TWAS hub - WNT4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0290	0.0119	2.3e-04	0.013	0.020	0.016	NA	0.014	7.7e-04	3.8e-05	2.3e-04	NA	5.5e-04
2	TCGA	Prostate Adenocarcinoma	0.0521	0.0244	3.0e-03	0.014	0.014	0.012	NA	0.005	1.1e-02	1.1e-02	1.8e-02	NA	8.5e-02
3	TCGA	Thyroid Carcinoma	0.1410	0.0380	5.4e-11	0.057	0.120	0.117	NA	0.097	2.9e-06	9.7e-12	1.7e-11	NA	1.1e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	36.5	290.5	470.9	-21.7	14.5	13.8
Heel bone mineral density (BMD) T-score, automated (right)	17.2	39.4	68.4	-8.3	5.3	4.6
Heel bone mineral density (BMD) T-score, automated (left)	16.9	38.3	72.8	-8.5	4.7	4.5
Sitting height	16.4	116.4	237.2	15.4	-7.1	-7.9
Bilateral oophorectomy (both ovaries removed)	13.7	15.8	29.1	5.4	-2.9	-3.2
Number of live births	10.0	14.1	26.3	-5.1	2.2	3.3
Waist Hip Ratio (WHR)	8.7	39.1	58.8	-7.7	5.0	5.8
Forced vital capacity (FVC), Best measure	8.3	30.5	63.0	7.9	-2.1	-4.9
Forced vital capacity (FVC)	7.3	28.1	57.3	7.6	-2.4	-4.6
Birth weight of first child	7.0	12.8	21.4	4.6	-2.6	-3.2
Number of full sisters	6.1	7.5	12.7	-3.6	2.3	2.1
Ovarian Cancer	5.9	7.9	13.1	-3.6	2.9	1.5
Birth weight	5.9	12.8	19.2	4.4	-2.8	-3.4
Osteoporosis (self-reported)	5.9	7.3	9.3	3.0	-2.9	-2.1
Impedance of leg (right)	5.7	27.8	48.0	-6.9	3.5	4.8
Impedance of leg (left)	5.3	25.7	47.1	-6.9	3.2	4.4
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.9	39.4	6.3	-1.4	-3.0
Smoking status: Previous	5.3	7.9	12.5	3.5	-1.1	-3.1
Leg predicted mass (right)	5.0	26.5	56.6	7.5	-2.4	-4.2
Lung FVC	4.9	25.1	50.0	7.1	-2.2	-4.5
Leg fat-free mass (right)	4.9	26.3	55.7	7.5	-2.4	-4.2
Past tobacco smoking	4.8	8.9	15.2	-3.9	1.0	3.2
Hip circumference	4.4	18.9	37.5	6.1	-2.6	-3.6
Unable to work because of sickness or disability	4.4	5.8	8.8	-2.2	1.9	3.0
Leg fat-free mass (left)	4.3	22.8	50.7	7.1	-2.0	-3.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.3	9.1	19.5	4.4	-1.7	-2.2
Forced expiratory volume in 1-second (FEV1)	4.2	14.3	32.3	5.7	-1.7	-2.8
Suffer from ‘nerves’	4.2	6.5	7.5	-2.4	2.7	2.5
Fractured/broken bones in last 5 years	4.2	5.4	8.6	2.9	-1.7	-2.2
Leg predicted mass (left)	4.1	21.5	48.2	6.9	-1.9	-3.6
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	9.7	-2.1	1.3	3.1
Age at first live birth	3.7	6.6	12.8	3.6	-1.4	-2.3
Medication: Paracetamol	3.5	5.7	7.0	-2.4	2.6	2.1
Medication: Gliclazide	3.5	3.9	6.7	-1.4	1.8	2.6
Mouth/teeth dental problems: Loose teeth	3.4	4.0	6.8	1.9	-2.6	-1.3
Eye problems/disorders: Glaucoma	3.4	4.0	8.4	2.9	-1.9	0.1
Medication for pain relief, constipation, heartburn	3.3	5.7	8.4	2.7	-1.1	-2.9
Pain experienced in last month	3.2	5.4	10.1	3.2	-1.2	-2.1
Type 2 Diabetes (T2D) (2012)	3.1	3.5	7.5	-1.3	1.2	2.7
Ever had hysterectomy (womb removed)	3.1	3.5	5.5	2.3	-2.1	-0.8
