Best TWAS P=6.44e-11 · Best GWAS P=4.52e-11 conditioned to 0.0114
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ARHGEF40 | 0.34 | 0.32 | enet | 17 | 0.31 | 1.5e-17 | -5.8 | -5.5 | 3.4e-08 | -0.07 | 0.17 | 0.83 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | TOX4 | 0.19 | 0.06 | lasso | 7 | 0.05 | 6.6e-05 | -6.5 | -5.4 | 5.1e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Testis | TOX4 | 0.31 | 0.00 | enet | 24 | 0.04 | 6.8e-03 | -6.5 | -6.5 | 9.4e-11 | 0.65 | 0.02 | 0.79 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -6.4 | -6.4 | 1.7e-10 | 0.95 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -6.5 | -6.5 | 1.1e-10 | 0.96 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -6.5 | -6.5 | 6.4e-11 | 0.92 | 0.01 | 0.79 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAB2B | 0.12 | 0.04 | blup | 52 | 0.07 | 2.1e-03 | -4.0 | -5.7 | 1.2e-08 | 0.73 | 0.01 | 0.38 | FALSE |