Hub : Genes

TUBG1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.061 0.030 0.00430 0.026 NA 0.047 NA 0.034 4.3e-03 NA 0.00020 NA 1.4e-03
2 GTEx Esophagus Muscularis 0.144 0.062 0.00210 0.014 NA 0.003 NA -0.005 4.4e-02 NA 0.19000 NA 9.0e-01
3 GTEx Skin Not Sun Exposed Suprapubic 0.110 0.054 0.00220 0.013 NA -0.001 NA 0.005 5.8e-02 NA 0.40000 NA 1.7e-01
4 GTEx Skin Sun Exposed Lower leg 0.041 0.021 0.00800 0.055 NA 0.040 NA 0.047 2.3e-05 NA 0.00029 NA 8.3e-05
5 GTEx Testis 0.119 0.048 0.00035 0.094 NA 0.081 NA 0.048 5.9e-05 NA 0.00018 NA 3.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 1.7 0.3 0.0 1.3 -0.6 0.7
Bipolar Disorder or Schizophrenia 0.2 0.6 2.6 -0.1 0.0 1.6 0.1 0.4
Depressed Affect (Nagel 2018) 0.3 0.6 1.8 1.4 0.0 -0.7 -0.6 0.4
Depression (Nagel 2018) 0.1 0.1 0.3 -0.4 0.0 -0.5 0.2 0.1
Intelligence (Savage-Jansen 2018) 2.2 6.7 11.4 2.4 0.0 3.4 -2.8 2.9
Neuroticism (Nagel 2018) 0.1 0.3 1.1 1.1 0.0 -0.4 -0.1 0.1
Schizophrenia (2018) 0.1 0.3 1.0 -0.3 0.0 1.0 0.6 -0.1
Schizophrenia vs Biploar Disorder 1.9 2.5 4.9 -2.2 0.0 -1.2 2.0 -1.5
Worry (Nagel 2018) 0.9 1.8 4.5 -1.2 0.0 -1.1 2.1 -1.5
Alzheimer’s Disease (in mother) 1.1 1.2 3.0 -1.3 0.0 -1.7 0.8 -0.9
Alzheimer’s Disease (in father) 1.6 1.8 3.7 -1.8 0.0 0.1 1.9 -1.4
Alzheimer’s Disease (including proxy) 2.0 2.8 4.3 -2.1 0.0 -2.0 1.8 -1.6
Crohns Disease (2017) 1.2 2.6 12.0 -0.3 0.0 3.5 -0.4 0.8
Irritable Bowel Disease (IBD) 1.4 3.3 13.6 -1.5 0.0 3.7 0.7 -0.1
Ulcerative Colitis (UC) 1.6 2.9 5.2 -2.3 0.0 2.1 1.9 -1.2
Major Depression (MDD) 0.1 0.1 0.4 -0.6 0.0 -0.1 0.4 -0.4
Reaction Time 1.0 1.9 5.3 -0.9 0.0 -2.3 1.3 -1.3
Verbal and Numeric Reasoning (VNR) 1.0 2.3 4.3 0.9 0.0 2.1 -1.8 1.8
Breast Cancer 0.6 1.5 3.5 -1.9 0.0 1.6 1.1 0.4
Ovarian Cancer 4.1 5.4 8.5 -2.0 0.0 -2.5 2.9 -2.8
Prostate Cancer 1.2 1.6 4.2 -0.3 0.0 -2.1 1.4 -1.3
Age at First Birth 4.3 6.2 8.9 2.7 0.0 2.7 -2.8 3.0
Bipolar Disorder (2011) 0.3 0.3 1.1 -0.4 0.0 1.1 0.2 0.3
Body Mass Index (BMI) (2010) 1.3 1.8 3.4 -1.8 0.0 -0.9 1.5 -1.5
Coronary Artery Disease (CAD) 0.5 0.6 2.6 1.6 0.0 -0.6 -0.1 0.3
Crohns Disease (2012) 1.7 2.7 11.0 0.3 0.0 3.3 -0.7 1.3
Mean Putamen Volume 1.5 1.8 2.9 -1.0 0.0 -1.6 1.5 -1.7
Fasting Glucose 0.1 0.2 0.6 -0.2 0.0 0.1 0.7 -0.4
HbA1C 0.3 0.3 0.6 0.3 0.0 -0.8 0.6 -0.8
HDL Cholesterol 3.4 5.6 9.8 2.1 0.0 2.5 -3.1 2.8
LDL Cholesterol 0.9 1.4 3.0 1.7 0.0 0.0 -1.4 1.4
Lupus 0.7 1.1 2.9 1.7 0.0 -0.0 -1.4 0.8
Neuroticism (2016) 1.6 2.3 7.2 -1.1 0.0 -2.7 0.7 -1.7
Primary Biliary Cirrhosis 0.2 0.2 1.0 1.0 0.0 0.2 -0.1 0.2
Rheumatoid Arthritis 0.2 0.3 0.8 0.7 0.0 0.3 -0.3 0.9
Schizophrenia (2014) 0.2 0.5 1.9 -0.5 0.0 1.4 0.6 0.1
Triglycerides 0.2 0.3 0.8 0.1 0.0 -0.6 0.9 -0.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.0 0.7 0.0 -0.3 1.4 -1.0
