Hub : Genes

RAB2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1860	0.0670	8.7e-03	0.083	NA	0.030	NA	0.081	2.4e-05	NA	8.5e-03	NA	3.2e-05
2	GTEx	Artery Tibial	0.1370	0.0501	4.8e-03	0.088	NA	0.062	NA	0.065	2.1e-07	NA	1.2e-05	NA	7.7e-06
3	GTEx	Skin Sun Exposed Lower leg	0.1660	0.0480	2.0e-04	0.079	NA	0.063	NA	0.067	4.3e-07	NA	5.8e-06	NA	3.4e-06
4	YFS	Blood	0.0632	0.0140	3.1e-09	0.063	0.041	0.058	0.062	0.062	8.4e-20	2.1e-13	3.4e-18	2.1e-19	1.6e-19
5	TCGA	Pheochromocytoma and Paraganglioma	0.1210	0.0540	1.7e-03	0.080	0.059	0.066	NA	0.068	4.4e-04	2.3e-03	1.3e-03	NA	1.1e-03
6	TCGA	Prostate Adenocarcinoma	0.0484	0.0244	2.3e-03	0.009	0.017	0.002	NA	0.004	3.3e-02	6.2e-03	1.8e-01	NA	1.1e-01
7	TCGA	Testicular Germ Cell Tumors	0.1180	0.0610	8.3e-03	0.040	0.068	0.057	NA	0.063	1.5e-02	2.1e-03	4.4e-03	NA	3.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	2.0	-0.5	0.3	-0.7	0.8	1.4	0.9	0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	-1.0	-1.3	-1.1	-0.7	-0.4	0.0	0.5
Depressed Affect (Nagel 2018)	2.4	5.1	11.3	-2.5	-3.2	-2.0	-3.4	-0.0	0.3	2.0
Depression (Nagel 2018)	1.4	2.1	3.3	-1.6	-1.4	-1.8	-1.6	-1.5	-1.5	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.3	-0.1	-1.5	-0.5	-1.8	1.2	-1.1	0.6
Neuroticism (Nagel 2018)	1.3	2.9	6.4	-1.9	-2.3	-1.4	-2.5	0.3	0.8	1.6
Schizophrenia (2018)	0.8	1.6	3.6	-0.9	-1.9	-0.9	-1.6	-1.7	-0.7	0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.4	-1.0	0.2	-0.8	-1.0	-0.5	0.4
Worry (Nagel 2018)	0.7	1.4	3.6	-0.4	-0.6	-0.1	-1.2	0.9	1.8	1.9
Alzheimer’s Disease (in mother)	0.7	0.9	2.3	-0.6	-1.5	-0.1	-1.0	-1.4	0.4	0.4
Alzheimer’s Disease (in father)	0.9	0.9	2.0	0.4	0.6	1.2	1.2	-1.4	0.8	-0.7
Alzheimer’s Disease (including proxy)	0.7	0.9	4.6	-0.3	-0.7	0.7	-0.0	-2.1	0.9	0.2
Crohns Disease (2017)	1.1	2.4	5.5	1.0	1.6	1.1	2.3	-0.7	-0.3	-2.3
Irritable Bowel Disease (IBD)	1.0	2.5	5.9	1.3	1.7	1.1	2.2	-0.9	-0.7	-2.4
Ulcerative Colitis (UC)	0.6	1.1	2.2	1.0	1.0	0.8	1.1	-0.8	-0.9	-1.5
Major Depression (MDD)	1.5	1.9	3.3	1.8	0.9	1.5	-0.0	1.6	1.8	1.1
Reaction Time	0.7	1.3	3.3	1.7	-0.1	1.8	-0.2	-1.4	0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.8	0.4	-1.8	0.1	-2.0	0.1	-0.9	1.0
Breast Cancer	0.6	1.5	2.7	-1.3	-0.8	-1.6	-1.2	-1.6	-1.1	-0.0
Ovarian Cancer	1.5	2.0	5.7	-2.0	-0.9	-2.4	-0.9	-0.6	-1.6	0.1
Prostate Cancer	0.6	0.9	2.2	-0.7	-0.7	-0.9	-1.1	0.9	0.2	1.5
Age at First Birth	2.2	3.2	10.3	0.9	0.1	0.8	-0.5	3.2	2.2	2.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.2	-0.1	0.1	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.7	2.3	4.9	-1.6	0.9	-2.2	0.7	-1.0	-2.1	-1.3
Coronary Artery Disease (CAD)	1.0	1.2	3.2	0.5	1.2	1.7	1.8	0.3	0.6	-0.0
Crohns Disease (2012)	1.0	1.6	4.2	0.9	1.5	1.1	2.1	1.3	1.2	-0.1
Mean Putamen Volume	0.5	0.6	1.2	1.0	-0.6	0.7	-0.6	0.5	1.1	0.6
Fasting Glucose	0.9	1.1	3.6	-1.5	1.0	-1.9	0.8	0.5	-0.3	0.1
HbA1C	0.9	1.0	2.6	-1.6	-0.5	-1.4	-0.3	1.3	-0.8	0.1
HDL Cholesterol	0.2	0.4	1.3	1.0	0.1	0.6	-0.3	-1.1	-0.1	0.1
LDL Cholesterol	0.1	0.1	0.7	0.2	0.5	-0.0	0.1	0.8	-0.1	-0.1
Lupus	0.6	0.9	2.6	-0.0	0.4	-0.2	0.5	1.6	1.4	1.0
Neuroticism (2016)	0.8	1.1	2.7	-1.7	-0.9	-1.6	-0.7	0.3	-0.3	1.0
Primary Biliary Cirrhosis	1.0	1.5	3.8	1.3	-0.0	1.8	0.5	1.9	1.1	0.4
Rheumatoid Arthritis	0.3	0.4	0.7	0.7	0.8	0.3	0.7	-0.1	-0.5	-0.7
