TWAS hub - TUBG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.061	0.030	0.00430	0.026	NA	0.047	NA	0.034	4.3e-03	NA	0.00020	NA	1.4e-03
2	GTEx	Esophagus Muscularis	0.144	0.062	0.00210	0.014	NA	0.003	NA	-0.005	4.4e-02	NA	0.19000	NA	9.0e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.110	0.054	0.00220	0.013	NA	-0.001	NA	0.005	5.8e-02	NA	0.40000	NA	1.7e-01
4	GTEx	Skin Sun Exposed Lower leg	0.041	0.021	0.00800	0.055	NA	0.040	NA	0.047	2.3e-05	NA	0.00029	NA	8.3e-05
5	GTEx	Testis	0.119	0.048	0.00035	0.094	NA	0.081	NA	0.048	5.9e-05	NA	0.00018	NA	3.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Medication: Metformin	6.5	9.1	16.8	-2.0	-4.1	3.8	-3.3
Arm fat mass (left)	5.3	21.8	31.6	-4.2	-5.5	5.6	-5.4
Mouth/teeth dental problems: Dentures	5.2	8.8	17.5	-2.3	-4.2	2.7	-3.7
Trunk fat mass	5.0	21.5	33.0	-4.2	-5.3	5.7	-5.3
Arm fat mass (right)	4.9	20.3	29.7	-4.0	-5.4	5.5	-5.2
Weight	4.8	23.6	32.3	-4.9	-5.7	5.5	-5.6
Migraine (self-reported)	4.6	5.7	9.7	2.7	2.0	-3.1	2.8
Number of treatments/medications taken	4.5	8.0	16.4	4.0	2.5	-2.6	3.3
Hayfever/allergic rhinitis (self-reported)	4.5	6.0	11.5	2.6	3.4	-2.3	2.5
Whole body fat mass	4.4	18.3	27.3	-4.0	-5.0	5.2	-4.9
Age at First Birth	4.3	6.2	8.9	2.7	2.7	-2.8	3.0
Diabetes diagnosed by doctor	4.3	7.1	16.2	-1.0	-4.0	3.2	-2.8
Blood White Count	4.2	31.0	51.4	-4.1	-7.2	6.8	-6.3
Illnesses of father: Heart disease	4.2	5.8	8.9	-2.1	-2.6	3.0	-3.0
Ovarian Cancer	4.1	5.4	8.5	-2.0	-2.5	2.9	-2.8
Alcohol intake frequency.	4.1	9.7	16.0	-1.7	-3.7	3.9	-4.0
Arm fat percentage (left)	4.0	15.8	25.5	-3.1	-4.8	5.0	-4.6
Leg predicted mass (left)	3.9	20.7	32.6	-4.8	-5.7	4.6	-5.2
Exposure to tobacco smoke outside home	3.9	5.2	6.9	-2.4	-2.6	2.6	-2.6
Worry too long after embarrassment	3.9	6.6	9.0	2.5	3.0	-3.0	2.9
Mouth/teeth dental problems: Loose teeth	3.9	4.7	7.2	-2.0	-2.4	2.7	-2.5
Leg fat-free mass (left)	3.8	20.0	32.1	-4.7	-5.7	4.5	-5.1
Trunk fat percentage	3.8	15.4	27.4	-3.3	-4.3	5.2	-4.5
Arm fat percentage (right)	3.8	14.8	25.3	-2.9	-4.6	5.0	-4.4
Hayfever, allergic rhinitis or eczema	3.7	8.1	13.1	2.3	3.6	-3.2	3.5
Basal metabolic rate	3.6	19.7	28.9	-4.8	-5.4	4.5	-5.1
HDL Cholesterol	3.4	5.6	9.8	2.1	2.5	-3.1	2.8
Maternal smoking around birth	3.4	5.0	9.2	-2.0	-3.0	2.5	-2.4
Hip circumference	3.4	14.8	22.2	-3.8	-4.1	4.5	-4.7
Leg fat-free mass (right)	3.4	18.3	30.7	-4.5	-5.5	4.2	-4.8
Leg predicted mass (right)	3.4	18.1	30.5	-4.4	-5.5	4.2	-4.8
Arm fat-free mass (left)	3.2	16.1	22.5	-4.5	-4.6	4.0	-4.7
Body mass index (BMI)	3.1	13.2	19.6	-3.3	-4.4	4.3	-4.1
Body fat percentage	3.1	12.3	21.4	-2.8	-4.0	4.6	-4.0