Ulcerative Colitis 1.5 2.1 9.7 -0.3 0.0 3.1 -0.2 0.8
Blood Eosinophil Count 1.9 14.9 33.3 -5.8 0.0 -2.1 4.5 -4.1
Blood Platelet Count 0.1 1.0 3.4 1.8 0.0 0.7 -0.8 0.8
Blood Red Count 0.1 0.9 3.0 -1.0 0.0 0.0 1.7 -0.6
Blood White Count 4.2 31.0 51.4 -4.1 0.0 -7.2 6.8 -6.3
Heel T-Score 0.2 1.7 6.4 0.7 0.0 -0.8 2.5 -1.0
BMI 1.8 10.7 18.0 -2.8 0.0 -3.6 4.2 -3.8
Height 2.2 41.8 59.9 -7.7 0.0 -6.8 6.7 -7.6
Waist Hip Ratio (WHR) 1.2 5.2 16.6 4.1 0.0 -1.1 -1.4 2.5
Systolic Blood Pressure 0.3 1.5 3.0 -1.1 0.0 1.7 1.7 -0.6
Smoking Status 0.1 0.2 0.4 -0.4 0.0 -0.5 -0.1 -0.6
Allergy or Eczema 2.8 7.3 15.3 1.9 0.0 3.9 -2.7 3.2
Cardiovascular Disease 1.3 4.2 9.7 -1.1 0.0 -2.4 3.1 -2.0
Hypothyroidism (self reported) 0.4 0.9 1.8 -0.9 0.0 -1.3 0.7 -1.2
Respiratory disease 0.5 1.0 3.5 -0.3 0.0 1.9 -0.8 1.0
Type 2 Diabetes (T2D) (2018) 2.5 4.6 12.6 -0.2 0.0 -3.5 2.5 -2.1
Lung FEV1/FVC ratio 0.1 0.4 1.2 0.8 0.0 -1.1 -0.5 0.4
Lung FVC 0.2 1.2 3.7 -1.9 0.0 0.5 0.9 -1.1
Neuroticism 0.1 0.3 1.3 1.1 0.0 -0.3 -0.2 0.2
Chronotype (morning person) 0.1 0.3 1.2 1.1 0.0 -0.1 0.2 0.4
Hair Pigment 0.0 0.0 0.0 0.0 0.0 0.1 -0.1 0.1
Tanning 0.3 3.4 6.1 2.0 0.0 1.8 -2.5 1.9
Hand grip strength (left) 1.7 4.6 9.3 -2.1 0.0 -1.1 3.0 -2.8
Number of treatments/medications taken 4.5 8.0 16.4 4.0 0.0 2.5 -2.6 3.3
Average weekly spirits intake 0.1 0.1 0.2 -0.2 0.0 -0.5 -0.1 -0.3
Sensitivity / hurt feelings 0.7 1.2 5.8 2.4 0.0 -0.4 -0.3 0.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.0 -0.0 0.0 -0.1 -0.7 1.0
Hearing difficulty/problems: Yes 2.3 3.5 6.7 1.5 0.0 2.6 -2.4 1.7
Relative age of first facial hair 0.1 0.2 0.7 -0.1 0.0 0.3 0.4 -0.8
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.2 0.0 0.2 0.2 0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.1 -1.4 0.0 -0.9 1.4 -1.0
Ever had hysterectomy (womb removed) 0.6 0.7 1.2 -1.1 0.0 -0.6 0.9 -1.0
Systolic blood pressure, automated reading 0.7 2.1 4.6 -2.1 0.0 0.9 2.0 -1.1
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 3.9 -0.5 0.0 -2.0 1.5 -1.7
Angina 1.0 1.3 2.3 -0.7 0.0 -1.5 1.4 -1.4
Medication for hormone replacement therapy 2.1 2.4 4.2 -1.5 0.0 -1.5 2.0 -1.7
Vitamin and mineral supplements 0.6 0.8 2.0 -1.4 0.0 -0.5 0.7 -1.1
Supplements: Zinc 0.6 0.7 1.5 0.8 0.0 0.7 -0.9 1.2
Medication: Co-codamol 2.0 2.3 4.0 -1.2 0.0 -2.0 2.0 -1.6
Medication: Metformin 6.5 9.1 16.8 -2.0 0.0 -4.1 3.8 -3.3
Diabetes (father) 2.0 2.5 7.0 -0.4 0.0 -2.6 1.8 -1.5
Diabetes (mother) 0.5 0.6 2.0 0.8 0.0 -1.4 0.5 -0.4
Severe depression (siblings) 1.0 1.1 2.6 0.9 0.0 0.9 -1.6 1.2
Pack years adult smoking proportion 1.5 2.3 5.6 -1.2 0.0 -2.4 1.3 -1.7
Impedance of leg (right) 1.7 8.4 18.0 2.9 0.0 4.2 -2.4 3.1
Leg fat-free mass (left) 3.8 20.0 32.1 -4.7 0.0 -5.7 4.5 -5.1
Trunk fat percentage 3.8 15.4 27.4 -3.3 0.0 -4.3 5.2 -4.5
