3
Lupus	3.9	5.9	13.7	1.5	3.2	3.0	2.3	3.7	2.5	3.1	0.5	2.5	2.3	-1.3
Ever had bowel cancer screening	3.4	3.9	12.0	1.4	3.1	2.5	1.2	1.6	2.4	2.1	0.3	1.8	3.5	0.3
Fed-up feelings	3.3	6.1	12.1	-1.0	-2.9	-3.5	-3.0	-2.9	-1.3	-3.2	1.8	-3.5	-1.9	-1.7
Medication for cholesterol	3.3	5.0	10.8	2.2	1.9	2.8	3.3	3.0	-0.3	2.5	-2.5	2.9	0.4	1.7
Cholesterol lowering medication	3.3	4.8	8.4	-2.5	-1.5	-2.5	-2.9	-2.2	0.7	-2.5	2.7	-2.9	-1.0	-2.5
Comparative body size at age 10	3.1	8.6	35.0	-0.9	-3.9	-1.9	0.9	-0.9	-5.9	-1.1	-4.8	0.3	-3.8	3.0
BMI	3.0	17.1	46.6	-2.3	-5.9	-3.8	-0.2	-2.0	-6.8	-4.1	-5.3	-1.6	-6.6	3.1
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	10.2	-2.1	-2.1	-2.3	-1.9	-3.2	-1.1	-2.7	0.6	-2.5	-1.2	-0.0
Unable to work because of sickness or disability	3.0	3.9	8.1	-2.0	-1.8	-2.4	-2.0	-2.5	-0.3	-2.8	2.0	-2.8	-1.2	-1.5
Supplements: Glucosamine	2.9	3.8	8.5	1.6	2.9	2.5	2.0	1.8	2.4	2.1	0.1	2.0	2.6	0.9
Average weekly champagne plus white wine intake	2.9	3.9	7.8	2.8	2.3	2.5	1.7	1.1	0.1	2.6	-1.7	2.6	2.1	1.6
Ever depressed for a whole week	2.9	3.6	15.2	-2.1	-1.8	-1.9	-1.7	-3.9	-0.4	-2.4	0.9	-2.1	-1.5	-0.7
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	6.8	1.9	2.6	2.6	1.7	1.5	1.6	2.2	-1.2	2.5	2.1	1.2
Leg fat mass (right)	2.7	10.7	30.8	-1.2	-4.3	-2.7	-0.0	-1.7	-5.5	-2.8	-5.0	-0.8	-4.8	3.2
Ever highly irritable/argumentative for 2 days	2.6	3.2	5.9	-1.5	-2.2	-2.3	-2.2	-1.8	-0.9	-2.3	1.2	-2.4	-1.3	-1.7
Arm fat mass (left)	2.6	10.5	30.5	-0.7	-4.2	-2.5	0.1	-1.8	-5.5	-2.5	-5.2	-0.5	-4.5	3.8
Average weekly beer plus cider intake	2.6	3.8	7.1	-0.7	-2.2	-2.5	-1.9	-2.2	-0.1	-2.5	1.8	-2.7	-2.4	-1.6
LDL Cholesterol	2.5	4.0	8.7	-2.0	-2.9	-2.3	-1.4	-1.1	-2.7	-2.5	-0.0	-1.9	-2.9	-1.0
Body mass index (BMI)	2.5	10.5	29.2	-1.5	-4.5	-2.8	-0.2	-1.8	-5.4	-2.9	-4.5	-0.9	-5.2	2.7
Hip circumference	2.5	10.8	32.3	-0.1	-4.0	-2.1	0.4	-1.2	-5.5	-1.9	-5.7	0.2	-4.7	4.3
Arm fat mass (right)	2.5	10.4	29.6	-0.9	-4.1	-2.4	0.2	-1.6	-5.4	-2.4	-5.2	-0.4	-4.6	3.7
Medication: Paracetamol	2.5	4.1	8.0	0.2	-2.5	-2.1	-0.4	-1.9	-2.5	-2.3	-2.8	-0.8	-2.7	2.8
Whole body fat mass	2.5	10.3	27.8	-0.9	-4.1	-2.6	0.1	-1.6	-5.3	-2.5	-5.1	-0.5	-4.5	3.9
Alcohol drinker status: Previous	2.5	2.8	12.2	-0.0	-2.4	-1.8	-0.8	0.3	-3.5	-1.7	-1.5	-1.1	-2.3	0.1
Ovarian Cancer	2.4	3.2	5.6	1.7	2.4	2.3	2.1	2.3	2.0	2.0	0.1	1.9	1.8	-0.6
Medication: Levothyroxine sodium	2.4	4.0	8.8	-1.0	-2.5	-2.8	-2.1	-2.7	-1.6	-3.0	0.4	-2.6	-1.8	-0.2
Trunk fat mass	2.4	10.2	26.7	-0.5	-4.0	-2.4	0.1	-1.6	-5.1	-2.4	-5.2	-0.4	-4.6	4.1
Father’s age at death	2.4	3.2	6.7	0.8	2.3	1.9	1.0	2.6	2.3	2.6	1.3	1.7	1.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	5.8	0.5	2.2	2.4	1.9	1.4	0.8	2.1	-1.7	2.2	1.5	1.2
Medication: Paracetamol	2.4	3.7	6.8	-0.8	-2.6	-2.4	-1.0	-2.0	-2.0	-2.5	-1.8	-1.4	-2.5	2.2
Leg fat mass (left)	2.4	9.4	26.0	-1.0	-4.0	-2.5	0.1	-1.5	-5.1	-2.5	-4.8	-0.6	-4.6	3.1
Mouth/teeth dental problems: Dentures	2.3	3.9	7.4	-2.1	-2.6	-2.6	-2.3	-1.3	-1.6	-2.7	1.1	-2.6	-1.8	-0.8
Weight	2.2	10.8	35.6	0.1	-3.8	-2.1	0.8	-0.9	-5.7	-2.0	-6.0	0.1	-4.2	4.5
Leg fat percentage (right)	2.2	8.1	23.9	-2.0	-4.0	-2.7	-0.6	-1.9	-4.5	-2.8	-3.3	-1.3	-4.9	1.5
Arm fat percentage (left)	2.2	8.9	24.0	-1.2	-4.1	-2.6	-0.3	-2.1	-4.9	-2.5	-4.3	-0.7	-4.4	3.2
Body fat percentage	2.1	8.2	20.2	-1.2	-3.9	-2.5	-0.2	-1.8	-4.4	-2.4	-4.1	-0.7	-4.5	3.1
Leg fat-free mass (left)	2.0	10.6	41.1	0.8	-3.2	-1.6	1.0	-0.5	-5.8	-1.5	-6.4	0.6	-3.0	5.1
Waist circumference	2.0	7.1	27.2	0.6	-2.6	-1.1	1.2	-0.7	-4.0	-1.1	-5.2	0.8	-3.6	4.2
Arm fat percentage (right)	2.0	7.9	21.7	-1.0	-3.7	-2.2	-0.1	-1.6	-4.7	-2.2	-4.2	-0.5	-4.2	3.0
Pulse wave Arterial Stiffness index	2.0	2.4	4.9	1.2	2.2	2.0	1.1	1.4	1.4	1.8	-0.8	1.9	2.1	1.2
Pulse wave peak to peak time	2.0	2.3	5.2	-0.9	-2.3	-2.0	-0.9	-1.5	-1.7	-1.9	0.3	-1.8	-2.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	5.5	1.4	2.1	2.1	1.5	1.1	1.3	1.4	-0.7	1.7	2.3	1.3
Wears glasses or contact lenses	2.0	2.3	5.1	-0.3	-2.3	-2.2	-1.9	-1.3	-1.1	-1.8	0.5	-1.7	-2.0	-0.9