Medication: Ibuprofen	3.0	3.5	6.2	-1.8	1.1	2.5
Heart disease (mother)	3.0	3.6	6.2	1.7	-2.5	-1.3
Age at last live birth	2.8	4.1	7.4	2.7	-1.2	-1.9
Back pain experienced in last month	2.8	4.1	7.4	-2.7	0.8	2.0
Whole body water mass	2.8	16.2	37.6	6.1	-0.8	-3.2
Glaucoma (self-reported)	2.7	3.2	6.4	2.5	-1.7	-0.5
Whole body fat-free mass	2.7	15.2	35.5	6.0	-0.8	-3.1
Basal cell carcinoma (self-reported)	2.7	3.3	8.6	-0.3	1.0	2.9
Ever smoked	2.6	4.5	7.9	2.8	0.1	-2.4
Basal metabolic rate	2.6	14.2	33.3	5.8	-0.8	-3.0
Alzheimer’s Disease (including proxy)	2.5	3.6	6.6	-1.9	2.6	0.8
Comparative height size at age 10	2.5	13.8	25.3	5.0	-1.2	-3.8
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	3.6	-1.0	1.9	1.8
Age at First Birth	2.3	3.3	9.3	3.0	-0.4	-0.7
Medication: Amlodipine	2.3	3.3	7.1	2.7	-1.5	-0.6
Medication: Paracetamol	2.3	3.5	4.5	-2.1	1.9	1.5
Schizophrenia (2014)	2.2	4.9	8.8	1.3	-3.0	-2.1
Smoking Status	2.2	5.3	8.6	2.3	-1.4	-2.9
Ever used hormone-replacement therapy (HRT)	2.2	2.8	5.6	1.1	-2.4	-1.2
Hand grip strength (right)	2.1	5.7	11.2	2.4	0.6	-3.4
Illnesses of father: Heart disease	2.1	2.9	4.4	-1.6	1.3	2.1
Osteoarthritis (self-reported)	2.1	2.7	4.3	-1.8	0.8	2.1
Alzheimer’s Disease (in mother)	2.0	2.4	5.5	-1.3	2.3	0.1
Nervous feelings	2.0	3.7	4.8	-2.2	1.2	2.2
Trunk fat-free mass	2.0	11.5	28.0	5.3	0.0	-2.6
Trunk predicted mass	2.0	11.4	27.9	5.3	-0.0	-2.5
Shortness of breath walking on level ground	2.0	2.4	4.6	1.4	-0.7	-2.1
Bipolar Disorder or Schizophrenia	1.9	4.6	7.4	2.0	-2.7	-1.6
Pack years adult smoking proportion	1.9	2.9	4.3	-2.1	1.2	1.7
Supplements: Vitamin C	1.8	2.1	2.9	1.4	-1.2	-1.7
Illnesses of father: None of the above (group 1)	1.8	2.3	3.9	1.5	-0.8	-2.0
Pack years of smoking	1.8	2.7	4.1	-2.0	1.0	1.7
Schizophrenia (2018)	1.7	3.6	6.3	1.1	-2.5	-1.8
Lung FEV1/FVC ratio	1.7	8.5	18.4	-1.9	1.9	4.3
Standing height	1.7	17.1	39.6	6.3	-0.6	-3.4
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.1	2.0	-1.0	-0.9
Number of full brothers	1.7	2.2	3.6	-1.9	1.4	0.9
Weight	1.6	7.9	19.6	4.4	-0.5	-2.0
Length of working week for main job	1.6	1.8	2.2	-1.2	1.5	1.4
Leg pain on walking	1.6	2.1	5.0	-0.7	0.9	2.2
Worry (Nagel 2018)	1.5	3.1	3.8	-1.8	2.0	1.5
Depression (self-reported)	1.5	1.8	3.1	-1.8	0.8	1.2
Arm predicted mass (right)	1.5	7.7	19.1	4.4	0.1	-2.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.7	-2.2	-0.3	0.8
Height	1.4	27.0	66.7	8.2	0.4	-3.8
Age when periods started (menarche)	1.4	3.5	5.1	2.2	-0.6	-2.3
Medication: Allopurinol	1.4	1.8	3.2	-1.8	1.4	0.3
Heart disease (siblings)	1.4	1.7	2.2	1.5	-1.0	-1.4
Major Depression (MDD)	1.3	1.6	3.4	1.0	-1.8	-0.6
HbA1C	1.3	1.5	1.8	-1.4	-1.0	1.3
Hand grip strength (left)	1.3	3.5	7.7	1.5	0.8	-2.8