Hand grip strength (right) 2.0 5.4 10.5 -2.0 0.0 -1.8 3.0 -3.2
Townsend deprivation index at recruitment 0.4 0.5 1.3 0.8 0.0 0.1 -1.1 0.8
Current tobacco smoking 0.8 1.3 2.3 -1.5 0.0 -0.9 1.0 -1.5
Average weekly fortified wine intake 0.1 0.1 0.4 -0.7 0.0 0.4 -0.2 0.1
Maternal smoking around birth 3.4 5.0 9.2 -2.0 0.0 -3.0 2.5 -2.4
Fed-up feelings 0.3 0.5 2.3 0.6 0.0 -1.5 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.6 -1.3 0.0 -0.9 0.7 -0.7
Relative age voice broke 0.0 0.1 0.2 0.2 0.0 -0.2 -0.1 -0.4
Taking other prescription medications 0.8 1.3 3.2 1.8 0.0 1.0 -1.0 1.2
Age when periods started (menarche) 0.1 0.1 0.5 0.1 0.0 -0.7 0.1 -0.3
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.5 0.7 0.0 -0.6 -0.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.9 -1.2 0.0 -0.8 1.4 -0.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.5 -0.5 0.0 -0.2 1.1 -1.2
Qualifications: CSEs or equivalent 2.4 3.2 10.1 -1.3 0.0 -3.2 1.1 -1.7
Serious illness, injury or assault to yourself 0.1 0.1 0.5 0.3 0.0 -0.7 0.0 -0.1
High blood pressure 0.1 0.3 1.6 -0.1 0.0 -0.1 1.3 -0.3
Hayfever, allergic rhinitis or eczema 3.7 8.1 13.1 2.3 0.0 3.6 -3.2 3.5
Multivitamins +/- minerals 0.7 0.9 1.9 1.4 0.0 0.6 -1.0 1.0
Stomach or abdominal pain in last month 1.1 1.3 2.2 1.4 0.0 1.5 -0.9 1.3
Supplements: Glucosamine 0.4 0.5 1.6 0.3 0.0 1.3 -0.4 0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.4 0.9 0.0 1.2 -0.4 0.6
Medication: Atenolol 0.3 0.4 1.6 -0.0 0.0 -1.3 0.5 -0.3
Medication: Levothyroxine sodium 1.4 2.4 4.1 -1.7 0.0 -1.8 1.4 -2.0
Sitting height 0.8 5.6 12.4 -3.5 0.0 -2.2 2.0 -2.6
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.3 0.0 -0.5 -0.2 -0.3
High blood pressure (mother) 2.8 3.9 11.9 1.4 0.0 3.4 -1.1 2.2
Body mass index (BMI) 3.1 13.2 19.6 -3.3 0.0 -4.4 4.3 -4.1
Impedance of leg (left) 2.1 10.3 18.4 3.4 0.0 4.3 -2.9 3.6
Leg predicted mass (left) 3.9 20.7 32.6 -4.8 0.0 -5.7 4.6 -5.2
Trunk fat mass 5.0 21.5 33.0 -4.2 0.0 -5.3 5.7 -5.3
Waist circumference 2.5 9.1 18.1 -2.2 0.0 -4.3 3.5 -3.2
Number of incorrect matches in round 0.4 0.7 2.4 -0.4 0.0 1.6 -0.3 0.8
Past tobacco smoking 0.2 0.3 1.1 -0.2 0.0 -1.1 0.2 -0.6
Alcohol usually taken with meals 0.2 0.3 0.6 0.3 0.0 0.8 -0.8 0.4
Nervous feelings 0.6 1.1 2.0 -1.1 0.0 -0.8 1.2 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.7 -0.7 0.0 -0.7 0.5 -0.8
Hearing difficulty/problems with background noise 1.8 3.0 8.6 1.2 0.0 2.9 -1.8 1.3
Hair/balding pattern: Pattern 2 1.2 1.5 2.1 1.3 0.0 1.4 -1.2 1.4
Had menopause 2.6 3.2 9.9 -3.1 0.0 0.1 1.8 -1.7
Had other major operations 0.2 0.2 1.0 0.2 0.0 1.0 -0.2 0.4
Forced vital capacity (FVC) 1.1 4.2 6.8 -2.5 0.0 -1.6 2.3 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.9 -1.7 0.0 -0.8 1.5 -0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.1 -0.3 0.0 -0.9 0.9 -1.1