Depressed Affect (Nagel 2018)	1.9	4.1	8.4	-0.7	-2.5	-2.9	-2.3	-2.2	-1.8	-2.5	1.0	-2.6	-2.1	-1.5
Triglycerides	1.9	3.0	8.7	-0.8	-2.5	-1.8	-1.2	-1.5	-2.5	-2.0	-1.5	-1.0	-2.9	0.8
Ever had hysterectomy (womb removed)	1.9	2.2	10.6	-2.5	1.4	0.9	-0.1	0.7	3.3	1.1	1.9	0.2	1.0	-0.6
Leg predicted mass (left)	1.9	10.3	39.6	0.7	-3.2	-1.6	1.0	-0.5	-5.7	-1.5	-6.3	0.5	-2.9	5.1
Noisy workplace	1.9	2.4	8.4	-1.6	-0.5	-1.0	-1.9	-1.2	0.6	-0.9	2.9	-1.9	-0.4	-2.6
Leg pain on walking	1.9	2.4	4.5	-1.4	-2.0	-2.0	-1.6	-2.1	-1.0	-2.0	0.1	-1.8	-1.9	0.5
Supplements: Vitamin C	1.9	2.2	4.5	2.1	1.8	1.8	1.1	1.2	1.0	1.2	-0.9	1.6	1.8	1.8
Mineral and other dietary supplements	1.9	2.5	6.5	-2.6	-2.0	-1.8	-1.7	-2.0	-1.0	-1.4	0.4	-1.5	-1.8	-0.9
Medication: Lisinopril	1.9	2.5	4.8	-2.2	-2.2	-2.2	-1.7	-2.0	-1.0	-1.9	0.4	-1.8	-0.8	-0.6
Leg fat percentage (left)	1.9	7.0	21.9	-1.9	-3.7	-2.6	-0.7	-1.8	-4.0	-2.6	-2.9	-1.2	-4.7	1.3
Major Depression (MDD)	1.8	2.2	6.2	-1.4	-2.1	-1.8	-1.3	-1.4	-1.7	-1.5	-0.2	-1.3	-2.5	-0.2
Type 2 Diabetes (T2D) (2018)	1.8	3.4	9.3	-0.5	-2.5	-1.7	0.1	-1.0	-2.7	-1.6	-3.0	-0.4	-2.8	1.8
Diabetes (mother)	1.8	2.3	4.2	-1.3	-1.9	-2.1	-1.8	-1.3	-1.0	-1.7	1.1	-2.0	-1.6	-1.0
Trunk fat percentage	1.8	7.3	17.1	-0.8	-3.5	-2.3	-0.2	-1.7	-4.1	-2.2	-4.0	-0.6	-4.1	3.4
Average weekly red wine intake	1.8	2.7	5.4	-1.9	-2.2	-1.9	-1.4	-0.8	-1.8	-1.7	0.5	-1.6	-2.3	-1.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	9.5	-3.1	-1.1	-1.1	-1.1	-0.2	-0.9	-0.9	1.3	-1.4	-0.7	-1.7
Lung cancer (father)	1.7	2.0	4.6	0.1	-1.6	-1.9	-2.1	-1.5	-0.3	-2.1	1.1	-2.0	-1.0	-0.8
Leg fat-free mass (right)	1.7	9.0	34.9	0.8	-2.9	-1.4	1.0	-0.4	-5.2	-1.3	-5.9	0.6	-2.8	4.9
Leg predicted mass (right)	1.7	9.1	36.0	0.8	-2.9	-1.4	1.1	-0.3	-5.1	-1.2	-6.0	0.7	-2.7	5.0
Basal metabolic rate	1.7	9.5	36.7	0.9	-3.1	-1.4	1.2	-0.3	-5.5	-1.4	-6.1	0.6	-3.1	4.5
Schizophrenia (2018)	1.6	3.3	12.7	-0.3	2.4	1.3	-0.1	1.0	3.6	1.4	3.0	0.0	1.8	-2.1
Breast Cancer	1.6	3.8	10.6	2.1	0.4	1.4	2.3	0.8	-1.5	1.8	-3.3	2.5	-0.9	3.2
Had other major operations	1.6	1.9	5.1	-2.0	-1.5	-1.1	-0.8	-0.7	-2.3	-1.8	-1.4	-0.9	-1.2	1.4
Worrier / anxious feelings	1.6	3.0	7.9	-0.8	-1.0	-1.9	-2.8	-1.4	0.4	-1.5	2.7	-2.1	-0.1	-2.8
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	5.2	2.1	1.5	1.8	1.6	0.9	0.6	1.7	-1.9	2.3	1.0	2.0
Pulse wave reflection index	1.6	2.0	4.2	-0.7	2.0	1.6	-0.5	1.0	2.0	1.3	1.6	0.7	1.9	-1.9
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.2	-1.9	-1.7	-1.4	-1.3	-1.1	-2.1	-1.5	-0.4	-1.3	-1.7	-0.7
Arm fat-free mass (left)	1.6	8.2	30.4	0.7	-3.0	-1.5	1.0	-0.1	-5.3	-1.6	-5.5	0.3	-3.3	3.8
Arm predicted mass (left)	1.6	8.0	30.2	0.9	-3.0	-1.5	1.0	-0.0	-5.2	-1.5	-5.5	0.3	-3.2	3.8
Neuroticism (Nagel 2018)	1.5	3.5	8.7	-0.9	-1.0	-2.1	-3.0	-1.8	0.3	-1.7	2.7	-2.5	-0.4	-2.6
Reaction Time	1.5	2.9	5.8	-1.5	-1.8	-1.7	-1.7	-2.4	-1.6	-2.2	0.2	-1.8	-2.3	-1.2
Neuroticism	1.5	3.7	7.3	-0.6	-1.8	-2.7	-2.7	-1.8	-0.2	-2.1	2.1	-2.7	-1.5	-2.0
Birth weight of first child	1.5	2.7	9.3	3.0	0.6	1.3	1.5	1.3	-0.7	0.9	-2.6	1.8	0.6	2.4
Arm fat-free mass (right)	1.5	7.8	28.3	0.8	-3.1	-1.7	0.8	-0.2	-5.0	-1.7	-5.3	0.2	-3.1	3.7
Health satisfaction	1.5	1.9	4.6	0.2	-1.7	-1.3	0.1	-1.2	-2.1	-1.5	-1.8	-0.6	-1.5	2.0
Arm predicted mass (right)	1.5	7.8	29.3	0.8	-3.0	-1.5	0.9	-0.2	-5.0	-1.6	-5.4	0.3	-3.1	3.7
Whole body water mass	1.5	8.4	33.3	1.0	-2.8	-1.3	1.1	-0.0	-5.3	-1.3	-5.8	0.6	-2.7	4.3
Prostate Cancer	1.4	1.9	6.6	0.8	2.0	1.2	0.8	1.2	2.0	1.7	1.0	0.7	2.6	0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	7.7	2.5	0.2	0.9	1.6	0.9	-1.4	1.1	-2.8	1.8	-0.5	1.4
Age at first live birth	1.4	2.4	5.6	2.4	1.1	1.6	0.9	1.5	-1.1	1.8	-1.8	2.3	1.3	1.4
Medication: Ibuprofen	1.4	1.7	3.5	-1.3	-1.8	-1.7	-1.0	-1.6	-0.5	-1.7	0.5	-1.4	-1.9	-0.2
Whole body fat-free mass	1.4	8.3	33.4	1.0	-2.8	-1.2	1.2	0.0	-5.2	-1.2	-5.8	0.7	-2.7	4.3
Miserableness	1.4	2.5	5.4	-0.1	-2.0	-2.3	-2.1	-1.6	-0.4	-1.8	1.3	-2.0	-1.7	-1.3
