TWAS hub - HSD17B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0600	0.0270	3.0e-04	0.068	NA	0.063	NA	0.062	2.9e-06	NA	6.8e-06	NA	7.9e-06
2	GTEx	Artery Aorta	0.0620	0.0320	7.1e-03	0.051	NA	0.015	NA	-0.001	8.8e-04	NA	4.7e-02	NA	3.9e-01
3	GTEx	Artery Tibial	0.1233	0.0447	4.6e-06	0.071	NA	0.064	NA	0.069	3.0e-06	NA	1.0e-05	NA	4.4e-06
4	GTEx	Cells EBV-transformed lymphocytes	0.1360	0.0590	2.7e-03	0.133	NA	0.122	NA	0.098	4.4e-05	NA	8.9e-05	NA	4.4e-04
5	GTEx	Colon Transverse	0.1510	0.0550	2.3e-05	0.137	NA	0.098	NA	0.124	4.8e-07	NA	2.1e-05	NA	1.6e-06
6	GTEx	Esophagus Gastroesophageal Junction	0.2040	0.0880	4.5e-03	-0.006	NA	0.008	NA	0.011	6.3e-01	NA	1.6e-01	NA	1.2e-01
7	GTEx	Esophagus Muscularis	0.0830	0.0400	1.2e-03	0.035	NA	0.031	NA	0.057	3.2e-03	NA	5.4e-03	NA	2.3e-04
8	GTEx	Muscle Skeletal	0.0446	0.0199	9.5e-04	0.028	NA	0.032	NA	0.031	8.9e-04	NA	3.9e-04	NA	5.0e-04
9	METSIM	Adipose	0.0792	0.0262	1.3e-09	0.077	0.053	0.059	0.055	0.059	1.4e-11	1.8e-08	3.3e-09	1.0e-08	3.1e-09
10	YFS	Blood	0.0202	0.0088	3.3e-04	0.008	0.010	0.011	0.012	0.014	8.5e-04	2.2e-04	9.0e-05	7.9e-05	1.4e-05
11	TCGA	Colon Adenocarcinoma	0.0300	0.0210	9.8e-03	0.014	0.005	0.005	NA	0.001	4.7e-02	1.5e-01	1.6e-01	NA	2.8e-01
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0607	0.0408	1.2e-05	0.040	0.048	0.048	NA	0.058	2.5e-05	4.3e-06	3.5e-06	NA	4.0e-07
13	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0530	0.0340	4.7e-04	0.051	0.044	0.045	NA	0.043	6.9e-04	1.5e-03	1.4e-03	NA	1.7e-03
14	TCGA	Brain Lower Grade Glioma	0.3034	0.3208	5.6e-06	0.046	0.031	0.059	NA	0.043	6.0e-06	1.7e-04	2.8e-07	NA	1.2e-05
15	TCGA	Prostate Adenocarcinoma	0.0242	0.0146	3.1e-04	0.029	0.030	0.011	NA	0.022	4.8e-04	4.0e-04	2.3e-02	NA	2.1e-03
16	TCGA	Skin Cutaneous Melanoma	0.2880	0.1470	3.9e-03	0.089	-0.003	0.054	NA	0.051	2.2e-03	3.9e-01	1.4e-02	NA	1.7e-02
17	TCGA	Thyroid Carcinoma	0.0550	0.0330	6.2e-07	0.067	0.070	0.041	NA	0.064	3.9e-07	2.3e-07	7.1e-05	NA	7.4e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Medication: Metformin	9.3	13.2	18.5	-3.7	-4.1	-4.0	-1.6	-3.7	-3.6	3.6	-3.6	-3.7	-3.4	-3.8	-3.3	-4.0	-3.7	-3.7	-3.1	-4.3
Migraine (self-reported)	7.1	8.8	12.9	3.1	2.7	3.4	2.5	3.1	3.5	-3.1	3.4	3.2	3.2	2.9	2.6	3.6	2.2	3.0	1.4	2.6
Trunk fat mass	6.5	27.8	36.0	-5.7	-5.4	-5.8	-3.5	-5.7	-4.7	5.6	-5.0	-5.7	-4.6	-5.7	-5.2	-5.2	-5.8	-5.7	-3.1	-6.0
Arm fat mass (left)	6.5	26.8	38.9	-5.6	-5.1	-5.6	-2.9	-5.6	-4.2	5.5	-5.0	-5.5	-4.1	-5.7	-5.4	-5.3	-6.2	-6.0	-1.8	-6.2
Arm fat mass (right)	6.1	25.2	36.5	-5.5	-5.0	-5.5	-2.8	-5.4	-4.1	5.3	-4.8	-5.3	-4.1	-5.5	-5.1	-5.2	-6.0	-5.8	-1.9	-6.0
Ovarian Cancer	6.0	8.0	12.5	-3.0	-2.8	-2.9	-1.8	-3.0	-2.2	2.8	-3.2	-2.9	-2.2	-3.0	-3.5	-3.1	-2.2	-3.1	-2.0	-3.4
Diabetes diagnosed by doctor	5.9	9.6	17.7	-3.2	-3.2	-3.4	-0.6	-3.1	-2.4	3.0	-2.9	-3.1	-2.7	-3.3	-3.3	-3.4	-3.6	-3.3	-2.6	-4.2
Trunk fat percentage	5.7	23.0	29.3	-5.0	-5.2	-5.4	-3.0	-5.1	-4.2	5.0	-4.2	-5.3	-4.8	-5.1	-4.5	-4.8	-5.1	-4.9	-4.0	-5.4
Mouth/teeth dental problems: Loose teeth	5.5	6.6	9.3	-2.5	-2.5	-2.8	-1.2	-2.8	-2.5	2.7	-2.3	-2.7	-2.2	-2.7	-2.8	-3.0	-3.0	-3.0	-0.5	-2.9
Whole body fat mass	5.5	23.1	32.1	-5.2	-4.8	-5.3	-3.0	-5.2	-4.2	5.1	-4.5	-5.2	-4.1	-5.3	-4.8	-4.9	-5.4	-5.3	-2.6	-5.7
Alcohol intake frequency.	5.5	12.7	26.0	-3.6	-3.1	-3.9	-1.2	-3.8	-2.3	3.8	-2.7	-3.8	-2.7	-4.2	-3.9	-3.0	-5.1	-4.2	-2.0	-5.0
Blood White Count	5.4	39.7	53.9	-7.0	-6.5	-7.1	-3.0	-6.8	-4.4	6.5	-6.8	-6.8	-6.4	-6.7	-5.4	-6.8	-6.7	-6.9	-4.2	-7.3
Arm fat percentage (right)	5.4	21.5	31.1	-4.8	-4.8	-5.2	-2.0	-5.0	-3.8	4.7	-4.3	-5.0	-4.7	-4.9	-4.3	-4.8	-5.6	-5.1	-2.6	-5.5
Arm fat percentage (left)	5.4	21.6	31.7	-4.8	-4.8	-5.2	-2.2	-5.0	-3.7	4.8	-4.3	-5.0	-4.4	-5.0	-4.4	-4.9	-5.6	-5.1	-2.7	-5.6
Weight	5.3	25.9	36.6	-5.7	-4.8	-5.4	-3.7	-5.5	-4.1	5.6	-5.2	-5.3	-3.5	-5.7	-5.5	-4.8	-6.0	-6.0	-0.9	-5.9
HDL Cholesterol	5.2	8.7	11.3	2.9	3.2	3.4	2.1	3.1	2.6	-3.0	3.0	3.2	3.1	3.0	3.3	3.0	2.5	3.0	2.2	3.1
Illnesses of father: Heart disease	5.0	7.0	10.0	-2.7	-2.7	-3.1	-1.9	-2.9	-2.1	3.2	-1.9	-2.8	-1.9	-3.0	-3.1	-2.4	-3.0	-3.0	-1.3	-3.1
Illnesses of father: None of the above (group 1)	5.0	6.2	8.2	2.2	2.9	2.8	2.5	2.7	2.3	-2.7	1.4	2.6	2.4	2.6	2.6	2.5	2.0	2.3	2.8	2.5
Age at First Birth	4.8	6.9	9.3	2.9	2.5	3.0	2.3	3.0	1.7	-3.0	2.8	2.8	1.9	2.9	2.8	2.5	2.7	2.9	1.5	2.9
Qualifications: O levels/GCSEs or equivalent	4.7	7.6	11.7	2.7	3.2	3.0	2.9	2.9	2.6	-2.9	1.4	2.9	2.4	3.0	2.8	2.4	2.1	2.5	3.4	2.9
Body fat percentage	4.6	18.0	24.8	-4.4	-4.3	-4.7	-2.2	-4.6	-3.6	4.3	-3.8	-4.7	-4.2	-4.5	-3.9	-4.4	-4.9	-4.5	-3.1	-5.0
Worry too long after embarrassment	4.6	7.7	11.5	3.1	2.9	2.8	1.9	3.0	2.8	-2.9	2.4	2.9	2.1	3.1	2.9	3.2	2.3	3.3	1.3	3.4
Exposure to tobacco smoke outside home	4.5	6.0	8.0	-2.6	-2.6	-2.7	-1.5	-2.7	-2.3	2.7	-2.7	-2.7	-1.8	-2.7	-2.7	-2.2	-2.5	-2.8	-0.7	-2.7
Mouth/teeth dental problems: Dentures	4.4	7.5	15.7	-3.2	-1.4	-2.7	-1.5	-2.9	-1.2	3.3	-2.5	-2.6	-0.3	-3.5	-2.5	-3.5	-3.4	-3.7	-0.0	-4.0
Maternal smoking around birth	4.3	6.3	9.4	-2.5	-2.6	-2.7	-1.1	-2.5	-3.1	2.5	-2.9	-2.5	-2.2	-2.5	-2.3	-3.0	-2.3	-2.6	-1.6	-2.9
Birth weight of first child	4.3	7.7	15.7	2.7	3.0	2.9	2.7	3.0	4.0	-2.5	2.1	3.0	3.3	2.7	3.0	2.8	1.8	2.5	2.2	2.2
Hayfever/allergic rhinitis (self-reported)	4.2	5.5	9.3	2.9	1.4	2.3	0.3	2.5	2.8	-2.5	2.6	2.3	1.1	2.6	1.9	2.9	2.7	3.0	-0.5	3.1
Hayfever, allergic rhinitis or eczema	4.1	8.8	17.2	3.4	1.6	3.0	0.3	3.1	2.6	-3.1	2.3	3.1	1.8	3.4	2.3	4.1	4.0	4.0	-0.1	4.2