Schizophrenia (2014)	0.5	1.1	3.6	-0.9	-1.0	-0.9	-0.6	-1.9	-1.2	-0.3
Triglycerides	0.5	0.8	1.9	-0.5	1.2	-0.3	1.3	0.5	-0.4	-1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	1.0	1.6	1.0	1.5	0.9	0.3	-0.2
Ulcerative Colitis	0.5	0.8	1.4	1.1	1.1	0.8	1.2	0.3	-0.7	-0.7
Blood Eosinophil Count	0.4	3.2	9.4	-0.3	-2.6	-0.6	-3.1	-2.1	-1.2	0.3
Blood Platelet Count	0.3	3.0	15.8	-0.8	-0.7	0.2	-0.6	-4.0	-1.8	-0.9
Blood Red Count	0.9	8.7	17.8	2.7	4.2	2.0	3.8	-1.5	-1.0	-3.8
Blood White Count	0.2	1.2	3.0	-0.6	0.8	-0.1	1.0	-1.7	-1.2	-1.5
Heel T-Score	0.5	3.9	7.7	-1.5	-2.5	-1.2	-2.8	-0.7	1.3	2.7
BMI	1.1	6.4	20.5	0.7	2.0	0.5	2.7	-1.5	-3.2	-4.5
Height	1.1	21.8	51.6	5.2	5.0	4.2	4.8	1.8	-2.3	-7.2
Waist Hip Ratio (WHR)	0.9	4.1	7.6	1.0	2.4	0.9	2.2	-2.8	-1.4	-2.5
Systolic Blood Pressure	0.2	0.8	1.4	0.9	0.7	0.7	0.3	-1.2	1.2	0.9
Smoking Status	3.8	9.0	21.1	0.9	4.0	-0.1	3.7	-2.9	-1.6	-4.6
Allergy or Eczema	0.4	1.1	4.8	0.2	-1.6	-0.2	-2.2	0.3	-0.0	0.7
Cardiovascular Disease	0.2	0.7	1.5	-0.9	-1.2	-0.6	-1.1	-1.0	0.0	0.3
Hypothyroidism (self reported)	0.4	0.9	2.3	0.8	0.9	0.0	0.4	0.6	-1.4	-1.5
Respiratory disease	1.4	3.2	8.3	-2.4	-1.5	-2.9	-1.4	-0.3	-2.0	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.6	-0.3	0.8	-0.2	1.0	0.7	0.3
Lung FEV1/FVC ratio	0.5	2.6	5.1	1.5	2.3	1.0	1.8	-1.3	-0.3	-2.1
Lung FVC	0.4	2.0	2.8	-1.7	-1.5	-1.5	-1.6	-1.6	-1.2	-0.1
Neuroticism	0.8	1.9	4.9	-2.2	-1.0	-2.2	-1.2	-0.7	-0.9	0.2
Chronotype (morning person)	0.5	1.1	2.4	0.1	1.1	-0.2	1.3	-1.2	-1.0	-1.5
Hair Pigment	0.1	2.2	5.7	1.1	-0.9	1.3	-0.5	1.3	2.4	2.0
Tanning	0.2	2.5	3.6	-1.8	1.2	-1.9	1.6	0.2	-1.7	-1.9
Hand grip strength (left)	0.5	1.3	3.6	0.7	1.3	0.5	1.7	0.7	-0.4	-1.9
Number of treatments/medications taken	0.7	1.2	2.2	-0.5	1.5	-1.2	1.3	0.2	-0.9	-1.4
Average weekly spirits intake	0.2	0.3	0.9	-0.2	0.7	-0.4	0.9	0.4	0.1	-0.3
Sensitivity / hurt feelings	0.9	1.5	3.8	-1.8	-1.3	-1.9	-1.1	-0.7	-0.2	0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.2	-1.1	-1.4	-1.1	-1.8	-1.1	-1.2	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.0	0.3	0.4	0.6	0.7	0.6	0.0
Relative age of first facial hair	0.2	0.4	1.5	-0.0	-1.2	0.7	-0.6	-0.2	0.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.4	1.5	0.2	1.6	0.1	1.1	1.0	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	0.9	-1.3	0.7	-1.6	-1.2	0.0	0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	0.5	-0.6	0.4	-0.8	-1.0	-1.2	-0.5
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.8	0.2	0.4	-0.4	-0.8	0.4	0.4
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	5.4	2.0	0.2	2.3	0.5	-0.3	0.9	-0.2
Angina	0.2	0.3	1.2	-0.6	-0.5	-0.5	-0.4	-0.1	-1.1	0.0
Medication for hormone replacement therapy	0.2	0.2	0.3	0.5	-0.3	0.4	-0.5	-0.3	-0.4	-0.6
Vitamin and mineral supplements	0.7	1.0	3.6	-0.6	-1.9	-0.1	-1.2	0.6	0.4	0.9
Supplements: Zinc	0.9	0.9	2.5	0.9	-0.4	0.6	-0.5	1.1	1.6	1.1
Medication: Co-codamol	1.2	1.4	3.1	0.6	1.6	0.6	1.7	-0.6	-0.2	-1.8
Medication: Metformin	0.7	1.0	2.7	1.4	0.7	1.1	0.8	-0.1	-0.3	-1.6
Diabetes (father)	0.4	0.4	1.0	1.0	0.7	1.0	0.3	-0.2	-0.1	-0.7
Diabetes (mother)	1.5	1.9	3.9	1.6	-0.5	2.0	-0.3	1.5	1.9	0.8
Severe depression (siblings)	1.0	1.1	2.1	-0.1	1.1	-0.6	0.9	-1.0	-1.4	-1.5
