TWAS hub - GTF3A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1510	0.0300	9.8e-12	0.114	0.106	0.126	0.114	0.118	1.1e-13	7.7e-13	4.1e-15	9.3e-14	3.2e-14
2	GTEx	Brain Nucleus accumbens basal ganglia	0.3790	0.1200	9.0e-03	0.025	NA	0.015	NA	0.005	7.2e-02	NA	1.3e-01	NA	2.3e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.2180	0.0810	4.6e-03	0.186	NA	0.144	NA	0.137	1.1e-06	NA	2.0e-05	NA	3.2e-05
4	GTEx	Skin Sun Exposed Lower leg	0.1060	0.0420	5.9e-03	0.002	NA	-0.003	NA	-0.001	2.0e-01	NA	6.5e-01	NA	3.6e-01
5	YFS	Blood	0.1723	0.0255	0.0e+00	0.152	0.163	0.180	0.149	0.186	2.8e-47	5.2e-51	1.8e-56	2.4e-46	1.1e-58
6	TCGA	Colon Adenocarcinoma	0.0600	0.0330	3.7e-03	0.003	0.037	0.009	NA	0.002	2.1e-01	3.4e-03	8.7e-02	NA	2.4e-01
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0604	0.0251	3.0e-06	0.021	0.048	0.046	NA	0.034	1.9e-03	4.3e-06	5.9e-06	NA	8.6e-05
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0552	0.0326	6.2e-04	0.008	0.019	0.023	NA	0.014	3.4e-02	3.0e-03	1.2e-03	NA	9.8e-03
9	TCGA	Brain Lower Grade Glioma	0.0343	0.0219	8.8e-03	-0.002	0.005	0.010	NA	0.008	7.7e-01	7.4e-02	2.3e-02	NA	3.6e-02
10	TCGA	Stomach Adenocarcinoma	0.0660	0.0300	2.8e-04	0.042	0.029	0.022	NA	0.019	5.3e-04	3.4e-03	9.2e-03	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Body Mass Index (BMI) (2010)	7.1	9.8	23.3	0.8	-0.4	-3.9	-2.7	-4.8	-3.4	-3.4	0.6	2.6	-4.5
Cholesterol lowering medication	4.8	7.1	14.1	1.1	1.8	3.4	2.6	3.2	3.4	3.1	1.8	-0.3	3.8
Comparative body size at age 10	3.9	10.9	28.2	3.9	1.4	-3.8	0.5	-5.3	-1.0	-2.1	1.5	5.3	-3.6
Average weekly champagne plus white wine intake	3.6	5.0	7.1	-2.0	-2.5	-2.2	-2.6	-1.9	-2.7	-2.4	-2.0	0.8	-2.6
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.0	8.5	-1.5	-2.0	-1.6	-2.1	-1.5	-2.9	-2.5	-2.4	-0.6	-1.9
Medication for cholesterol	3.5	5.4	10.9	-0.8	-1.1	-2.2	-2.8	-2.3	-3.3	-2.4	-2.4	1.5	-3.1
Hip circumference	3.2	13.6	35.9	4.5	2.0	-3.8	1.3	-5.6	-1.2	-2.8	2.0	6.0	-4.0
Noisy workplace	3.2	3.9	7.8	0.2	0.7	2.4	1.8	2.6	2.2	2.8	2.1	0.1	2.6
Average weekly beer plus cider intake	3.2	4.6	7.1	2.4	2.5	2.6	2.1	1.4	2.5	2.7	1.8	0.3	1.9
Unable to work because of sickness or disability	3.2	4.1	8.1	2.5	1.5	2.1	1.8	1.6	2.8	2.5	1.4	0.2	2.4
Leg fat-free mass (left)	3.0	15.7	43.1	3.8	1.8	-4.6	0.2	-6.1	-2.1	-3.2	0.8	6.6	-4.7
Leg fat mass (right)	3.0	11.8	37.6	4.5	2.1	-3.1	1.3	-4.9	-0.8	-2.2	2.2	6.1	-3.2
BMI	2.9	16.9	45.3	6.6	3.6	-3.2	1.9	-5.5	0.2	-1.5	3.3	6.7	-3.0
Leg predicted mass (left)	2.9	15.1	42.8	3.8	1.8	-4.5	0.3	-6.0	-2.0	-3.1	0.7	6.5	-4.6
Weight	2.9	14.1	38.6	4.4	2.3	-3.9	0.8	-5.6	-1.5	-2.8	1.9	6.2	-4.1
Arm fat mass (right)	2.9	12.0	33.2	4.7	2.1	-3.2	1.3	-5.1	-0.9	-2.4	1.9	5.8	-3.5
Arm fat mass (left)	2.9	11.9	30.6	4.6	2.2	-3.3	1.1	-5.2	-0.9	-2.6	1.8	5.5	-3.6
Supplements: Glucosamine	2.7	3.5	7.8	-2.8	-2.8	-0.4	-1.9	0.5	-1.7	-1.5	-2.3	-2.2	-0.6
Whole body fat mass	2.7	11.3	31.0	4.3	2.4	-3.2	1.4	-5.0	-0.8	-2.5	1.9	5.6	-3.3
Leg fat mass (left)	2.7	10.5	31.8	4.2	2.1	-3.0	1.1	-4.7	-0.8	-2.2	2.0	5.6	-3.1
Lupus	2.6	3.9	10.5	-2.7	-1.9	-0.8	-2.3	0.2	-2.5	-1.3	-1.8	-3.2	-1.0
Body mass index (BMI)	2.6	11.2	32.2	5.1	2.3	-2.6	1.6	-4.6	-0.3	-1.7	2.6	5.7	-2.9
Trunk fat mass	2.6	11.3	28.3	4.3	2.5	-3.2	1.2	-5.1	-0.9	-2.5	1.9	5.3	-3.5
Waist circumference	2.6	9.4	22.5	3.4	1.5	-3.2	0.3	-4.7	-1.7	-3.2	1.1	4.4	-3.7
Leg predicted mass (right)	2.6	13.6	37.4	3.5	1.9	-4.3	0.2	-5.7	-1.9	-2.9	0.7	6.1	-4.3
Basal metabolic rate	2.6	14.3	42.2	3.9	2.0	-4.1	0.1	-5.7	-2.0	-2.8	1.3	6.5	-4.4
Fed-up feelings	2.5	4.6	9.1	2.3	1.6	1.8	3.0	1.8	2.9	2.0	2.2	0.4	2.3
Supplements: Vitamin C	2.5	2.9	5.1	-1.9	-2.3	-1.5	-1.9	-0.9	-1.6	-1.9	-1.0	-2.2	-1.3
Leg fat-free mass (right)	2.5	13.3	38.1	3.6	2.0	-4.2	0.3	-5.6	-1.8	-2.9	0.7	6.2	-4.2
Ever had bowel cancer screening	2.5	2.9	11.2	-3.4	-1.9	-0.1	-2.1	0.9	-1.5	-0.9	-1.9	-1.6	0.1