Whole body fat-free mass	3.1	17.6	25.6	-4.7	-5.1	4.0	-4.9
Whole body water mass	3.1	17.6	25.6	-4.6	-5.1	4.1	-4.9
Diabetes (self-reported)	3.0	4.6	13.2	-0.5	-3.6	2.3	-2.1
Medication: Allopurinol	3.0	4.1	6.1	2.3	2.5	-1.9	2.4
Leg fat mass (right)	3.0	11.7	17.9	-3.2	-3.9	4.2	-3.9
Medication: Gliclazide	3.0	3.3	5.8	-1.5	-2.4	2.2	-1.9
Leg fat mass (left)	3.0	11.8	17.8	-3.2	-4.0	4.2	-3.9
Eye problems/disorders: None of the above	2.9	3.3	9.3	-3.0	-1.7	1.1	-1.8
Illnesses of father: None of the above (group 1)	2.9	3.6	7.5	1.5	1.5	-2.7	2.4
Arm predicted mass (left)	2.9	14.8	20.7	-4.3	-4.5	3.8	-4.5
Allergy or Eczema	2.8	7.3	15.3	1.9	3.9	-2.7	3.2
High blood pressure (mother)	2.8	3.9	11.9	1.4	3.4	-1.1	2.2
Arm fat-free mass (right)	2.8	14.3	21.2	-4.6	-4.3	3.6	-4.3
Arm predicted mass (right)	2.8	14.1	20.2	-4.4	-4.5	3.4	-4.4
Average weekly champagne plus white wine intake	2.8	3.9	5.7	2.1	2.1	-2.2	2.4
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	8.6	2.1	1.2	-2.9	2.6
Had menopause	2.6	3.2	9.9	-3.1	0.1	1.8	-1.7
Type 2 Diabetes (T2D) (2018)	2.5	4.6	12.6	-0.2	-3.5	2.5	-2.1
Waist circumference	2.5	9.1	18.1	-2.2	-4.3	3.5	-3.2
Trunk fat-free mass	2.5	14.5	20.0	-4.5	-4.5	3.5	-4.5
Trunk predicted mass	2.5	14.2	19.7	-4.4	-4.4	3.5	-4.4
Birth weight of first child	2.5	4.6	9.3	2.8	1.0	-3.1	2.2
Qualifications: CSEs or equivalent	2.4	3.2	10.1	-1.3	-3.2	1.1	-1.7
Medication: Lansoprazole	2.4	2.8	5.9	2.4	1.1	-1.7	2.0
Number of full brothers	2.4	3.0	4.7	-1.8	-2.2	1.6	-2.2
Hearing difficulty/problems: Yes	2.3	3.5	6.7	1.5	2.6	-2.4	1.7
Mother’s age at death	2.3	2.9	4.8	1.6	2.2	-1.8	1.9
Intelligence (Savage-Jansen 2018)	2.2	6.7	11.4	2.4	3.4	-2.8	2.9
Height	2.2	41.8	59.9	-7.7	-6.8	6.7	-7.6
Illnesses of siblings	2.2	3.0	6.5	0.9	2.6	-2.2	1.7
Qualifications: A levels/AS levels or equivalent	2.2	4.8	9.6	2.1	1.9	-3.1	2.5
Knee pain experienced in last month	2.2	3.4	8.3	-0.7	-2.9	2.1	-2.0
Medication for hormone replacement therapy	2.1	2.4	4.2	-1.5	-1.5	2.0	-1.7
Impedance of leg (left)	2.1	10.3	18.4	3.4	4.3	-2.9	3.6
Age started oral contraceptive pill	2.1	2.6	5.2	1.2	1.9	-1.7	2.3
Alzheimer’s Disease (including proxy)	2.0	2.8	4.3	-2.1	-2.0	1.8	-1.6
Medication: Co-codamol	2.0	2.3	4.0	-1.2	-2.0	2.0	-1.6
Diabetes (father)	2.0	2.5	7.0	-0.4	-2.6	1.8	-1.5
Hand grip strength (right)	2.0	5.4	10.5	-2.0	-1.8	3.0	-3.2
Allergy	2.0	4.5	7.0	-1.7	-2.5	2.6	-2.5
Tense / ‘highly strung’	2.0	3.3	4.8	-1.9	-2.0	2.2	-2.0
Glaucoma (self-reported)	2.0	2.3	3.9	2.0	1.7	-1.3	1.8
Illnesses of siblings: Diabetes	2.0	2.5	8.4	-0.1	-2.9	1.5	-1.3
Schizophrenia vs Biploar Disorder	1.9	2.5	4.9	-2.2	-1.2	2.0	-1.5