Pack years adult smoking proportion	0.9	1.3	2.5	0.3	1.5	0.2	1.6	-1.1	-1.2	-1.4
Impedance of leg (right)	0.3	1.6	4.9	1.0	0.5	0.6	-0.1	0.8	2.2	1.9
Leg fat-free mass (left)	1.6	8.7	25.7	2.7	2.5	2.6	3.2	-0.4	-2.1	-5.1
Trunk fat percentage	2.4	9.7	14.5	3.7	3.5	3.4	3.6	-1.4	-0.4	-3.8
Hand grip strength (right)	0.8	2.1	4.6	1.0	2.1	0.3	2.1	0.8	-0.5	-1.9
Townsend deprivation index at recruitment	0.1	0.1	0.6	0.2	0.3	-0.1	-0.0	-0.3	-0.7	-0.4
Current tobacco smoking	1.4	2.3	4.8	0.3	1.8	-0.4	1.4	-2.2	-1.5	-1.9
Average weekly fortified wine intake	0.4	0.4	1.6	-0.6	-0.2	-0.7	-1.3	-0.7	0.1	0.2
Maternal smoking around birth	2.1	3.0	6.3	1.7	1.7	1.6	2.3	-1.0	-0.1	-2.5
Fed-up feelings	0.4	0.7	1.6	-1.1	-1.3	-0.8	-1.1	-0.2	-0.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	-0.9	-1.2	-1.0	-1.4	-1.0	-0.9	0.3
Relative age voice broke	0.2	0.3	0.9	0.1	-1.0	0.4	-0.3	0.7	0.4	0.2
Taking other prescription medications	0.3	0.4	0.8	0.4	0.7	0.1	0.7	-0.9	-0.5	-0.9
Age when periods started (menarche)	0.7	1.6	5.7	1.3	0.6	1.2	0.6	1.3	2.4	0.4
Bilateral oophorectomy (both ovaries removed)	2.8	3.3	8.9	3.0	1.5	2.5	1.0	-1.0	-0.3	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-0.8	-1.2	-0.5	-1.1	-1.0	-0.0	0.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	6.5	-0.5	1.8	-0.0	2.5	0.1	0.1	-0.9
Qualifications: CSEs or equivalent	0.8	1.1	2.9	-0.1	1.4	-0.0	1.7	0.2	-0.8	-1.5
Serious illness, injury or assault to yourself	0.5	0.6	1.0	1.0	1.0	0.6	0.7	0.6	0.1	-0.9
High blood pressure	0.1	0.3	0.8	-0.7	-0.5	-0.9	-0.3	-0.6	-0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	0.1	-0.7	0.1	-1.1	0.1	-0.4	0.1
Multivitamins +/- minerals	0.4	0.5	2.0	-0.1	1.4	-0.2	0.9	0.4	-0.3	-0.7
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.6	-0.1	-0.8	0.4	0.4	-1.2	-1.0
Supplements: Glucosamine	0.3	0.4	1.0	1.0	-0.1	1.0	-0.2	0.6	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.7	0.7	-0.7	0.5	-0.3	-0.6	-0.4
Medication: Atenolol	1.0	1.3	4.2	0.2	1.2	0.2	2.1	-0.6	0.0	-1.7
Medication: Levothyroxine sodium	0.6	1.0	2.9	0.6	1.3	0.0	1.2	-0.0	-0.6	-1.7
Sitting height	1.0	6.8	12.2	2.6	2.9	2.2	3.1	2.3	-0.6	-3.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.9	-0.6	-0.4	-0.9	-0.3	-0.1	-0.1	-0.6
High blood pressure (mother)	0.4	0.6	1.2	0.5	-0.7	1.1	-0.2	0.6	1.1	0.9
Body mass index (BMI)	1.3	5.6	15.4	1.6	2.2	1.5	3.0	-1.4	-1.8	-3.9
Impedance of leg (left)	0.3	1.2	3.6	0.7	0.6	0.3	-0.3	0.7	1.9	1.8
Leg predicted mass (left)	1.6	8.7	25.3	2.7	2.6	2.6	3.2	-0.5	-2.1	-5.0
Trunk fat mass	3.0	13.1	25.6	3.9	4.0	3.6	4.4	-1.1	-1.0	-5.1
Waist circumference	2.3	8.6	19.1	2.7	3.2	2.6	3.6	-1.3	-1.3	-4.4
Number of incorrect matches in round	1.5	2.5	4.5	-2.1	-2.0	-1.8	-1.8	-0.3	-0.3	1.3
Past tobacco smoking	2.5	4.5	10.9	-1.3	-3.3	-0.6	-3.1	0.2	-0.0	3.0
Alcohol usually taken with meals	1.4	2.2	4.1	-1.3	-0.8	-0.9	-1.2	2.0	2.0	1.8
Nervous feelings	0.3	0.6	1.9	-0.4	-0.0	-0.3	-0.6	0.3	1.4	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.5	0.4	-0.4	0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.6	0.7	0.7	0.8	0.5	0.0	0.4	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.9	0.6	-0.4	1.0	-1.0	0.9	1.0	1.7
Had menopause	0.4	0.5	1.0	-0.0	-0.9	0.3	-1.0	0.0	0.9	1.0
Had other major operations	0.3	0.4	1.2	0.6	0.2	0.7	0.7	0.2	0.6	-1.1