Worry (Nagel 2018)	1.3	2.8	10.2	-0.5	0.4	-0.9	-2.4	-1.1	1.9	-0.8	3.2	-1.7	0.9	-2.9
Alzheimer’s Disease (in father)	1.3	1.4	4.3	0.5	1.7	1.4	1.3	1.4	0.6	1.2	-0.4	1.1	2.1	0.1
Age at First Birth	1.3	1.8	4.7	2.2	1.1	1.4	1.5	2.1	0.7	1.9	-0.3	1.7	0.4	0.3
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.9	-0.8	-1.8	-2.0	-1.0	-1.8	-1.3	-1.7	0.6	-1.6	-1.2	-0.8
Stomach or abdominal pain in last month	1.3	1.6	4.2	1.1	1.4	1.5	1.1	0.5	0.7	1.4	-1.1	1.7	1.4	2.0
Past tobacco smoking	1.3	2.5	7.3	-0.2	2.3	2.1	0.4	1.5	1.3	2.2	0.2	1.7	2.7	-0.0
Breastfed as a baby	1.3	1.6	6.0	1.0	1.8	1.5	0.8	0.5	2.4	1.4	1.0	1.0	1.1	-0.6
Smoking status: Previous	1.3	2.0	5.3	-0.0	-2.0	-1.9	-0.7	-1.4	-1.4	-2.0	-0.3	-1.6	-2.3	0.3
Mood swings	1.3	2.4	4.5	-0.1	-1.6	-2.0	-1.7	-1.8	-0.3	-1.8	1.6	-2.0	-1.1	-2.1
Fractured/broken bones in last 5 years	1.3	1.7	5.9	1.0	1.9	1.8	0.9	0.5	1.4	0.8	-0.4	1.0	2.4	1.3
Bipolar Disorder (2011)	1.2	1.2	3.1	-1.6	1.3	0.7	-0.0	0.8	1.8	0.8	1.5	0.4	1.3	-0.8
Schizophrenia (2014)	1.2	2.8	11.1	0.5	2.3	1.4	0.1	1.6	3.3	1.5	2.1	0.5	2.0	-1.2
Age when periods started (menarche)	1.2	2.9	12.8	1.3	2.4	1.5	0.6	0.8	3.6	1.5	1.6	0.7	2.5	-0.4
Impedance of leg (left)	1.2	5.7	20.8	0.5	2.9	1.6	-0.4	0.5	4.6	1.6	4.3	-0.0	2.6	-3.0
Number of incorrect matches in round	1.2	2.0	5.4	-0.1	2.0	1.8	1.3	1.2	2.3	1.7	1.1	1.2	1.6	-0.4
Diabetes (self-reported)	1.2	1.9	6.1	-1.1	-2.1	-1.7	-0.0	-0.8	-1.3	-1.6	-1.4	-0.8	-2.5	0.5
Loud music exposure frequency	1.2	1.3	2.0	0.6	-1.4	-1.4	-1.3	-1.4	-1.3	-1.3	0.5	-1.4	-1.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.6	-0.9	-1.2	-1.6	-1.4	-1.2	-0.4	-1.5	0.8	-1.6	-0.9	-1.3
Medication: Allopurinol	1.2	1.6	4.2	0.6	0.6	1.2	2.1	1.2	-0.2	1.3	-1.6	1.6	-0.5	2.0
Mean time to correctly identify matches	1.2	2.3	4.2	-1.2	-1.7	-1.7	-1.7	-1.7	-1.0	-2.1	0.5	-1.7	-2.0	-1.4
Tinnitus: Yes, now most or all of the time	1.2	1.3	3.3	-1.1	-0.8	-1.5	-1.2	-0.3	0.0	-1.1	1.8	-1.6	-0.1	-1.8
Crohns Disease (2012)	1.1	1.8	7.3	-1.9	-0.1	-0.5	-1.3	-0.4	1.2	-1.1	2.7	-1.4	0.2	-2.2
Medication for hormone replacement therapy	1.1	1.2	3.5	-0.4	-0.8	-1.0	-1.9	-1.5	0.8	-1.1	1.6	-1.4	-0.4	-0.7
Vitamin and mineral supplements	1.1	1.5	6.1	-2.5	-1.2	-1.1	-0.6	-1.6	-0.4	-0.6	0.9	-0.9	-1.9	-1.0
Neuroticism score	1.1	2.3	5.2	0.8	-0.9	-1.8	-2.3	-1.4	0.3	-1.6	2.2	-2.0	-0.1	-2.0
Trunk fat-free mass	1.1	6.3	26.1	1.2	-2.3	-0.9	1.2	0.3	-4.6	-0.9	-5.1	0.7	-2.3	3.5
Trunk predicted mass	1.1	6.2	26.1	1.2	-2.3	-0.9	1.2	0.3	-4.6	-0.9	-5.1	0.7	-2.3	3.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.2	-0.6	-1.7	-1.9	-1.8	-2.0	-1.7	-2.0	0.0	-1.7	-1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.0	-0.4	1.2	0.6	-0.1	-0.0	2.2	0.8	2.2	-0.0	1.1	-1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	5.8	-0.0	-1.6	-1.1	-0.9	-0.2	-1.4	-1.1	-0.6	-0.7	-2.4	-0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.2	-0.6	-1.4	-1.6	-1.2	-1.2	-0.8	-1.8	0.1	-1.4	-1.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.8	-1.6	-1.7	-1.5	-1.1	-1.1	-1.1	-1.5	0.1	-1.4	-1.0	-0.5
Chronotype (morning person)	1.0	2.3	6.5	-0.2	-2.1	-1.8	-1.3	-1.0	-2.5	-1.8	-1.1	-1.1	-2.2	0.2
Hearing difficulty/problems: Yes	1.0	1.5	5.0	-2.2	-1.6	-1.4	-1.1	-0.4	-1.1	-1.3	0.5	-1.3	-1.6	-0.6
Systolic blood pressure, automated reading	1.0	3.0	12.4	-3.5	-0.3	-0.9	-0.7	0.6	1.4	-0.8	3.2	-1.4	-0.6	-2.7
Had menopause	1.0	1.2	3.4	-1.8	-0.2	-0.8	-1.0	0.5	1.0	-0.8	1.8	-1.1	-0.4	-1.7
Qualifications: None of the above	1.0	2.2	4.2	-1.5	-1.7	-1.9	-1.4	-1.8	-0.5	-2.1	0.6	-1.9	-1.5	-1.1
Heart attack	1.0	1.2	2.3	-1.4	-1.5	-1.4	-1.1	-1.0	-0.9	-1.4	0.4	-1.4	-0.8	-0.7
Impedance of arm (right)	1.0	4.7	14.6	0.7	3.2	2.2	0.3	0.7	3.8	2.3	2.7	1.0	3.4	-0.5
Happiness	1.0	1.2	2.8	0.1	-1.7	-1.4	-0.4	-1.4	-1.7	-1.0	-1.0	-0.7	-1.6	0.2
Length of working week for main job	1.0	1.1	3.0	-1.6	-1.3	-1.0	-0.3	-0.5	-0.8	-0.9	1.0	-1.1	-1.3	-1.7
Migraine (self-reported)	1.0	1.2	4.0	-0.9	-1.5	-0.9	-0.0	-0.6	-2.0	-0.3	-1.6	0.1	-1.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.7	-1.0	-0.3	-0.9	-1.4	-1.9	0.4	-1.0	1.7	-1.4	0.5	-0.4