Blood Eosinophil Count	1.9	14.9	33.3	-5.8	-2.1	4.5	-4.1
Qualifications: None of the above	1.9	4.1	6.9	-1.9	-2.1	2.4	-2.6
Birth weight	1.9	4.1	6.7	2.1	2.5	-2.6	1.8
Pulse rate, automated reading	1.9	6.1	12.5	-2.6	-3.5	2.5	-2.2
Commuting to job workplace: Cycle	1.9	2.3	3.6	1.4	1.7	-1.9	1.7
BMI	1.8	10.7	18.0	-2.8	-3.6	4.2	-3.8
Hearing difficulty/problems with background noise	1.8	3.0	8.6	1.2	2.9	-1.8	1.3
Mouth/teeth dental problems	1.8	2.8	6.1	1.4	1.8	-1.7	2.5
Osteoporosis (self-reported)	1.8	2.2	4.0	1.3	2.0	-1.7	1.5
Commuting to job workplace: Public transport	1.8	2.1	3.0	1.4	1.7	-1.7	1.6
Eye problems/disorders: Glaucoma	1.8	2.2	5.9	2.4	1.5	-1.1	1.3
Crohns Disease (2012)	1.7	2.7	11.0	0.3	3.3	-0.7	1.3
Hand grip strength (left)	1.7	4.6	9.3	-2.1	-1.1	3.0	-2.8
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.9	-0.5	-2.0	1.5	-1.7
Impedance of leg (right)	1.7	8.4	18.0	2.9	4.2	-2.4	3.1
Breastfed as a baby	1.7	2.1	4.5	0.2	1.9	-2.1	1.5
Heart disease (siblings)	1.7	2.1	4.2	-1.0	-2.0	1.7	-1.6
Alzheimer’s Disease (in father)	1.6	1.8	3.7	-1.8	0.1	1.9	-1.4
Ulcerative Colitis (UC)	1.6	2.9	5.2	-2.3	2.1	1.9	-1.2
Neuroticism (2016)	1.6	2.3	7.2	-1.1	-2.7	0.7	-1.7
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	5.0	-2.0	-1.9	1.8	-2.2
Pack years of smoking	1.6	2.3	5.9	-1.0	-2.4	1.3	-1.7
Mean Putamen Volume	1.5	1.8	2.9	-1.0	-1.6	1.5	-1.7
Ulcerative Colitis	1.5	2.1	9.7	-0.3	3.1	-0.2	0.8
Pack years adult smoking proportion	1.5	2.3	5.6	-1.2	-2.4	1.3	-1.7
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	7.1	-2.4	-2.5	2.4	-2.7
Length of working week for main job	1.5	1.6	3.3	-1.8	-1.8	0.3	-1.3
Mineral and other dietary supplements	1.5	2.0	3.1	-1.3	-1.7	1.6	-1.8
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	1.0	1.9	-1.3	1.6
Irritable Bowel Disease (IBD)	1.4	3.3	13.6	-1.5	3.7	0.7	-0.1
Medication: Levothyroxine sodium	1.4	2.4	4.1	-1.7	-1.8	1.4	-2.0
Father’s age at death	1.4	1.9	5.8	-0.6	2.4	-1.5	1.1
Standing height	1.4	13.8	20.5	-4.5	-3.6	3.8	-4.5
Age at first live birth	1.4	2.5	3.8	1.7	1.8	-1.5	1.9
Ever had bowel cancer screening	1.4	1.6	2.5	1.4	1.6	-1.2	1.5
Eye problems/disorders: Cataract	1.4	1.7	3.3	1.8	1.8	-0.3	1.4
Asthma (self-reported)	1.4	2.7	7.1	0.9	2.7	-1.7	1.7
Body Mass Index (BMI) (2010)	1.3	1.8	3.4	-1.8	-0.9	1.5	-1.5
Cardiovascular Disease	1.3	4.2	9.7	-1.1	-2.4	3.1	-2.0
Gout (self-reported)	1.3	1.8	3.3	1.2	1.1	-1.8	1.7
Leg fat percentage (right)	1.3	4.9	9.2	-1.8	-2.4	3.0	-2.5
Supplements: Vitamin C	1.3	1.5	3.2	1.2	1.2	-1.3	1.8
Leg fat percentage (left)	1.3	4.6	8.6	-1.6	-2.5	2.9	-2.4
Crohns Disease (2017)	1.2	2.6	12.0	-0.3	3.5	-0.4	0.8