Forced vital capacity (FVC)	0.5	2.0	8.7	0.7	0.6	0.6	1.1	-0.7	-1.6	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	-0.8	-0.5	-0.4	-0.6	-1.2	-0.1	0.6
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.1	-0.2	-1.3	-0.2	-1.7	1.8	0.9	1.8
Qualifications: None of the above	0.6	1.3	3.2	0.1	1.6	0.0	1.8	-1.6	-0.6	-0.9
Financial difficulties in last 2 years	0.5	0.6	1.6	1.2	0.8	0.7	0.7	-0.1	-0.3	-1.1
Mouth/teeth dental problems	0.6	0.9	2.6	-0.8	-1.1	-0.2	-0.7	1.1	0.6	1.6
Heart attack	1.1	1.3	4.2	-1.8	-0.5	-2.1	-0.1	-0.1	-1.2	-0.4
Allergy	0.4	0.9	2.9	0.4	1.5	0.5	1.7	-0.0	0.7	-0.2
Pain all over the body in last month	2.5	2.6	5.0	0.7	2.2	0.2	1.8	-2.2	-1.0	-1.9
Diabetes (self-reported)	0.7	1.0	3.1	0.9	0.9	0.6	1.3	-0.0	-0.4	-1.8
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.3	-1.1	-2.3	-0.4	-1.7	0.7	0.9	1.7
Medication: Ramipril	1.9	2.4	7.4	0.4	2.2	0.6	2.7	0.8	0.2	-1.9
Medication: Simvastatin	0.3	0.4	0.7	0.8	0.7	0.4	0.7	-0.1	-0.5	-0.9
Fluid intelligence score	0.5	1.0	2.7	0.1	-1.6	0.3	-1.6	1.0	-0.4	0.8
Illnesses of siblings	0.7	1.0	2.2	-0.6	-1.0	-1.0	-1.5	0.5	0.3	1.5
Neuroticism score	0.6	1.3	2.8	-1.7	-1.0	-1.6	-1.4	-0.9	-0.3	0.5
Weight	2.8	13.8	35.7	3.3	3.8	3.0	4.6	-0.9	-2.1	-6.0
Impedance of arm (right)	0.5	2.3	6.3	1.1	-0.4	1.1	-1.6	0.2	2.2	2.5
Arm fat percentage (right)	1.2	4.9	10.0	2.1	2.2	2.1	2.7	-1.4	-0.9	-3.2
Trunk fat-free mass	1.4	8.1	27.7	1.9	2.4	1.7	3.1	-0.0	-2.5	-5.3
Hip circumference	1.2	5.2	14.3	1.9	2.1	2.0	2.8	-0.3	-1.3	-3.8
Time employed in main current job	4.4	5.1	10.4	2.3	3.0	2.0	3.2	2.2	1.0	-1.1
Alcohol intake versus 10 years previously	0.4	0.6	1.8	1.3	0.3	1.3	0.3	-0.3	0.2	-0.6
Father’s age at death	2.1	2.9	5.8	1.8	-0.4	2.3	0.1	1.6	2.4	1.7
Worrier / anxious feelings	1.6	3.1	8.8	-3.0	-0.9	-2.9	-1.2	-0.2	-1.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-1.2	-0.6	-1.0	-0.1	-0.2	-0.7	0.0
Falls in the last year	0.5	0.7	4.3	-0.2	0.3	0.2	0.5	-2.1	-0.2	-0.2
Hair/balding pattern: Pattern 3	0.8	1.1	2.4	-1.4	-1.0	-1.5	-0.9	0.6	0.0	1.2
Number of live births	0.3	0.5	1.7	0.1	1.2	0.1	1.3	0.0	0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	6.4	0.6	0.4	0.5	0.9	-0.6	-1.3	-2.5
Pulse rate	1.9	3.2	7.9	-2.4	-1.1	-2.8	-1.4	-1.4	-1.7	0.4
Happiness	1.5	1.9	4.9	-0.4	-1.7	0.3	-2.1	0.2	0.6	2.2
Noisy workplace	0.9	1.1	2.8	0.6	1.7	0.3	1.4	-0.6	-0.5	-1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.2	0.9	-1.0	0.8	-1.4	1.4	1.8	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.1	0.9	-1.2	0.7	-1.8	0.9	1.0	1.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	1.0	0.6	0.6	0.2	-0.7	-0.1	-1.0
Asthma	0.9	1.8	3.1	-1.3	-1.8	-1.7	-1.7	1.2	-0.6	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.3	0.0	1.1	-0.3	0.8	0.1	-1.1	-1.5
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.3	-0.3	-0.4	-0.1	-0.2	-0.6	-0.6
Depression (self-reported)	0.3	0.4	0.6	-0.8	-0.3	-0.6	-0.7	-0.6	-0.5	0.7
Medication: Lansoprazole	1.4	1.6	3.8	-1.4	0.2	-1.7	0.5	-1.1	-1.9	-0.9
Prospective memory result	0.2	0.2	0.9	-0.2	-0.3	-0.4	0.1	-0.9	0.0	-0.5
Lung cancer (father)	5.0	5.9	13.7	-1.3	1.1	-2.1	0.7	-3.0	-3.7	-3.3
Illnesses of mother	0.5	0.7	1.6	-0.3	1.2	-0.6	1.0	-0.6	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	6.6	-0.6	-0.1	-0.7	0.4	-1.1	-2.0	-2.6
