Best TWAS P=6.96e-13 · Best GWAS P=6.56e-26 conditioned to 6.28e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | -5.0 | -6.7 | 1.9e-11 | 0.77 | 0.06 | 0.67 | FALSE |
| 2 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | -5.1 | -7.2 | 7.0e-13 | 0.61 | 0.61 | 0.39 | TRUE |
| 3 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | -8.6 | -6.0 | 2.5e-09 | 0.56 | 0.99 | 0.01 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | 4.3 | 5.7 | 1.6e-08 | -0.04 | 0.45 | 0.06 | TRUE |