Arm fat-free mass (left)	2.5	12.5	39.9	3.9	2.2	-3.6	0.0	-5.1	-1.8	-2.5	1.5	6.3	-3.9
Fractured/broken bones in last 5 years	2.5	3.2	8.6	-2.9	-1.1	-1.4	-2.1	-0.2	-1.5	-1.8	-2.7	-1.6	-0.9
Arm predicted mass (left)	2.4	12.0	36.4	3.8	2.1	-3.7	0.0	-5.0	-1.8	-2.6	1.5	6.0	-3.8
Arm predicted mass (right)	2.3	11.8	38.7	3.8	1.8	-3.5	-0.0	-4.9	-1.8	-2.4	1.2	6.2	-3.9
Whole body fat-free mass	2.3	12.9	40.6	3.6	1.9	-3.9	-0.0	-5.3	-1.9	-2.5	1.0	6.4	-4.1
Arm fat percentage (left)	2.3	9.1	23.4	4.2	1.9	-2.7	1.6	-4.5	-0.3	-2.1	1.8	4.8	-2.9
Whole body water mass	2.3	13.1	40.1	3.7	1.8	-4.0	-0.1	-5.4	-2.0	-2.6	1.1	6.3	-4.2
Alcohol drinker status: Previous	2.3	2.6	8.9	3.0	0.9	-1.3	0.6	-1.8	-0.3	-1.1	1.3	2.5	-1.4
Alzheimer’s Disease (in father)	2.2	2.3	4.3	-2.1	-1.8	-1.2	-1.9	-0.6	-1.7	-1.2	-1.8	-1.4	-0.9
Arm fat percentage (right)	2.2	8.6	21.7	4.0	1.9	-2.7	1.3	-4.4	-0.5	-2.0	2.0	4.7	-2.8
Lung cancer (father)	2.2	2.5	7.0	0.9	2.7	1.5	1.8	1.2	2.2	1.4	0.9	-0.6	1.5
Medication: Paracetamol	2.2	3.6	6.9	2.5	2.1	-2.0	0.6	-2.6	-0.4	-1.9	1.3	2.2	-1.8
Arm fat-free mass (right)	2.2	11.4	37.5	3.8	1.8	-3.4	0.2	-4.9	-1.6	-2.3	1.3	6.1	-3.7
Medication: Lisinopril	2.2	2.8	5.3	1.8	1.3	0.4	2.0	0.2	2.0	2.1	2.3	1.3	1.7
Neuroticism (Nagel 2018)	2.1	4.9	11.0	0.6	0.0	2.8	2.0	3.2	2.5	2.4	1.7	-0.5	3.3
Worry (Nagel 2018)	2.1	4.5	11.5	-0.4	-0.4	2.8	1.0	3.4	2.0	2.2	0.8	-2.3	3.1
Breast Cancer	2.1	5.0	12.0	0.5	-0.3	-2.8	-2.0	-3.3	-2.6	-2.9	0.7	0.2	-3.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	8.3	-1.4	-2.9	-0.6	-1.8	-0.6	-2.1	-1.3	-1.8	-1.3	-1.5
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	6.5	0.9	-0.8	-1.9	-1.6	-2.5	-2.3	-2.1	-0.7	1.8	-2.5
Ever had hysterectomy (womb removed)	2.0	2.3	5.4	-1.1	0.4	1.9	1.0	2.1	1.1	0.9	-1.1	-2.3	2.0
Body fat percentage	2.0	7.9	18.3	3.9	2.1	-2.4	1.5	-4.1	-0.3	-2.0	2.1	4.3	-2.6
Leg fat percentage (right)	2.0	7.3	23.7	4.0	1.7	-1.7	1.6	-3.4	0.0	-1.1	2.8	4.9	-1.9
Commuting to job workplace: Car/motor vehicle	2.0	2.3	7.3	2.7	2.7	0.3	0.7	-0.8	0.5	0.5	2.1	1.4	-0.4
Miserableness	2.0	3.5	5.6	2.0	1.2	2.1	2.0	1.5	2.4	2.0	2.0	1.1	2.0
Schizophrenia (2018)	1.9	4.0	9.9	-1.6	-1.4	2.6	-0.2	3.1	0.8	2.0	-0.8	-2.5	2.6
Major Depression (MDD)	1.9	2.4	8.6	2.6	1.0	0.0	1.3	-0.3	1.4	1.2	1.4	2.9	0.6
LDL Cholesterol	1.9	3.0	10.8	3.3	1.5	0.7	2.0	-0.3	1.3	0.8	1.6	2.8	0.1
Type 2 Diabetes (T2D) (2018)	1.9	3.6	9.2	2.4	1.4	-1.8	0.7	-3.0	-0.3	-0.8	1.9	3.0	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.5	-2.3	-1.5	-0.9	-1.2	-0.7	-1.5	-1.3	-2.2	-1.0	-1.1
Depressed Affect (Nagel 2018)	1.8	3.9	6.9	2.6	1.3	1.8	2.1	1.6	2.2	1.8	2.6	1.3	1.9
Trunk fat percentage	1.8	7.0	15.8	3.6	2.2	-2.4	1.3	-4.0	-0.4	-2.2	1.7	3.8	-2.7
Trunk fat-free mass	1.8	10.4	35.0	3.2	1.9	-3.4	-0.3	-4.7	-1.8	-2.0	1.2	5.9	-3.6
Worrier / anxious feelings	1.8	3.4	7.5	0.2	0.1	1.8	1.7	2.3	2.2	2.2	2.0	-1.3	2.7
Trunk predicted mass	1.8	10.3	34.5	3.2	1.9	-3.4	-0.3	-4.6	-1.8	-2.0	1.2	5.9	-3.6
Birth weight of first child	1.8	3.3	8.4	-1.0	0.3	-2.9	-1.6	-2.9	-2.1	-1.7	0.7	0.4	-2.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.2	1.6	1.7	1.5	2.0	1.2	2.0	1.3	1.0	0.0	1.5
Number of full brothers	1.8	2.2	7.9	0.2	0.7	2.8	0.4	2.4	1.2	1.5	-0.6	-0.6	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.9	-1.1	-0.4	2.2	-0.0	2.2	1.2	2.1	-0.2	-1.0	1.9
Average weekly red wine intake	1.8	2.7	7.5	2.7	1.3	0.7	1.8	-0.1	1.3	1.3	2.7	1.7	0.5
Wears glasses or contact lenses	1.8	2.1	7.6	2.0	1.1	1.0	1.2	0.4	1.6	1.2	0.8	2.7	0.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	7.6	0.9	2.1	-1.9	-0.1	-2.8	-1.0	-0.4	1.4	0.7	-1.7
Ovarian Cancer	1.7	2.2	9.5	-1.9	0.5	-0.4	-2.2	0.5	-1.7	-0.8	-0.6	-3.1	-0.1
Systolic blood pressure, automated reading	1.7	4.8	12.2	0.5	-1.3	3.4	2.3	3.5	2.2	1.7	-0.0	-1.5	2.7
Diabetes (mother)	1.7	2.2	5.1	1.3	1.6	1.4	2.3	1.1	1.9	1.3	0.4	1.2	1.5
Impedance of leg (left)	1.7	8.2	24.5	-3.9	-1.4	2.9	-0.7	4.3	0.6	1.5	-1.1	-4.9	2.9