Pulse wave Arterial Stiffness index	1.2	1.4	3.5	-0.3	1.5	-1.0	1.0	-0.3	-1.9	-1.3
Impedance of arm (left)	0.4	1.7	4.8	1.2	0.2	0.9	-1.2	0.4	1.8	2.2
Arm fat mass (right)	2.1	8.8	21.7	2.6	3.0	2.5	3.7	-1.3	-1.6	-4.7
Trunk predicted mass	1.4	8.0	27.5	2.0	2.4	1.7	3.2	0.1	-2.5	-5.2
Standing height	1.3	13.1	27.9	4.1	4.1	3.5	4.0	0.8	-1.1	-5.3
Length of working week for main job	0.8	0.9	2.2	0.5	1.1	0.5	1.0	-0.5	-0.9	-1.5
Exposure to tobacco smoke at home	1.7	1.9	3.9	-1.2	-0.4	-1.3	-0.3	-1.5	-2.0	-2.0
Breastfed as a baby	1.7	2.1	3.9	-1.8	-1.4	-1.3	-2.0	-0.6	-0.9	1.7
Tense / ‘highly strung’	0.5	0.8	2.2	-0.2	-0.3	-0.2	-0.8	0.8	1.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-1.0	-0.4	-0.8	-0.6	0.2	0.2	1.0
Hair/balding pattern: Pattern 4	0.9	2.1	4.7	1.6	0.9	1.8	1.1	-2.2	0.2	-1.5
Birth weight of first child	1.5	2.7	6.3	0.8	2.2	0.8	2.5	1.0	-0.5	-2.3
Peak expiratory flow (PEF)	0.4	1.0	4.7	0.4	-0.0	0.6	0.7	-0.1	-1.0	-2.2
Pulse wave reflection index	0.3	0.4	1.0	0.2	0.8	-0.3	0.4	0.1	-1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.9	0.3	-0.6	0.1	-0.3	-0.5	-0.2
Loud music exposure frequency	1.0	1.1	2.8	-1.7	-0.8	-1.3	-0.9	-0.6	-1.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.8	0.5	0.2	-0.5	1.3	0.7	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.6	0.2	0.5	-0.4	-0.8	0.5	0.2
Blood clot in the leg (DVT)	0.5	0.6	2.9	0.4	-0.9	0.4	-0.5	-1.7	-0.2	-0.6
Medication: Paracetamol	0.4	0.6	1.7	-1.1	0.3	-1.3	0.3	-0.1	-1.1	-0.3
Headache pain in last month	0.6	1.0	1.7	-1.0	-1.3	-1.0	-0.9	-1.2	-1.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	1.0	-0.1	1.3	-0.2	0.1	1.3	0.8
Glaucoma (self-reported)	0.3	0.4	0.9	0.2	0.7	0.3	0.9	-0.9	-0.2	-0.4
Gout (self-reported)	0.4	0.5	1.6	0.4	0.3	0.8	0.7	-1.3	-0.0	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	0.8	1.2	0.1	0.7	1.1	-0.4	-1.1
Medication: Amlodipine	0.3	0.5	1.2	-0.9	-0.1	-0.7	0.6	1.1	-0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	-0.9	0.7	-1.2	0.1	-0.1	-1.5	-0.6
Birth weight	0.3	0.6	2.0	0.9	0.0	0.9	-0.1	1.4	0.6	-0.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	0.5	0.4	0.7	0.9	-0.4	-0.3	-0.9
High blood pressure (siblings)	0.2	0.3	1.2	-0.3	0.2	0.3	0.7	-0.6	-0.3	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.3	8.1	-0.6	-0.0	-0.8	0.5	-1.3	-2.2	-2.9
Body fat percentage	2.2	8.5	13.1	3.4	3.3	3.1	3.6	-1.0	-0.3	-3.6
Leg fat percentage (right)	1.8	6.5	12.2	2.5	2.9	2.4	3.5	-0.7	-0.3	-3.4
Arm fat-free mass (right)	1.9	10.0	29.6	2.4	3.2	2.0	3.9	-0.1	-2.1	-5.4
Exposure to tobacco smoke outside home	0.3	0.3	0.7	-0.7	-0.1	-0.7	0.3	-0.8	-0.4	-0.6
Comparative body size at age 10	0.4	1.2	2.9	-0.8	-1.4	-1.0	-1.7	-1.2	0.1	0.6
Number of full brothers	0.5	0.6	1.5	-0.8	0.7	-0.5	1.2	-0.4	-0.6	-0.8
Worry too long after embarrassment	0.4	0.6	2.2	-0.6	0.1	-1.5	-1.1	-0.2	-0.6	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.5	0.7	-0.7	0.8	-0.5	0.7	1.6	2.1
Wheeze or whistling in the chest in last year	0.5	0.9	1.9	1.2	1.4	1.1	0.9	0.3	0.2	-0.8
Number of children fathered	1.0	1.2	3.1	0.3	1.5	-0.0	1.4	-0.5	-0.6	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.2	0.3	1.5	0.3	1.2	1.1	1.3	0.7
Age at first live birth	1.5	2.6	5.1	-0.4	-2.0	0.3	-1.6	1.9	1.8	2.3