Medication for hormone replacement therapy	1.3	1.4	2.1	1.4	-0.6	-1.5
Supplements: Glucosamine	1.3	1.7	3.1	-1.8	0.2	1.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.5	-1.4	0.3	1.6
Pulse rate	1.3	2.1	2.7	-1.2	1.6	1.5
Lung cancer (father)	1.3	1.5	4.2	2.0	-0.4	-0.4
Illnesses of mother	1.3	1.6	3.3	-1.8	1.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.8	0.9	-0.9	-1.7
Arm fat-free mass (left)	1.3	6.7	16.9	4.1	0.2	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.1	-0.8	0.5	2.0
Breast Cancer	1.2	2.9	5.9	2.4	-1.2	-1.2
Diabetes (mother)	1.2	1.5	2.7	-1.4	0.2	1.6
Arm fat mass (right)	1.2	5.0	11.5	3.4	-0.7	-1.8
Hair/balding pattern: Pattern 4	1.2	2.8	7.4	-0.1	1.0	2.7
Arm fat-free mass (right)	1.2	6.2	15.7	4.0	0.2	-1.7
Neck or shoulder pain in last month	1.2	1.7	3.8	-1.2	0.0	1.9
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.3	-1.8	-0.0	0.9
Arm fat mass (left)	1.2	4.8	11.1	3.3	-0.7	-1.7
Impedance of whole body	1.2	6.3	13.2	-3.6	1.1	2.1
Arm predicted mass (left)	1.2	6.3	15.9	4.0	0.5	-1.7
Supplements: Zinc	1.1	1.2	1.8	0.8	-1.4	-1.0
Trunk fat mass	1.1	4.8	10.6	3.3	-0.8	-1.8
Number of incorrect matches in round	1.1	1.8	2.4	-1.2	1.3	1.5
Number of children fathered	1.1	1.3	3.2	0.2	-0.7	-1.8
Migraine (self-reported)	1.1	1.4	1.7	-1.3	0.9	1.3
Pulse rate, automated reading	1.1	3.7	4.8	-2.1	2.2	1.4
Loneliness, isolation	1.1	1.5	1.7	-1.3	1.3	1.1
Ever taken oral contraceptive pill	1.1	1.2	2.3	-1.2	1.5	0.1
Bipolar Disorder (2018)	1.0	1.7	3.4	1.8	-1.2	-0.3
Serious illness, injury or assault to yourself	1.0	1.2	2.2	-0.6	-1.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.2	2.3	0.5	0.9
Commuting to job workplace: Walk	1.0	1.0	2.4	0.1	0.9	1.5
Guilty feelings	1.0	1.4	2.2	-1.5	0.8	1.2
Wears glasses or contact lenses	1.0	1.2	2.5	-1.6	0.9	0.6
Rheumatoid Arthritis	0.9	1.2	2.2	0.6	-1.1	-1.5
Overall health rating	0.9	2.0	3.6	-0.9	1.3	1.9
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	0.8	0.8	1.4
Mineral and other dietary supplements	0.9	1.3	2.8	1.7	0.3	-1.0
Smoking status: Current	0.9	1.4	3.9	0.3	-0.4	-2.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.3	-1.1	-0.8	1.1
Schizophrenia vs Biploar Disorder	0.8	1.0	2.6	-0.2	-1.6	-0.6
Fasting Glucose	0.8	1.0	1.7	1.3	-1.0	0.5
Had menopause	0.8	1.0	2.8	-0.1	-1.7	0.4
Fluid intelligence score	0.8	1.7	4.2	2.1	-0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.1	1.4	-0.4	-1.0
Blood clot in the leg (DVT)	0.8	1.1	3.1	-0.4	0.3	1.8
Leg fat percentage (right)	0.8	2.9	3.7	-1.9	1.7	1.5
Whole body fat mass	0.8	3.5	8.2	2.9	-0.6	-1.4
Friendships satisfaction	0.8	1.0	1.5	1.2	-0.9	-0.8
Number of operations (self-reported)	0.8	1.1	1.6	1.3	-1.0	-0.9
Alcohol drinker status: Previous	0.8	0.9	2.0	1.4	-0.8	0.2
Cardiovascular Disease	0.7	2.2	6.0	-0.6	0.4	2.4