Nervous feelings	1.7	3.2	10.9	-1.0	-0.6	2.4	0.5	3.3	1.4	1.7	-0.7	-1.0	2.7
Blood clot in the leg (DVT)	1.7	2.2	7.8	1.2	1.7	-1.7	-0.1	-2.8	-1.0	-0.6	1.0	0.7	-1.9
Medication: Paracetamol	1.7	2.6	7.1	2.5	2.7	-1.2	1.2	-1.7	0.5	-0.9	1.3	2.0	-0.7
Leg fat percentage (left)	1.7	6.1	19.5	3.8	2.0	-1.4	1.6	-2.9	0.2	-1.0	2.7	4.4	-1.6
Crohns Disease (2012)	1.6	2.6	5.8	-0.0	-0.1	2.1	1.7	2.4	1.8	2.0	-0.4	-1.2	1.9
Pulse wave Arterial Stiffness index	1.6	1.9	6.9	-1.7	-1.0	-0.4	-2.6	0.0	-1.7	-1.3	-1.6	-0.2	-0.9
Medication: Ibuprofen	1.6	1.9	5.0	2.2	1.3	1.7	1.9	0.8	1.6	0.8	0.7	1.0	0.8
Handedness (chirality/laterality): Left-handed	1.6	1.9	6.1	1.7	1.7	-0.4	1.5	-0.9	0.6	0.8	1.8	2.5	0.0
Mean Putamen Volume	1.5	1.7	3.5	1.7	1.4	1.9	0.7	1.4	1.2	1.7	1.0	0.1	1.3
Triglycerides	1.5	2.5	9.3	3.1	1.1	-0.3	1.5	-1.1	0.4	-0.2	1.7	2.6	-0.8
Neuroticism	1.5	3.7	7.4	1.4	0.0	2.5	1.9	2.7	2.5	1.9	0.9	-0.0	2.7
Pain all over the body in last month	1.5	1.6	5.8	-0.4	-0.7	1.6	0.3	1.6	0.8	1.2	-0.4	-2.4	1.3
Age at first live birth	1.5	2.6	5.5	-0.7	-1.2	-2.3	-1.4	-2.0	-2.0	-1.6	0.2	1.2	-2.2
Mood swings	1.5	2.7	4.1	1.7	1.3	1.6	1.6	1.6	1.8	1.9	1.8	0.6	2.0
Mineral and other dietary supplements	1.5	2.0	3.9	2.0	1.7	1.1	1.8	0.2	1.7	1.4	1.1	1.3	0.8
Age started oral contraceptive pill	1.5	1.8	4.7	-2.2	-1.7	-1.5	-1.4	-0.3	-1.1	-1.8	-1.0	-0.4	-0.6
Ever depressed for a whole week	1.5	1.9	4.5	1.4	1.0	2.1	1.8	1.5	1.8	1.2	0.1	-0.2	1.2
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.7	1.5	-0.6	1.9	1.9	1.5	1.7	0.5	0.1	0.7	1.3
Had menopause	1.4	1.7	5.0	-0.3	-0.2	1.8	1.3	2.2	1.2	1.0	0.4	-0.6	2.0
Mouth/teeth dental problems: Dentures	1.4	2.4	6.2	1.9	1.7	0.4	1.7	0.7	2.5	1.1	1.6	1.0	1.8
Exposure to tobacco smoke at home	1.4	1.6	4.0	1.2	0.9	0.9	0.9	0.3	1.4	1.7	1.3	2.0	1.3
Pulse wave peak to peak time	1.4	1.7	6.0	1.8	1.1	-0.0	2.5	-0.5	1.5	0.9	1.6	0.5	0.5
Migraine (self-reported)	1.4	1.7	8.6	1.1	-0.4	-1.0	0.1	-1.8	-0.3	0.1	0.9	2.9	-1.4
Impedance of whole body	1.4	7.2	27.7	-3.9	-1.8	2.2	-0.5	3.4	0.4	0.8	-2.0	-5.3	2.1
Frequency of depressed mood in last 2 weeks	1.3	1.9	5.2	1.3	1.2	0.9	1.6	0.6	1.6	1.3	2.3	1.2	1.1
Impedance of leg (right)	1.3	6.5	19.9	-3.6	-1.6	2.4	-0.6	3.8	0.5	1.3	-0.9	-4.5	2.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.8	1.4	0.8	1.4	2.0	1.0	1.8	0.7	-0.2	1.5	1.0
Leg pain on walking	1.3	1.6	3.9	2.0	1.4	1.0	2.0	0.3	1.4	0.3	1.1	1.2	0.6
Guilty feelings	1.3	2.0	5.1	-0.8	-0.6	1.2	0.4	1.9	1.1	1.9	1.6	-1.0	2.3
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.3	1.0	0.6	1.8	0.9	1.8	1.6	1.4	-0.1	-0.3	1.6
Irritable Bowel Disease (IBD)	1.2	2.8	7.8	0.3	-2.7	1.3	2.8	1.6	1.9	1.5	-0.1	-0.6	1.7
Prostate Cancer	1.2	1.7	6.9	-2.6	-1.1	0.1	-1.1	1.4	-0.3	-0.5	-1.6	-1.3	0.7
HDL Cholesterol	1.2	2.0	7.6	-1.3	0.7	1.3	0.0	1.9	0.8	1.3	0.0	-2.8	1.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	6.4	0.9	0.5	-1.2	-0.2	-1.6	-0.7	-0.7	0.6	2.5	-1.2
Allergy or Eczema	1.2	3.1	4.9	-1.0	-1.4	-2.2	-2.0	-2.1	-2.2	-1.7	0.5	1.4	-2.2
Relative age of first facial hair	1.2	2.5	8.2	-0.6	-0.5	2.5	0.4	2.9	1.3	1.4	-1.5	0.4	2.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.7	-1.6	-0.1	1.0	1.1	1.5	0.8	0.6	-0.5	-1.6	1.6
Stomach or abdominal pain in last month	1.2	1.4	4.0	-1.1	-1.2	-0.9	-1.1	-0.4	-1.3	-1.8	-2.0	-0.2	-0.9
Neuroticism score	1.2	2.5	6.2	0.6	0.1	1.9	1.2	2.5	1.9	1.8	0.9	-0.1	2.5
Impedance of arm (left)	1.2	5.7	23.3	-3.7	-2.2	1.3	-0.7	2.4	0.0	0.1	-2.4	-4.8	1.2
Tense / ‘highly strung’	1.2	2.1	6.1	-1.4	-0.9	1.4	0.6	2.5	1.3	1.6	-0.3	-0.4	2.2
Pulse wave reflection index	1.2	1.5	3.5	-1.9	0.2	1.3	-1.8	1.8	-0.4	0.8	-0.1	-1.4	1.0
Crohns Disease (2017)	1.1	2.4	6.6	0.1	-0.5	1.2	2.6	1.4	2.1	2.2	0.9	-0.3	1.9
Hearing difficulty/problems: Yes	1.1	1.6	4.4	2.1	1.9	0.7	1.2	0.3	1.0	0.7	1.7	1.1	0.6
Medication for hormone replacement therapy	1.1	1.2	3.0	0.3	-0.1	1.5	1.2	1.2	1.7	1.2	0.4	-0.8	1.2
Age when periods started (menarche)	1.1	2.7	6.2	-2.2	-0.8	1.7	-0.6	2.4	0.2	1.1	-1.5	-2.5	1.7