Guilty feelings	1.0	1.4	5.8	-0.2	0.4	-0.4	-1.6	-0.7	1.1	-0.2	2.4	-1.1	0.8	-2.2
Ever taken oral contraceptive pill	1.0	1.1	4.3	-0.2	-1.3	-1.6	-0.4	-2.1	-1.1	-1.3	-0.1	-1.2	-0.5	0.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	5.6	0.4	1.2	0.6	0.2	1.5	0.3	0.7	1.3	0.3	1.3	-2.4
HDL Cholesterol	0.9	1.4	4.7	-0.6	1.2	0.6	0.6	1.3	2.0	0.7	2.2	-0.1	1.1	-1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	-1.6	-1.1	-1.3	-1.0	-0.8	0.4	-1.2	1.2	-1.3	-1.6	0.5
Diabetes (father)	0.9	1.1	3.0	-1.2	-1.3	-1.0	-1.5	-1.0	-0.5	-1.1	-0.4	-0.8	-1.7	0.7
Impedance of leg (right)	0.9	4.3	13.9	0.4	2.6	1.4	-0.4	0.2	3.7	1.3	3.7	-0.2	2.4	-2.7
Nervous feelings	0.9	1.7	8.2	-0.2	0.7	-0.6	-1.2	-0.4	1.5	-0.7	2.9	-1.2	1.2	-2.1
Pain all over the body in last month	0.9	1.0	3.6	0.5	0.8	0.0	0.0	-0.4	1.8	-0.1	1.9	-0.6	1.2	-1.5
Depression (self-reported)	0.9	1.1	2.1	-0.2	-1.4	-1.3	-1.4	-1.1	-1.4	-1.3	0.1	-1.3	-1.0	-0.3
Prospective memory result	0.9	1.1	3.8	-0.9	-1.6	-2.0	-1.0	-0.5	-0.3	-1.4	0.6	-1.6	-0.3	-0.0
Impedance of arm (left)	0.9	4.2	14.5	0.7	2.9	1.9	0.4	0.5	3.8	2.1	2.5	0.9	3.3	-0.2
Tense / ‘highly strung’	0.9	1.5	6.5	0.0	0.6	-0.3	-1.4	-0.5	1.8	-0.1	2.5	-1.0	1.4	-1.7
Number of full brothers	0.9	1.1	3.2	-1.1	0.4	-0.1	-0.8	-1.1	1.7	-0.7	1.8	-0.9	0.1	-1.6
Illnesses of father: Heart disease	0.9	1.3	3.0	1.4	1.2	1.2	1.2	0.7	0.2	1.7	-1.1	1.5	1.4	0.7
Back pain experienced in last month	0.9	1.3	3.4	0.3	1.8	1.6	0.4	1.0	1.8	1.4	-0.3	1.3	0.8	0.9
Mother’s age at death	0.9	1.1	2.3	0.8	1.4	1.5	0.9	1.4	0.6	1.3	-0.2	1.2	1.4	0.2
Commuting to job workplace: Cycle	0.9	1.1	3.8	0.4	0.7	1.0	1.9	0.7	1.2	1.7	-0.2	1.6	-0.0	0.1
Impedance of whole body	0.9	4.8	18.3	0.6	2.9	1.7	-0.0	0.4	4.3	1.8	3.5	0.4	3.0	-1.5
Bipolar Disorder or Schizophrenia	0.8	1.9	7.3	-0.3	1.8	1.0	-0.3	1.1	2.7	0.8	2.2	-0.0	1.4	-1.4
Schizophrenia vs Biploar Disorder	0.8	1.0	3.8	-0.3	0.0	-0.6	-0.9	-0.3	0.8	-0.7	2.0	-1.4	0.7	-1.8
Mean Putamen Volume	0.8	0.9	2.4	-0.9	-0.5	-0.7	-1.5	-0.7	0.4	-0.7	1.0	-1.0	-1.4	-1.5
Hypothyroidism (self reported)	0.8	1.8	3.1	-0.9	-1.4	-1.4	-1.8	-1.7	-1.5	-1.6	0.5	-1.6	-1.3	-1.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.8	-1.4	0.8	0.2	-0.3	0.2	2.2	0.8	1.4	0.0	0.7	-0.2
High blood pressure (mother)	0.8	1.1	3.0	-1.1	-1.0	-1.4	-1.7	-1.3	-1.1	-1.3	0.0	-1.1	-0.4	0.4
Medication: Cholesterol lowering	0.8	1.2	2.8	-0.6	0.9	1.5	1.7	1.7	0.5	1.3	-1.1	1.6	0.2	0.4
Medication: Lansoprazole	0.8	0.9	3.8	1.2	1.4	1.1	0.2	1.0	-0.0	0.6	-0.3	0.8	1.9	-0.4
Blood clot in the leg (DVT)	0.8	1.1	3.8	0.1	-1.0	-0.4	0.4	-1.2	-1.3	-0.9	-1.9	0.2	-1.6	1.1
Medication for pain relief, constipation, heartburn	0.8	1.3	3.4	0.9	1.6	1.4	0.2	0.8	0.8	1.5	1.4	0.5	1.9	-1.4
Comparative height size at age 10	0.8	4.5	18.9	2.1	-0.0	0.8	1.9	0.5	-2.3	0.8	-4.0	1.9	-0.1	4.4
Financial situation satisfaction	0.8	1.0	2.4	0.0	-1.5	-1.3	-0.4	-1.6	-1.1	-1.3	-0.1	-1.2	-1.1	-0.1
High cholesterol (Self-reported)	0.8	1.4	8.1	-2.8	-0.7	-0.8	-0.9	-1.0	0.4	-1.2	0.5	-1.1	-1.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	0.3	1.4	1.4	1.1	1.6	0.9	1.3	0.5	1.1	0.7	-0.5
Neuroticism (2016)	0.7	1.0	4.2	-0.4	-0.8	-1.3	-0.8	0.1	-0.4	-0.9	1.2	-1.3	-0.8	-2.1
Allergy or Eczema	0.7	1.8	4.4	1.1	1.0	1.5	2.1	1.6	-0.8	1.9	-1.5	1.9	0.3	0.9
Relative age of first facial hair	0.7	1.4	5.3	-1.0	0.9	-0.0	-0.8	-0.3	2.1	-0.5	2.3	-0.9	1.2	-1.1
Supplements: Zinc	0.7	0.8	2.0	1.2	-0.9	-0.3	-0.1	-0.7	-1.4	-0.4	-1.3	-0.0	-1.4	0.7
Townsend deprivation index at recruitment	0.7	0.9	2.4	0.1	-0.9	-0.9	0.0	-1.5	0.3	-1.3	-0.9	-0.6	-1.4	1.5
Medication: Atenolol	0.7	0.9	2.1	-1.2	-0.7	-1.1	-1.4	-1.2	-0.5	-1.0	0.7	-1.2	0.7	-0.6
Sitting height	0.7	4.8	19.8	1.4	-1.6	-0.5	1.2	-0.0	-3.9	-0.2	-4.4	1.0	-1.2	3.8