Pulse wave peak to peak time	1.2	1.5	4.0	0.5	-1.4	1.3	-0.8	0.6	2.0	1.1
Health satisfaction	0.9	1.2	2.3	1.3	1.4	1.5	0.9	0.9	0.4	-0.5
Shortness of breath walking on level ground	0.4	0.5	1.7	-0.0	1.3	0.4	1.2	0.1	-0.3	-0.5
Qualifications: College or University degree	1.5	4.7	9.5	0.2	-2.6	0.7	-2.8	1.9	2.0	3.1
Eye problems/disorders: None of the above	0.4	0.5	0.9	-0.1	-0.4	-0.6	-1.0	1.0	0.4	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.5	0.7	-0.5	0.7	-0.2	0.3	0.3
Emphysema/chronic bronchitis	0.7	0.8	2.6	-0.5	1.0	-0.3	0.9	1.6	0.8	0.1
Medication for pain relief, constipation, heartburn	1.1	1.9	4.8	2.0	0.9	2.2	0.8	-0.1	1.7	0.0
Neck or shoulder pain in last month	0.3	0.4	2.0	0.1	-0.0	0.1	0.1	-1.4	-0.3	-0.6
Medication: Blood pressure	0.9	1.6	4.5	-1.9	-0.2	-2.1	0.3	1.4	-0.9	0.0
Angina (self-reported)	0.2	0.3	1.1	-0.7	-0.4	-0.6	-0.2	-0.0	-1.1	0.1
Migraine (self-reported)	1.2	1.5	4.3	-1.3	-2.1	-0.9	-1.5	0.6	-0.2	1.0
Medication: Ibuprofen	1.1	1.3	3.6	-0.6	0.9	-0.9	0.8	0.1	-1.6	-1.9
Medication: Allopurinol	0.8	1.0	2.7	-0.5	0.5	-0.2	1.0	-1.6	-1.0	-1.4
Medication: Omeprazole	0.5	0.6	1.1	0.8	0.8	0.8	1.0	1.0	0.6	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	2.1	0.4	1.0	0.1	1.0	0.1	-0.8	-1.4
Mean time to correctly identify matches	0.8	1.5	4.7	2.0	0.5	2.2	0.5	-0.4	0.8	-0.4
Heart disease (mother)	0.8	1.0	4.6	-0.2	1.0	-0.3	0.9	2.1	-0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.6	1.4	0.6	1.3	0.8	2.0	2.2	0.9
Whole body fat mass	2.9	12.1	25.1	3.5	3.9	3.2	4.4	-0.9	-1.1	-5.0
Leg fat mass (right)	2.9	11.2	24.7	3.2	3.7	2.9	4.4	-0.8	-1.2	-5.0
Arm predicted mass (right)	2.1	10.5	32.3	2.2	3.4	1.8	4.1	-0.1	-2.3	-5.7
Pulse rate, automated reading	0.2	0.6	3.1	-0.3	0.7	-0.6	0.4	-1.8	-0.3	-0.3
Alcohol intake frequency.	0.7	1.7	2.7	-1.5	-1.4	-1.5	-1.6	-1.1	-1.2	0.8
Comparative height size at age 10	1.1	6.1	14.4	2.8	2.8	2.1	2.1	-0.5	-1.9	-3.8
Number of full sisters	0.6	0.7	1.7	0.7	1.1	0.2	1.1	-0.5	-0.6	-1.3
Suffer from ‘nerves’	0.8	1.3	3.9	1.1	0.7	1.5	0.5	0.7	2.0	0.6
Overall health rating	0.8	1.8	4.3	0.5	1.4	0.2	1.7	-0.3	-1.7	-2.1
Chest pain or discomfort	0.1	0.2	0.4	-0.0	0.4	0.5	0.6	0.0	-0.6	-0.5
Had major operations	0.3	0.3	1.0	0.3	0.7	-0.0	0.4	0.6	-1.0	-0.6
Age at last live birth	0.5	0.8	1.5	0.6	-0.9	0.8	-0.7	0.8	1.1	1.2
Family relationship satisfaction	0.6	0.7	1.5	1.2	1.2	1.1	0.8	-0.1	0.6	-0.1
Leg pain on walking	1.8	2.3	5.9	0.3	2.4	0.2	2.4	0.1	-0.7	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.4	-1.3	-0.7	-1.6	0.0	-1.3	-0.9	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.0	0.3	1.4	0.7	1.5	-1.7	-0.4	-1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	-1.3	-1.0	-1.1	-0.8	-0.1	-0.7	0.6
Medication: Aspirin	1.4	1.8	4.4	-1.2	-2.1	-0.8	-2.0	-0.0	0.1	1.5
Supplements: Vitamin C	0.3	0.4	2.1	0.1	-0.0	-0.1	-0.7	-1.4	-0.0	0.2
Knee pain experienced in last month	1.1	1.8	3.8	0.5	2.0	0.5	1.8	-0.8	-1.1	-1.7
Hypertension (Self-reported)	0.1	0.2	0.5	-0.6	-0.3	-0.7	0.0	-0.5	-0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.3	-0.3	-1.1	-0.2	-0.7	-0.2	-0.7	0.4
Illnesses of father: Heart disease	0.9	1.3	4.6	-0.0	-0.8	0.1	-1.4	0.7	1.2	2.1
Illnesses of siblings: Diabetes	1.0	1.3	3.4	-0.4	0.9	-0.2	1.3	-0.7	-1.6	-1.8
