Best TWAS P=9.9e-09 · Best GWAS P=1.3e-07 conditioned to 0.649
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADORA2B | 0.06 | 0.07 | blup | 304 | 0.07 | 5.0e-09 | -4.9 | -5.4 | 6.0e-08 | 0.92 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Artery Aorta | TTC19 | 0.06 | 0.00 | lasso | 3 | 0.00 | 7.1e-01 | -5.0 | 5.6 | 2.1e-08 | -0.87 | 0.07 | 0.39 | FALSE |
| 3 | GTEx | Pancreas | TTC19 | 0.12 | 0.09 | enet | 9 | 0.07 | 8.5e-04 | -4.6 | 5.2 | 1.6e-07 | -0.86 | 0.10 | 0.74 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | ADORA2B | 0.15 | 0.13 | lasso | 3 | 0.12 | 3.8e-07 | -5.3 | -5.3 | 1.4e-07 | 1.00 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Spleen | ADORA2B | 0.23 | 0.27 | enet | 10 | 0.24 | 7.4e-07 | -5.1 | -5.3 | 1.1e-07 | 0.96 | 0.05 | 0.94 | FALSE |
| 6 | GTEx | Whole Blood | ADORA2B | 0.08 | 0.00 | lasso | 5 | 0.00 | 2.5e-01 | -4.3 | -5.4 | 8.3e-08 | 0.85 | 0.04 | 0.64 | FALSE |
| 7 | YFS | Blood | PIGL | 0.02 | 0.02 | blup | 279 | 0.02 | 1.5e-06 | -3.4 | -5.7 | 9.9e-09 | 0.88 | 0.20 | 0.79 | TRUE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ADORA2B | 0.13 | 0.17 | blup | 37 | 0.16 | 8.2e-08 | -4.8 | -5.2 | 2.3e-07 | 0.96 | 0.02 | 0.97 | FALSE |