Hayfever, allergic rhinitis or eczema	1.1	2.3	3.7	-1.1	-1.1	-1.8	-1.6	-1.6	-1.9	-1.6	-0.1	1.5	-1.9
Sitting height	1.1	8.1	21.0	1.9	1.4	-3.4	-0.2	-4.2	-2.1	-2.4	0.5	4.6	-3.8
Number of incorrect matches in round	1.1	1.8	6.5	-1.8	-2.6	0.8	-0.5	0.8	-0.6	-0.3	-1.6	-2.0	0.1
Diabetes (self-reported)	1.1	1.7	5.4	2.3	0.9	0.1	1.4	-1.1	0.5	0.2	1.7	2.1	0.0
Impedance of arm (right)	1.1	5.4	21.2	-3.9	-1.6	1.2	-0.9	2.5	-0.1	0.4	-2.1	-4.6	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.3	-0.8	-0.8	-1.1	-1.8	-1.3	-1.8	-1.2	-0.8	1.3	-1.6
Loud music exposure frequency	1.1	1.2	3.3	1.4	-0.3	0.5	1.2	0.3	1.0	1.2	1.8	1.6	0.6
Comparative height size at age 10	1.1	6.2	13.8	0.3	-0.2	-3.0	-1.9	-3.6	-2.6	-3.2	-0.4	2.3	-3.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.4	0.3	-2.1	1.4	0.6	1.5	1.4	0.6	-0.7	0.3	1.3
Medication: Blood pressure	1.1	2.1	4.6	-0.2	0.4	0.8	1.2	1.4	1.8	1.3	1.9	-2.1	2.0
Heart disease (siblings)	1.1	1.3	2.7	0.1	-0.5	-1.4	-1.2	-1.3	-1.4	-1.6	-0.5	1.1	-1.2
Ulcerative Colitis (UC)	1.0	1.8	11.3	0.1	-3.4	0.5	1.8	1.0	0.9	0.2	-0.8	-0.7	0.7
Bipolar Disorder (2011)	1.0	1.0	2.1	-1.0	-0.5	1.2	0.7	1.5	0.4	1.0	0.0	-1.1	1.4
Schizophrenia (2014)	1.0	2.2	4.6	-1.6	-1.4	1.8	-0.5	2.2	0.3	1.3	-1.0	-1.6	2.0
Ulcerative Colitis	1.0	1.4	7.6	1.3	-2.8	0.9	1.4	0.8	0.7	-0.2	-0.6	-0.3	0.4
Systolic Blood Pressure	1.0	4.9	11.0	-0.3	-1.6	3.0	2.0	3.3	2.5	2.4	0.2	-1.6	2.9
Supplements: Zinc	1.0	1.1	3.4	1.8	-0.2	-0.8	-0.6	-1.5	-0.3	-0.7	1.2	0.9	-1.2
Medication: Levothyroxine sodium	1.0	1.8	4.5	2.1	1.2	0.7	1.6	0.6	1.8	0.8	1.2	1.5	1.1
Father’s age at death	1.0	1.3	6.4	-2.5	-1.1	0.3	-0.8	1.3	-0.5	0.5	0.1	-1.4	0.9
Prospective memory result	1.0	1.2	3.6	0.6	1.1	0.1	1.5	0.1	1.9	1.5	0.4	0.1	1.4
Length of working week for main job	1.0	1.1	2.3	1.5	0.5	1.3	1.2	0.7	1.0	1.3	1.0	1.0	0.5
Breastfed as a baby	1.0	1.2	3.6	-0.9	-1.2	1.8	-0.4	1.3	-0.1	0.6	-1.9	-0.5	0.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	7.7	-0.9	-1.7	0.9	-0.4	1.6	0.6	0.2	-0.1	-2.8	1.0
Health satisfaction	1.0	1.3	5.0	1.6	0.7	-0.8	0.3	-1.4	-0.2	-0.9	0.1	2.2	-1.1
Heart disease (mother)	1.0	1.2	4.0	-0.2	-0.1	2.0	1.0	1.6	1.2	0.9	-0.2	-0.7	1.3
Illnesses of father: Heart disease	1.0	1.4	2.8	-0.4	-0.8	-1.5	-1.7	-1.6	-1.3	-0.8	-0.3	-1.2	-1.2
Illnesses of siblings: Diabetes	1.0	1.3	2.4	0.2	-1.6	-0.8	-1.1	-1.3	-1.2	-1.4	-0.9	0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.6	0.2	-1.6	-1.7	-1.9	-1.5	-1.3	-0.9	-0.1	-0.1	-1.4
High cholesterol (Self-reported)	1.0	1.7	3.2	0.5	1.8	1.5	1.1	0.9	1.3	1.8	0.8	1.1	1.6
Bipolar Disorder or Schizophrenia	0.9	2.2	5.0	-1.0	-1.0	2.1	-0.2	2.2	0.7	1.7	-0.0	-1.7	2.1
Schizophrenia vs Biploar Disorder	0.9	1.2	3.4	-0.4	0.1	1.0	-0.0	1.8	1.1	0.9	-0.3	-1.8	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.0	0.7	1.4	1.2	1.3	1.0	1.1	0.8	0.7	-0.0	0.8
Vitamin and mineral supplements	0.9	1.2	2.7	1.1	0.5	1.6	1.6	0.7	1.2	0.8	1.0	1.1	0.8
Severe depression (siblings)	0.9	1.1	3.1	-1.1	-0.8	1.0	0.6	1.5	0.5	0.3	-0.7	-1.8	1.1
Relative age voice broke	0.9	1.4	5.5	-0.4	0.2	1.7	0.5	2.3	0.9	0.8	-0.8	1.0	1.6
Serious illness, injury or assault to yourself	0.9	1.1	2.7	0.0	-0.2	-1.5	-0.8	-1.7	-1.3	-0.9	0.6	0.1	-1.5
Had other major operations	0.9	1.1	4.6	0.7	0.0	-1.0	0.5	-1.3	-0.3	-1.0	0.8	2.1	-1.2
Number of live births	0.9	1.2	2.9	0.5	1.2	1.7	0.7	1.5	0.8	0.4	-0.2	-1.6	1.2
Worry too long after embarrassment	0.9	1.5	4.2	-0.7	-1.0	1.5	0.5	2.0	0.8	0.7	-1.1	-1.3	1.6
Medication: Allopurinol	0.9	1.2	2.7	0.1	0.1	-1.0	-0.7	-1.6	-1.2	-1.2	0.4	1.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.1	0.8	1.0	1.0	1.2	0.8	1.8	1.4	0.2	-0.2	1.1
Back pain experienced in last month	0.9	1.3	4.3	-1.8	-2.1	-0.5	-1.2	-0.2	-1.0	-0.7	-0.1	-1.3	-0.1
Chronotype (morning person)	0.8	1.8	5.2	2.0	2.1	-0.9	1.0	-1.2	0.0	-0.5	1.0	2.3	-0.5
Diabetes (father)	0.8	1.0	2.3	1.5	1.0	0.8	1.4	-0.0	1.0	0.8	1.2	0.9	0.6