Hip circumference	4.0	17.0	24.1	-4.5	-4.7	-4.5	-3.9	-4.5	-3.1	4.7	-3.0	-4.4	-2.9	-4.8	-4.3	-3.1	-4.9	-4.6	-2.0	-4.7
Medication: Gliclazide	4.0	4.5	6.1	-2.3	-2.3	-2.3	-1.5	-2.1	-2.2	2.2	-2.1	-2.1	-1.8	-2.2	-2.1	-1.9	-1.8	-2.0	-2.4	-2.5
Leg fat mass (right)	3.9	15.1	21.7	-4.2	-3.8	-4.2	-2.1	-4.2	-3.5	4.1	-3.8	-4.2	-3.3	-4.3	-3.6	-4.0	-4.7	-4.4	-1.7	-4.6
Leg fat mass (left)	3.9	15.1	23.3	-4.2	-3.8	-4.2	-2.0	-4.2	-3.4	4.1	-3.8	-4.1	-3.2	-4.3	-3.6	-4.0	-4.8	-4.4	-1.6	-4.6
Body mass index (BMI)	3.8	16.1	29.4	-4.3	-3.9	-4.3	-1.6	-4.3	-3.4	4.2	-3.8	-4.2	-3.1	-4.4	-4.0	-4.2	-5.4	-4.8	-0.5	-4.9
Qualifications: A levels/AS levels or equivalent	3.7	8.2	17.8	2.9	2.9	2.8	2.1	3.1	3.1	-2.5	1.8	3.0	2.9	2.9	2.6	4.2	1.8	2.8	3.2	3.0
Leg predicted mass (left)	3.6	18.9	29.5	-4.9	-3.9	-4.4	-3.3	-4.5	-3.4	5.0	-4.3	-4.4	-2.0	-5.1	-4.9	-4.2	-5.3	-5.4	0.1	-5.3
Medication for hormone replacement therapy	3.5	3.9	5.9	-1.9	-2.2	-2.2	-1.2	-1.9	-2.4	1.8	-1.9	-2.2	-2.4	-1.9	-2.3	-2.0	-1.8	-1.9	-1.1	-1.9
Diabetes (self-reported)	3.5	5.4	12.7	-2.4	-2.2	-2.4	0.2	-2.2	-1.6	2.2	-2.3	-2.2	-1.6	-2.5	-2.3	-2.8	-2.9	-2.6	-1.8	-3.6
Type 2 Diabetes (T2D) (2018)	3.4	6.4	11.4	-2.4	-2.8	-2.8	-0.1	-2.4	-1.9	2.4	-2.8	-2.4	-2.6	-2.4	-2.7	-2.6	-3.4	-2.5	-1.8	-3.2
Leg fat-free mass (left)	3.4	18.2	28.6	-4.8	-3.7	-4.3	-3.2	-4.5	-3.2	4.9	-4.2	-4.3	-1.9	-5.0	-4.8	-4.1	-5.3	-5.3	0.2	-5.2
Breastfed as a baby	3.4	4.2	13.0	2.0	2.5	2.2	1.4	2.0	1.8	-1.7	1.7	2.1	2.5	2.0	1.1	1.9	1.4	1.6	3.6	2.1
Illnesses of siblings	3.3	4.6	7.5	1.9	1.8	2.2	0.3	2.2	2.4	-1.9	2.5	2.3	2.3	2.2	2.3	2.6	2.3	2.4	1.0	2.7
Basal metabolic rate	3.3	18.1	28.5	-4.9	-3.6	-4.3	-3.4	-4.5	-3.3	4.9	-4.4	-4.3	-1.8	-5.0	-4.9	-3.8	-5.3	-5.3	0.7	-5.0
Waist circumference	3.2	11.6	20.8	-3.7	-3.0	-3.6	-0.5	-3.6	-3.0	3.4	-3.6	-3.4	-2.6	-3.7	-3.3	-3.9	-4.3	-4.0	-1.1	-4.6
Average weekly champagne plus white wine intake	3.2	4.3	7.4	2.6	1.4	2.0	1.7	2.3	1.4	-2.2	2.7	2.1	1.4	2.4	2.3	2.3	1.9	2.4	0.9	2.4
Number of treatments/medications taken	3.1	5.6	10.0	2.8	1.1	2.4	1.9	2.7	1.6	-2.7	3.0	2.7	1.3	2.9	2.5	1.4	3.2	3.0	-0.2	2.6
Medication: Co-codamol	3.1	3.6	9.6	-1.8	-2.2	-2.0	-1.8	-1.9	-1.5	1.8	-1.5	-2.1	-2.0	-1.9	-1.2	-2.0	-1.1	-1.6	-3.1	-1.9
Diabetes (father)	3.1	3.9	7.3	-1.8	-2.4	-2.2	-0.1	-1.9	-1.9	1.7	-1.6	-1.9	-2.4	-1.8	-1.4	-2.1	-2.0	-1.7	-2.7	-2.5
Medication for cholesterol	3.1	4.7	12.1	1.9	2.4	2.2	0.3	1.8	3.1	-1.5	1.7	2.0	2.8	1.7	1.7	3.5	0.8	1.7	2.9	2.2
Hearing difficulty/problems: Yes	3.0	4.5	6.0	2.4	1.8	2.3	1.0	2.3	2.2	-2.1	2.5	2.2	2.2	2.2	2.1	2.2	2.2	2.2	1.5	2.3
Birth weight	3.0	6.5	10.6	2.5	3.2	2.8	1.6	2.5	3.0	-2.2	2.4	2.7	3.2	2.4	2.2	2.7	1.8	2.2	3.0	2.5
Leg fat-free mass (right)	3.0	16.0	25.6	-4.5	-3.5	-4.0	-2.9	-4.1	-3.0	4.6	-4.0	-4.0	-1.6	-4.7	-4.5	-3.8	-5.1	-5.0	0.3	-5.0
Leg predicted mass (right)	3.0	15.9	25.4	-4.5	-3.5	-4.0	-2.9	-4.1	-3.0	4.6	-3.9	-4.0	-1.6	-4.7	-4.6	-3.9	-5.0	-5.0	0.3	-5.0
Mother’s age at death	3.0	3.8	8.7	2.2	2.2	2.0	-0.1	1.9	2.3	-1.9	1.4	1.7	1.2	2.1	1.5	2.2	2.2	2.3	1.2	3.0
Cardiovascular Disease	2.9	9.7	20.9	-3.1	-3.6	-3.5	-1.5	-3.0	-3.8	2.6	-2.9	-3.1	-4.6	-2.7	-3.0	-3.3	-2.1	-2.5	-3.6	-2.8
Arm fat-free mass (left)	2.9	14.8	25.2	-4.4	-3.0	-3.7	-3.0	-4.1	-3.0	4.4	-4.0	-3.8	-1.3	-4.5	-4.6	-3.2	-5.0	-5.0	1.5	-4.5
Alzheimer’s Disease (in father)	2.8	3.0	7.3	-1.8	-1.9	-1.9	-2.3	-1.8	-2.7	1.6	-1.4	-1.9	-2.3	-1.5	-2.0	-1.3	-1.1	-1.4	-0.8	-0.7
Ulcerative Colitis (UC)	2.8	5.2	20.4	-1.7	-3.4	-2.1	-4.5	-1.9	-3.2	1.7	-0.6	-2.1	-3.3	-1.3	-1.2	-1.6	1.4	-0.7	-3.0	0.4
Allergy or Eczema	2.8	7.4	17.1	3.1	1.0	2.7	-0.5	2.8	1.9	-2.8	2.4	2.7	1.4	3.0	2.1	3.9	3.6	3.8	-0.6	4.1
Hand grip strength (left)	2.8	7.4	10.0	-2.8	-2.9	-3.0	-3.2	-3.1	-2.9	2.8	-2.4	-3.0	-3.0	-2.8	-2.9	-2.0	-2.6	-2.6	-1.6	-2.1
Allergy	2.7	6.1	11.7	-2.7	-1.6	-2.7	0.1	-2.5	-2.5	2.4	-2.2	-2.6	-2.5	-2.5	-1.9	-3.4	-3.2	-3.0	-0.3	-3.1
Tense / ‘highly strung’	2.7	4.4	5.3	-2.2	-2.3	-2.3	-1.6	-2.3	-2.2	2.1	-2.2	-2.2	-2.3	-2.2	-2.0	-2.3	-1.4	-2.1	-1.8	-2.1
Whole body water mass	2.7	15.5	25.3	-4.6	-3.2	-3.8	-3.3	-4.1	-3.0	4.5	-4.0	-3.9	-1.3	-4.6	-4.6	-3.3	-4.9	-5.0	1.2	-4.6
BMI	2.6	15.1	27.1	-4.2	-3.8	-4.2	-2.0	-4.3	-3.1	4.0	-3.4	-4.1	-3.5	-4.2	-4.1	-3.9	-5.2	-4.4	-1.4	-4.6
Knee pain experienced in last month	2.6	4.1	8.1	-2.2	-2.4	-2.1	-0.6	-2.1	-1.3	2.0	-2.5	-2.1	-1.6	-2.1	-1.7	-2.0	-2.8	-2.4	0.1	-2.4
Whole body fat-free mass	2.6	15.1	24.9	-4.5	-3.2	-3.8	-3.3	-4.1	-3.0	4.5	-4.0	-3.8	-1.2	-4.6	-4.5	-3.4	-4.8	-5.0	1.3	-4.5
Arm predicted mass (left)	2.6	13.3	22.4	-4.2	-2.9	-3.5	-2.8	-3.9	-2.8	4.2	-3.9	-3.6	-1.2	-4.3	-4.3	-3.0	-4.7	-4.7	1.4	-4.3
Hand grip strength (right)	2.5	6.9	9.8	-2.8	-2.5	-2.8	-3.1	-3.0	-1.8	3.0	-2.0	-2.9	-2.0	-3.1	-2.8	-2.1	-2.9	-2.8	-1.4	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	9.3	2.1	2.1	1.9	2.0	1.8	3.0	-1.5	2.2	2.1	2.5	1.6	2.1	2.6	0.1	1.6	1.9	1.3
Headache pain in last month	2.5	4.3	14.8	2.2	1.7	2.0	1.6	2.0	3.9	-1.4	1.8	2.1	3.1	1.6	1.6	2.7	0.5	1.5	2.0	1.3
Schizophrenia vs Biploar Disorder	2.4	3.2	6.2	-1.8	-1.8	-2.0	-2.2	-1.9	-1.6	1.8	-2.5	-1.9	-2.2	-1.7	-2.1	0.1	-2.0	-1.6	-0.1	-0.9
Father’s age at death	2.4	3.2	10.6	1.6	1.8	1.6	-0.3	1.4	1.2	-1.4	1.6	1.4	1.2	1.6	1.7	3.3	1.0	1.7	2.5	2.7
Medication: Allopurinol	2.4	3.1	8.2	1.8	1.4	1.8	1.2	1.8	1.5	-2.1	2.4	1.8	0.6	1.9	1.6	0.7	2.9	2.2	-1.4	1.7
Heart disease (siblings)	2.4	2.9	5.6	-1.9	-1.1	-1.6	-1.2	-1.9	-1.4	1.6	-2.4	-1.7	-1.5	-1.9	-2.2	-1.8	-1.1	-1.9	-1.1	-2.0