Number of treatments/medications taken	0.7	1.2	2.2	-1.5	0.6	1.1
Chronic bronchitis/emphysema (father)	0.7	0.9	1.0	-1.0	1.0	0.8
Loud music exposure frequency	0.7	0.7	1.6	1.3	-0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	-0.6	-0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.8	0.7	0.5	-1.3
Arm fat percentage (left)	0.7	2.9	6.2	2.5	-0.9	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.8	-1.2	0.3	1.4
Medication: Blood pressure	0.7	1.3	2.4	1.2	-1.5	-0.5
High cholesterol (Self-reported)	0.7	1.2	2.3	-0.8	0.8	1.5
Alcohol drinker status: Never	0.7	0.8	1.8	-0.8	-0.2	1.3
Supplements: Calcium	0.7	0.7	1.7	0.7	-1.3	-0.2
Coronary Artery Disease (CAD)	0.6	0.8	1.1	0.7	-0.8	-1.1
LDL Cholesterol	0.6	1.0	1.9	-0.9	-0.4	1.4
Hypothyroidism (self reported)	0.6	1.3	3.6	-0.4	-0.1	-1.9
Average weekly spirits intake	0.6	0.8	2.0	-1.4	0.3	-0.4
Sensitivity / hurt feelings	0.6	1.0	1.7	0.2	-1.1	-1.3
Current tobacco smoking	0.6	0.9	2.7	-0.1	-0.4	-1.6
Maternal smoking around birth	0.6	0.9	1.3	1.1	-1.1	-0.6
Fed-up feelings	0.6	1.1	1.8	-1.3	0.8	0.9
Qualifications: None of the above	0.6	1.2	2.1	-1.2	0.2	1.5
Neuroticism score	0.6	1.2	2.0	-1.4	1.1	0.4
Arm fat percentage (right)	0.6	2.5	5.2	2.3	-0.7	-1.3
Pulse wave reflection index	0.6	0.8	1.5	0.4	-1.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.4	-1.0	1.2	-1.0
Medication: Omeprazole	0.6	0.7	1.8	-1.3	-0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	-1.4	0.3	0.3
Number of self-reported non-cancer illnesses	0.6	1.1	1.4	-1.2	0.8	1.1
Leg fat percentage (left)	0.6	2.2	3.2	-1.8	1.4	1.3
Myopia	0.6	0.9	1.7	-1.3	0.5	0.9
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.6	0.9	1.9	0.5
Alzheimer’s Disease (in father)	0.5	0.6	1.0	-0.7	1.0	0.5
Mean Putamen Volume	0.5	0.6	0.8	0.4	0.8	0.9
Systolic blood pressure, automated reading	0.5	1.4	2.8	1.7	-0.9	0.8
Medication: Co-codamol	0.5	0.6	0.8	-0.9	0.5	0.8
Severe depression (siblings)	0.5	0.5	1.6	0.0	0.2	1.2
Trunk fat percentage	0.5	2.0	3.9	2.0	-0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.6	0.7	-0.8	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	2.0	-1.4	-0.2	0.1
Medication: Atenolol	0.5	0.6	1.5	0.4	-1.2	-0.4
High blood pressure (mother)	0.5	0.6	1.8	0.3	-0.1	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-1.1	-0.7	0.4
Happiness	0.5	0.6	1.5	1.2	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.7	-1.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	1.4	0.4	-0.6
Exposure to tobacco smoke outside home	0.5	0.7	1.6	1.3	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	-1.3	0.4	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	-0.1	1.2	0.4
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.1	0.6	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.2	1.1	0.0	0.7