Pack years adult smoking proportion	0.8	1.2	4.3	-0.7	0.5	-2.1	-1.1	-1.7	-1.1	-0.7	0.0	0.1	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	7.3	2.7	1.4	-0.2	0.8	-1.2	0.1	0.6	1.5	1.6	-0.9
Qualifications: None of the above	0.8	1.8	7.4	0.5	2.7	0.8	1.6	0.7	1.4	1.1	0.9	0.2	1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.8	1.0	-0.5	-1.3	-1.1	-1.8	-1.7	-0.9	0.5	1.4	-1.9
Depression (self-reported)	0.8	0.9	3.2	1.8	0.2	0.3	1.2	-0.2	0.7	0.4	0.6	1.8	-0.1
Headache pain in last month	0.8	1.4	2.8	0.2	-0.9	-1.7	-0.5	-1.6	-0.7	-1.6	0.4	1.6	-1.2
Medication for pain relief, constipation, heartburn	0.8	1.4	4.9	-1.6	-2.2	0.5	-1.0	1.1	-0.1	0.6	-1.7	-1.1	0.4
Family relationship satisfaction	0.8	1.0	2.7	1.2	1.7	1.2	1.4	0.5	0.8	0.6	-0.9	0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.9	1.4	1.7	-0.4	1.3	-1.1	0.1	0.2	0.6	1.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	1.4	0.8	0.5	1.0	0.4	1.0	0.5	1.5	1.3	1.0
Diastolic blood pressure, automated reading	0.8	2.4	6.5	1.6	-0.2	2.6	1.8	2.3	1.5	1.0	-0.3	0.3	1.6
Heart attack/myocardial infarction (self-reported)	0.8	1.0	4.6	2.2	0.6	0.1	1.2	-0.3	1.0	0.6	1.2	1.0	0.3
Pack years of smoking	0.8	1.1	4.5	-0.9	0.3	-2.1	-0.9	-1.8	-0.8	-0.6	0.1	-0.0	-0.9
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	0.2	1.1	-0.9	0.3	-1.3	-0.7	-1.1	-1.0	0.1	-1.2
Reaction Time	0.7	1.3	5.6	2.4	0.7	0.9	1.2	-0.1	0.9	0.7	1.5	1.0	0.1
Age at First Birth	0.7	1.0	4.3	-0.7	-2.1	-0.5	-0.6	-0.7	-1.2	-1.0	-0.4	-0.7	-1.1
Blood Eosinophil Count	0.7	5.4	14.9	1.2	0.9	-2.8	-1.0	-3.5	-2.0	-1.6	1.0	3.9	-2.8
Height	0.7	12.8	26.1	-0.5	0.5	-5.0	-1.9	-5.1	-3.8	-4.6	-1.9	3.6	-4.6
Smoking Status	0.7	1.6	6.0	1.9	2.0	-0.3	-0.2	-0.9	0.2	0.5	2.5	0.9	-0.4
Qualifications: CSEs or equivalent	0.7	0.9	1.5	0.4	0.8	-1.0	-1.0	-1.1	-1.0	-0.8	1.2	0.5	-1.2
High blood pressure (mother)	0.7	0.9	3.2	0.5	1.8	0.3	1.6	0.3	1.1	0.7	0.5	0.8	0.8
Past tobacco smoking	0.7	1.3	3.8	-1.9	-0.2	-0.5	-0.7	0.0	-1.3	-0.8	-1.9	-1.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.9	-0.3	-0.4	-1.2	-0.8	-1.1	-0.7	-0.5	-0.2	2.0	-1.0
Medication: Ramipril	0.7	0.8	3.1	1.5	0.9	0.1	0.9	-0.6	0.1	0.1	1.0	1.8	-0.4
Happiness	0.7	0.8	2.5	1.6	1.3	-0.2	0.7	-0.7	0.0	-0.1	0.2	1.5	-0.5
Asthma	0.7	1.3	2.4	0.6	0.3	0.9	1.5	0.9	1.3	1.6	1.3	1.2	1.2
Medication: Lansoprazole	0.7	0.8	2.4	-0.9	-1.2	-0.7	-1.5	-0.7	-1.2	-0.5	-0.6	-0.2	-0.8
Illnesses of mother	0.7	0.9	2.7	-0.1	-1.4	-0.8	-1.6	-0.6	-1.1	-0.9	-0.8	-0.2	-1.0
Hair/balding pattern: Pattern 4	0.7	1.8	4.3	0.3	-0.3	-1.9	-1.6	-2.1	-1.2	-0.8	0.4	1.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	1.4	0.1	1.1	1.3	0.9	1.1	0.5	0.1	0.6	0.7
Eye problems/disorders: None of the above	0.7	0.8	2.9	-0.7	-0.4	-1.7	-0.2	-0.9	-0.5	-1.0	-0.1	1.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	4.9	1.3	-0.2	-0.1	0.6	-0.2	0.7	0.1	-0.8	2.2	-0.1
Medication: Blood pressure	0.7	1.3	5.9	1.1	0.8	-0.7	0.4	-1.3	-0.7	-0.8	-0.3	2.4	-1.2
Mean time to correctly identify matches	0.7	1.3	3.0	1.7	0.6	1.2	1.6	0.5	1.2	0.9	1.2	1.1	0.8
Suffer from ‘nerves’	0.7	1.1	3.0	-1.6	-0.1	1.2	-0.3	1.7	0.3	0.7	-0.7	-1.1	1.3
Medication: Aspirin	0.7	0.9	4.1	0.3	2.0	0.9	0.3	0.6	0.7	0.9	1.0	0.5	1.1
Medication: Gliclazide	0.7	0.8	2.1	0.4	1.5	-0.6	-0.1	-0.6	-0.4	-1.0	-1.3	1.1	-0.9
Illnesses of father: High blood pressure	0.7	0.9	1.9	-0.7	0.1	1.3	0.0	1.2	0.8	1.1	-0.4	-1.0	1.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.7	-1.4	-0.1	-0.1	-1.0	0.9	-0.3	0.6	0.9	-1.7	0.7
Alzheimer’s Disease (including proxy)	0.6	0.9	4.5	-0.6	0.0	-0.9	-0.8	-0.8	-1.0	-0.8	-2.1	-0.0	-0.9
HbA1C	0.6	0.7	1.6	0.7	-0.1	-0.3	0.0	-1.2	-0.9	-0.9	-1.3	0.1	-1.3
Sensitivity / hurt feelings	0.6	1.1	3.3	-1.6	-1.2	0.6	-0.3	1.8	0.4	0.2	-0.1	-0.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	-0.1	0.8	-1.1	-1.2	-1.1	-1.0	-1.0	-0.1	0.5	-1.2
Heart attack	0.6	0.8	3.5	1.9	0.4	0.3	1.1	0.0	1.0	0.7	1.0	0.8	0.5
