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chr17:39,993,748-41,538,783

Best TWAS P=7.33e-09 · Best GWAS P=1.98e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MLX	0.03	0.03	enet	12	0.02	6.5e-04	-5.6	-5.7	1.1e-08	0.94	0.02	0.97	FALSE
2	GTEx	Adipose Subcutaneous	TUBG2	0.21	0.18	enet	17	0.26	2.1e-21	-5.4	-5.1	2.7e-07	0.94	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	HSD17B1P1	0.06	0.09	enet	6	0.09	4.0e-08	-5.3	-5.7	9.7e-09	0.92	0.03	0.97	FALSE
4	GTEx	Brain Cerebellum	HSD17B1P1	0.17	0.16	lasso	4	0.20	1.7e-06	-5.6	-5.5	3.0e-08	0.95	0.04	0.94	FALSE
5	GTEx	Breast Mammary Tissue	TUBG2	0.15	0.06	enet	18	0.08	4.5e-05	-5.3	-5.6	1.9e-08	0.94	0.02	0.98	FALSE
6	GTEx	Breast Mammary Tissue	CNTNAP1	0.06	0.03	lasso	2	0.05	9.9e-04	-5.4	5.5	5.2e-08	-0.98	0.02	0.95	FALSE
7	GTEx	Colon Sigmoid	TUBG2	0.16	0.04	lasso	5	0.05	6.7e-03	-5.6	-5.4	5.2e-08	0.99	0.02	0.91	FALSE
8	GTEx	Colon Transverse	HSD17B1P1	0.14	0.11	lasso	4	0.09	3.8e-05	-5.4	-5.2	1.8e-07	0.97	0.04	0.94	FALSE
9	GTEx	Esophagus Muscularis	HSD17B1P1	0.08	0.03	lasso	3	0.01	6.8e-02	-5.3	-5.4	6.2e-08	0.96	0.04	0.88	FALSE
10	GTEx	Heart Atrial Appendage	TUBG2	0.07	0.05	lasso	2	0.02	2.9e-02	-5.6	-5.3	1.3e-07	0.98	0.03	0.89	FALSE
11	GTEx	Nerve Tibial	TUBG2	0.26	0.28	enet	39	0.28	2.2e-20	-5.5	-5.2	1.9e-07	0.92	0.01	0.99	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	TUBG1	0.11	0.01	lasso	6	0.00	1.7e-01	4.4	-5.4	7.4e-08	0.88	0.03	0.77	FALSE
13	GTEx	Skin Sun Exposed Lower leg	NAGLU	0.08	0.06	enet	9	0.09	5.8e-08	4.0	-5.5	5.0e-08	0.84	0.02	0.97	FALSE
14	GTEx	Testis	TUBG1	0.12	0.09	enet	18	0.08	1.8e-04	-5.4	-5.1	2.7e-07	0.98	0.02	0.97	FALSE
15	GTEx	Thyroid	TUBG2	0.19	0.21	lasso	7	0.20	3.5e-15	-5.5	-5.3	1.2e-07	0.98	0.01	0.99	FALSE
16	METSIM	Adipose	TUBG2	0.08	0.09	lasso	6	0.09	5.2e-13	4.3	-5.2	2.6e-07	0.87	0.03	0.97	FALSE
17	NTR	Blood	TUBG2	0.01	0.00	blup	247	0.01	4.0e-03	-4.3	5.4	7.7e-08	-0.75	0.13	0.75	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	CNTNAP1	0.06	0.05	blup	27	0.03	7.3e-03	-5.5	5.8	7.3e-09	-0.95	0.01	0.95	TRUE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NAGLU	0.13	0.02	enet	8	0.04	1.6e-05	4.0	-5.4	6.5e-08	0.78	0.01	0.87	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TUBG2	0.08	0.05	blup	29	0.07	3.5e-08	-4.4	-5.1	2.8e-07	0.96	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B1	0.30	0.05	enet	14	0.06	2.8e-07	-5.6	-5.3	1.4e-07	0.88	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	CNTNAP1	0.06	0.05	lasso	1	0.04	6.8e-06	-5.4	5.4	8.3e-08	-0.97	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNTNAP1	0.06	0.04	blup	27	0.04	8.9e-05	-5.4	5.5	4.0e-08	-0.92	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B1	0.02	0.03	blup	30	0.03	4.0e-04	-5.6	-5.3	9.1e-08	0.98	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	CNTNAP1	0.04	0.03	blup	27	0.05	2.7e-05	-5.3	5.5	4.7e-08	-0.89	0.01	0.98	FALSE