Qualifications: None of the above 1.9 4.1 6.9 -1.9 0.0 -2.1 2.4 -2.6
Financial difficulties in last 2 years 0.4 0.6 2.7 0.5 0.0 -1.6 -0.1 -0.3
Mouth/teeth dental problems 1.8 2.8 6.1 1.4 0.0 1.8 -1.7 2.5
Heart attack 0.1 0.2 0.5 0.7 0.0 -0.3 -0.3 0.3
Allergy 2.0 4.5 7.0 -1.7 0.0 -2.5 2.6 -2.5
Pain all over the body in last month 0.2 0.2 1.0 1.0 0.0 -0.1 0.2 0.3
Diabetes (self-reported) 3.0 4.6 13.2 -0.5 0.0 -3.6 2.3 -2.1
Hayfever/allergic rhinitis (self-reported) 4.5 6.0 11.5 2.6 0.0 3.4 -2.3 2.5
Medication: Ramipril 0.6 0.8 2.0 -0.8 0.0 -0.8 1.4 -0.7
Medication: Simvastatin 0.2 0.4 1.0 0.7 0.0 -0.5 1.0 0.1
Fluid intelligence score 0.5 1.0 1.8 0.0 0.0 1.3 -1.3 1.3
Illnesses of siblings 2.2 3.0 6.5 0.9 0.0 2.6 -2.2 1.7
Neuroticism score 0.4 0.8 2.4 1.5 0.0 -0.3 -1.0 0.8
Weight 4.8 23.6 32.3 -4.9 0.0 -5.7 5.5 -5.6
Impedance of arm (right) 0.2 0.8 2.3 1.2 0.0 1.5 0.2 0.7
Arm fat percentage (right) 3.8 14.8 25.3 -2.9 0.0 -4.6 5.0 -4.4
Trunk fat-free mass 2.5 14.5 20.0 -4.5 0.0 -4.5 3.5 -4.5
Hip circumference 3.4 14.8 22.2 -3.8 0.0 -4.1 4.5 -4.7
Time employed in main current job 0.4 0.5 1.0 0.4 0.0 1.0 -0.6 1.0
Alcohol intake versus 10 years previously 0.6 0.8 2.2 -0.3 0.0 -1.0 1.0 -1.5
Father’s age at death 1.4 1.9 5.8 -0.6 0.0 2.4 -1.5 1.1
Worrier / anxious feelings 0.2 0.4 1.2 1.1 0.0 0.2 -0.4 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.7 1.6 0.0 0.6 -1.9 1.5
Falls in the last year 0.6 0.8 1.2 -1.0 0.0 -0.8 1.1 -1.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 -0.3 0.0 -0.8 0.7 -0.6
Number of live births 0.1 0.1 0.3 -0.4 0.0 -0.3 0.2 -0.5
Forced expiratory volume in 1-second (FEV1) 1.5 4.9 7.1 -2.4 0.0 -2.5 2.4 -2.7
Pulse rate 0.2 0.3 1.0 -0.6 0.0 -1.0 0.2 -0.1
Happiness 1.0 1.3 2.5 1.6 0.0 0.8 -1.3 1.3
Noisy workplace 0.2 0.2 0.8 -0.2 0.0 -0.2 0.3 -0.9
Qualifications: A levels/AS levels or equivalent 2.2 4.8 9.6 2.1 0.0 1.9 -3.1 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.1 -1.0 0.0 0.1 -0.0 0.2
Mouth/teeth dental problems: Dentures 5.2 8.8 17.5 -2.3 0.0 -4.2 2.7 -3.7
Asthma 0.8 1.7 4.7 0.6 0.0 2.2 -1.4 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.5 0.6 0.0 -0.6 -0.5 0.7
Medication: Cholesterol lowering 0.4 0.7 1.7 -0.1 0.0 -1.2 1.3 -0.4
Depression (self-reported) 0.2 0.2 0.6 0.8 0.0 -0.4 -0.3 0.3
Medication: Lansoprazole 2.4 2.8 5.9 2.4 0.0 1.1 -1.7 2.0
Prospective memory result 1.1 1.4 3.5 0.3 0.0 1.9 -1.1 1.5
Lung cancer (father) 1.1 1.3 2.9 -0.9 0.0 -0.8 1.7 -1.5
Illnesses of mother 0.4 0.5 1.5 0.5 0.0 -0.2 -1.2 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 4.6 -1.7 0.0 -2.1 1.9 -2.0
Pulse wave Arterial Stiffness index 0.7 0.8 1.7 0.5 0.0 1.3 -0.9 1.1
Impedance of arm (left) 0.1 0.4 1.5 0.6 0.0 1.2 0.3 0.3