Alcohol intake versus 10 years previously	0.6	1.0	2.7	-1.3	-0.6	0.8	0.4	1.2	0.5	0.5	-1.0	-1.6	1.1
Pulse rate	0.6	1.0	2.4	0.9	1.0	-0.4	0.1	-0.9	-0.9	-1.5	-1.6	0.7	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.4	1.8	0.4	0.5	0.9	-0.5	0.3	-0.6	0.2	1.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.9	1.1	0.7	0.2	1.5	0.2	0.9	0.0	1.7	-0.2	0.5
Number of children fathered	0.6	0.7	1.7	0.2	1.3	-1.0	0.5	-0.5	0.5	0.8	1.0	1.2	0.0
Neck or shoulder pain in last month	0.6	0.8	2.8	-0.7	-1.0	-0.4	-0.9	-0.6	-0.7	-1.2	-0.5	-1.7	-0.6
Number of full sisters	0.6	0.7	3.6	-0.7	-0.7	-0.1	-1.9	0.3	-0.7	-0.5	-0.9	-0.9	-0.3
Smoking status: Previous	0.6	0.8	2.2	1.5	0.2	0.3	1.1	-0.3	1.1	0.3	1.2	1.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.0	-1.7	0.1	-1.2	-1.5	-0.6	-1.7	-1.0	0.3	-0.8	-1.1
Eye problems/disorders: Cataract	0.6	0.7	2.0	0.2	0.3	1.4	0.6	1.1	0.8	0.9	0.6	-1.0	0.6
Asthma (self-reported)	0.6	1.3	2.4	0.2	-0.0	0.9	1.4	1.1	1.3	1.6	1.1	1.3	1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	1.1	0.8	-0.6	0.6	-0.6	-0.2	-1.1	-0.8	1.0	-1.2
Myopia	0.6	0.8	2.8	1.7	1.1	0.7	0.6	0.5	0.6	0.5	0.0	1.6	0.2
Supplements: Calcium	0.6	0.7	2.9	-1.0	-1.3	0.3	-0.7	0.5	-0.0	-0.4	0.1	-1.7	0.0
Depression (Nagel 2018)	0.5	0.7	3.8	1.2	0.5	-0.3	0.2	-0.7	0.1	0.1	2.0	0.8	-0.5
Blood Red Count	0.5	4.7	12.7	-2.4	-1.5	1.8	0.4	3.3	1.3	0.6	-2.0	-3.6	2.3
Waist Hip Ratio (WHR)	0.5	2.0	9.4	-1.9	-0.4	1.2	-0.7	1.6	-0.3	-0.5	-1.4	-3.1	0.7
Hand grip strength (right)	0.5	1.3	2.4	0.4	-0.6	1.5	1.5	1.5	1.1	1.5	0.0	0.8	1.4
Multivitamins +/- minerals	0.5	0.6	1.2	0.5	0.9	-1.1	-0.7	-0.8	-0.7	-0.2	0.3	1.1	-0.8
Medication: Simvastatin	0.5	0.7	1.7	0.4	1.0	1.2	0.5	0.6	0.8	1.3	0.4	0.3	1.2
Medication: Cholesterol lowering	0.5	0.8	2.3	-0.2	0.6	-0.7	-1.2	-1.5	-1.2	-0.3	0.0	0.9	-1.1
Standing height	0.5	4.5	8.6	-1.0	0.2	-2.9	-1.4	-2.7	-2.6	-2.7	-1.3	1.6	-2.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.5	1.4	0.8	0.3	1.0	0.3	1.0	0.6	1.2	1.9	0.7
Medication: Amlodipine	0.5	0.6	2.4	-0.8	-1.1	-0.3	-0.0	0.1	-0.8	-1.1	-1.5	0.1	-0.5
High blood pressure (siblings)	0.5	0.7	1.4	-0.1	0.6	1.0	1.0	1.0	0.8	1.1	-0.0	0.5	1.2
Angina (self-reported)	0.5	0.7	1.8	0.4	0.9	-1.0	-1.3	-1.1	-0.7	-0.9	0.2	0.1	-0.8
Had major operations	0.5	0.5	1.4	0.3	-0.3	-0.9	0.2	-0.9	-0.4	-1.2	-0.6	0.7	-1.1
Loneliness, isolation	0.5	0.7	3.5	0.6	0.7	-0.5	0.5	0.0	0.4	0.2	1.9	1.4	0.3
Diabetes diagnosed by doctor	0.5	0.7	2.6	1.1	1.0	-0.2	0.4	-1.1	-0.0	0.2	1.0	1.6	-0.2
Ever taken oral contraceptive pill	0.5	0.5	2.0	1.4	0.5	0.3	0.6	0.4	0.6	-0.4	-1.1	0.9	0.2
Commuting to job workplace: Public transport	0.5	0.6	2.6	-1.4	-1.6	0.6	0.2	0.9	-0.1	0.2	-0.7	-0.2	0.3
Ever smoked	0.5	0.8	2.5	1.3	0.4	0.7	0.4	0.1	0.9	1.1	1.6	0.9	0.6
Irritability	0.5	0.9	2.8	0.5	0.2	0.4	1.7	0.8	1.3	1.1	0.9	0.8	1.1
Risk taking	0.5	0.8	2.3	0.3	-1.0	-0.6	-0.6	-0.8	-0.9	-1.0	-1.5	-0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.3	0.9	-0.4	-0.9	-1.1	-1.8	-1.4	-1.1	-0.6	0.7	-1.8
Coronary Artery Disease (CAD)	0.4	0.5	3.0	-0.3	1.7	-0.3	-0.5	-0.6	-0.6	-0.7	0.0	-0.0	-0.9
Neuroticism (2016)	0.4	0.6	0.9	0.9	-0.3	0.9	0.5	0.9	0.8	0.9	0.8	0.4	0.8
Cardiovascular Disease	0.4	1.2	5.2	1.1	1.3	-0.7	0.9	-1.2	0.2	-0.4	1.0	2.3	-0.4
Hypothyroidism (self reported)	0.4	0.9	2.8	1.1	1.1	0.3	0.5	0.6	1.0	0.9	1.0	1.7	0.7
Medication: Metformin	0.4	0.6	3.5	0.4	0.5	0.5	0.1	-0.3	0.1	0.8	0.7	1.9	0.3
Maternal smoking around birth	0.4	0.5	1.2	0.9	1.1	0.6	0.6	0.6	0.9	0.4	0.7	-0.5	0.6
Medication: Atenolol	0.4	0.6	1.2	0.2	0.7	-0.0	0.6	0.5	1.1	0.7	0.9	-1.1	0.9
Alcohol usually taken with meals	0.4	0.6	1.8	0.4	-0.2	-0.6	-1.0	-0.6	-1.0	-0.5	-0.2	1.3	-0.9
Hearing difficulty/problems with background noise	0.4	0.6	2.1	0.9	-0.0	0.9	0.6	0.8	0.6	0.8	1.5	0.0	0.8
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	1.5	-0.2	0.2	0.9	0.2	0.3	-0.1	0.6	1.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	5.0	2.2	0.6	0.3	0.8	-0.7	0.1	0.2	0.4	1.3	-0.7