Hearing difficulty/problems with background noise	2.3	3.6	8.5	2.2	1.2	2.0	-0.3	1.8	2.4	-1.6	2.4	1.7	1.8	1.7	1.7	2.9	1.9	2.1	0.2	2.4
Qualifications: None of the above	2.3	4.9	9.1	-2.6	-1.9	-2.2	-1.8	-2.3	-1.9	2.5	-1.3	-2.3	-0.9	-2.7	-2.3	-2.5	-1.9	-2.5	-2.1	-3.0
Arm fat-free mass (right)	2.3	11.6	19.4	-4.0	-2.6	-3.2	-3.0	-3.6	-2.9	4.0	-3.5	-3.3	-0.9	-4.1	-3.9	-2.8	-4.3	-4.4	1.1	-4.0
High cholesterol (Self-reported)	2.3	4.1	9.1	-2.1	-1.7	-2.2	-0.4	-1.8	-2.6	1.5	-1.7	-2.0	-3.0	-1.7	-1.9	-2.7	-0.9	-1.5	-3.0	-2.1
Worry (Nagel 2018)	2.2	4.6	8.8	-2.1	-3.0	-2.3	-2.3	-2.1	-2.1	1.8	-2.2	-2.2	-2.9	-1.9	-2.6	-1.2	-1.0	-1.5	-2.8	-1.5
Alzheimer’s Disease (including proxy)	2.2	3.1	6.3	-1.9	-2.0	-1.8	-1.1	-1.8	-2.5	1.6	-2.0	-1.8	-1.8	-1.7	-1.6	-2.1	-1.6	-1.9	0.3	-1.5
Lung cancer (father)	2.2	2.5	3.9	-1.8	-1.3	-1.6	-1.0	-1.8	-1.9	1.4	-1.5	-1.7	-1.9	-1.6	-2.0	-1.5	-1.2	-1.6	-1.2	-1.7
Arm predicted mass (right)	2.2	11.3	19.6	-3.9	-2.5	-3.1	-2.7	-3.5	-2.5	3.9	-3.6	-3.2	-0.6	-4.0	-3.9	-2.8	-4.4	-4.4	1.5	-4.1
Commuting to job workplace: Cycle	2.2	2.6	3.8	1.7	1.4	1.5	1.1	1.9	1.2	-1.5	1.4	1.8	1.4	1.9	1.6	1.9	1.9	1.8	1.1	1.9
Alcohol drinker status: Previous	2.2	2.6	4.8	-1.5	-1.7	-1.7	-0.7	-1.6	-2.2	1.4	-1.9	-1.5	-1.9	-1.5	-1.4	-0.8	-1.8	-1.4	-1.6	-1.6
Intelligence (Savage-Jansen 2018)	2.1	6.5	9.4	2.6	2.4	2.7	2.4	2.7	1.9	-2.8	2.2	2.8	2.1	2.9	2.6	2.6	1.8	2.7	2.7	3.1
Blood Eosinophil Count	2.1	16.4	30.4	-4.3	-4.5	-4.4	-5.5	-4.6	-3.7	4.4	-3.1	-4.5	-4.0	-4.3	-4.5	-2.8	-3.4	-3.8	-2.9	-3.1
Height	2.1	41.3	73.4	-7.5	-5.6	-6.4	-8.6	-6.8	-4.2	7.3	-6.8	-6.6	-3.6	-7.3	-8.2	-6.3	-5.2	-7.0	-2.4	-6.2
Had menopause	2.1	2.7	9.2	-1.6	-1.6	-1.7	-3.0	-1.8	-2.2	1.9	-1.1	-1.8	-1.3	-1.7	-1.3	-1.2	-1.0	-1.5	-0.7	-0.8
Trunk fat-free mass	2.1	12.0	20.2	-4.1	-2.6	-3.2	-3.3	-3.6	-2.6	4.0	-3.7	-3.3	-0.8	-4.1	-4.1	-2.7	-4.3	-4.5	1.8	-3.9
Medication: Lansoprazole	2.1	2.4	3.9	1.6	1.4	1.7	1.7	1.6	2.0	-1.9	1.6	1.7	1.0	1.8	1.5	0.6	1.4	1.6	1.1	1.5
Trunk predicted mass	2.1	12.0	20.0	-4.1	-2.7	-3.3	-3.3	-3.6	-2.6	4.0	-3.7	-3.3	-0.9	-4.1	-4.1	-2.7	-4.2	-4.5	1.8	-3.8
Leg fat percentage (right)	2.1	7.7	12.1	-2.9	-2.7	-3.1	-1.0	-3.1	-2.6	2.8	-2.7	-3.0	-2.8	-2.9	-2.1	-3.1	-3.5	-3.0	-1.6	-3.2
Medication: Aspirin	2.1	2.7	8.9	-1.3	-2.4	-1.8	-0.9	-1.3	-2.1	1.1	-1.3	-1.5	-3.0	-0.8	-2.0	-1.5	-0.2	-0.6	-2.5	-0.8
Illnesses of siblings: Diabetes	2.1	2.6	6.0	-1.6	-1.7	-1.6	0.4	-1.6	-1.5	1.4	-2.0	-1.5	-1.2	-1.7	-1.0	-1.6	-2.1	-1.9	-0.9	-2.5
Medication: Aspirin	2.1	2.7	8.9	-1.3	-2.5	-1.8	-1.0	-1.4	-2.2	1.1	-1.1	-1.5	-3.0	-0.9	-1.8	-1.3	-0.3	-0.6	-2.5	-0.7
Commuting to job workplace: Public transport	2.1	2.6	3.5	1.8	1.9	1.9	0.9	1.8	1.5	-1.6	1.1	1.7	1.8	1.7	1.3	1.8	1.6	1.7	1.0	1.7
Osteoporosis (self-reported)	2.0	2.5	5.5	2.0	1.1	1.5	0.2	1.7	1.2	-1.4	2.1	1.7	1.1	1.7	1.1	1.8	2.3	2.0	-0.4	1.9
Leg fat percentage (left)	2.0	7.3	12.8	-2.8	-2.6	-3.0	-0.7	-3.0	-2.5	2.7	-2.6	-2.9	-2.7	-2.8	-2.1	-3.0	-3.6	-2.9	-1.6	-3.2
Age started oral contraceptive pill	2.0	2.5	5.2	1.9	1.0	1.6	1.0	1.9	0.9	-1.7	1.2	1.6	0.8	2.1	1.9	0.9	1.9	2.1	0.7	2.3
Medication: Cholesterol lowering	1.9	2.9	9.2	-1.3	-1.9	-1.6	0.5	-1.1	-2.7	0.8	-1.6	-1.3	-2.8	-1.0	-1.4	-2.3	-0.3	-0.9	-3.0	-1.7
Gout (self-reported)	1.9	2.5	4.8	1.4	1.6	1.9	1.4	1.8	1.8	-1.8	1.6	1.8	1.7	1.6	1.7	0.8	2.2	1.7	-0.1	1.3
Number of full brothers	1.9	2.4	5.3	-1.8	-0.5	-1.6	-0.7	-1.6	-1.4	1.9	-1.4	-1.6	-0.4	-2.0	-1.4	-1.6	-1.8	-2.1	-0.5	-2.3
Mean Putamen Volume	1.8	2.1	4.6	-1.9	-1.2	-1.6	-0.3	-1.6	-0.4	1.5	-1.1	-1.5	-1.0	-1.8	-1.3	-1.4	-1.8	-1.9	-0.5	-2.1
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	5.2	-1.2	-1.3	-1.3	-0.5	-1.3	-0.3	1.4	-1.3	-1.4	-0.8	-1.7	-1.7	-1.3	-2.3	-1.8	-0.5	-2.1
Severe depression (siblings)	1.8	2.0	3.0	1.2	1.3	1.7	0.5	1.5	1.7	-1.4	1.3	1.5	1.6	1.5	1.4	1.2	1.7	1.4	1.0	1.6
High blood pressure (mother)	1.8	2.5	6.2	1.6	-0.0	0.8	0.2	1.2	-1.0	-1.6	1.8	0.9	-1.3	1.8	1.7	1.3	2.5	2.2	-1.8	2.4
Impedance of leg (left)	1.8	8.8	19.8	3.2	1.9	2.6	1.4	2.9	1.8	-3.2	2.6	2.7	0.5	3.4	3.5	2.9	4.5	4.1	-2.8	3.7
Mouth/teeth dental problems	1.8	2.8	5.2	1.8	0.5	1.6	1.9	2.0	0.2	-2.2	0.9	1.7	0.0	2.3	2.2	1.1	1.9	2.1	0.7	2.2
Eye problems/disorders: None of the above	1.8	2.1	5.3	-1.5	-0.3	-1.4	-0.5	-1.2	-2.3	1.7	-1.3	-1.3	-0.1	-1.5	-1.8	-1.9	-1.4	-1.8	0.5	-1.9
Mineral and other dietary supplements	1.8	2.4	4.0	-1.9	-1.4	-1.6	-0.7	-1.7	-1.5	1.7	-1.7	-1.5	-0.7	-1.8	-1.4	-1.8	-1.4	-1.8	-1.0	-2.0
Asthma (self-reported)	1.8	3.6	8.6	1.9	0.7	1.7	-1.2	1.6	1.6	-1.5	2.8	1.6	1.3	1.8	1.7	2.2	2.9	2.4	-1.0	2.6
Wears glasses or contact lenses	1.8	2.0	4.6	1.4	1.5	1.6	0.5	1.5	1.1	-1.1	1.8	1.5	2.2	1.3	1.3	1.1	1.1	1.3	1.7	1.5
Cholesterol lowering medication	1.8	2.6	6.6	-1.5	-1.3	-1.8	-0.4	-1.4	-2.2	1.4	-1.9	-1.5	-1.9	-1.3	-1.2	-2.6	-0.7	-1.2	-2.1	-1.5
Glaucoma (self-reported)	1.7	2.0	5.7	1.7	1.4	1.3	1.6	1.3	1.3	-1.5	1.5	1.4	0.3	1.6	0.9	2.4	0.7	1.7	0.7	1.6
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	11.6	-2.0	-1.8	-1.6	-3.4	-1.8	-0.8	2.0	-1.5	-1.7	-0.5	-2.1	-1.9	-1.6	-0.4	-1.7	-2.0	-1.7
Pulse rate, automated reading	1.7	5.4	8.4	-2.5	-2.2	-2.5	-1.4	-2.6	-2.2	2.4	-2.9	-2.5	-1.9	-2.5	-2.2	-2.3	-2.6	-2.7	-0.1	-2.4
Angina	1.6	2.1	4.7	-1.4	-1.4	-1.5	-0.6	-1.4	-1.8	1.5	-1.3	-1.4	-1.0	-1.4	-2.0	-2.2	-1.0	-1.4	-0.9	-1.6
Ever taken oral contraceptive pill	1.6	1.7	6.7	1.3	0.5	1.3	1.3	1.4	0.4	-1.3	1.6	1.3	0.8	1.4	2.6	1.3	1.5	1.4	-0.1	1.2