Smoking status: Previous	2.3	3.4	8.6	1.1	2.9	0.7	2.9	0.6	0.7	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.9	1.8	1.8	1.8	2.6	0.7	0.1	-1.7
Whole body fat-free mass	1.5	8.6	27.8	2.3	2.5	2.1	3.2	-0.1	-2.4	-5.3
Leg fat-free mass (right)	1.5	8.0	24.4	2.5	2.5	2.4	2.9	-0.4	-2.2	-4.9
Arm fat percentage (left)	1.4	5.5	10.7	2.3	2.5	2.3	3.0	-1.2	-0.9	-3.3
Average weekly red wine intake	0.2	0.3	1.2	-0.1	0.4	-0.3	-0.2	-1.1	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.2	-0.6	0.2	-0.9	0.1	-1.1	-0.4	-0.8
Mood swings	2.0	3.6	8.0	-1.9	-2.8	-1.8	-2.8	-0.1	0.4	1.5
Loneliness, isolation	1.3	1.8	3.3	-1.6	-1.5	-1.4	-1.8	0.4	-0.1	1.6
Long-standing illness, disability or infirmity	2.3	3.6	6.6	2.1	2.5	1.8	2.6	0.9	0.3	-2.0
Ever had bowel cancer screening	1.0	1.2	3.5	-1.7	-0.7	-1.9	-0.8	0.3	-0.8	0.3
Diabetes diagnosed by doctor	0.3	0.5	1.7	0.8	0.5	0.4	0.6	-0.1	-0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	4.1	4.3	10.5	3.0	2.0	3.2	1.8	0.8	1.5	-0.7
Friendships satisfaction	1.3	1.6	4.0	0.9	-1.0	1.2	-1.5	0.7	1.1	2.0
Qualifications: nursing, teaching	0.2	0.4	1.1	-0.4	-0.7	-0.4	-0.7	-0.4	-1.0	0.2
Commuting to job workplace: Walk	1.0	1.1	2.4	-0.7	-1.3	-1.0	-1.5	-1.0	-1.1	-0.4
Eye problems/disorders: Cataract	1.0	1.1	3.3	-1.8	-0.3	-1.3	0.1	-1.0	-1.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	0.2	0.5	0.2	0.8	-0.6	-0.8	-1.4
Medication for cholesterol	0.0	0.0	0.2	-0.3	0.2	-0.1	0.2	0.4	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	1.8	-1.0	-0.6	-0.9	-0.4	-0.6	-1.4	0.1
Back pain experienced in last month	0.4	0.6	1.6	1.3	0.7	1.3	0.5	0.3	0.1	-0.6
Mineral and other dietary supplements	0.3	0.4	1.1	-0.1	-1.0	0.1	-0.8	-0.4	0.0	0.8
Breast cancer (self-reported)	0.8	1.0	1.9	1.1	-1.2	1.1	-1.4	0.1	0.5	1.1
Asthma (self-reported)	0.9	1.8	3.1	-1.4	-1.6	-1.8	-1.6	1.4	-0.4	0.7
Osteoporosis (self-reported)	0.4	0.5	1.8	0.5	-0.1	0.7	-0.6	-1.3	-0.7	0.4
Osteoarthritis (self-reported)	0.8	1.0	2.1	1.1	1.2	0.5	1.0	1.5	0.7	-0.7
Medication: Aspirin	1.1	1.4	3.7	-1.0	-1.9	-0.5	-1.7	-0.1	0.3	1.3
Medication: Gliclazide	0.7	0.8	2.2	0.9	0.7	0.9	0.8	-0.8	-0.5	-1.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	-0.7	-0.1	-0.5	0.4	-1.1	-1.2	-0.7
Smoking status: Current	1.4	2.2	4.4	0.4	1.7	-0.3	1.3	-2.1	-1.5	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	-1.4	-1.2	-1.2	-1.2	-0.6	-0.7	0.2
Whole body water mass	1.5	8.6	27.7	2.3	2.5	2.1	3.2	-0.1	-2.4	-5.3
Leg predicted mass (right)	1.5	7.8	23.7	2.5	2.4	2.3	2.9	-0.4	-2.2	-4.9
Arm fat mass (left)	2.2	9.2	22.9	2.6	3.2	2.4	3.8	-1.3	-1.8	-4.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.0	-1.2	0.1	-0.6	1.0	0.6	0.7
Average weekly champagne plus white wine intake	1.9	2.7	4.0	-1.9	-2.0	-1.1	-1.7	1.8	0.7	1.8
Miserableness	0.5	0.9	2.5	-1.6	-0.2	-1.5	-0.5	-0.8	-0.6	-0.3
Guilty feelings	1.2	1.8	3.0	-1.5	-1.7	-1.1	-1.6	-1.4	-1.2	0.0
Wears glasses or contact lenses	0.0	0.0	0.1	0.3	-0.0	0.1	0.1	-0.3	-0.3	0.0
Ever taken oral contraceptive pill	0.2	0.3	0.8	0.6	-0.2	0.8	0.2	-0.1	-0.2	-0.9
Hearing aid user	1.1	1.2	3.4	-0.0	0.5	-0.1	0.5	-1.4	-1.6	-1.8
Mother’s age at death	1.0	1.2	2.9	-0.1	-1.4	0.2	-1.2	0.2	1.5	1.7
Financial situation satisfaction	1.4	1.8	3.2	1.8	1.7	1.5	1.4	-0.4	0.4	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.3	-0.7	0.3	-1.2	-0.5	1.2	1.0