Financial difficulties in last 2 years	0.4	0.5	1.1	0.3	0.5	1.0	0.7	1.0	0.5	0.8	0.7	0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	-1.1	0.1	-1.5	-1.2	-1.3	-1.4	-1.2	-0.9	0.8	-1.5
Qualifications: College or University degree	0.4	1.2	5.6	-1.0	-2.4	-0.7	-0.9	-0.5	-1.3	-0.2	-1.1	0.1	-1.1
Medication: Aspirin	0.4	0.5	3.1	0.5	1.7	0.7	0.0	0.3	0.3	0.3	0.5	0.5	0.5
Breast cancer (self-reported)	0.4	0.5	2.3	-0.7	-1.5	-0.4	-0.2	-0.3	-0.5	-0.6	-0.1	-0.8	-0.5
Hearing aid user	0.4	0.5	1.5	0.7	1.2	-0.7	-0.2	-0.9	-0.2	-0.6	-0.1	0.3	-0.9
Mother’s age at death	0.4	0.5	1.1	-1.1	-0.8	-0.6	-0.9	-0.3	-0.9	-0.0	-0.4	-0.7	-0.4
Financial situation satisfaction	0.4	0.5	1.6	0.9	1.3	0.0	0.9	-0.3	0.7	0.5	1.1	0.4	0.2
Medication: Bendroflumethiazide	0.4	0.5	1.8	1.0	-0.2	0.3	1.3	0.1	1.0	0.8	0.0	0.7	0.7
Alcohol drinker status: Never	0.4	0.4	2.4	-1.5	-0.4	0.1	-0.4	0.6	-0.2	0.1	-0.3	-1.1	0.2
Number of operations (self-reported)	0.4	0.6	1.4	0.1	-0.2	-1.0	0.7	-1.0	-0.4	-1.2	-0.1	1.1	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.4	-1.6	0.2	-0.2	-0.9	0.1	-1.2	-0.4	-0.2	-0.3	-0.4
Fasting Glucose	0.3	0.4	1.2	-0.6	-1.1	0.2	-0.8	0.5	-0.5	-0.6	-1.0	-0.1	-0.3
Rheumatoid Arthritis	0.3	0.5	2.3	0.0	-0.2	1.0	-0.2	0.9	0.1	0.1	-0.2	-1.5	0.6
Respiratory disease	0.3	0.6	2.0	-1.2	-0.1	-0.3	0.5	0.3	0.4	0.9	1.4	0.7	0.8
Hand grip strength (left)	0.3	0.8	2.1	-0.1	-0.6	1.3	0.7	1.3	0.7	1.4	0.1	-0.4	1.1
Angina	0.3	0.5	1.8	0.2	0.8	-0.7	-1.3	-0.7	-0.6	-0.7	-0.1	0.0	-0.5
Current tobacco smoking	0.3	0.4	1.4	0.1	1.1	-0.4	-1.2	-0.4	-0.8	-0.2	0.4	-0.5	-0.5
High blood pressure	0.3	0.8	2.8	1.3	0.9	0.1	1.7	0.1	0.9	-0.1	1.2	0.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.0	-1.0	-0.9	-0.1	-0.4	0.4	0.2	-0.1	-0.5	-0.6	0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	0.6	1.1	0.0	0.5	-0.5	0.2	0.4	0.6	0.8	-0.1
Allergy	0.3	0.6	2.3	-0.0	0.4	0.9	-0.4	0.8	0.3	0.2	-1.1	-1.5	0.6
Time employed in main current job	0.3	0.3	1.6	-0.7	0.8	-0.0	-0.2	0.2	-0.3	-0.3	0.6	-1.3	0.1
Falls in the last year	0.3	0.5	1.8	1.3	0.5	0.1	0.6	-0.5	0.4	0.1	1.3	0.5	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.5	-0.8	0.2	-0.9	-1.0	-1.1	-1.0	-0.7	-1.1	0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	-0.2	-0.6	1.3	-0.2	1.1	0.2	0.5	0.7	0.8	0.8
Gout (self-reported)	0.3	0.4	0.8	-0.6	-0.4	-0.6	-0.6	-0.8	-0.8	-0.9	-0.1	0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.9	-0.4	0.7	-0.6	1.1	-0.5	0.1	0.4	-0.8	0.6
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	-0.7	0.0	0.3	0.2	0.8	0.8	1.2	1.1	0.1	1.2
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.1	0.6	0.8	0.7	0.7	0.9	-0.0	-0.4	-0.0	0.5
Medication: Omeprazole	0.3	0.3	0.8	-0.9	0.9	-0.2	-0.6	-0.3	-0.9	-0.0	0.4	0.4	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.6	1.0	-0.1	0.1	-0.1	0.2	0.2	1.1	0.7	-0.4
Commuting to job workplace: Walk	0.3	0.3	1.4	0.3	-1.2	-0.4	-0.3	-0.4	-0.1	-0.6	-0.7	0.4	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	3.3	0.6	0.4	0.0	1.0	-0.2	0.2	0.1	0.5	1.8	-0.1
Medication: Atorvastatin	0.3	0.4	2.0	0.6	0.8	0.6	0.5	0.2	0.5	0.2	0.1	1.4	0.2
Pain experienced in last month	0.3	0.5	0.9	0.4	0.6	0.8	1.0	0.8	0.5	0.7	-0.8	0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	0.2	-0.5	-0.2	-0.9	-0.5	-0.8	-0.3	-0.8	0.4	-1.0
Heel T-Score	0.2	1.5	4.4	2.1	0.9	1.0	1.4	0.4	1.2	1.2	1.8	-0.4	0.7
Medication: Co-codamol	0.2	0.3	0.6	0.1	0.0	-0.3	0.7	-0.6	0.6	0.4	0.7	0.8	0.3
Average weekly fortified wine intake	0.2	0.2	0.6	-0.3	-0.7	-0.1	-0.8	-0.1	-0.8	-0.7	-0.0	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.5	-0.2	0.9	-0.4	0.5	-0.0	0.6	0.5	0.8	0.5
Forced vital capacity (FVC)	0.2	0.9	1.8	-0.7	0.2	-1.2	-0.9	-1.2	-1.1	-0.9	-0.6	0.9	-1.3
Mouth/teeth dental problems	0.2	0.3	1.4	-0.6	0.3	1.2	0.2	0.2	-0.8	0.3	-0.5	-0.1	-0.5
Illnesses of siblings	0.2	0.3	0.8	-0.7	-0.1	0.4	0.1	0.6	0.4	0.9	0.2	-0.9	0.4