Number of operations (self-reported)	1.6	2.4	4.0	1.8	1.1	1.7	1.8	1.5	1.9	-1.7	1.8	1.6	1.4	1.5	1.1	2.0	0.5	1.4	1.7	1.3
Irritable Bowel Disease (IBD)	1.5	3.5	17.0	-0.3	-2.4	-0.9	-4.1	-0.6	-2.2	0.5	0.9	-0.9	-2.4	-0.2	-0.3	-0.2	2.6	0.7	-3.7	1.4
Verbal and Numeric Reasoning (VNR)	1.5	3.7	12.1	1.8	1.9	1.7	1.9	1.8	1.3	-1.7	1.2	1.9	1.6	1.9	2.0	2.7	0.4	1.5	3.5	2.1
Prostate Cancer	1.5	2.1	6.8	-1.4	-1.0	-1.4	-1.5	-1.6	-0.8	1.3	-2.6	-1.5	-1.2	-1.5	-1.8	-0.6	-1.2	-1.2	-1.5	-1.4
Qualifications: CSEs or equivalent	1.5	1.9	6.2	-1.5	-1.1	-1.4	0.1	-1.3	0.1	1.6	-1.2	-1.1	-0.0	-1.7	-0.7	-1.8	-1.8	-1.9	-0.6	-2.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	10.0	-2.5	-1.7	-2.5	-2.9	-2.4	-2.1	2.6	-3.2	-2.4	-1.8	-2.5	-1.8	-1.6	-1.4	-2.3	-1.6	-2.1
Medication: Amlodipine	1.5	2.1	5.6	-1.5	-1.0	-1.5	-0.7	-1.6	-2.4	1.2	-0.6	-1.4	-1.9	-1.3	-1.5	-2.1	-1.0	-1.4	-0.7	-1.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.2	-1.4	-1.1	-1.4	-1.3	-1.5	-0.7	1.5	-2.0	-1.5	-1.2	-1.5	-1.0	-0.5	-1.5	-1.4	-0.4	-1.1
Angina (self-reported)	1.5	2.0	5.0	-1.4	-1.4	-1.5	-0.5	-1.3	-1.8	1.5	-1.2	-1.3	-0.8	-1.4	-1.9	-2.2	-0.9	-1.4	-0.8	-1.7
Suffer from ‘nerves’	1.5	2.4	4.6	-1.6	-1.6	-1.6	-1.1	-1.5	-1.2	1.4	-1.9	-1.4	-1.4	-1.5	-1.2	-2.1	-0.7	-1.4	-2.1	-1.7
Supplements: Vitamin C	1.5	1.8	4.9	1.4	1.0	1.3	0.5	1.3	0.5	-1.4	1.5	1.4	0.5	1.4	1.3	0.9	2.2	1.8	-1.8	1.3
Loneliness, isolation	1.5	2.1	6.0	1.1	1.7	1.3	1.9	1.1	2.2	-0.8	1.3	1.2	2.2	0.8	0.1	2.0	-1.0	0.6	2.5	0.3
Pack years of smoking	1.5	2.1	5.9	-1.4	-0.9	-1.5	0.3	-1.4	-0.1	1.6	-1.4	-1.4	-0.4	-1.7	-1.3	-1.9	-2.2	-1.9	-0.4	-2.4
Breast Cancer	1.4	3.5	13.9	-0.8	-2.4	-1.3	-3.5	-1.1	-2.4	0.7	-0.6	-1.2	-3.2	-0.3	0.1	0.0	1.8	0.5	-3.7	1.4
Pack years adult smoking proportion	1.4	2.1	6.1	-1.4	-0.6	-1.5	0.6	-1.3	0.2	1.6	-1.3	-1.3	-0.3	-1.6	-1.3	-1.6	-2.5	-1.9	-0.1	-2.5
Impedance of leg (right)	1.4	6.7	17.0	2.8	1.5	2.2	0.8	2.4	1.4	-2.7	2.2	2.3	0.2	2.9	3.0	2.6	4.1	3.6	-2.6	3.5
Medication: Simvastatin	1.4	2.0	9.4	-1.0	-1.4	-1.2	0.3	-0.8	-2.0	0.4	-0.9	-0.9	-2.6	-0.6	-1.2	-1.9	0.3	-0.4	-3.1	-1.0
Illnesses of mother	1.4	1.7	6.2	0.9	1.3	1.4	1.4	1.2	1.8	-0.9	1.1	1.4	2.5	0.8	1.2	1.6	-0.0	0.6	1.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.8	1.6	1.2	1.1	0.9	1.3	1.3	-1.0	1.6	1.2	1.1	1.3	1.2	2.2	0.8	1.3	1.0	1.4
Body Mass Index (BMI) (2010)	1.3	1.8	3.0	-1.3	-1.2	-1.5	-1.1	-1.5	-1.6	1.5	-1.7	-1.4	-1.1	-1.4	-1.1	-1.1	-1.7	-1.6	0.6	-1.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.1	-1.2	-1.3	-1.4	-1.2	-1.4	-1.8	1.3	-1.5	-1.3	-1.1	-1.2	-1.1	-1.5	-1.0	-1.3	-0.5	-1.1
Systolic blood pressure, automated reading	1.3	3.9	10.0	-1.7	-2.0	-1.7	-3.0	-1.9	-3.0	1.5	-1.3	-1.9	-2.7	-1.5	-1.5	-2.2	0.5	-1.0	-3.2	-0.6
Forced vital capacity (FVC)	1.3	5.1	13.2	-2.4	-1.9	-2.4	-3.6	-2.4	-2.5	2.5	-2.7	-2.4	-2.0	-2.4	-1.7	-1.3	-0.9	-2.0	-2.3	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	10.9	-1.5	-1.7	-1.7	0.4	-1.5	-3.3	1.0	-2.1	-1.5	-2.8	-1.1	-0.8	-2.4	-1.0	-1.4	-1.1	-1.4
Medication: Ramipril	1.3	1.7	4.3	-1.3	-1.9	-1.6	-0.8	-1.4	-1.5	1.2	-1.2	-1.5	-2.1	-1.1	-1.2	-0.3	-1.3	-0.9	-1.2	-0.8
Fluid intelligence score	1.3	2.7	12.4	1.4	1.1	1.3	1.3	1.3	1.5	-1.1	0.7	1.4	1.5	1.5	1.5	2.7	-0.3	1.1	3.5	1.8
Asthma	1.3	2.5	6.7	1.5	0.5	1.3	-1.4	1.2	1.4	-1.1	2.6	1.3	1.3	1.3	1.3	1.8	2.5	1.9	-0.9	2.1
Prospective memory result	1.3	1.7	5.1	1.0	0.8	1.3	-0.4	1.1	0.0	-1.4	1.5	1.2	0.4	1.3	1.5	0.8	2.3	1.7	-0.9	2.0
Standing height	1.3	13.3	31.1	-4.2	-3.5	-3.7	-5.6	-3.8	-2.6	4.4	-4.1	-3.8	-1.9	-4.1	-4.7	-2.2	-2.7	-3.8	-1.4	-3.2
Comparative height size at age 10	1.3	7.1	12.7	-2.9	-2.4	-2.8	-3.6	-2.7	-2.9	3.0	-3.1	-2.7	-2.0	-2.8	-3.5	-2.2	-1.3	-2.6	-1.6	-2.3
Eye problems/disorders: Glaucoma	1.3	1.5	4.2	1.2	1.6	1.1	1.4	0.9	1.5	-1.2	1.2	1.1	0.5	1.2	0.4	2.1	-0.0	1.2	1.3	1.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.8	1.7	1.1	1.4	0.8	1.5	1.3	-1.6	1.4	1.4	0.9	1.5	1.0	1.1	1.4	1.5	0.6	1.4
Reaction Time	1.2	2.2	5.3	-1.7	-1.3	-1.4	-0.0	-1.5	-1.4	1.4	-1.7	-1.2	-1.0	-1.6	-0.3	-2.3	-0.9	-1.5	-2.1	-2.2
Heel T-Score	1.2	9.3	36.6	-2.4	-3.6	-3.5	1.2	-2.5	-4.8	1.8	-3.4	-2.8	-6.0	-1.8	-2.3	-3.0	-1.7	-2.0	-2.7	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	11.7	-1.4	-1.7	-1.5	0.6	-1.3	-3.4	0.8	-1.7	-1.4	-2.7	-1.0	-1.0	-1.9	-1.0	-1.1	-2.0	-1.5
Medication: Levothyroxine sodium	1.2	2.1	8.1	-1.7	-0.8	-1.3	-2.8	-1.5	0.1	1.8	-1.4	-1.3	0.0	-1.8	-1.9	-0.9	-0.7	-1.5	-0.7	-1.4
Hair/balding pattern: Pattern 2	1.2	1.6	4.3	1.5	0.4	1.4	0.7	1.4	0.9	-1.5	1.5	1.3	0.7	1.3	1.3	2.1	0.4	1.5	0.3	1.5
Happiness	1.2	1.5	2.2	1.3	1.3	1.1	1.2	1.3	1.5	-1.2	1.0	1.2	0.7	1.4	1.2	1.4	0.5	1.3	1.4	1.4
Age at first live birth	1.2	2.1	4.3	1.7	1.3	1.3	1.2	1.5	1.6	-1.7	0.8	1.4	0.1	1.9	1.3	1.7	1.5	2.0	0.4	2.1
Chest pain or discomfort	1.2	1.7	2.9	-1.2	-1.7	-1.3	-1.4	-1.3	-1.6	1.3	-0.8	-1.2	-0.8	-1.4	-0.9	-1.5	-0.8	-1.3	-1.6	-1.5
Age at last live birth	1.2	1.7	4.0	1.3	1.3	1.0	1.9	1.2	1.4	-1.3	0.4	1.2	0.4	1.5	1.3	1.2	0.3	1.3	2.0	1.6
Medication: Lisinopril	1.2	1.6	6.3	-1.0	-1.7	-1.3	-0.9	-1.2	-1.5	0.8	-0.5	-1.2	-2.5	-0.8	-1.8	-1.1	-0.6	-0.7	-1.3	-0.6
Supplements: Calcium	1.2	1.3	2.2	1.4	1.1	1.0	0.2	1.2	1.4	-1.0	1.5	1.1	0.6	1.3	0.8	1.2	1.3	1.5	0.1	1.5
Basal cell carcinoma (self-reported)	1.2	1.5	3.0	1.3	1.2	1.2	0.9	1.2	1.0	-1.3	1.1	1.3	0.4	1.6	0.7	1.3	1.3	1.6	0.8	1.7
Crohns Disease (2012)	1.1	1.8	5.9	1.5	0.1	0.8	-1.3	0.9	-0.3	-1.2	1.5	0.8	-0.8	1.2	0.0	0.6	2.4	1.9	-2.1	2.0
