[Hub]/) : Traits : Basal metabolic rate : ← →

chr17:6,518,588-8,265,776

Best TWAS P=2.38e-11 · Best GWAS P=1.41e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	6.57	6.7	2.4e-11	0.29	0.98	0.01	TRUE
7	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	6.57	6.1	1.2e-09	0.46	0.96	0.04	TRUE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	6.57	5.9	2.8e-09	0.30	0.00	1.00	TRUE
12	GTEx	Prostate	RP11-104H15.8	0.54	0.01	enet	1	0.06	1.6e-02	-5.93	-5.9	3.0e-09	-0.17	0.07	0.10	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-3.93	-5.8	5.8e-09	-0.05	1.00	0.00	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	6.53	5.8	6.4e-09	0.32	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	6.57	5.6	1.8e-08	0.34	0.00	0.88	TRUE
17	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-0.78	-5.6	1.9e-08	-0.02	0.11	0.02	TRUE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-4.57	-5.4	6.4e-08	0.00	0.01	0.60	TRUE
9	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	5.39	5.4	8.1e-08	0.26	0.96	0.00	TRUE
22	The Cancer Genome Atlas	Esophageal Carcinoma	EIF5A	0.16	0.00	blup	50	0.03	5.0e-02	-3.95	-5.2	2.5e-07	0.08	0.02	0.05	TRUE
6	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	6.57	5.2	2.6e-07	0.20	0.07	0.07	TRUE
4	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	6.57	6.6	4.9e-11	0.27	0.95	0.01	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	6.57	6.5	1.1e-10	0.29	0.99	0.01	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	3.29	6.3	2.9e-10	0.20	0.21	0.52	FALSE
19	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	6.53	6.3	3.0e-10	0.31	0.99	0.01	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-2.93	-6.2	6.7e-10	-0.46	0.04	0.08	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	6.57	6.1	1.2e-09	0.16	0.98	0.02	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	5.04	6.1	1.4e-09	0.23	0.00	1.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	6.57	6.0	1.6e-09	0.30	0.99	0.01	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-3.67	-6.0	2.7e-09	-0.45	0.01	0.66	FALSE
15	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	6.57	5.8	6.9e-09	0.15	0.96	0.01	FALSE
5	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	5.72	5.7	1.0e-08	0.52	0.26	0.66	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	3.31	5.6	2.1e-08	0.34	0.00	0.76	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	5.24	5.5	3.4e-08	0.18	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFNB3	0.06	0.03	lasso	4	0.05	1.0e-05	-5.93	5.5	3.4e-08	0.19	0.91	0.00	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFNB3	0.07	0.04	blup	34	0.04	4.0e-05	-5.93	5.5	4.2e-08	0.34	0.16	0.07	FALSE
10	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	5.35	5.3	1.1e-07	0.26	0.28	0.24	FALSE
14	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	5.45	5.3	1.3e-07	0.22	1.00	0.00	FALSE
11	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-3.64	-5.2	1.6e-07	-0.02	0.96	0.00	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-3.67	-5.2	1.9e-07	-0.08	0.03	0.08	FALSE
16	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-3.71	-5.1	2.9e-07	-0.43	0.43	0.44	FALSE