Medication: Lisinopril	0.5	0.7	1.3	1.1	-0.3	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.5	-0.0	-0.2	-1.2
Age started oral contraceptive pill	0.5	0.6	1.3	-0.6	-0.3	1.1
Ever depressed for a whole week	0.5	0.6	1.7	-0.1	-1.3	0.3
Lupus	0.4	0.5	0.9	0.8	1.0	-0.1
Primary Biliary Cirrhosis	0.4	0.5	1.5	-0.1	-1.2	0.1
Neuroticism	0.4	0.9	1.5	-1.2	0.9	0.6
Relative age of first facial hair	0.4	0.8	1.4	-1.1	1.2	-0.1
Multivitamins +/- minerals	0.4	0.5	0.7	-0.8	0.5	0.8
Medication: Levothyroxine sodium	0.4	0.8	2.1	-0.1	0.4	-1.5
Alcohol usually taken with meals	0.4	0.6	1.4	0.6	0.3	-1.2
Had other major operations	0.4	0.5	0.7	0.8	0.3	-0.8
Medication: Ramipril	0.4	0.6	1.2	-0.6	0.3	1.1
Alcohol intake versus 10 years previously	0.4	0.7	1.0	0.6	-0.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.2	-0.5	0.8	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	0.3	-1.0	-1.0
Worry too long after embarrassment	0.4	0.6	1.1	-1.0	0.5	-0.6
Wheeze or whistling in the chest in last year	0.4	0.6	1.3	0.4	-1.2	-0.6
Eye problems/disorders: None of the above	0.4	0.5	1.1	-0.6	-0.0	-1.0
Family relationship satisfaction	0.4	0.4	0.9	1.0	0.2	0.6
Mother’s age at death	0.4	0.5	1.0	1.0	-0.8	-0.0
Financial situation satisfaction	0.4	0.5	1.0	1.0	-0.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.9	-1.0	-0.6	0.6
Risk taking	0.4	0.6	1.0	-0.0	-0.8	-1.0
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.2	-0.2	1.3
Bipolar Disorder (2011)	0.3	0.3	0.6	0.3	-0.8	0.4
Ulcerative Colitis	0.3	0.4	0.6	0.7	-0.5	0.7
BMI	0.3	1.9	4.0	2.0	-0.6	-1.1
Systolic Blood Pressure	0.3	1.7	2.3	1.5	-0.8	1.4
Chronotype (morning person)	0.3	0.6	0.9	-0.5	-0.9	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.3	1.0	-0.4
Diabetes (father)	0.3	0.4	0.9	0.5	0.3	0.9
Body mass index (BMI)	0.3	1.1	2.9	1.7	-0.2	-0.6
Allergy	0.3	0.7	2.0	0.0	1.4	0.3
Medication: Simvastatin	0.3	0.4	0.9	-0.1	0.9	0.6
Father’s age at death	0.3	0.4	0.8	-0.5	-0.2	0.9
Falls in the last year	0.3	0.4	0.9	-0.6	-0.1	0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	0.4	-1.1	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	1.1	0.7	0.3
Asthma	0.3	0.5	0.9	0.1	-1.0	-0.8
Exposure to tobacco smoke at home	0.3	0.4	0.9	0.1	1.0	-0.4
Knee pain experienced in last month	0.3	0.5	0.8	-0.0	-0.8	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.5	-0.0	0.9
Ever had bowel cancer screening	0.3	0.3	0.8	-0.9	0.4	0.3
Breast cancer (self-reported)	0.3	0.4	0.8	-0.0	-0.6	-0.9
Asthma (self-reported)	0.3	0.6	1.0	0.2	-1.0	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.3	1.1	-0.3
Medication: Atorvastatin	0.3	0.4	1.1	0.0	0.4	1.0
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-1.0	0.7	0.3
Crohns Disease (2017)	0.2	0.4	0.6	-0.3	-0.8	0.7