Prostate Cancer	1.2	1.6	4.2	-0.3	-2.1	1.4	-1.3
Waist Hip Ratio (WHR)	1.2	5.2	16.6	4.1	-1.1	-1.4	2.5
Hair/balding pattern: Pattern 2	1.2	1.5	2.1	1.3	1.4	-1.2	1.4
Blood clot in the leg (DVT)	1.2	1.6	5.8	-0.7	-2.4	0.3	-1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.5	-1.0	-1.1	1.6	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.1	0.6	1.8	-1.4	1.2
Age at last live birth	1.2	1.8	4.0	2.0	0.9	-1.3	1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.6	1.0	1.4	-1.5	1.6
Supplements: Calcium	1.2	1.3	2.7	0.9	1.6	-1.2	1.3
Alcohol drinker status: Previous	1.2	1.3	2.7	-1.0	-1.2	1.6	-1.2
Alzheimer’s Disease (in mother)	1.1	1.2	3.0	-1.3	-1.7	0.8	-0.9
Stomach or abdominal pain in last month	1.1	1.3	2.2	1.4	1.5	-0.9	1.3
Forced vital capacity (FVC)	1.1	4.2	6.8	-2.5	-1.6	2.3	-2.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.7	1.6	0.6	-1.9	1.5
Prospective memory result	1.1	1.4	3.5	0.3	1.9	-1.1	1.5
Lung cancer (father)	1.1	1.3	2.9	-0.9	-0.8	1.7	-1.5
Headache pain in last month	1.1	1.9	4.1	2.0	0.2	-2.0	1.3
Pulse wave peak to peak time	1.1	1.3	2.4	-0.9	-1.5	1.2	-1.3
High cholesterol (Self-reported)	1.1	1.9	3.8	-0.9	-1.8	1.9	-1.3
Number of operations (self-reported)	1.1	1.7	2.7	1.6	1.2	-1.5	1.4
Irritability	1.1	1.9	5.0	2.2	-0.1	-1.4	1.6
Reaction Time	1.0	1.9	5.3	-0.9	-2.3	1.3	-1.3
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.3	0.9	2.1	-1.8	1.8
Angina	1.0	1.3	2.3	-0.7	-1.5	1.4	-1.4
Severe depression (siblings)	1.0	1.1	2.6	0.9	0.9	-1.6	1.2
Happiness	1.0	1.3	2.5	1.6	0.8	-1.3	1.3
Angina (self-reported)	1.0	1.4	2.9	-0.6	-1.7	1.3	-1.4
Comparative height size at age 10	1.0	5.8	8.1	-2.6	-2.5	2.8	-2.8
Suffer from ‘nerves’	1.0	1.6	4.1	-0.8	-2.0	1.4	-1.2
Average weekly red wine intake	1.0	1.5	4.2	0.8	2.0	-1.1	1.2
Medication for cholesterol	1.0	1.6	3.8	0.6	1.6	-1.9	1.1
Wears glasses or contact lenses	1.0	1.2	2.2	1.1	1.1	-1.5	1.1
Ever taken oral contraceptive pill	1.0	1.1	2.1	0.5	1.2	-1.3	1.5
Medication: Paracetamol	1.0	1.6	3.2	1.8	1.3	-0.8	1.6
Medication: Atorvastatin	1.0	1.2	3.1	-0.8	-1.8	0.9	-1.1
Cholesterol lowering medication	1.0	1.5	3.6	-0.8	-1.9	1.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.4	-0.5	-2.3	0.0	-0.9
Worry (Nagel 2018)	0.9	1.8	4.5	-1.2	-1.1	2.1	-1.5
LDL Cholesterol	0.9	1.4	3.0	1.7	0.0	-1.4	1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.1	-1.4	-0.9	1.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	4.6	-1.7	-2.1	1.9	-2.0
Pulse wave reflection index	0.9	1.1	2.4	0.6	1.5	-1.3	1.1
Medication: Paracetamol	0.9	1.4	3.5	1.9	1.3	-0.3	1.4
Medication: Amlodipine	0.9	1.3	2.3	-1.5	-1.0	1.5	-1.1