Arm fat mass (right) 4.9 20.3 29.7 -4.0 0.0 -5.4 5.5 -5.2
Trunk predicted mass 2.5 14.2 19.7 -4.4 0.0 -4.4 3.5 -4.4
Standing height 1.4 13.8 20.5 -4.5 0.0 -3.6 3.8 -4.5
Length of working week for main job 1.5 1.6 3.3 -1.8 0.0 -1.8 0.3 -1.3
Exposure to tobacco smoke at home 0.2 0.2 1.0 -0.0 0.0 -1.0 0.3 -0.1
Breastfed as a baby 1.7 2.1 4.5 0.2 0.0 1.9 -2.1 1.5
Tense / ‘highly strung’ 2.0 3.3 4.8 -1.9 0.0 -2.0 2.2 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.0 0.0 -0.4 -0.4 -0.2
Hair/balding pattern: Pattern 4 0.4 1.0 3.5 -1.9 0.0 0.4 1.0 -0.7
Birth weight of first child 2.5 4.6 9.3 2.8 0.0 1.0 -3.1 2.2
Peak expiratory flow (PEF) 0.8 1.8 3.8 -1.3 0.0 -1.9 1.3 -1.4
Pulse wave reflection index 0.9 1.1 2.4 0.6 0.0 1.5 -1.3 1.1
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.1 0.3 0.0 -1.0 -0.1 -0.3
Loud music exposure frequency 0.1 0.1 0.4 0.4 0.0 -0.2 0.3 -0.6
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 8.6 2.1 0.0 1.2 -2.9 2.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.7 0.9 0.0 -0.4 -0.7 0.5
Blood clot in the leg (DVT) 1.2 1.6 5.8 -0.7 0.0 -2.4 0.3 -1.2
Medication: Paracetamol 0.9 1.4 3.5 1.9 0.0 1.3 -0.3 1.4
Headache pain in last month 1.1 1.9 4.1 2.0 0.0 0.2 -2.0 1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 -0.4 0.0 0.5 -1.0 -0.0
Glaucoma (self-reported) 2.0 2.3 3.9 2.0 0.0 1.7 -1.3 1.8
Gout (self-reported) 1.3 1.8 3.3 1.2 0.0 1.1 -1.8 1.7
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 5.0 -2.0 0.0 -1.9 1.8 -2.2
Medication: Amlodipine 0.9 1.3 2.3 -1.5 0.0 -1.0 1.5 -1.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.1 0.8 0.0 1.1 -0.6 0.7
Birth weight 1.9 4.1 6.7 2.1 0.0 2.5 -2.6 1.8
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.5 -1.0 0.0 -1.1 1.6 -1.5
High blood pressure (siblings) 0.1 0.1 0.3 0.5 0.0 0.3 0.5 0.2
Forced vital capacity (FVC), Best measure 0.6 2.0 3.3 -1.7 0.0 -1.3 1.5 -1.8
Body fat percentage 3.1 12.3 21.4 -2.8 0.0 -4.0 4.6 -4.0
Leg fat percentage (right) 1.3 4.9 9.2 -1.8 0.0 -2.4 3.0 -2.5
Arm fat-free mass (right) 2.8 14.3 21.2 -4.6 0.0 -4.3 3.6 -4.3
Exposure to tobacco smoke outside home 3.9 5.2 6.9 -2.4 0.0 -2.6 2.6 -2.6
Comparative body size at age 10 0.2 0.6 1.2 -1.1 0.0 -0.7 0.6 -0.9
Number of full brothers 2.4 3.0 4.7 -1.8 0.0 -2.2 1.6 -2.2
Worry too long after embarrassment 3.9 6.6 9.0 2.5 0.0 3.0 -3.0 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.5 0.0 -0.7 0.8 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 -0.4 0.0 -0.4 0.2 -0.8
Number of children fathered 0.6 0.7 1.8 -0.6 0.0 -1.3 0.5 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.2 0.0 0.1 -0.2 0.2
Age at first live birth 1.4 2.5 3.8 1.7 0.0 1.8 -1.5 1.9
Pulse wave peak to peak time 1.1 1.3 2.4 -0.9 0.0 -1.5 1.2 -1.3