Irritable Bowel Disease (IBD)	0.2	0.6	1.2	-0.4	-0.6	1.1
Reaction Time	0.2	0.5	1.1	1.1	-0.1	-0.5
Prostate Cancer	0.2	0.3	0.4	-0.4	0.6	-0.4
Neuroticism (2016)	0.2	0.3	0.7	-0.5	0.9	-0.1
Blood Eosinophil Count	0.2	1.2	3.3	-0.3	0.3	-1.8
Respiratory disease	0.2	0.5	0.9	-0.6	-1.0	-0.4
Hair Pigment	0.2	6.0	8.0	-2.3	2.8	2.1
Tanning	0.2	2.0	3.1	1.4	-1.8	-0.9
Hearing difficulty/problems: Yes	0.2	0.4	1.0	0.1	0.2	-1.0
Angina	0.2	0.3	0.4	0.4	-0.4	-0.7
Vitamin and mineral supplements	0.2	0.2	0.4	-0.5	0.6	-0.3
Medication: Metformin	0.2	0.3	0.6	0.4	0.2	-0.8
Average weekly fortified wine intake	0.2	0.2	0.3	0.3	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.3	0.8	0.0
Taking other prescription medications	0.2	0.3	0.9	-0.1	-0.9	-0.4
High blood pressure	0.2	0.5	1.1	0.5	0.1	1.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	0.5	-1.0	-0.6
Waist circumference	0.2	0.6	1.6	1.3	0.2	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.1	0.3	0.9
Financial difficulties in last 2 years	0.2	0.2	0.6	0.8	-0.1	-0.1
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	0.4	0.3
Heart attack	0.2	0.2	0.7	0.8	0.0	0.0
Illnesses of siblings	0.2	0.3	0.7	-0.0	-0.9	0.2
Medication: Cholesterol lowering	0.2	0.4	0.9	-0.1	0.9	0.4
Medication: Lansoprazole	0.2	0.2	0.4	-0.4	-0.6	0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.7	-0.0	0.3
Peak expiratory flow (PEF)	0.2	0.5	1.4	1.2	-0.3	-0.2
Headache pain in last month	0.2	0.3	0.5	-0.6	-0.7	0.2
High blood pressure (siblings)	0.2	0.2	0.4	0.4	0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.2	0.5	0.7
Health satisfaction	0.2	0.3	0.7	0.8	-0.1	0.4
Had major operations	0.2	0.2	0.3	-0.5	0.6	0.0
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.7	0.4	-0.0
Average weekly red wine intake	0.2	0.2	0.5	0.7	0.4	0.1
Mood swings	0.2	0.4	0.7	0.8	-0.7	-0.2
Long-standing illness, disability or infirmity	0.2	0.4	1.0	-0.3	0.1	1.0
Hearing aid user	0.2	0.2	0.3	-0.5	0.5	0.4
Medication: Bendroflumethiazide	0.2	0.3	0.4	-0.6	0.5	0.6
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.8	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.8	-0.0	-0.2
Depression (Nagel 2018)	0.1	0.2	0.4	0.2	0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.9	0.2	-0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.1	-0.7	0.2
Crohns Disease (2012)	0.1	0.2	0.4	0.2	-0.7	0.4
HDL Cholesterol	0.1	0.2	0.4	0.6	-0.0	0.6
Blood Platelet Count	0.1	0.7	0.9	0.8	-1.0	0.8
Blood Red Count	0.1	0.9	1.9	1.4	-0.4	0.7
Blood White Count	0.1	0.4	0.7	0.2	0.7	0.9
Allergy or Eczema	0.1	0.3	0.7	0.8	-0.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.5	0.6	-0.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	0.3	-0.1	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.5	-0.1	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.2	0.4	0.5
