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chr1:182,298,784-184,739,300

Best TWAS P=9.97e-15 · Best GWAS P=5.76e-17 conditioned to 0.00599

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TSEN15	0.23	0.18	lasso	9	0.18	4.7e-21	7.8	7.7	1.0e-14	0.90	0.03	0.97	TRUE
2	GTEx	Adipose Visceral Omentum	RP11-181K3.4	0.13	0.06	lasso	3	0.14	8.3e-08	5.1	5.7	1.1e-08	0.04	0.04	0.95	TRUE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GLT25D2	0.05	0.01	enet	10	0.04	6.3e-05	4.2	-7.5	5.4e-14	-0.69	0.01	0.94	FALSE
6	GTEx	Brain Cerebellar Hemisphere	TSEN15	0.38	0.08	lasso	13	0.16	5.3e-05	7.9	7.3	1.9e-13	0.83	0.01	0.96	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSEN15	0.11	0.08	blup	52	0.10	6.7e-12	7.9	6.9	4.5e-12	0.78	0.03	0.97	FALSE
14	METSIM	Adipose	TSEN15	0.06	0.02	enet	28	0.04	1.3e-06	7.8	6.8	1.2e-11	0.76	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GLT25D2	0.11	0.02	blup	119	0.05	5.1e-06	-1.9	-5.8	7.1e-09	-0.50	0.14	0.31	FALSE
9	GTEx	Esophagus Muscularis	RP11-181K3.4	0.05	0.09	lasso	1	0.07	3.9e-05	5.4	5.4	8.4e-08	0.03	0.04	0.95	FALSE
11	GTEx	Nerve Tibial	LAMC1	0.07	0.08	enet	30	0.05	1.1e-04	5.4	5.3	1.2e-07	0.07	0.03	0.96	FALSE
12	GTEx	Nerve Tibial	RP11-181K3.4	0.18	0.24	enet	30	0.24	2.9e-17	5.3	5.2	1.6e-07	0.03	0.03	0.97	FALSE
5	GTEx	Brain Cerebellar Hemisphere	LAMC1	0.50	0.16	enet	13	0.13	3.8e-04	5.4	5.2	1.8e-07	0.04	0.05	0.94	FALSE
3	GTEx	Artery Tibial	LAMC1	0.10	0.10	lasso	5	0.10	2.2e-08	5.0	-5.2	1.9e-07	-0.03	0.06	0.94	FALSE
4	GTEx	Artery Tibial	RP11-181K3.4	0.07	0.07	lasso	15	0.05	1.1e-04	5.1	5.2	1.9e-07	0.06	0.07	0.92	FALSE
7	GTEx	Brain Cerebellum	LAMC1	0.27	0.36	enet	29	0.29	3.5e-09	5.4	5.2	2.5e-07	0.00	0.04	0.96	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LAMC1	0.04	0.03	blup	108	0.04	1.2e-05	5.3	-5.2	2.6e-07	-0.04	0.04	0.95	FALSE
10	GTEx	Lung	LAMC1	0.18	0.20	enet	33	0.19	2.3e-14	5.4	-5.1	2.7e-07	-0.04	0.04	0.96	FALSE
13	GTEx	Thyroid	RP11-181K3.4	0.12	0.07	lasso	4	0.05	5.7e-05	5.0	5.1	3.0e-07	0.05	0.07	0.93	FALSE
8	GTEx	Colon Transverse	TSEN15	0.17	0.05	enet	18	0.06	7.2e-04	4.8	5.1	3.1e-07	0.63	0.27	0.50	FALSE