Health satisfaction 0.2 0.2 0.4 -0.1 0.0 -0.6 0.6 -0.5
Shortness of breath walking on level ground 0.8 1.0 1.8 1.2 0.0 1.4 -0.9 1.0
Qualifications: College or University degree 0.9 2.8 5.9 0.8 0.0 2.4 -1.8 2.1
Eye problems/disorders: None of the above 2.9 3.3 9.3 -3.0 0.0 -1.7 1.1 -1.8
Mouth/teeth dental problems: Loose teeth 3.9 4.7 7.2 -2.0 0.0 -2.4 2.7 -2.5
Emphysema/chronic bronchitis 0.4 0.4 1.1 0.8 0.0 -1.1 0.2 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 2.5 -1.6 0.0 -0.6 -0.1 -1.2
Neck or shoulder pain in last month 0.2 0.3 1.0 0.4 0.0 -1.0 -0.7 0.0
Medication: Blood pressure 0.1 0.2 0.5 0.7 0.0 -0.1 0.5 0.1
Angina (self-reported) 1.0 1.4 2.9 -0.6 0.0 -1.7 1.3 -1.4
Migraine (self-reported) 4.6 5.7 9.7 2.7 0.0 2.0 -3.1 2.8
Medication: Ibuprofen 0.3 0.4 1.1 0.4 0.0 -0.4 -0.8 1.0
Medication: Allopurinol 3.0 4.1 6.1 2.3 0.0 2.5 -1.9 2.4
Medication: Omeprazole 0.1 0.1 0.3 -0.4 0.0 -0.2 0.6 -0.0
Medication: Seretide 50 evohaler 0.8 1.0 1.9 -1.1 0.0 -1.1 0.8 -1.4
Mean time to correctly identify matches 0.8 1.6 3.2 -1.4 0.0 -1.8 1.3 -1.1
Heart disease (mother) 0.2 0.3 0.9 -0.5 0.0 -0.9 0.4 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.1 0.6 0.0 1.8 -1.4 1.2
Whole body fat mass 4.4 18.3 27.3 -4.0 0.0 -5.0 5.2 -4.9
Leg fat mass (right) 3.0 11.7 17.9 -3.2 0.0 -3.9 4.2 -3.9
Arm predicted mass (right) 2.8 14.1 20.2 -4.4 0.0 -4.5 3.4 -4.4
Pulse rate, automated reading 1.9 6.1 12.5 -2.6 0.0 -3.5 2.5 -2.2
Alcohol intake frequency. 4.1 9.7 16.0 -1.7 0.0 -3.7 3.9 -4.0
Comparative height size at age 10 1.0 5.8 8.1 -2.6 0.0 -2.5 2.8 -2.8
Number of full sisters 0.1 0.1 0.3 0.4 0.0 0.6 0.5 0.1
Suffer from ‘nerves’ 1.0 1.6 4.1 -0.8 0.0 -2.0 1.4 -1.2
Overall health rating 0.6 1.2 2.5 -0.3 0.0 -1.6 1.4 -1.2
Chest pain or discomfort 0.8 1.2 2.2 -0.5 0.0 -1.4 1.2 -1.5
Had major operations 0.2 0.2 0.4 0.6 0.0 -0.5 -0.4 0.2
Age at last live birth 1.2 1.8 4.0 2.0 0.0 0.9 -1.3 1.6
Family relationship satisfaction 0.2 0.3 1.0 0.4 0.0 -1.0 0.3 -0.2
Leg pain on walking 0.2 0.2 0.5 0.4 0.0 -0.7 -0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.4 0.0 0.4 -0.0 -0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 -0.4 0.0 -0.2 0.8 -0.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -1.0 0.0 0.8 0.2 -0.3
Medication: Aspirin 0.4 0.5 2.0 -0.1 0.0 -0.3 1.4 -0.5
Supplements: Vitamin C 1.3 1.5 3.2 1.2 0.0 1.2 -1.3 1.8
Knee pain experienced in last month 2.2 3.4 8.3 -0.7 0.0 -2.9 2.1 -2.0
Hypertension (Self-reported) 0.1 0.2 0.9 0.1 0.0 0.0 0.9 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.5 1.1 0.0 0.7 -1.2 1.1
Illnesses of father: Heart disease 4.2 5.8 8.9 -2.1 0.0 -2.6 3.0 -3.0
Illnesses of siblings: Diabetes 2.0 2.5 8.4 -0.1 0.0 -2.9 1.5 -1.3
Smoking status: Previous 0.5 0.7 1.4 0.7 0.0 1.2 -0.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.9 -0.9 0.0 -1.4 0.7 -0.9