Commuting to job workplace: Public transport	1.2	1.5	2.6	0.7	-1.0	0.6	-1.2	1.5	1.4	1.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-0.4	0.7	-0.6	0.6	-1.1	-0.7	-0.5
Medication: Blood pressure	0.1	0.1	0.5	-0.3	-0.5	-0.3	-0.2	-0.7	-0.0	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.9	0.4	-0.6	0.1	-0.2	-0.8	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.3	1.3	0.2	1.0	0.7	-0.0	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.0	0.1	-1.0	0.2	-1.0	-0.8	-0.5	0.0
Medication: Bendroflumethiazide	0.5	0.7	1.8	-1.3	-0.8	-1.1	-0.7	0.2	-0.2	0.9
Medication: Paracetamol	0.7	1.0	2.2	-0.8	1.0	-1.4	0.8	0.2	-1.5	-0.9
Medication: Lisinopril	0.8	1.1	2.3	-0.7	-1.0	-0.9	-0.6	-1.2	-1.5	-0.9
Medication: Atorvastatin	0.8	1.0	2.1	-0.9	-1.3	-0.7	-1.4	0.8	0.3	1.2
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.4	0.4	-0.0	0.7	0.8	-0.8	-0.5
Alcohol drinker status: Never	3.7	4.4	7.5	-2.4	-2.6	-1.9	-2.7	-0.1	-0.3	2.7
Ever smoked	1.0	1.8	3.8	1.2	2.0	0.7	1.8	-0.2	0.5	-1.8
Basal metabolic rate	1.9	10.7	32.5	2.7	3.0	2.5	3.7	-0.4	-2.4	-5.7
Leg fat percentage (left)	1.7	6.1	12.1	2.3	2.9	2.1	3.3	-0.8	-0.7	-3.5
Arm fat-free mass (left)	1.9	9.9	30.7	2.4	2.9	2.1	3.7	-0.4	-2.3	-5.5
Number of operations (self-reported)	0.5	0.7	2.6	0.6	0.3	0.3	0.7	0.8	-0.8	-1.6
Average weekly beer plus cider intake	2.0	3.0	5.2	2.2	1.8	1.7	1.6	-1.3	-0.5	-2.3
Irritability	0.5	0.9	1.8	-0.8	0.5	-0.8	0.7	-1.2	-1.0	-1.3
Risk taking	0.5	0.7	2.4	0.1	-0.4	0.5	-0.0	0.4	1.6	1.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.5	1.1	1.0	0.5	0.7	2.1	1.1	0.2
Fractured/broken bones in last 5 years	1.8	2.3	4.2	-2.0	-1.2	-1.9	-1.6	-1.4	-1.6	0.0
Age started oral contraceptive pill	4.0	5.1	8.2	1.5	-2.8	2.1	-2.9	0.8	2.4	2.6
Diastolic blood pressure, automated reading	0.3	0.8	1.9	1.4	0.5	1.1	0.4	-0.5	1.3	-0.1
Ever depressed for a whole week	1.4	1.8	4.6	-0.1	-1.4	0.1	-1.8	1.3	0.8	2.1
Unable to work because of sickness or disability	1.1	1.4	5.2	-0.5	0.5	-0.6	0.5	-2.3	-1.4	-1.3
Commuting to job workplace: Cycle	3.8	4.5	9.4	-3.0	-2.1	-3.1	-1.9	1.8	0.0	1.3
Myopia	0.8	1.1	2.5	0.9	-0.6	1.3	-0.5	0.8	1.6	1.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	0.8	0.2	1.0	-0.0	0.5	0.5	0.4
Cholesterol lowering medication	0.2	0.2	0.7	0.6	-0.4	0.4	-0.8	-0.2	-0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	0.6	0.7	0.5	0.8	1.4	0.4	0.1
Pain experienced in last month	0.2	0.3	0.7	-0.5	-0.8	-0.3	-0.4	-0.2	0.9	0.7
Supplements: Calcium	0.7	0.7	1.5	-1.2	-0.7	-1.2	-0.7	-0.2	-1.1	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-1.1	-0.4	-1.1	-0.5	-0.8	0.2	0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.2	-1.9	-0.5	-2.0	-0.1	-0.2	-1.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.1	0.3	-1.2	0.3	-0.8	-1.8	-0.2	-0.3
Heart disease (siblings)	0.9	1.1	3.5	1.7	0.5	1.9	0.9	0.3	0.6	-0.0
Alcohol drinker status: Previous	1.3	1.5	3.7	-1.5	0.1	-1.5	-0.1	-0.6	-1.9	-1.2
Pack years of smoking	0.6	0.9	1.6	0.5	1.1	0.5	1.2	-1.3	-0.8	-1.0
Impedance of whole body	0.3	1.7	5.1	1.1	0.4	0.7	-0.8	0.3	2.1	2.3
Leg fat mass (left)	2.8	10.9	24.8	3.0	3.7	2.7	4.3	-0.9	-1.3	-5.0
Arm predicted mass (left)	1.8	9.1	28.7	2.3	2.8	2.0	3.6	-0.3	-2.2	-5.4