LDL Cholesterol	1.1	1.7	9.2	1.3	2.0	1.4	3.0	1.4	0.6	-1.5	0.7	1.4	1.0	1.2	1.0	0.3	0.6	1.0	0.1	0.2
Pulse wave reflection index	1.1	1.3	1.7	1.2	1.2	1.3	0.7	1.2	0.9	-1.1	1.3	1.3	1.2	1.1	1.2	1.3	1.0	1.1	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	7.4	0.9	1.7	1.3	-0.1	0.8	1.7	-0.6	1.3	0.9	2.5	0.6	0.9	1.4	-0.2	0.4	2.7	0.9
Average weekly red wine intake	1.1	1.6	5.2	1.1	1.0	1.1	-0.7	1.1	1.1	-1.2	1.0	1.0	0.2	1.3	0.5	2.3	1.3	1.7	0.4	2.2
Ever had bowel cancer screening	1.1	1.3	4.6	1.2	0.0	1.1	0.1	1.2	-0.1	-1.4	1.5	1.1	0.3	1.4	1.0	0.4	2.1	1.5	-0.4	1.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.5	1.2	1.9	1.4	-1.2	1.0	1.5	-0.8	1.8	1.1	1.6	0.9	-0.2	2.1	1.2	1.1	0.9	1.5
Vascular/heart problems diagnosed by doctor	1.1	2.9	8.4	1.6	1.8	1.8	0.6	1.6	2.9	-1.1	1.5	1.5	2.9	1.1	1.8	2.2	0.6	1.0	2.0	1.1
Crohns Disease (2017)	1.0	2.3	12.6	0.8	-0.8	0.3	-2.6	0.5	-0.6	-0.5	1.2	0.3	-0.9	0.7	0.5	0.6	2.8	1.6	-3.6	1.7
Lupus	1.0	1.6	4.1	1.1	1.6	1.5	1.2	1.3	1.7	-1.1	1.2	1.4	2.0	1.0	1.5	0.3	0.9	0.9	0.9	0.6
Supplements: Zinc	1.0	1.1	3.2	1.1	-0.1	0.9	0.6	0.8	-0.4	-1.1	1.6	0.7	0.1	1.0	1.8	0.1	1.6	1.2	-1.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	7.0	-2.0	-1.7	-1.9	-2.0	-1.9	-2.0	1.9	-2.6	-1.9	-1.9	-2.0	-1.1	-0.9	-1.4	-1.8	-1.7	-1.7
Length of working week for main job	1.0	1.1	6.6	-0.5	0.2	-0.2	0.4	-0.3	1.0	0.9	-0.1	-0.2	1.6	-0.8	-0.5	-0.0	-1.6	-1.4	2.6	-1.3
Qualifications: College or University degree	1.0	3.3	10.1	1.8	0.9	1.5	-0.0	1.8	0.2	-1.8	0.8	1.6	0.1	2.2	1.8	3.0	2.2	2.4	1.2	3.2
Mean time to correctly identify matches	1.0	1.9	4.1	-1.6	-1.2	-1.4	-0.4	-1.4	-1.4	1.3	-1.9	-1.2	-1.1	-1.4	-0.8	-2.0	-0.8	-1.4	-1.5	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	1.0	0.9	1.2	0.7	1.2	1.3	-1.1	1.4	1.1	1.3	1.1	0.7	1.0	1.2	1.2	0.1	1.0
Qualifications: nursing, teaching	1.0	1.5	3.2	1.4	0.6	1.1	0.4	1.2	1.6	-1.2	1.0	1.2	0.7	1.3	1.2	1.8	0.7	1.3	1.4	1.7
Commuting to job workplace: Walk	1.0	1.1	2.7	1.2	0.3	0.9	0.1	1.1	1.1	-0.9	1.1	0.9	0.3	1.1	1.1	1.6	1.2	1.4	-0.6	1.3
Osteoarthritis (self-reported)	1.0	1.3	2.4	1.0	1.0	1.5	0.9	1.3	1.4	-1.4	1.3	1.2	1.4	1.1	1.1	0.5	1.4	1.1	-0.1	0.6
Neuroticism (2016)	0.9	1.3	5.9	-1.3	-0.3	-0.4	-0.9	-1.0	0.7	1.0	-1.0	-0.6	1.1	-1.4	-0.2	-2.4	-0.9	-1.5	0.3	-1.6
Triglycerides	0.9	1.5	4.8	-0.8	-1.4	-1.3	0.5	-0.9	-1.4	0.6	-2.1	-1.1	-2.2	-0.6	-1.0	-1.6	-0.8	-0.6	-1.4	-0.9
Systolic Blood Pressure	0.9	4.3	17.9	-1.3	-2.2	-1.6	-2.8	-1.6	-3.7	1.0	-0.8	-1.7	-3.5	-1.1	-1.1	-1.2	1.2	-0.4	-4.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.0	-0.9	-1.4	-0.9	-1.3	-1.1	-0.9	0.9	-0.6	-1.0	-0.9	-1.0	-0.7	-1.2	-0.9	-1.0	-0.4	-0.7
Alcohol intake versus 10 years previously	0.9	1.3	4.2	-1.3	0.2	-0.7	-0.2	-1.1	0.3	1.1	-0.6	-0.9	0.3	-1.4	-2.0	-1.7	-1.0	-1.5	0.2	-1.9
Pulse wave peak to peak time	0.9	1.0	3.2	-1.1	-0.6	-1.0	-0.5	-1.0	-0.6	1.1	-1.0	-1.1	-0.6	-1.1	-1.1	-0.7	-1.8	-1.1	-0.4	-1.3
Shortness of breath walking on level ground	0.9	1.1	3.6	1.1	-0.0	1.0	0.5	0.9	1.2	-1.1	1.9	0.8	0.4	0.9	1.3	0.4	1.3	1.1	-1.4	0.7
Irritability	0.9	1.6	6.2	1.3	0.8	1.3	2.5	1.4	1.3	-1.5	0.9	1.5	0.9	1.3	1.1	1.2	0.0	1.2	0.8	0.7
Alzheimer’s Disease (in mother)	0.8	0.9	2.0	-1.1	-1.4	-1.0	-0.5	-1.0	-0.6	1.0	-1.3	-0.8	-0.6	-1.0	-0.7	-1.1	-0.9	-1.1	0.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	1.0	4.1	-0.7	-1.5	-0.8	-0.9	-1.0	0.3	0.8	-0.0	-0.7	-0.7	-1.0	-0.8	-1.2	-0.4	-0.7	-2.0	-1.1
Waist Hip Ratio (WHR)	0.8	3.8	34.5	1.1	2.0	1.2	5.9	1.3	0.1	-1.9	-0.9	1.6	0.2	1.4	2.2	-1.4	0.9	1.1	-1.6	-0.8
Current tobacco smoking	0.8	1.4	2.5	-1.4	-0.9	-1.2	-0.7	-1.3	-1.0	1.5	-0.9	-1.1	-0.0	-1.3	-1.6	-0.7	-1.6	-1.4	0.8	-1.2
High blood pressure	0.8	2.2	7.1	-1.3	-1.7	-1.5	-0.4	-1.3	-2.4	0.9	-1.3	-1.3	-2.7	-0.8	-1.2	-1.9	-0.1	-0.7	-2.0	-0.8
Stomach or abdominal pain in last month	0.8	1.0	2.1	1.3	0.6	0.9	0.4	0.8	0.7	-1.1	1.2	0.8	0.0	1.1	1.1	1.4	1.2	1.2	0.0	1.4
Falls in the last year	0.8	1.1	3.5	-1.1	-1.1	-1.0	-0.8	-1.1	-0.5	1.0	-1.2	-1.1	-1.0	-0.9	-1.9	0.0	-1.4	-1.1	0.6	-0.8
Peak expiratory flow (PEF)	0.8	1.9	4.8	-1.4	-1.1	-1.5	-1.6	-1.4	-1.3	1.6	-2.2	-1.3	-1.1	-1.5	-0.9	-1.2	-0.4	-1.4	-1.3	-1.4
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-0.9	-1.0	-0.8	-1.4	-1.0	-0.1	1.2	-0.6	-0.7	0.3	-1.1	-1.3	-0.4	-1.1	-1.2	0.6	-1.0
Overall health rating	0.8	1.8	2.6	-1.6	-1.4	-1.5	-1.2	-1.6	-0.5	1.4	-1.3	-1.4	-1.4	-1.4	-1.4	-0.9	-1.3	-1.3	-1.1	-1.4
Eye problems/disorders: Cataract	0.8	0.9	2.5	0.7	-0.3	0.4	-0.0	0.4	0.9	-1.0	0.4	0.4	-1.2	0.9	1.4	1.3	0.9	1.3	-1.6	1.4
Number of self-reported non-cancer illnesses	0.8	1.4	4.4	1.1	-0.1	1.0	0.1	1.1	0.7	-1.1	1.4	1.1	0.5	1.1	0.8	1.3	2.1	1.5	-2.0	1.0
Guilty feelings	0.8	1.1	3.6	1.3	0.9	1.0	0.9	1.0	1.9	-1.1	0.7	1.0	0.5	1.2	0.7	1.5	0.3	1.2	0.9	1.2
Medication: Atorvastatin	0.8	1.0	2.5	-1.0	-0.7	-1.1	0.0	-0.8	-0.4	1.1	-1.1	-0.9	-0.4	-1.1	-1.1	-1.5	-1.3	-1.1	-0.9	-1.6
Risk taking	0.8	1.2	3.5	1.0	0.3	1.0	0.9	1.1	0.9	-1.0	1.0	0.9	0.8	1.1	1.4	1.6	-0.2	0.9	1.9	1.1
Myopia	0.8	1.2	2.6	1.2	1.6	1.1	1.3	1.2	0.3	-1.0	0.7	1.2	1.2	1.2	1.1	1.0	0.7	1.1	1.2	1.0
Ulcerative Colitis	0.7	1.1	3.8	0.5	-0.5	0.2	-1.4	0.3	-1.4	-0.6	1.4	0.2	-1.2	0.9	-0.1	0.9	1.9	1.1	-0.4	2.0
Taking other prescription medications	0.7	1.1	3.1	1.1	-0.3	0.9	-0.2	0.8	0.9	-0.8	1.6	1.1	0.9	0.8	0.6	0.9	1.8	1.2	-1.5	0.8
Nervous feelings	0.7	1.4	2.7	-1.2	-1.0	-1.3	-1.6	-1.3	-0.6	1.3	-0.6	-1.3	-1.2	-1.3	-1.2	-1.0	-1.0	-1.1	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.8	-0.9	-1.3	-0.8	-1.0	-1.1	-0.2	0.9	-0.4	-0.8	-0.5	-1.1	-1.7	-0.9	-0.7	-1.1	-0.4	-1.2