Mouth/teeth dental problems	0.7	1.1	2.5	0.1	1.5	1.4	1.4	0.6	1.6	1.3	-0.3	1.3	0.3	0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.0	1.7	0.5	1.0	1.3	2.0	-1.0	1.5	-1.5	1.7	-0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.3	-1.0	-1.3	-0.9	-0.1	-0.8	-0.9	-0.9	-0.8	-0.4	-1.5	1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.0	-0.0	-1.2	-1.4	-1.0	-0.9	-0.7	-1.4	0.2	-1.2	-1.1	-0.1
Worry too long after embarrassment	0.7	1.1	3.1	0.7	0.5	-0.3	-1.8	-1.5	0.9	-0.4	1.7	-0.7	1.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	0.1	1.4	1.2	0.2	0.8	1.3	0.9	1.5	0.5	0.5	-1.4
Suffer from ‘nerves’	0.7	1.2	2.9	1.7	1.2	0.5	-0.6	0.7	1.5	0.6	1.7	-0.0	1.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.9	1.6	1.6	1.5	1.0	1.6	-0.1	1.7	-0.7	1.5	1.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.4	-0.4	-1.4	-1.1	-0.1	-1.1	-0.9	-0.9	-1.1	-0.4	-1.5	0.4
Medication: Blood pressure	0.7	1.4	2.8	-1.4	-0.8	-1.5	-1.6	-1.2	0.5	-0.8	1.7	-1.3	0.7	-1.4
Crohns Disease (2017)	0.6	1.4	3.7	-1.9	-0.9	-1.2	-1.0	0.4	-0.1	-1.0	1.8	-1.5	0.0	-1.9
Coronary Artery Disease (CAD)	0.6	0.7	1.6	-0.2	0.7	1.0	0.4	0.8	-0.1	1.0	-1.1	1.2	0.6	1.3
Primary Biliary Cirrhosis	0.6	0.9	3.1	1.7	0.6	0.7	0.5	1.7	0.3	0.9	0.5	0.6	0.1	-1.2
Systolic Blood Pressure	0.6	3.1	11.7	-3.0	-0.2	-0.9	-1.6	-0.9	1.5	-1.0	3.4	-1.6	0.6	-2.6
Cardiovascular Disease	0.6	2.0	7.8	-2.8	-1.4	-1.0	-0.7	-1.9	-1.7	-1.3	-1.1	-0.7	-1.3	1.1
Severe depression (siblings)	0.6	0.7	2.7	-1.4	0.7	0.3	-0.2	-0.6	1.3	-0.1	1.6	-0.3	0.6	-0.4
Relative age voice broke	0.6	0.9	4.2	0.0	0.6	-0.3	-1.2	-0.8	0.6	-0.5	2.1	-1.0	1.2	-0.9
High blood pressure	0.6	1.7	6.1	-2.5	-1.6	-1.6	-1.1	-1.3	-1.2	-1.4	-0.1	-1.1	-1.2	-0.0
Medication: Ramipril	0.6	0.8	1.8	-1.3	-1.0	-0.8	0.1	-1.1	-1.2	-0.8	-0.7	-0.4	-1.3	0.2
Asthma	0.6	1.2	2.9	-0.7	-1.1	-1.3	-1.7	-0.9	-0.3	-1.1	1.2	-1.3	-1.1	-1.4
Exposure to tobacco smoke at home	0.6	0.7	2.5	-1.0	-0.9	-1.2	-0.8	-0.2	-0.2	-0.4	0.5	-0.7	-1.6	-0.6
Hair/balding pattern: Pattern 4	0.6	1.6	4.7	1.8	0.4	1.0	1.5	1.4	-0.8	0.8	-2.2	1.6	0.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.4	-0.1	-0.8	-1.1	-1.5	-1.5	-0.6	-0.5	0.6	-1.0	0.7	-0.4
Number of full sisters	0.6	0.7	1.7	0.8	1.2	1.3	0.7	1.2	0.8	0.7	0.4	0.5	1.2	-0.4
Family relationship satisfaction	0.6	0.8	2.0	-0.4	-1.4	-1.2	-0.6	-0.8	-0.4	-1.0	0.1	-1.0	-1.4	-0.1
Loneliness, isolation	0.6	0.9	2.9	0.3	-1.2	-1.1	-1.2	-1.0	-1.7	-1.0	0.2	-1.0	-0.5	-0.2
Asthma (self-reported)	0.6	1.2	3.1	-0.5	-0.9	-1.2	-1.8	-1.0	-0.1	-1.0	1.4	-1.3	-0.9	-1.5
Medication: Gliclazide	0.6	0.6	1.3	-0.6	-1.1	-0.8	0.6	-0.9	-1.0	-0.9	-1.1	-0.5	-0.5	0.8
Illnesses of father: None of the above (group 1)	0.6	0.8	2.5	1.1	-1.1	-0.8	0.2	-0.4	-1.6	-1.1	-0.9	-0.5	-1.0	0.8
Hearing aid user	0.6	0.7	1.6	-1.3	-0.9	-0.4	0.8	0.0	-0.8	-0.6	-1.3	0.1	-0.8	1.1
Ever smoked	0.6	1.0	3.1	0.3	-1.4	-1.3	-0.1	-1.0	-0.6	-1.6	-0.0	-1.2	-1.8	-0.2
Irritability	0.6	1.1	2.6	-0.2	-1.2	-1.5	-1.5	-0.9	-0.4	-1.2	0.9	-1.6	-0.6	-1.0
Age started oral contraceptive pill	0.6	0.8	1.7	0.4	1.2	1.2	0.3	1.3	-0.3	1.2	-0.0	0.9	1.3	0.5
Myopia	0.6	0.8	1.6	-0.4	-1.1	-1.2	-1.0	-0.0	-0.8	-1.2	0.6	-1.3	-1.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.4	0.1	-0.9	-0.4	0.3	-0.9	-1.2	-0.7	-1.9	0.3	-1.3	0.9
Height	0.5	9.5	40.7	3.6	0.0	0.9	2.7	1.1	-2.7	1.1	-6.0	2.5	0.5	6.4
Sensitivity / hurt feelings	0.5	0.8	3.0	0.8	0.5	-0.2	-1.4	-0.0	0.9	0.1	1.7	-0.5	0.8	-1.6
Pack years adult smoking proportion	0.5	0.8	3.4	0.3	0.2	0.7	0.8	0.6	-0.9	0.3	-1.9	0.8	0.8	1.6
Serious illness, injury or assault to yourself	0.5	0.6	1.5	0.9	0.3	0.8	1.2	0.9	-0.8	0.6	-1.1	1.0	-0.2	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.1	0.8	0.7	1.2	1.4	1.3	-0.9	1.5	-1.2	1.4	0.3	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	0.1	-1.0	-1.1	-1.1	-1.1	-0.5	-0.6	-0.3	-0.7	-1.3	0.1
Standing height	0.5	4.8	16.9	3.1	0.9	1.2	2.1	1.6	-1.1	1.5	-3.5	2.0	1.4	4.1
Headache pain in last month	0.5	0.8	4.7	-0.1	-0.5	-0.2	-0.3	-0.7	-0.9	0.0	-1.5	0.5	-0.7	2.2
Gout (self-reported)	0.5	0.7	2.2	-0.6	0.7	0.9	1.3	0.5	0.1	0.8	-1.0	1.0	0.0	1.5