Qualifications: College or University degree	0.9	2.8	5.9	0.8	2.4	-1.8	2.1
Commuting to job workplace: Walk	0.9	0.9	2.3	0.6	1.5	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	5.8	0.2	2.4	-1.1	0.6
Current tobacco smoking	0.8	1.3	2.3	-1.5	-0.9	1.0	-1.5
Taking other prescription medications	0.8	1.3	3.2	1.8	1.0	-1.0	1.2
Sitting height	0.8	5.6	12.4	-3.5	-2.2	2.0	-2.6
Asthma	0.8	1.7	4.7	0.6	2.2	-1.4	1.2
Peak expiratory flow (PEF)	0.8	1.8	3.8	-1.3	-1.9	1.3	-1.4
Shortness of breath walking on level ground	0.8	1.0	1.8	1.2	1.4	-0.9	1.0
Medication: Seretide 50 evohaler	0.8	1.0	1.9	-1.1	-1.1	0.8	-1.4
Mean time to correctly identify matches	0.8	1.6	3.2	-1.4	-1.8	1.3	-1.1
Chest pain or discomfort	0.8	1.2	2.2	-0.5	-1.4	1.2	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.5	1.1	0.7	-1.2	1.1
Guilty feelings	0.8	1.2	2.5	1.6	0.9	-1.1	1.1
Unable to work because of sickness or disability	0.8	1.1	2.0	-0.7	-1.4	0.9	-1.4
Lupus	0.7	1.1	2.9	1.7	-0.0	-1.4	0.8
Sensitivity / hurt feelings	0.7	1.2	5.8	2.4	-0.4	-0.3	0.4
Systolic blood pressure, automated reading	0.7	2.1	4.6	-2.1	0.9	2.0	-1.1
Multivitamins +/- minerals	0.7	0.9	1.9	1.4	0.6	-1.0	1.0
Pulse wave Arterial Stiffness index	0.7	0.8	1.7	0.5	1.3	-0.9	1.1
Osteoarthritis (self-reported)	0.7	1.0	1.9	1.2	0.4	-1.4	1.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	1.0	1.2	-1.1	1.5
Breast Cancer	0.6	1.5	3.5	-1.9	1.6	1.1	0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.7	-0.3	1.4	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	-1.1	-0.6	0.9	-1.0
Vitamin and mineral supplements	0.6	0.8	2.0	-1.4	-0.5	0.7	-1.1
Supplements: Zinc	0.6	0.7	1.5	0.8	0.7	-0.9	1.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.5	-0.5	-0.2	1.1	-1.2
Nervous feelings	0.6	1.1	2.0	-1.1	-0.8	1.2	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.9	-1.7	-0.8	1.5	-0.8
Medication: Ramipril	0.6	0.8	2.0	-0.8	-0.8	1.4	-0.7
Alcohol intake versus 10 years previously	0.6	0.8	2.2	-0.3	-1.0	1.0	-1.5
Falls in the last year	0.6	0.8	1.2	-1.0	-0.8	1.1	-1.0
Forced vital capacity (FVC), Best measure	0.6	2.0	3.3	-1.7	-1.3	1.5	-1.8
Number of children fathered	0.6	0.7	1.8	-0.6	-1.3	0.5	-1.0
Overall health rating	0.6	1.2	2.5	-0.3	-1.6	1.4	-1.2
Mood swings	0.6	1.1	3.6	1.9	-0.8	-0.8	0.7
Qualifications: nursing, teaching	0.6	0.9	1.5	0.9	1.2	-1.1	1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	0.8	1.4	-0.6	0.8
Diastolic blood pressure, automated reading	0.6	2.0	3.5	-1.9	-1.7	1.6	-1.1
Impedance of whole body	0.6	3.0	7.3	1.8	2.7	-1.1	1.8
Coronary Artery Disease (CAD)	0.5	0.6	2.6	1.6	-0.6	-0.1	0.3