Blood clot in the leg (DVT)	0.7	0.9	4.0	-0.8	-0.2	-0.2	-0.0	-0.3	0.2	0.7	-0.7	-0.3	1.6	-0.8	-0.3	-0.5	-1.5	-1.2	2.0	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.4	6.6	-1.6	-1.5	-1.5	-2.6	-1.6	-1.9	1.6	-2.0	-1.6	-1.5	-1.6	-0.9	-0.2	-0.7	-1.2	-1.8	-1.0
Hearing aid user	0.7	0.8	1.6	0.9	1.2	1.1	0.3	1.0	1.0	-0.9	0.5	1.0	1.1	0.8	0.8	0.6	1.3	0.9	0.2	0.8
Diastolic blood pressure, automated reading	0.7	2.1	3.4	-1.7	-1.2	-1.4	-0.6	-1.6	-1.3	1.3	-1.7	-1.5	-1.5	-1.5	-1.4	-1.8	-1.5	-1.8	0.5	-1.5
Unable to work because of sickness or disability	0.7	1.0	4.1	-1.1	-0.2	-0.7	-0.2	-1.0	0.2	1.0	-0.4	-0.8	0.2	-1.1	-0.6	-0.4	-2.0	-1.4	1.5	-1.2
HbA1C	0.6	0.6	3.6	-0.7	-0.7	-0.6	0.3	-0.6	-0.0	0.5	-0.8	-0.6	-0.1	-0.8	-0.6	-1.9	-1.0	-0.9	-0.1	-1.1
Respiratory disease	0.6	1.3	4.2	1.2	0.1	0.7	-1.5	0.7	0.3	-0.7	1.8	0.7	0.3	0.9	1.0	1.1	2.0	1.4	-0.8	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	-0.7	-0.9	-0.9	-0.9	-1.0	-1.1	0.9	-0.7	-0.8	-0.7	-0.8	-0.5	-1.3	-0.1	-0.9	-0.2	-0.7
Townsend deprivation index at recruitment	0.6	0.9	2.4	0.8	0.9	1.2	1.3	0.9	0.2	-0.9	1.3	1.2	1.6	0.7	1.2	0.1	1.2	0.6	0.1	0.1
Multivitamins +/- minerals	0.6	0.8	1.7	0.8	1.0	1.0	0.6	0.9	0.6	-1.0	1.3	1.0	0.7	0.9	0.9	1.0	1.0	1.0	-0.0	0.7
Medication: Atenolol	0.6	0.7	3.4	-0.6	-0.9	-0.7	0.8	-0.4	-0.8	0.3	-0.8	-0.5	-1.1	-0.4	-0.3	-1.9	-0.3	-0.4	-1.3	-1.0
Sitting height	0.6	4.6	17.0	-2.4	-1.7	-2.0	-4.1	-2.1	-2.3	2.6	-2.6	-2.1	-0.7	-2.3	-2.7	-1.0	-0.8	-1.9	-1.1	-1.4
Financial difficulties in last 2 years	0.6	0.8	3.9	-0.2	0.6	0.0	2.0	-0.0	0.4	0.1	-0.8	0.2	0.8	-0.3	-0.5	-0.3	-1.6	-0.7	1.4	-1.3
Pulse wave Arterial Stiffness index	0.6	0.7	2.6	0.9	0.4	0.8	0.1	0.8	0.5	-0.8	0.8	0.9	0.6	0.9	0.8	0.6	1.6	0.9	0.4	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	-0.8	-1.2	-0.9	-0.5	-1.1	-0.9	0.9	-0.2	-0.9	-0.6	-1.0	-0.9	-0.7	-1.2	-0.9	-0.5	-1.0
Number of children fathered	0.6	0.6	2.2	-1.1	-0.2	-0.3	-0.6	-0.6	0.9	0.7	-0.7	-0.4	0.7	-0.8	-0.5	-0.2	-1.3	-1.0	1.5	-0.7
Smoking status: Current	0.6	0.9	2.1	-1.1	-0.6	-0.9	-0.3	-1.0	-0.7	1.3	-0.9	-0.8	0.2	-1.0	-1.4	-0.5	-1.5	-1.2	0.9	-1.1
Financial situation satisfaction	0.6	0.7	4.3	0.3	0.6	0.4	1.1	0.4	1.8	-0.3	-0.3	0.4	1.0	0.2	-0.4	0.6	-1.0	-0.2	2.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	4.2	-0.6	0.1	0.1	0.2	-0.1	0.4	0.4	-0.5	-0.1	1.8	-0.6	-0.2	-0.3	-1.3	-1.0	2.0	-1.0
Impedance of whole body	0.6	3.0	16.2	1.5	0.0	0.7	-0.4	1.2	0.8	-1.3	1.3	0.8	-1.0	1.6	1.7	1.3	2.9	2.4	-4.0	2.0
Hypothyroidism (self reported)	0.5	1.1	4.8	-0.9	-1.0	-0.7	-2.2	-0.7	0.1	1.1	-0.4	-0.7	0.2	-1.1	-0.9	-0.6	0.3	-0.7	-2.2	-1.1
Tanning	0.5	5.7	12.6	2.2	3.5	2.7	2.1	2.3	2.5	-2.3	1.8	2.6	3.0	2.3	2.3	1.6	2.7	1.9	2.1	1.8
Vitamin and mineral supplements	0.5	0.6	2.6	-0.8	-0.6	-0.6	-0.1	-0.6	-0.0	0.8	-1.0	-0.7	0.1	-0.7	-0.6	-0.2	-1.5	-1.0	1.6	-0.5
Hair/balding pattern: Pattern 4	0.5	1.1	4.9	-0.7	-1.1	-1.1	-1.8	-1.0	-2.2	1.1	-0.8	-1.0	-1.0	-0.7	-1.1	-1.1	0.1	-0.7	-0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	0.9	-0.6	0.6	-0.9	0.6	0.7	-0.6	0.7	0.7	0.4	0.6	1.1	0.8	1.0	0.9	-0.7	1.0
Medication: Ibuprofen	0.5	0.7	3.0	0.8	0.7	0.8	1.0	0.8	0.1	-0.9	0.2	1.0	0.7	0.9	0.5	-0.1	0.6	0.6	1.7	0.8
Medication: Omeprazole	0.5	0.6	3.2	-0.5	-1.1	-0.7	-0.9	-0.6	-1.3	0.6	-0.2	-0.6	-0.8	-0.5	-0.5	-0.7	0.4	-0.2	-1.8	-0.4
Number of full sisters	0.5	0.6	4.5	-0.4	-0.6	-0.2	0.1	-0.4	-1.1	-0.2	0.3	-0.4	-1.2	-0.2	0.1	-2.1	0.7	-0.3	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.1	-0.6	-0.7	-0.8	0.6	-0.7	-0.8	0.5	-0.3	-0.8	-1.0	-0.5	-0.5	-0.1	-1.5	-0.7	0.6	-0.6
Hypertension (Self-reported)	0.5	1.4	5.1	-1.0	-1.4	-1.2	-0.1	-0.9	-2.1	0.6	-0.8	-0.9	-2.3	-0.5	-0.9	-1.5	-0.1	-0.5	-1.6	-0.6
Medication: Paracetamol	0.5	0.8	1.9	1.1	-0.2	0.8	0.2	0.8	0.5	-1.1	1.2	0.8	-0.3	1.1	1.2	1.1	0.9	1.2	0.0	1.4
Illnesses of father: High blood pressure	0.5	0.6	3.5	0.3	-0.9	-0.2	-0.4	-0.0	-0.9	-0.2	0.3	-0.1	-1.4	0.4	0.6	-0.4	1.1	0.7	-1.9	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	3.3	0.5	0.5	0.4	1.8	0.5	1.4	-0.3	0.1	0.6	0.9	0.4	0.6	1.8	-1.6	0.2	1.4	-0.1
Depression (Nagel 2018)	0.4	0.5	3.2	0.1	-0.6	-0.4	-0.2	-0.2	0.8	0.2	-0.3	-0.4	-0.7	-0.1	-0.4	1.3	-1.8	-0.2	1.4	0.3
Schizophrenia (2018)	0.4	0.8	3.7	-0.4	-0.7	-0.7	-1.3	-0.7	-1.1	0.3	-1.2	-0.7	-1.9	-0.1	-1.0	-0.9	0.7	0.0	-0.7	0.7
Bipolar Disorder (2011)	0.4	0.4	2.8	-0.1	-0.3	-0.1	-0.9	-0.2	-1.0	-0.1	0.2	-0.2	-0.7	-0.0	-0.6	-0.2	0.7	0.3	-1.7	0.2
Schizophrenia (2014)	0.4	0.8	4.8	-0.3	-0.8	-0.6	-1.2	-0.6	-1.3	0.1	-0.9	-0.7	-2.2	0.1	-1.2	0.0	0.4	0.3	-0.5	1.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.9	0.8	0.3	0.5	0.8	0.6	1.1	-0.7	0.6	0.8	0.3	0.7	1.4	0.6	0.2	0.6	0.7	0.7
Diabetes (mother)	0.4	0.5	1.2	-0.5	-0.6	-0.7	0.7	-0.5	-0.6	0.4	-0.4	-0.7	-1.0	-0.4	-0.8	-1.1	-0.6	-0.5	-0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.2	-0.5	-0.9	-0.9	-0.8	-0.8	-0.2	0.9	-0.6	-0.7	-0.4	-0.7	-0.1	0.7	-1.8	-0.7	0.4	-0.4
Number of incorrect matches in round	0.4	0.7	2.3	0.5	-0.6	0.4	-1.4	0.3	-0.6	-0.6	0.5	0.3	-0.7	0.7	0.6	0.5	1.5	1.0	-0.7	1.5
Alcohol usually taken with meals	0.4	0.7	2.4	0.7	1.1	0.9	-0.0	0.8	1.5	-0.7	0.5	0.7	1.0	0.7	0.5	1.0	0.6	0.7	1.0	1.0
Neuroticism score	0.4	0.7	2.9	0.7	0.9	0.9	1.3	0.8	1.7	-0.8	0.5	1.0	1.0	0.7	0.7	0.9	0.1	0.8	0.1	0.3
Impedance of arm (right)	0.4	2.0	21.0	0.4	-1.3	-0.6	-1.1	-0.0	-0.2	-0.1	0.4	-0.4	-2.2	0.3	0.4	0.0	1.8	1.1	-4.6	0.6