Whole body fat-free mass 3.1 17.6 25.6 -4.7 0.0 -5.1 4.0 -4.9
Leg fat-free mass (right) 3.4 18.3 30.7 -4.5 0.0 -5.5 4.2 -4.8
Arm fat percentage (left) 4.0 15.8 25.5 -3.1 0.0 -4.8 5.0 -4.6
Average weekly red wine intake 1.0 1.5 4.2 0.8 0.0 2.0 -1.1 1.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 -0.2 0.0 0.9 -0.4 0.3
Mood swings 0.6 1.1 3.6 1.9 0.0 -0.8 -0.8 0.7
Loneliness, isolation 0.5 0.6 1.7 1.0 0.0 -0.5 -1.3 0.7
Long-standing illness, disability or infirmity 0.2 0.4 0.8 0.9 0.0 -0.7 -0.5 0.5
Ever had bowel cancer screening 1.4 1.6 2.5 1.4 0.0 1.6 -1.2 1.5
Diabetes diagnosed by doctor 4.3 7.1 16.2 -1.0 0.0 -4.0 3.2 -2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.3 0.0 0.1 0.4 -0.4
Friendships satisfaction 0.2 0.3 0.6 -0.4 0.0 -0.8 0.6 -0.6
Qualifications: nursing, teaching 0.6 0.9 1.5 0.9 0.0 1.2 -1.1 1.0
Commuting to job workplace: Walk 0.9 0.9 2.3 0.6 0.0 1.5 -1.1 0.9
Eye problems/disorders: Cataract 1.4 1.7 3.3 1.8 0.0 1.8 -0.3 1.4
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 5.8 0.2 0.0 2.4 -1.1 0.6
Medication for cholesterol 1.0 1.6 3.8 0.6 0.0 1.6 -1.9 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.1 0.0 -0.0 -0.6 0.5
Back pain experienced in last month 0.3 0.4 1.3 -1.1 0.0 -0.3 0.4 -0.6
Mineral and other dietary supplements 1.5 2.0 3.1 -1.3 0.0 -1.7 1.6 -1.8
Breast cancer (self-reported) 0.1 0.1 0.5 -0.7 0.0 0.1 -0.3 -0.3
Asthma (self-reported) 1.4 2.7 7.1 0.9 0.0 2.7 -1.7 1.7
Osteoporosis (self-reported) 1.8 2.2 4.0 1.3 0.0 2.0 -1.7 1.5
Osteoarthritis (self-reported) 0.7 1.0 1.9 1.2 0.0 0.4 -1.4 1.2
Medication: Aspirin 0.4 0.5 2.1 -0.2 0.0 -0.2 1.5 -0.5
Medication: Gliclazide 3.0 3.3 5.8 -1.5 0.0 -2.4 2.2 -1.9
Illnesses of father: None of the above (group 1) 2.9 3.6 7.5 1.5 0.0 1.5 -2.7 2.4
Smoking status: Current 0.5 0.8 1.6 -1.0 0.0 -0.8 0.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.5 -0.1 0.0 -0.7 0.6 -0.5
Whole body water mass 3.1 17.6 25.6 -4.6 0.0 -5.1 4.1 -4.9
Leg predicted mass (right) 3.4 18.1 30.5 -4.4 0.0 -5.5 4.2 -4.8
Arm fat mass (left) 5.3 21.8 31.6 -4.2 0.0 -5.5 5.6 -5.4
Number of self-reported non-cancer illnesses 0.7 1.2 2.3 1.0 0.0 1.2 -1.1 1.5
Average weekly champagne plus white wine intake 2.8 3.9 5.7 2.1 0.0 2.1 -2.2 2.4
Miserableness 0.2 0.3 0.7 0.3 0.0 -0.8 -0.8 0.4
Guilty feelings 0.8 1.2 2.5 1.6 0.0 0.9 -1.1 1.1
Wears glasses or contact lenses 1.0 1.2 2.2 1.1 0.0 1.1 -1.5 1.1
Ever taken oral contraceptive pill 1.0 1.1 2.1 0.5 0.0 1.2 -1.3 1.5
Hearing aid user 0.4 0.5 1.0 0.3 0.0 0.6 -1.0 0.9
Mother’s age at death 2.3 2.9 4.8 1.6 0.0 2.2 -1.8 1.9
Financial situation satisfaction 0.2 0.2 0.7 0.5 0.0 -0.8 -0.4 0.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.9 0.8 0.0 1.0 0.1 -0.1