Respiratory disease	0.5	1.0	3.5	-0.3	1.9	-0.8	1.0
Diabetes (mother)	0.5	0.6	2.0	0.8	-1.4	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	-1.3	-0.9	0.7	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	0.9	1.2	-0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-0.3	-0.9	0.9	-1.1
Fluid intelligence score	0.5	1.0	1.8	0.0	1.3	-1.3	1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	-1.6	-0.6	-0.1	-1.2
Smoking status: Previous	0.5	0.7	1.4	0.7	1.2	-0.6	1.1
Loneliness, isolation	0.5	0.6	1.7	1.0	-0.5	-1.3	0.7
Smoking status: Current	0.5	0.8	1.6	-1.0	-0.8	0.7	-1.3
Illnesses of father: High blood pressure	0.5	0.6	2.4	-0.0	1.5	-0.0	0.8
Risk taking	0.5	0.7	0.9	0.9	0.9	-1.0	0.9
Myopia	0.5	0.7	1.8	0.4	0.7	-1.3	1.1
Hypothyroidism (self reported)	0.4	0.9	1.8	-0.9	-1.3	0.7	-1.2
Townsend deprivation index at recruitment	0.4	0.5	1.3	0.8	0.1	-1.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.9	-1.2	-0.8	1.4	-0.5
Supplements: Glucosamine	0.4	0.5	1.6	0.3	1.3	-0.4	0.9
Number of incorrect matches in round	0.4	0.7	2.4	-0.4	1.6	-0.3	0.8
Financial difficulties in last 2 years	0.4	0.6	2.7	0.5	-1.6	-0.1	-0.3
Neuroticism score	0.4	0.8	2.4	1.5	-0.3	-1.0	0.8
Time employed in main current job	0.4	0.5	1.0	0.4	1.0	-0.6	1.0
Medication: Cholesterol lowering	0.4	0.7	1.7	-0.1	-1.2	1.3	-0.4
Illnesses of mother	0.4	0.5	1.5	0.5	-0.2	-1.2	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	3.5	-1.9	0.4	1.0	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	0.8	1.1	-0.6	0.7
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.8	-1.1	0.2	-0.5
Medication: Aspirin	0.4	0.5	2.0	-0.1	-0.3	1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	-0.9	-1.4	0.7	-0.9
Medication: Aspirin	0.4	0.5	2.1	-0.2	-0.2	1.5	-0.5
Hearing aid user	0.4	0.5	1.0	0.3	0.6	-1.0	0.9
Medication: Lisinopril	0.4	0.5	1.7	0.0	0.4	1.3	-0.7
Ever smoked	0.4	0.7	2.5	-0.8	1.6	-0.2	0.4
Ever depressed for a whole week	0.4	0.5	1.2	-0.8	-0.4	0.5	-1.1
Bipolar Disorder (2018)	0.3	0.5	1.7	0.3	1.3	-0.6	0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	1.4	-0.7	-0.6	0.4
Bipolar Disorder (2011)	0.3	0.3	1.1	-0.4	1.1	0.2	0.3
HbA1C	0.3	0.3	0.6	0.3	-0.8	0.6	-0.8
Systolic Blood Pressure	0.3	1.5	3.0	-1.1	1.7	1.7	-0.6
Tanning	0.3	3.4	6.1	2.0	1.8	-2.5	1.9
Fed-up feelings	0.3	0.5	2.3	0.6	-1.5	-0.2	-0.1
Medication: Atenolol	0.3	0.4	1.6	-0.0	-1.3	0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	-0.7	-0.7	0.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.5	0.6	-0.6	-0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.5	-0.7	0.8	-0.9
Medication: Ibuprofen	0.3	0.4	1.1	0.4	-0.4	-0.8	1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-1.0	0.8	0.2	-0.3