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.3	0.3
Diabetes (self-reported)	0.1	0.2	0.4	0.6	0.2	-0.2
Impedance of arm (right)	0.1	0.3	0.9	0.0	-0.9	-0.4
Worrier / anxious feelings	0.1	0.2	0.5	-0.4	0.3	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.6	-0.5	0.2
Prospective memory result	0.1	0.2	0.4	-0.6	0.4	0.0
Impedance of arm (left)	0.1	0.4	1.1	0.0	-1.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.0	0.1	0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.2	-0.4	0.3
Gout (self-reported)	0.1	0.1	0.3	-0.6	-0.2	-0.2
Body fat percentage	0.1	0.5	1.3	1.1	-0.4	-0.5
Comparative body size at age 10	0.1	0.2	0.4	0.6	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	0.2	0.1
Pulse wave peak to peak time	0.1	0.1	0.2	-0.3	0.1	-0.4
Qualifications: College or University degree	0.1	0.4	1.0	-0.1	1.0	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.4	-0.1	0.1	-0.6
Medication: Blood pressure	0.1	0.2	0.2	0.4	0.4	0.4
Angina (self-reported)	0.1	0.1	0.2	-0.0	-0.3	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.5	-0.3	-0.0
Mean time to correctly identify matches	0.1	0.2	0.4	0.6	-0.2	-0.3
Leg fat mass (right)	0.1	0.5	1.3	1.1	0.5	-0.3
Alcohol intake frequency.	0.1	0.3	0.8	-0.4	0.2	0.9
Chest pain or discomfort	0.1	0.1	0.3	-0.1	-0.2	0.5
Hypertension (Self-reported)	0.1	0.4	0.9	0.4	-0.2	1.0
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.5	-0.1	0.6
Miserableness	0.1	0.1	0.4	-0.0	0.2	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	0.1	-0.3
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.4	0.1	0.5
Irritability	0.1	0.2	0.6	0.7	0.1	-0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.6	-0.4	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.4	-0.2	-0.9
Cholesterol lowering medication	0.1	0.1	0.3	-0.1	0.5	0.3
Leg fat mass (left)	0.1	0.5	1.3	1.2	0.4	-0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.2	-0.0	-0.3
Triglycerides	0.0	0.0	0.1	-0.3	-0.2	0.1
Relative age voice broke	0.0	0.0	0.1	-0.2	0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	0.1	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.3	0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	0.2	-0.3	-0.1
Time employed in main current job	0.0	0.0	0.1	-0.0	0.2	-0.3
Noisy workplace	0.0	0.1	0.1	-0.1	-0.2	0.3
Breastfed as a baby	0.0	0.0	0.0	-0.0	-0.1	0.0
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	0.1	0.3
Medication: Aspirin	0.0	0.0	0.0	-0.2	-0.1	0.2
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.4	0.1	0.1
Medication for cholesterol	0.0	0.0	0.1	0.1	0.2	-0.1
Medication: Aspirin	0.0	0.1	0.1	-0.2	0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.1	-0.0	0.3

Hub : Genes

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