Commuting to job workplace: Public transport 1.8 2.1 3.0 1.4 0.0 1.7 -1.7 1.6
Eye problems/disorders: Glaucoma 1.8 2.2 5.9 2.4 0.0 1.5 -1.1 1.3
Medication: Blood pressure 0.1 0.2 0.5 -0.1 0.0 0.7 0.3 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.9 -1.0 0.0 0.5 0.7 -0.6
Supplements: Fish oil (including cod liver oil) 1.2 1.6 2.6 1.0 0.0 1.4 -1.5 1.6
High cholesterol (Self-reported) 1.1 1.9 3.8 -0.9 0.0 -1.8 1.9 -1.3
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.5 0.0 -0.4 0.2 -0.1
Medication: Paracetamol 1.0 1.6 3.2 1.8 0.0 1.3 -0.8 1.6
Medication: Lisinopril 0.4 0.5 1.7 0.0 0.0 0.4 1.3 -0.7
Medication: Atorvastatin 1.0 1.2 3.1 -0.8 0.0 -1.8 0.9 -1.1
Illnesses of father: High blood pressure 0.5 0.6 2.4 -0.0 0.0 1.5 -0.0 0.8
Alcohol drinker status: Never 0.0 0.0 0.1 0.3 0.0 0.1 -0.3 0.1
Ever smoked 0.4 0.7 2.5 -0.8 0.0 1.6 -0.2 0.4
Basal metabolic rate 3.6 19.7 28.9 -4.8 0.0 -5.4 4.5 -5.1
Leg fat percentage (left) 1.3 4.6 8.6 -1.6 0.0 -2.5 2.9 -2.4
Arm fat-free mass (left) 3.2 16.1 22.5 -4.5 0.0 -4.6 4.0 -4.7
Number of operations (self-reported) 1.1 1.7 2.7 1.6 0.0 1.2 -1.5 1.4
Average weekly beer plus cider intake 0.1 0.1 0.2 -0.2 0.0 -0.4 0.5 -0.4
Irritability 1.1 1.9 5.0 2.2 0.0 -0.1 -1.4 1.6
Risk taking 0.5 0.7 0.9 0.9 0.0 0.9 -1.0 0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.8 0.8 0.0 1.4 -0.6 0.8
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.5 0.0 0.0 -0.3 0.4
Age started oral contraceptive pill 2.1 2.6 5.2 1.2 0.0 1.9 -1.7 2.3
Diastolic blood pressure, automated reading 0.6 2.0 3.5 -1.9 0.0 -1.7 1.6 -1.1
Ever depressed for a whole week 0.4 0.5 1.2 -0.8 0.0 -0.4 0.5 -1.1
Unable to work because of sickness or disability 0.8 1.1 2.0 -0.7 0.0 -1.4 0.9 -1.4
Commuting to job workplace: Cycle 1.9 2.3 3.6 1.4 0.0 1.7 -1.9 1.7
Myopia 0.5 0.7 1.8 0.4 0.0 0.7 -1.3 1.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 2.5 0.6 0.0 0.4 -1.6 0.5
Cholesterol lowering medication 1.0 1.5 3.6 -0.8 0.0 -1.9 1.5 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.1 0.0 -0.2 0.6 0.0
Pain experienced in last month 0.3 0.5 1.9 -0.6 0.0 1.4 0.2 0.1
Supplements: Calcium 1.2 1.3 2.7 0.9 0.0 1.6 -1.2 1.3
Basal cell carcinoma (self-reported) 1.5 1.8 3.6 1.0 0.0 1.9 -1.3 1.6
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.7 0.8 0.0 -0.2 -0.2 0.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 5.4 -0.5 0.0 -2.3 0.0 -0.9
Heart disease (siblings) 1.7 2.1 4.2 -1.0 0.0 -2.0 1.7 -1.6
Alcohol drinker status: Previous 1.2 1.3 2.7 -1.0 0.0 -1.2 1.6 -1.2
Pack years of smoking 1.6 2.3 5.9 -1.0 0.0 -2.4 1.3 -1.7
Impedance of whole body 0.6 3.0 7.3 1.8 0.0 2.7 -1.1 1.8
Leg fat mass (left) 3.0 11.8 17.8 -3.2 0.0 -4.0 4.2 -3.9
Arm predicted mass (left) 2.9 14.8 20.7 -4.3 0.0 -4.5 3.8 -4.5