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.2	0.3	-0.7	-0.3	-0.9	-0.5	-0.6	0.2	0.9	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.6	-0.7	-0.5	0.4	0.4	0.7	-0.2	-0.2	-0.5	0.8
Glaucoma (self-reported)	0.2	0.3	1.5	1.2	0.4	0.1	0.7	-0.5	0.2	-0.4	0.2	-0.0	-0.4
Birth weight	0.2	0.4	1.1	-1.0	-0.0	0.9	0.1	1.0	0.0	0.2	-0.5	-1.0	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.0	0.4	0.7	-0.2	0.3	0.4	0.4	0.7	0.2	0.4
Forced vital capacity (FVC), Best measure	0.2	0.7	1.2	-1.1	0.1	-0.7	-0.9	-0.8	-1.1	-0.6	-1.0	0.6	-1.1
Knee pain experienced in last month	0.2	0.4	1.0	0.5	-0.2	-0.6	-0.3	-0.9	-0.2	-0.8	1.0	-0.5	-0.5
Hypertension (Self-reported)	0.2	0.6	2.5	0.8	0.8	0.2	1.6	0.3	0.9	0.1	0.9	0.7	0.7
Long-standing illness, disability or infirmity	0.2	0.3	1.0	0.1	-0.0	-1.0	-0.1	-0.7	-0.6	-0.8	0.5	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.4	1.2	0.1	0.2	-0.2	-0.2	0.4	0.2	0.6	-0.6	0.4
Friendships satisfaction	0.2	0.3	0.7	-0.1	0.6	0.3	0.7	0.5	0.2	0.8	-0.8	0.1	0.2
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.7	-0.4	-0.4	-0.1	-0.4	-0.2	0.1	0.8	-0.7	0.2
Smoking status: Current	0.2	0.4	1.3	0.3	1.1	-0.2	-1.1	-0.3	-0.6	-0.0	0.6	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	0.1	-0.2	0.5	0.7	0.6	0.8	0.8	0.6	-0.1	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.8	-0.4	0.3	-0.1	0.4	0.1	0.2	0.3	1.3	-0.3	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-1.0	-1.1	-0.0	-1.3	-0.2	-0.8	-0.1	-1.1	-0.5	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.4	0.1	-0.5	0.5	-0.2	0.4	0.5	0.5	0.6	0.3
Bipolar Disorder (2018)	0.1	0.1	0.9	0.3	0.1	0.1	-0.1	-0.3	0.0	0.2	0.9	0.4	0.0
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.1	-0.4	-0.3	-0.6	-0.2	-0.6	0.3	0.5	0.0	-0.4
Blood Platelet Count	0.1	1.6	4.8	2.2	0.5	1.8	0.7	0.8	1.4	1.4	1.1	-0.4	0.9
Blood White Count	0.1	0.8	4.2	2.0	0.6	0.6	1.1	-0.1	0.9	-0.1	0.5	0.8	-0.2
Lung FEV1/FVC ratio	0.1	0.3	1.0	0.0	-0.8	-0.2	-0.5	-0.3	-0.7	-1.0	-0.4	-0.5	-0.6
Lung FVC	0.1	0.7	2.4	-1.5	0.1	0.7	0.1	1.4	0.3	0.4	-1.0	-0.4	0.8
Tanning	0.1	0.8	3.5	0.1	0.1	0.0	-0.1	0.1	0.9	0.9	1.9	-1.6	0.7
Number of treatments/medications taken	0.1	0.3	0.6	0.5	0.5	0.6	0.8	0.5	0.6	0.0	0.5	-0.1	0.5
Average weekly spirits intake	0.1	0.1	0.4	-0.4	0.1	-0.6	-0.2	-0.3	0.2	-0.2	-0.4	-0.2	0.3
Townsend deprivation index at recruitment	0.1	0.1	0.6	0.4	0.0	-0.3	0.2	-0.8	0.2	-0.4	-0.2	-0.1	-0.1
Taking other prescription medications	0.1	0.2	1.1	0.7	0.1	-0.0	0.1	-0.2	0.2	-0.0	1.1	0.6	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.9	0.2	0.1	0.4	-0.4	0.3	-0.3	-0.4	-0.3	0.9	0.1
Fluid intelligence score	0.1	0.2	0.8	0.9	-0.1	0.3	0.1	-0.1	0.3	0.9	0.3	0.5	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.7	-0.2	0.8	-0.0	0.3	-0.2	0.4	0.1	0.2	-0.7	0.2
Exposure to tobacco smoke outside home	0.1	0.2	1.5	0.2	1.2	0.0	-0.0	-0.0	0.3	-0.4	-0.3	0.1	0.0
Shortness of breath walking on level ground	0.1	0.1	0.2	0.0	-0.3	-0.5	-0.2	-0.2	0.4	-0.2	0.2	0.3	-0.0
Pulse rate, automated reading	0.1	0.3	0.8	0.3	0.9	0.2	0.7	-0.0	-0.2	-0.5	-0.9	0.2	-0.2
Alcohol intake frequency.	0.1	0.1	0.3	0.1	-0.5	-0.3	0.6	0.2	0.5	-0.4	-0.2	0.2	0.5
Overall health rating	0.1	0.3	1.0	1.0	0.3	0.0	0.4	-0.4	0.5	0.5	0.9	0.2	0.2
Chest pain or discomfort	0.1	0.1	0.4	0.7	0.0	0.1	0.2	-0.3	-0.2	-0.3	0.6	-0.0	-0.6
Age at last live birth	0.1	0.1	0.3	0.3	0.6	-0.3	-0.5	-0.1	-0.3	-0.2	0.2	-0.0	-0.2
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.4	-0.2	0.1	0.5	0.3	0.4	0.0
Osteoporosis (self-reported)	0.1	0.2	0.4	-0.5	0.0	-0.6	-0.4	-0.3	-0.2	-0.3	0.5	-0.6	-0.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.6	0.5	0.4	0.3	-0.1	0.1	-0.2	-0.7	-0.5	-0.0
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.3	0.4	0.3	-0.3	-0.1	-0.4	0.3	-0.3	0.4	-0.2
Hair Pigment	0.0	0.2	0.6	-0.1	0.4	-0.5	-0.4	-0.8	-0.4	-0.4	-0.3	-0.3	-0.4

Hub : Genes

GTF3A

Models

Trait associations