Qualifications: College or University degree	0.5	1.7	3.5	1.9	1.4	1.5	0.7	1.4	0.4	1.9	0.1	1.5	1.8	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.8	1.3	-0.5	-0.2	0.5	-0.8	-0.9	0.4	-1.2	0.5	0.3	1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-0.7	-1.2	-0.9	-0.3	-0.8	-0.9	-0.8	0.1	-0.7	-1.0	0.3
Medication: Omeprazole	0.5	0.6	2.2	0.1	0.8	1.1	0.9	1.5	0.4	1.0	0.1	0.9	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.2	-0.7	-1.0	-1.0	-0.6	-1.5	0.0	-0.7	0.7	-0.8	-0.5	-0.4
Hypertension (Self-reported)	0.5	1.4	6.3	-2.5	-1.3	-1.5	-1.0	-1.2	-0.8	-1.3	0.0	-1.1	-0.8	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	0.7	-0.7	-0.8	-1.3	-1.0	0.1	-1.1	0.3	-0.9	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.7	-0.7	-0.4	-0.5	-1.5	-2.2	-0.3	-0.2	1.3	-0.9	-0.1	-1.5
Diastolic blood pressure, automated reading	0.5	1.6	9.5	-3.1	-0.3	-0.8	-0.5	0.5	0.6	-0.7	2.0	-1.0	-1.0	-1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	5.5	2.4	1.3	1.3	0.9	1.2	1.0	1.2	-0.2	1.1	0.6	0.4
Depression (Nagel 2018)	0.4	0.6	3.1	-0.7	-0.8	-0.6	0.2	-0.6	-1.8	-0.5	-0.8	-0.3	-0.8	-0.0
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.3	0.1	0.3	1.0	1.0	1.5	-1.1	0.9	-2.1	1.3	-0.6	1.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.9	-1.5	-0.6	-1.0	-0.9	-0.1	0.1	-0.6	1.7	-1.1	0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.5	0.0	-0.6	-0.1	-0.8	0.5	-1.6	-0.4	-1.2	0.1	-0.6	0.6
Waist Hip Ratio (WHR)	0.4	1.9	7.3	1.5	2.0	1.3	1.0	0.5	2.7	1.4	1.0	0.8	1.8	0.2
Smoking Status	0.4	1.0	4.3	0.5	-1.5	-1.0	0.8	0.5	-1.4	-0.9	-1.0	-0.5	-2.1	-0.2
Hand grip strength (right)	0.4	1.0	4.3	-1.4	-0.3	-0.8	-0.8	-0.1	0.1	-0.3	1.6	-1.2	-0.3	-2.1
Hearing difficulty/problems with background noise	0.4	0.6	2.3	-0.7	-0.3	-0.4	-0.8	0.7	-0.2	-0.1	1.4	-0.6	-0.8	-1.5
Falls in the last year	0.4	0.5	1.9	-0.8	-1.0	-0.9	-0.4	-0.2	-0.7	-0.7	0.2	-0.9	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.9	2.0	1.1	1.1	0.6	-0.2	-0.5	1.4	-1.3	1.3	1.6	1.5
Pulse rate	0.4	0.8	3.9	-0.3	-0.1	0.2	0.7	-0.6	-0.7	-0.2	-1.6	0.6	-0.8	2.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	1.4	0.6	0.1	-0.5	-0.2	1.1	0.2	1.4	-0.3	1.2	-0.8
Glaucoma (self-reported)	0.4	0.4	1.5	-0.2	-1.0	-0.7	-0.5	-0.1	-0.7	-0.7	-0.3	-0.5	-1.2	0.6
High blood pressure (siblings)	0.4	0.6	2.0	-1.3	0.3	0.1	-0.3	0.8	0.8	0.6	1.4	0.0	0.5	-1.0
Medication: Blood pressure	0.4	0.8	2.4	-0.7	-0.8	-0.4	0.3	-0.3	-1.3	-0.6	-1.6	0.1	-1.3	1.3
Had major operations	0.4	0.5	2.4	0.9	-0.3	-0.2	-0.2	-0.2	-0.9	0.0	-1.2	0.4	-0.3	1.5
Knee pain experienced in last month	0.4	0.6	3.9	0.7	-0.3	-0.2	-0.4	-0.7	-0.3	-0.4	-1.1	0.1	-0.2	2.0
Illnesses of siblings: Diabetes	0.4	0.5	2.3	0.5	0.1	0.4	0.7	-0.2	-0.3	0.1	-1.5	0.7	-0.7	1.2
Diabetes diagnosed by doctor	0.4	0.6	2.0	-0.7	-1.1	-0.8	0.6	0.1	-0.7	-0.7	-1.4	-0.1	-1.2	0.5
Eye problems/disorders: Cataract	0.4	0.5	2.1	-1.0	0.2	-0.1	-0.3	0.4	0.5	-0.4	1.4	-0.5	-0.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.8	1.7	0.5	0.7	0.7	0.8	-0.8	0.5	-0.9	0.7	0.8	-0.0
Medication: Aspirin	0.4	0.5	3.7	-1.9	-0.4	-0.4	-0.3	-0.0	0.6	-0.6	0.4	-0.5	-0.6	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.6	-0.4	0.6	0.3	0.9	1.3	0.9	0.3	0.8	0.2	0.7	-0.8
Medication: Atorvastatin	0.4	0.6	1.1	-0.4	-0.9	-0.9	-1.0	-0.9	-0.8	-1.0	-0.1	-0.8	-0.8	-0.1
Illnesses of father: High blood pressure	0.4	0.5	2.0	-1.0	0.4	0.1	-0.5	-0.5	1.4	-0.1	1.1	-0.4	0.8	-0.9
Alcohol drinker status: Never	0.4	0.5	1.4	-0.1	1.0	0.8	0.3	0.6	0.3	0.5	0.6	0.4	1.1	-1.2
Number of operations (self-reported)	0.4	0.6	2.3	-1.5	-0.2	0.1	-0.4	-0.0	-0.9	-0.3	-1.0	0.2	0.2	1.5
Risk taking	0.4	0.6	2.5	0.3	0.5	0.7	1.6	0.3	1.1	0.8	-0.5	0.8	0.1	1.1
Pain experienced in last month	0.4	0.7	3.9	-0.9	-0.8	-0.6	-0.2	0.5	-0.9	-0.4	1.0	-0.9	-0.4	-2.0
Heart disease (siblings)	0.4	0.4	2.2	0.2	0.5	0.6	0.3	0.6	-0.9	0.1	-1.5	0.6	0.4	0.8
Pack years of smoking	0.4	0.6	3.0	0.1	0.0	0.5	0.6	0.6	-0.9	0.2	-1.7	0.6	0.8	1.4
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	0.1	-0.5	-0.0	0.4	0.8	-0.7	0.1	-1.1	0.1	-0.3	1.0