Time employed in main current job	0.4	0.5	1.3	0.5	0.0	0.5	1.1	0.7	-0.2	-0.8	0.7	0.6	-0.0	0.8	1.0	0.5	-0.3	0.7	0.9	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-0.9	-0.3	-0.8	0.6	-0.8	-0.8	0.7	-1.0	-0.6	-0.6	-0.7	-0.5	-0.2	-1.2	-1.0	0.8	-1.0
Impedance of arm (left)	0.4	1.9	20.0	0.1	-1.3	-0.7	-1.5	-0.2	0.1	0.2	0.2	-0.6	-2.0	0.1	0.1	-0.1	1.6	0.9	-4.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.0	0.8	1.1	0.8	0.5	0.6	1.4	-0.6	0.5	0.6	0.7	0.5	0.3	0.9	0.8	0.7	-1.0	0.2
Medication for pain relief, constipation, heartburn	0.4	0.6	4.2	-0.1	1.2	0.3	-0.2	0.1	0.5	0.5	-0.0	0.0	1.9	-0.4	0.3	0.1	-0.4	-0.7	2.0	-0.4
Medication: Blood pressure	0.4	0.7	2.8	-0.6	-1.1	-0.8	0.2	-0.4	-0.9	0.3	-0.8	-0.5	-1.6	-0.2	-0.4	-1.2	0.4	-0.1	-1.7	-0.4
Heart disease (mother)	0.4	0.5	1.9	-0.4	0.2	-0.7	0.0	-0.5	-1.0	0.4	-0.6	-0.7	-1.3	-0.4	-1.4	-0.7	-0.5	-0.4	0.0	-0.4
Leg pain on walking	0.4	0.5	3.5	0.0	0.4	0.7	0.0	0.3	1.9	-0.1	0.4	0.5	1.8	-0.2	0.0	0.4	-0.1	-0.0	-0.4	-0.6
Smoking status: Previous	0.4	0.6	3.6	0.5	0.6	0.7	0.0	0.6	0.1	-0.9	0.2	0.7	-0.1	0.9	1.1	-0.1	1.9	0.9	-0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	-1.0	-0.6	-1.0	-0.8	-0.7	-1.3	1.0	-1.5	-0.7	-0.9	-0.7	-1.0	-0.2	-0.5	-0.7	-0.5	-0.7
Mood swings	0.4	0.8	5.5	0.6	0.5	0.7	2.3	0.7	1.1	-0.8	0.5	0.8	0.8	0.5	0.6	0.6	-1.2	0.5	0.0	-0.5
Friendships satisfaction	0.4	0.5	1.9	-0.5	0.3	-0.4	-0.4	-0.6	0.5	0.6	-1.0	-0.6	0.0	-0.6	-1.1	0.3	-1.4	-0.7	1.3	-0.4
Miserableness	0.4	0.8	2.5	0.5	0.7	0.7	1.6	0.7	1.0	-0.5	0.7	0.8	1.4	0.5	1.0	1.3	-0.7	0.3	1.1	0.0
Average weekly beer plus cider intake	0.4	0.5	2.2	-0.8	-0.6	-0.5	1.0	-0.5	-0.6	0.4	-0.9	-0.4	-0.2	-0.6	-0.2	-1.5	-0.5	-1.0	0.2	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.6	0.4	-0.0	0.6	-0.1	0.6	0.2	-0.7	0.9	0.6	0.0	0.7	0.4	1.3	0.4	1.0	-0.2	1.0
Ever depressed for a whole week	0.4	0.5	2.2	-0.6	-0.1	-0.3	-1.0	-0.7	-0.3	0.8	0.0	-0.4	0.5	-0.8	-1.5	-1.1	-0.0	-0.9	0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.3	-0.5	-0.9	-0.7	-0.4	-0.6	-0.9	0.5	-0.4	-0.5	-1.0	-0.5	-0.5	-0.6	0.1	-0.3	-1.8	-0.6
Pain experienced in last month	0.4	0.7	3.7	-0.0	-0.7	-0.4	-0.5	-0.2	-1.9	-0.0	0.6	-0.3	-1.4	0.1	-0.3	-0.5	0.9	0.4	-1.7	0.3
Fasting Glucose	0.3	0.3	1.8	-0.5	-0.2	-0.4	-0.1	-0.4	-0.6	0.3	-0.8	-0.7	-0.5	-0.6	-0.5	-0.7	-0.1	-0.4	-1.4	-0.6
Blood Red Count	0.3	3.1	9.9	-1.6	-2.3	-2.2	-1.2	-1.8	-2.6	1.6	-1.9	-1.8	-3.1	-1.1	-1.1	-1.3	-1.0	-0.9	-1.6	-0.5
Sensitivity / hurt feelings	0.3	0.5	4.8	0.2	0.7	0.4	1.2	0.2	2.2	-0.5	-0.8	0.4	0.2	0.2	-0.2	0.0	-0.8	0.2	0.3	-0.2
Average weekly fortified wine intake	0.3	0.4	2.9	0.5	-0.5	0.1	-1.0	0.4	-0.0	-0.0	0.5	0.0	0.3	0.4	0.5	1.7	0.0	0.6	-0.1	1.0
Relative age voice broke	0.3	0.4	3.6	-0.0	0.5	0.2	-0.5	0.2	1.9	0.1	0.7	0.2	1.3	-0.2	0.2	0.3	-0.6	-0.1	0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.7	0.1	0.4	0.2	1.3	-0.0	-0.8	-0.4	0.2	0.2	0.0	-0.1	-0.1	-1.1	0.2	-0.2	-0.6	-0.8
Serious illness, injury or assault to yourself	0.3	0.4	3.5	-0.2	0.4	0.0	0.5	-0.1	1.0	0.0	-0.5	-0.0	0.1	-0.1	-0.6	-0.1	-1.1	-0.4	1.9	-0.3
Supplements: Glucosamine	0.3	0.3	1.2	0.4	0.2	0.4	-0.1	0.5	-0.4	-0.7	0.7	0.3	-0.5	0.7	0.4	0.6	0.7	0.8	0.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	0.8	-0.4	0.2	0.5	0.3	0.4	-0.4	1.2	0.3	-0.3	0.5	0.9	1.2	-0.2	0.6	-0.3	0.6
Noisy workplace	0.3	0.3	1.2	-0.2	-0.6	0.1	-0.8	-0.3	0.3	0.4	1.1	-0.2	1.1	-0.7	-0.1	-0.4	-0.4	-0.5	-0.8	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	4.3	-0.1	0.8	0.3	0.9	0.1	0.6	0.0	-0.3	0.3	1.3	-0.0	-0.0	0.2	-0.7	-0.4	2.1	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.1	-0.3	0.2	0.7	-0.0	1.2	-0.0	0.0	0.3	0.9	-0.4	0.5	0.2	-1.0	-0.5	0.6	-0.9
Loud music exposure frequency	0.3	0.3	1.9	-0.2	0.1	0.1	0.0	-0.3	0.2	0.3	0.6	-0.1	0.7	-0.6	-0.1	0.2	-0.3	-0.4	-1.4	-1.1
Medication: Paracetamol	0.3	0.5	1.7	0.6	-0.7	0.3	0.0	0.3	-0.2	-0.8	0.9	0.3	-1.1	0.7	0.8	0.3	0.8	0.9	-1.3	0.8
High blood pressure (siblings)	0.3	0.5	2.3	0.2	-0.8	-0.5	0.4	-0.3	-1.2	0.0	-0.0	-0.6	-1.5	-0.2	-0.1	-0.4	-0.5	-0.0	-1.4	-0.3
Comparative body size at age 10	0.3	0.9	6.4	-0.4	0.4	-0.2	-0.0	-0.6	-0.0	0.5	-1.1	-0.6	0.3	-0.6	-1.1	0.1	-1.7	-0.9	2.5	-0.3
Health satisfaction	0.3	0.4	1.5	-0.5	-1.0	-0.7	-0.5	-0.7	0.1	0.6	0.3	-0.6	-0.5	-0.6	-0.4	-0.1	-1.2	-0.4	-0.7	-0.5
Neck or shoulder pain in last month	0.3	0.4	2.2	0.3	0.7	0.7	0.6	0.5	0.8	-0.3	0.5	0.8	1.5	0.3	0.8	0.4	0.5	0.2	0.7	0.1
Had major operations	0.3	0.3	2.2	0.2	-0.0	0.5	0.7	0.4	1.5	-0.4	-0.3	0.4	0.7	0.3	0.5	0.5	-0.4	0.2	0.9	0.1
Family relationship satisfaction	0.3	0.4	1.9	-0.3	0.3	-0.2	0.4	-0.4	0.5	0.1	-0.7	-0.4	-0.4	-0.3	-0.9	0.5	-1.4	-0.5	1.2	-0.4
Breast cancer (self-reported)	0.3	0.3	1.6	0.4	1.1	0.4	-0.0	0.2	0.9	-0.0	0.2	0.2	0.9	0.1	-0.2	0.5	-0.2	-0.1	1.3	0.1
Medication: Blood pressure	0.3	0.6	3.9	-0.1	-0.7	-0.7	0.2	-0.3	-2.0	0.1	-0.4	-0.4	-1.8	0.1	-0.3	-0.9	0.6	0.1	-0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.9	-0.9	-0.7	-0.7	-1.4	-0.7	-0.3	0.7	0.0	-0.8	-0.8	-0.6	-0.8	-0.2	-0.2	-0.6	0.3	-0.0
Alcohol drinker status: Never	0.3	0.4	1.2	0.5	0.8	0.3	0.6	0.5	1.0	-0.2	0.5	0.3	0.6	0.3	0.4	1.1	-0.4	0.1	1.1	0.2
Bipolar Disorder (2018)	0.2	0.4	1.0	0.6	0.4	0.4	0.9	0.5	-0.8	-0.6	0.4	0.4	-0.4	0.9	0.3	0.4	0.8	0.8	0.2	1.0
Bipolar Disorder or Schizophrenia	0.2	0.6	3.1	0.0	-0.2	-0.3	-0.5	-0.2	-1.5	-0.2	-0.7	-0.3	-1.8	0.4	-0.6	-0.4	1.0	0.5	-0.5	1.1
Neuroticism (Nagel 2018)	0.2	0.4	3.4	0.1	-0.1	-0.0	0.4	0.1	1.0	-0.1	-0.6	0.1	-0.1	0.1	-0.2	1.8	-1.3	0.2	0.3	0.1
