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chr1:22,197,336-24,216,118

Best TWAS P=4.44e-13 · Best GWAS P=2.62e-12 conditioned to 0.0487

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HTR1D	0.24	0.12	lasso	4	0.12	1.2e-05	-6.8	7.2	4.4e-13	-0.76	0.01	0.98	TRUE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	WNT4	0.03	0.01	blup	72	0.02	3.8e-05	4.1	5.8	8.0e-09	-0.04	0.26	0.48	TRUE
2	GTEx	Brain Cortex	LUZP1	0.23	0.14	lasso	5	0.10	7.8e-04	-6.9	6.9	4.1e-12	-1.00	0.02	0.78	FALSE
4	GTEx	Cells Transformed fibroblasts	LUZP1	0.09	0.09	lasso	4	0.08	2.8e-06	-6.9	6.9	4.5e-12	-1.00	0.01	0.99	FALSE
7	GTEx	Testis	LUZP1	0.17	0.09	lasso	4	0.08	2.6e-04	-6.7	-6.5	5.8e-11	0.55	0.02	0.91	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	HTR1D	0.10	0.07	enet	7	0.08	3.8e-05	-5.6	6.4	1.6e-10	-0.94	0.02	0.98	FALSE
11	The Cancer Genome Atlas	Rectum Adenocarcinoma	HTR1D	0.19	0.12	enet	11	0.13	7.3e-04	-7.0	6.4	1.9e-10	-0.94	0.01	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HTR1D	0.11	0.07	enet	21	0.09	1.1e-10	-4.8	5.8	6.1e-09	-0.78	0.53	0.47	FALSE
3	GTEx	Brain Frontal Cortex BA9	RP1-184J9.2	0.38	0.00	lasso	11	0.00	4.3e-01	-6.7	5.4	8.5e-08	-0.54	0.04	0.38	FALSE
5	GTEx	Muscle Skeletal	LUZP1	0.07	0.08	enet	14	0.08	3.5e-08	2.9	5.2	1.7e-07	-0.62	0.09	0.91	FALSE
6	GTEx	Skin Sun Exposed Lower leg	KDM1A	0.09	0.01	lasso	5	0.01	1.1e-01	-6.7	-5.2	2.5e-07	0.39	0.03	0.81	FALSE