Best TWAS P=3.35e-09 · Best GWAS P=8.19e-08 conditioned to 0.599
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | TBC1D17 | 0.11 | 0.03 | enet | 23 | 0.04 | 6.5e-04 | -4.2 | 5.5 | 4.2e-08 | -0.79 | 0.10 | 0.87 | FALSE |
| 2 | GTEx | Colon Sigmoid | PRR12 | 0.20 | 0.01 | lasso | 8 | 0.00 | 4.9e-01 | 3.5 | 5.4 | 5.5e-08 | -0.28 | 0.04 | 0.25 | TRUE |
| 3 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | -4.7 | -5.8 | 6.3e-09 | 0.85 | 0.02 | 0.98 | TRUE |
| 4 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | -4.9 | -5.8 | 8.0e-09 | 0.84 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | RASIP1 | 0.15 | 0.04 | lasso | 6 | 0.08 | 2.9e-05 | -4.4 | -5.4 | 8.0e-08 | -0.02 | 0.22 | 0.56 | FALSE |
| 6 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | 3.5 | 5.6 | 2.6e-08 | -0.43 | 0.04 | 0.37 | FALSE |
| 7 | GTEx | Testis | NTN5 | 0.16 | 0.02 | enet | 23 | 0.06 | 9.6e-04 | -3.1 | -5.9 | 3.3e-09 | -0.01 | 0.04 | 0.61 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIN7B | 0.02 | 0.00 | enet | 7 | 0.02 | 5.1e-05 | 4.8 | -5.6 | 1.7e-08 | 0.05 | 0.01 | 0.90 | TRUE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | 4.6 | -5.8 | 6.7e-09 | 0.08 | 0.01 | 0.64 | FALSE |