Primary Biliary Cirrhosis	0.2	0.2	2.7	0.0	-0.1	0.0	0.4	0.1	0.2	-0.2	0.4	0.1	-0.4	0.1	0.2	-0.1	0.0	0.3	-1.6	-0.4
Rheumatoid Arthritis	0.2	0.3	1.2	0.6	-1.1	-0.0	0.3	0.4	-0.3	-0.4	0.3	0.2	-0.7	0.6	0.6	0.4	0.0	0.6	-0.3	0.7
Lung FEV1/FVC ratio	0.2	0.8	3.0	0.1	1.5	0.8	1.7	0.6	1.3	-0.7	-0.7	0.7	1.0	0.4	0.1	-0.4	-0.1	-0.1	1.7	-0.3
Lung FVC	0.2	1.2	6.2	-0.8	-0.8	-0.9	-2.5	-1.0	-1.9	1.0	-1.2	-1.1	-1.3	-0.7	0.1	-0.2	0.4	-0.5	-0.4	0.4
Average weekly spirits intake	0.2	0.3	1.4	-0.0	-0.1	-0.0	0.1	0.1	1.2	0.3	0.4	0.1	0.7	-0.1	-0.1	0.8	-0.7	-0.2	1.0	-0.1
Relative age of first facial hair	0.2	0.4	1.7	-0.7	0.2	-0.3	-1.3	-0.4	1.2	0.6	0.4	-0.3	0.4	-0.6	-0.6	-0.5	-0.1	-0.5	-0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.0	-0.7	-0.4	-0.4	-0.2	-0.8	0.2	0.0	-0.3	-0.8	-0.0	-0.5	-0.7	0.4	0.1	-1.0	0.1
Fed-up feelings	0.2	0.4	2.5	-0.0	0.5	0.1	1.6	0.0	0.4	0.1	-0.3	0.2	0.8	-0.3	0.1	-0.1	-1.3	-0.4	0.1	-1.1
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	0.1	0.7	0.4	-0.5	-0.0	1.0	-0.0	0.4	0.2	0.9	-0.2	-0.7	0.1	-0.2	-0.1	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.6	-0.7	-0.6	-1.0	-0.6	-0.1	0.9	-0.5	-0.6	0.1	-0.7	-0.0	0.3	-0.8	-0.6	-0.2	-0.4
Had other major operations	0.2	0.3	1.5	0.5	0.5	0.2	0.1	0.1	0.5	-0.2	0.1	0.2	-0.0	0.4	-0.4	1.1	0.2	0.3	1.2	0.7
Pain all over the body in last month	0.2	0.2	1.8	0.1	-0.4	-0.3	-0.0	-0.1	0.2	0.1	-0.1	-0.2	-0.8	-0.0	0.1	0.1	-0.1	0.1	-1.3	-0.2
Worrier / anxious feelings	0.2	0.4	3.5	0.4	-0.4	0.3	0.4	0.3	0.2	-0.5	0.8	0.4	-0.4	0.4	0.6	-0.0	1.0	0.7	-1.9	0.2
Number of live births	0.2	0.2	2.2	-0.2	0.0	-0.3	0.1	-0.2	-0.3	0.4	-0.3	-0.1	0.1	-0.2	0.6	-0.1	-0.7	-0.5	1.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.1	-0.6	-0.1	-0.4	0.1	-0.8	-0.1	-0.8	-0.0	-0.6	0.3	0.5	0.2	0.1	0.3	0.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.4	0.6	0.4	0.5	1.0	0.5	0.1	-0.6	-0.2	0.7	0.2	0.7	0.3	-0.4	0.2	0.4	1.2	0.4
Exposure to tobacco smoke at home	0.2	0.3	1.9	-0.3	0.2	-0.1	0.8	-0.4	0.1	0.1	-0.3	-0.1	0.1	-0.4	-0.4	-1.4	-0.1	-0.5	-0.3	-0.9
Wheeze or whistling in the chest in last year	0.2	0.4	2.8	-0.2	-1.2	-0.1	-1.7	-0.3	0.9	0.5	0.4	-0.1	0.7	-0.5	-0.2	0.7	-0.3	-0.2	0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.8	0.3	-0.7	0.0	0.1	0.4	-0.2	-0.2	0.1	0.2	-0.0	0.4	0.6	-0.0	-0.3	0.2	1.3	0.6
Emphysema/chronic bronchitis	0.2	0.2	0.8	-0.3	-0.2	-0.4	-0.1	-0.3	0.3	0.5	-0.6	-0.1	-0.0	-0.4	-0.2	-0.9	0.2	-0.6	-0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.1	0.2	0.1	-0.1	0.2	0.1	0.8	-0.0	0.5	-0.1	-0.2	0.1	-0.1	0.1	-1.0	-0.0	1.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.3	0.1	-0.0	-0.2	-1.1	-0.1	0.0	0.5	0.7	-0.1	0.2	-0.1	-0.1	0.8	0.2	0.1	-0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.2	-0.3	-0.7	-0.5	-0.1	-0.5	0.3	0.5	-0.1	-0.4	-0.5	-0.3	-0.5	0.8	-1.1	-0.3	0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.4	0.3	0.6	0.7	0.5	0.9	-0.6	0.5	0.7	0.6	0.5	0.2	0.9	0.2	0.5	0.3	0.3
Back pain experienced in last month	0.2	0.3	1.2	-0.4	-0.6	-0.6	-0.3	-0.4	-0.5	0.7	-1.1	-0.5	-0.2	-0.5	-0.6	0.3	-0.8	-0.6	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-0.6	-0.5	-0.8	-0.2	-0.6	-0.7	0.6	-0.9	-0.6	-0.9	-0.5	0.3	-0.3	-0.7	-0.5	-0.5	-0.5
Medication: Bendroflumethiazide	0.2	0.3	1.4	-0.2	-0.2	-0.7	0.5	-0.2	-0.7	0.4	-0.9	-0.3	-0.8	-0.1	-0.1	-1.2	0.1	-0.2	-0.5	-0.3
Ever smoked	0.2	0.4	1.9	0.2	0.1	0.3	-0.8	0.1	-0.8	-0.2	0.2	0.3	0.0	0.5	0.9	0.3	1.4	0.4	0.8	1.3
Fractured/broken bones in last 5 years	0.2	0.3	1.0	0.5	0.2	0.6	-0.3	0.4	0.8	-0.3	0.2	0.5	1.0	0.3	0.5	0.8	0.1	0.4	-0.2	0.4
Major Depression (MDD)	0.1	0.1	0.4	-0.4	-0.2	-0.2	-0.6	-0.4	-0.3	0.2	-0.5	-0.4	-0.2	-0.4	-0.4	-0.1	-0.1	-0.3	-0.5	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.2	-0.2	-0.1	0.6	-0.0	0.5	-0.0	-0.1	-0.1	-0.1	0.1	-0.1	-0.5	-0.0	-0.1	0.2	-0.2
Blood Platelet Count	0.1	1.1	8.3	0.8	1.0	0.6	1.5	0.7	0.7	-0.8	-0.2	0.8	0.2	0.8	1.3	2.9	0.8	0.7	0.1	0.5
Smoking Status	0.1	0.3	1.4	-0.6	0.4	0.2	-0.1	-0.3	0.4	0.2	-0.5	0.1	1.2	-0.4	-0.1	-1.1	0.2	-0.6	0.8	-0.5
Chronotype (morning person)	0.1	0.1	0.5	-0.2	-0.6	-0.2	0.4	-0.2	0.3	-0.1	0.2	-0.1	-0.7	-0.0	-0.5	-0.4	-0.2	0.0	-0.7	-0.3
Age when periods started (menarche)	0.1	0.2	1.1	-0.6	0.2	-0.2	-0.2	-0.2	1.1	0.4	-0.2	-0.1	0.6	-0.3	0.1	-0.4	0.2	-0.2	-0.8	-0.4
Past tobacco smoking	0.1	0.2	1.5	-0.2	-0.1	-0.2	0.3	-0.1	0.5	0.3	0.1	-0.3	0.2	-0.4	-0.8	0.0	-1.2	-0.4	-0.1	-0.9
Heart attack	0.1	0.2	1.0	0.2	0.7	0.4	1.0	0.3	0.5	-0.4	-0.0	0.4	0.4	0.2	-0.3	-0.0	0.2	0.0	0.6	-0.1
Pulse rate	0.1	0.1	0.7	-0.3	-0.3	-0.2	-0.3	-0.2	-0.5	0.3	-0.8	-0.2	0.1	-0.1	-0.1	-0.4	-0.1	-0.3	0.8	0.1
Depression (self-reported)	0.1	0.1	0.7	0.2	0.3	0.2	0.8	0.2	0.3	-0.2	0.4	0.3	0.3	0.2	0.4	0.2	0.1	0.2	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	0.1	-0.0	0.4	-0.3	0.2	0.1	-0.3	0.5	0.4	0.2	0.3	0.4	0.6	0.7	0.5	-0.3	0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.5	-0.7	0.1	0.5	0.4	0.1	-0.1	0.1	0.5	0.3	0.3	0.5	0.6	0.4	0.5	-0.7	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.8	-0.0	0.2	-0.0	-0.9	-0.2	-0.3	0.0	0.1	-0.2	-0.4	0.0	-0.0	-0.2	0.6	0.2	-0.5	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	0.3	0.7	0.3	1.0	0.3	0.3	-0.4	0.1	0.3	0.2	0.2	-0.5	-0.1	0.2	0.1	0.3	-0.2
Neuroticism	0.0	0.1	0.7	0.1	0.0	0.1	0.3	0.1	0.8	-0.1	-0.1	0.3	0.2	0.1	0.1	0.5	-0.2	0.3	-0.6	0.0
Hair Pigment	0.0	0.3	2.7	0.2	0.2	0.4	-0.4	0.2	0.4	-0.2	0.4	0.2	0.3	0.3	-0.2	1.6	0.4	0.3	1.1	0.9

Hub : Genes

HSD17B1

Models

Trait associations