Back pain experienced in last month	0.3	0.4	1.3	-1.1	-0.3	0.4	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.8	1.0	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-1.0	0.5	0.7	-0.6
Pain experienced in last month	0.3	0.5	1.9	-0.6	1.4	0.2	0.1
Bipolar Disorder or Schizophrenia	0.2	0.6	2.6	-0.1	1.6	0.1	0.4
Primary Biliary Cirrhosis	0.2	0.2	1.0	1.0	0.2	-0.1	0.2
Rheumatoid Arthritis	0.2	0.3	0.8	0.7	0.3	-0.3	0.9
Schizophrenia (2014)	0.2	0.5	1.9	-0.5	1.4	0.6	0.1
Triglycerides	0.2	0.3	0.8	0.1	-0.6	0.9	-0.3
Heel T-Score	0.2	1.7	6.4	0.7	-0.8	2.5	-1.0
Lung FVC	0.2	1.2	3.7	-1.9	0.5	0.9	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.0	-0.1	-0.7	1.0
Past tobacco smoking	0.2	0.3	1.1	-0.2	-1.1	0.2	-0.6
Alcohol usually taken with meals	0.2	0.3	0.6	0.3	0.8	-0.8	0.4
Had other major operations	0.2	0.2	1.0	0.2	1.0	-0.2	0.4
Pain all over the body in last month	0.2	0.2	1.0	1.0	-0.1	0.2	0.3
Medication: Simvastatin	0.2	0.4	1.0	0.7	-0.5	1.0	0.1
Impedance of arm (right)	0.2	0.8	2.3	1.2	1.5	0.2	0.7
Worrier / anxious feelings	0.2	0.4	1.2	1.1	0.2	-0.4	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	-0.8	0.7	-0.6
Pulse rate	0.2	0.3	1.0	-0.6	-1.0	0.2	-0.1
Noisy workplace	0.2	0.2	0.8	-0.2	-0.2	0.3	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.1	-1.0	0.1	-0.0	0.2
Depression (self-reported)	0.2	0.2	0.6	0.8	-0.4	-0.3	0.3
Exposure to tobacco smoke at home	0.2	0.2	1.0	-0.0	-1.0	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.1	0.3	-1.0	-0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	0.9	-0.4	-0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.4	0.5	-1.0	-0.0
Comparative body size at age 10	0.2	0.6	1.2	-1.1	-0.7	0.6	-0.9
Health satisfaction	0.2	0.2	0.4	-0.1	-0.6	0.6	-0.5
Neck or shoulder pain in last month	0.2	0.3	1.0	0.4	-1.0	-0.7	0.0
Heart disease (mother)	0.2	0.3	0.9	-0.5	-0.9	0.4	-0.3
Had major operations	0.2	0.2	0.4	0.6	-0.5	-0.4	0.2
Family relationship satisfaction	0.2	0.3	1.0	0.4	-1.0	0.3	-0.2
Leg pain on walking	0.2	0.2	0.5	0.4	-0.7	-0.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.4	-0.2	0.8	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.2	0.9	-0.4	0.3
Long-standing illness, disability or infirmity	0.2	0.4	0.8	0.9	-0.7	-0.5	0.5
Friendships satisfaction	0.2	0.3	0.6	-0.4	-0.8	0.6	-0.6
Miserableness	0.2	0.3	0.7	0.3	-0.8	-0.8	0.4
Financial situation satisfaction	0.2	0.2	0.7	0.5	-0.8	-0.4	0.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.5	0.6	0.4	-1.6	0.5
Depression (Nagel 2018)	0.1	0.1	0.3	-0.4	-0.5	0.2	0.1
Neuroticism (Nagel 2018)	0.1	0.3	1.1	1.1	-0.4	-0.1	0.1