HbA1C	0.3	0.3	1.6	-0.3	-0.1	0.3	0.7	0.1	0.1	-0.1	-0.8	0.4	-0.8	1.2
Rheumatoid Arthritis	0.3	0.5	1.3	-1.0	0.5	-0.0	-0.2	-0.9	1.1	-0.3	0.9	-0.5	0.3	-1.1
Ulcerative Colitis	0.3	0.4	0.8	-0.9	-0.3	-0.7	-0.9	-0.8	-0.2	-0.5	0.8	-0.7	-0.3	-0.5
Blood Eosinophil Count	0.3	2.2	9.5	0.8	-0.9	0.2	1.1	0.1	-3.0	-0.2	-3.1	0.9	-1.4	1.5
Medication: Co-codamol	0.3	0.4	1.1	-1.1	-0.5	-0.5	0.2	-0.8	-0.1	-0.6	-0.5	-0.1	-0.6	0.9
Current tobacco smoking	0.3	0.5	2.2	0.5	0.4	0.7	1.5	1.0	0.2	0.5	-0.6	0.8	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	0.9	0.0	0.2	1.0	0.2	-1.0	0.3	-1.1	0.6	0.4	0.7
Taking other prescription medications	0.3	0.4	1.8	0.1	-0.7	-0.7	-0.7	-0.6	-0.6	-1.3	-0.3	-0.7	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.4	-0.5	-1.2	-0.4	0.4	-0.3	-1.2	-0.1	-0.7	0.1	-1.9	0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.9	0.2	0.5	0.8	0.9	-0.6	0.4	-0.9	0.7	-0.3	0.8
Multivitamins +/- minerals	0.3	0.4	1.5	1.2	-0.0	0.2	0.1	1.2	-1.1	-0.3	-0.8	0.0	0.3	-0.1
Forced vital capacity (FVC)	0.3	1.0	2.5	1.6	0.8	0.8	0.5	-0.2	-0.5	1.2	-1.2	1.0	1.3	1.5
Financial difficulties in last 2 years	0.3	0.4	2.1	-0.8	-0.4	-0.6	0.1	-0.1	-0.4	-0.4	0.8	-0.6	-0.4	-1.4
Medication: Simvastatin	0.3	0.5	3.2	-1.8	0.0	-0.1	-0.1	0.3	1.2	-0.2	0.6	-0.4	-0.2	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	2.5	-0.6	0.7	0.1	0.1	-0.3	1.6	0.1	0.4	-0.0	1.1	0.1
Number of live births	0.3	0.4	2.5	-1.1	0.4	-0.1	-0.4	-0.5	1.6	-0.2	0.8	-0.3	0.1	0.3
Illnesses of mother	0.3	0.3	1.2	0.1	0.6	0.8	1.1	0.1	0.2	0.8	-0.3	0.7	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.3	1.8	0.9	0.9	0.4	-0.6	-0.1	1.1	-0.9	1.0	1.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	0.8	0.3	-0.3	-0.3	0.8	0.8	-0.1	1.2	-0.4	0.2	-0.9
Birth weight	0.3	0.6	2.7	1.7	0.9	0.6	-0.0	0.1	1.2	0.4	1.0	0.0	0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	1.7	1.1	1.1	0.4	-0.2	0.2	1.4	-0.6	1.1	1.3	1.0
Exposure to tobacco smoke outside home	0.3	0.4	2.0	-1.4	-0.7	-0.6	-0.1	-0.5	-0.4	-0.7	0.6	-0.8	-0.3	-0.2
Shortness of breath walking on level ground	0.3	0.3	1.1	0.7	-0.7	-0.8	-1.0	-0.2	-0.7	-0.5	-0.1	-0.6	0.2	0.3
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.9	-0.1	-0.1	-0.1	-0.6	0.7	-0.5	0.8	-0.5	-0.3	0.9
Neck or shoulder pain in last month	0.3	0.4	1.8	0.3	0.7	0.5	0.5	-0.4	0.7	0.2	-0.6	0.6	0.3	1.3
Heart disease (mother)	0.3	0.3	1.7	0.4	0.3	-0.0	-0.7	0.0	1.1	-0.0	1.3	-0.3	0.3	-0.4
Age at last live birth	0.3	0.4	1.0	1.0	0.6	0.6	-0.3	0.9	0.0	0.5	-0.3	0.8	1.0	0.2
Friendships satisfaction	0.3	0.4	1.4	1.2	-0.3	-0.4	-0.5	-0.7	-0.3	-0.7	0.6	-0.7	0.6	-0.8
Smoking status: Current	0.3	0.4	2.1	0.6	0.3	0.6	1.4	1.1	0.3	0.5	-0.6	0.7	-0.1	-0.0
Number of self-reported non-cancer illnesses	0.3	0.4	1.9	-1.4	-0.6	-0.6	-0.3	-0.4	-0.5	-0.9	-0.4	-0.4	-0.9	0.4
Fasting Glucose	0.2	0.2	0.4	0.6	0.6	0.6	-0.2	0.3	0.4	0.3	0.6	-0.0	0.4	-0.6
Blood Red Count	0.2	2.0	7.1	-0.9	1.3	0.1	-0.8	-0.1	2.5	-0.2	2.7	-0.8	2.4	-1.1
Hand grip strength (left)	0.2	0.6	2.3	-1.3	0.4	0.1	0.1	-0.1	0.8	0.3	1.4	-0.4	0.1	-1.5
Number of treatments/medications taken	0.2	0.4	1.5	-1.2	-0.4	-0.7	-0.1	-0.7	0.1	-1.2	0.3	-0.8	-0.2	0.0
Average weekly spirits intake	0.2	0.3	2.0	0.2	-0.2	-0.3	0.2	0.3	0.2	0.0	-0.8	0.2	-0.5	1.4
Medication: Metformin	0.2	0.3	1.6	-0.7	-0.0	0.1	1.3	0.5	0.5	0.2	-0.6	0.5	-0.5	0.2
Average weekly fortified wine intake	0.2	0.2	0.9	0.9	0.4	0.3	-0.3	0.5	0.2	0.4	-0.5	0.4	-0.0	-0.2
Maternal smoking around birth	0.2	0.2	0.8	-0.9	-0.7	-0.7	0.1	-0.4	-0.2	-0.7	-0.1	-0.6	-0.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	0.1	0.5	0.2	0.7	0.3	0.6	0.3	0.2	0.3	0.6	1.0
Alcohol usually taken with meals	0.2	0.3	1.3	-0.1	0.5	0.6	0.7	0.3	-1.1	0.5	-0.6	0.6	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.1	-0.2	-0.9	-0.3	0.7	-0.9	-0.7	-0.3	-0.5	-0.1	-1.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.9	0.9	-0.3	-0.1	-0.1	-0.3	-1.4	-0.1	-0.8	0.0	0.4	0.4
Illnesses of siblings	0.2	0.2	0.9	0.6	0.1	-0.1	-0.5	-0.5	0.2	-0.4	0.7	-0.4	0.6	-1.0
Peak expiratory flow (PEF)	0.2	0.4	1.5	1.2	0.0	0.2	-0.5	-0.5	-0.8	0.4	-0.9	0.4	0.1	0.5
Medication: Amlodipine	0.2	0.2	0.7	0.5	0.7	0.3	0.6	-0.1	-0.1	0.6	-0.0	0.4	0.9	0.3
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.8	0.2	-0.2	-0.7	0.7	0.5	-0.1	1.1	-0.5	0.4	-0.6
Number of children fathered	0.2	0.2	1.0	-0.4	-0.9	-0.6	0.4	-0.2	-1.0	-0.3	-0.3	-0.2	0.1	0.0
Medication: Seretide 50 evohaler	0.2	0.2	1.0	0.7	-0.5	-0.4	0.1	0.4	-1.0	-0.3	0.0	-0.3	-0.5	-0.0
Pulse rate, automated reading	0.2	0.6	2.0	-0.9	0.6	0.8	0.8	1.4	0.6	0.6	-0.2	0.8	-0.5	1.2
Overall health rating	0.2	0.4	1.1	-0.1	-1.0	-1.0	0.2	-0.1	-0.1	-1.0	-0.4	-0.5	-0.9	0.4
Chest pain or discomfort	0.2	0.2	0.7	0.7	-0.1	0.0	0.2	-0.8	-0.0	-0.4	-0.4	0.0	-0.7	0.9
Medication: Aspirin	0.2	0.3	2.4	-1.6	-0.3	-0.3	0.0	0.1	0.5	-0.5	-0.0	-0.2	-0.5	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	1.5	0.4	0.0	0.2	0.0	0.7	-0.2	0.2	-0.9	0.3	0.2	1.2
Osteoarthritis (self-reported)	0.2	0.2	0.8	0.3	0.5	0.3	0.4	0.4	0.8	0.2	-0.7	0.5	0.2	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.9	1.4	0.1	-0.3	-0.3	0.7	-0.1	-0.3	0.2	-0.4	0.1	0.1
Medication: Bendroflumethiazide	0.2	0.4	1.6	-1.3	-0.8	-0.8	-0.4	-0.6	-0.0	-0.5	0.1	-0.5	-0.5	0.3
Supplements: Calcium	0.2	0.2	0.6	0.2	0.4	0.3	-0.6	-0.5	0.7	-0.3	0.8	-0.4	0.4	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.6	-0.4	-0.5	-0.7	-0.8	-0.7	-0.3	0.1	-0.3	0.2	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	1.2	0.3	0.3	0.5	0.5	1.1	0.0	0.2	-0.6	0.1	0.2	0.1
Ulcerative Colitis (UC)	0.1	0.2	1.0	-0.7	-0.0	-0.3	-0.3	-0.3	0.0	0.2	1.0	-0.2	0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.8	0.0	0.4	0.6	0.8	1.4	-0.5	0.5	-0.5	0.6	0.1	-0.2
Blood White Count	0.1	1.0	2.5	-1.5	-1.5	-1.1	-0.1	-0.5	-1.6	-1.4	-0.0	-0.9	-0.6	0.1
Heel T-Score	0.1	1.1	5.2	-2.3	-1.2	-0.8	0.0	-0.5	-0.1	-0.6	0.8	-0.8	-1.4	-1.5
Respiratory disease	0.1	0.3	1.2	0.5	-0.0	-0.3	-1.1	-0.4	0.1	-0.1	1.0	-0.4	-0.1	-0.8
Lung FVC	0.1	0.7	1.9	1.4	0.9	0.3	-0.7	-1.2	0.9	0.2	1.1	-0.1	1.3	-0.6
Angina	0.1	0.1	0.4	0.2	-0.0	0.2	0.4	0.7	-0.2	-0.0	-0.5	0.2	-0.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.1	0.4	0.2	-0.3	-0.4	0.1	0.1	-0.0	-0.1	0.5	0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.4	-0.3	-0.1	-0.5	-0.0	-0.1	-0.2	0.0	0.0	-0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.9	0.4	0.2	0.6	-0.0	0.6	0.3	0.1	0.3	-0.3	-0.0
Allergy	0.1	0.3	1.6	0.1	0.6	0.4	0.5	0.5	1.3	0.4	0.1	0.4	0.7	0.4
Fluid intelligence score	0.1	0.2	1.1	-0.7	-0.2	-0.0	0.6	1.1	-0.2	0.1	-0.3	0.1	-0.6	-0.6
Time employed in main current job	0.1	0.1	0.5	-0.1	0.4	0.4	0.1	0.7	0.4	0.5	0.1	0.5	0.4	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	1.1	-1.0	0.0	0.1	-0.1	-0.1	0.0	-0.2	0.2	-0.1	-0.5	-0.2
Angina (self-reported)	0.1	0.2	0.6	0.2	-0.3	0.1	0.5	0.6	-0.6	-0.2	-0.8	0.1	-0.4	0.4
Alcohol intake frequency.	0.1	0.3	0.7	-0.7	-0.7	-0.8	-0.5	0.5	-0.6	-0.9	-0.1	-0.6	0.2	0.2
Qualifications: nursing, teaching	0.1	0.1	0.3	0.2	0.1	0.3	-0.3	0.6	-0.3	0.2	0.3	0.1	0.4	-0.5
Commuting to job workplace: Walk	0.1	0.2	0.7	0.1	0.1	0.2	-0.2	-0.8	-0.2	-0.2	-0.3	-0.1	0.5	0.9
Breast cancer (self-reported)	0.1	0.1	0.3	0.1	0.3	0.4	0.5	-0.0	0.0	0.6	-0.2	0.5	-0.1	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.4	0.5	-0.0	0.1	-0.1	0.7	-0.1	-0.1	0.0	-0.1	-0.2	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.0	0.4	0.3	-0.1	-0.3	-0.0	-0.6	0.5
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.1	-0.1	-0.0	-0.2	0.6	0.1	-0.5	-0.3	0.0	-0.0	0.3
Blood Platelet Count	0.0	0.6	3.3	-0.8	-0.9	-0.6	0.1	-0.7	0.4	-0.5	0.7	-0.2	-1.8	-0.6
Lung FEV1/FVC ratio	0.0	0.1	0.3	0.5	0.4	0.5	0.2	0.2	-0.0	0.4	-0.0	0.3	-0.4	-0.1
Hair Pigment	0.0	0.4	2.5	1.6	0.1	0.1	0.2	-0.6	0.5	-0.2	-0.8	0.4	0.3	0.8
Tanning	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.3	-0.3	0.2	0.2	0.4	-0.2	-0.0	-0.5
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	-0.4	-0.3	-0.3	-0.2	0.0	-0.1	-0.0	0.1	-0.3	0.1	0.3

Hub : Genes

MTIF3

Models

Trait associations