Schizophrenia (2018)	0.1	0.3	1.0	-0.3	1.0	0.6	-0.1
Major Depression (MDD)	0.1	0.1	0.4	-0.6	-0.1	0.4	-0.4
Fasting Glucose	0.1	0.2	0.6	-0.2	0.1	0.7	-0.4
Blood Platelet Count	0.1	1.0	3.4	1.8	0.7	-0.8	0.8
Blood Red Count	0.1	0.9	3.0	-1.0	0.0	1.7	-0.6
Smoking Status	0.1	0.2	0.4	-0.4	-0.5	-0.1	-0.6
Lung FEV1/FVC ratio	0.1	0.4	1.2	0.8	-1.1	-0.5	0.4
Neuroticism	0.1	0.3	1.3	1.1	-0.3	-0.2	0.2
Chronotype (morning person)	0.1	0.3	1.2	1.1	-0.1	0.2	0.4
Average weekly spirits intake	0.1	0.1	0.2	-0.2	-0.5	-0.1	-0.3
Relative age of first facial hair	0.1	0.2	0.7	-0.1	0.3	0.4	-0.8
Average weekly fortified wine intake	0.1	0.1	0.4	-0.7	0.4	-0.2	0.1
Age when periods started (menarche)	0.1	0.1	0.5	0.1	-0.7	0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.7	-0.6	-0.1	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.5	0.3	-0.7	0.0	-0.1
High blood pressure	0.1	0.3	1.6	-0.1	-0.1	1.3	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.3	-0.5	-0.2	-0.3
Heart attack	0.1	0.2	0.5	0.7	-0.3	-0.3	0.3
Number of live births	0.1	0.1	0.3	-0.4	-0.3	0.2	-0.5
Impedance of arm (left)	0.1	0.4	1.5	0.6	1.2	0.3	0.3
Loud music exposure frequency	0.1	0.1	0.4	0.4	-0.2	0.3	-0.6
High blood pressure (siblings)	0.1	0.1	0.3	0.5	0.3	0.5	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.4	-0.4	0.2	-0.8
Medication: Blood pressure	0.1	0.2	0.5	0.7	-0.1	0.5	0.1
Medication: Omeprazole	0.1	0.1	0.3	-0.4	-0.2	0.6	-0.0
Number of full sisters	0.1	0.1	0.3	0.4	0.6	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.4	-0.0	-0.2
Hypertension (Self-reported)	0.1	0.2	0.9	0.1	0.0	0.9	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.3	0.1	0.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	-0.0	-0.6	0.5
Breast cancer (self-reported)	0.1	0.1	0.5	-0.7	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.1	-0.7	0.6	-0.5
Medication: Blood pressure	0.1	0.2	0.5	-0.1	0.7	0.3	0.5
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.5	-0.4	0.2	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.2	-0.4	0.5	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.5	0.0	-0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.1	-0.2	0.6	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.7	0.8	-0.2	-0.2	0.3
Hair Pigment	0.0	0.0	0.0	0.0	0.1	-0.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	0.2	0.2	0.2
Relative age voice broke	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.0	-0.4	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.2	0.1	-0.2	0.2
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	0.1	-0.3	0.1

Hub : Genes

TUBG1

Models

Trait associations