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chr1:25,488,741-27,488,299

Best TWAS P=1.83e-12 · Best GWAS P=2.99e-12 conditioned to 0.223

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	6.8	7.0	1.8e-12	0.95	0.00	1.00	TRUE
6	GTEx	Thyroid	DHDDS	0.14	0.08	enet	22	0.07	5.8e-06	5.7	-5.5	4.2e-08	-0.12	0.65	0.06	TRUE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	7.0	7.0	3.1e-12	1.00	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDIK1L	0.03	0.01	blup	37	0.02	2.6e-03	5.8	-6.9	4.7e-12	-0.86	0.01	0.57	FALSE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	6.9	6.9	7.1e-12	0.98	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	6.8	6.8	7.6e-12	0.98	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDIK1L	0.02	0.02	blup	37	0.02	2.8e-03	6.9	-6.8	9.7e-12	-0.95	0.01	0.84	FALSE
2	GTEx	Esophagus Mucosa	PDIK1L	0.10	0.09	lasso	6	0.09	8.8e-07	6.8	-6.7	2.9e-11	-0.97	0.02	0.98	FALSE
8	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM63	0.03	0.02	blup	33	0.02	4.6e-03	7.0	6.7	2.9e-11	0.93	0.01	0.89	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	6.7	6.6	3.3e-11	0.97	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	6.8	6.5	9.7e-11	0.97	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	6.7	6.5	1.1e-10	0.97	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	6.7	6.3	2.2e-10	0.97	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	6.8	6.2	7.9e-10	0.97	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	6.8	6.0	1.5e-09	0.91	0.01	0.99	FALSE
7	GTEx	Thyroid	CNKSR1	0.10	0.04	lasso	7	0.03	2.1e-03	5.6	-6.0	1.9e-09	-0.71	0.10	0.88	FALSE
3	GTEx	Pancreas	CNKSR1	0.20	0.03	enet	20	0.04	7.3e-03	5.0	-5.7	9.9e-09	-0.56	0.08	0.43	FALSE
1	GTEx	Cells Transformed fibroblasts	RP1-125I3.2	0.06	0.04	enet	19	0.03	3.3e-03	5.2	-5.7	1.2e-08	-0.48	0.09	0.39	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH3BGRL3	0.05	0.03	lasso	2	0.03	9.3e-04	5.2	5.7	1.6e-08	0.53	0.00	0.93	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDIK1L	0.02	0.00	blup	37	0.02	1.2e-03	3.0	-5.6	2.1e-08	-0.90	0.02	0.74	FALSE
23	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM63	0.28	0.22	lasso	3	0.20	1.7e-05	4.5	5.6	2.6e-08	0.74	0.02	0.89	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC30A2	0.03	0.02	lasso	3	0.01	1.1e-02	4.5	-5.5	2.9e-08	-0.76	0.02	0.90	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRRP1	0.11	0.02	blup	52	0.03	8.8e-05	-2.9	5.3	1.0e-07	0.50	0.02	0.28	FALSE
4	GTEx	Pituitary	CNKSR1	0.38	0.16	lasso	7	0.15	1.4e-04	4.3	-5.3	1.4e-07	-0.71	0.07	0.80	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	CNKSR1	0.15	0.10	lasso	7	0.09	1.0e-05	4.3	-5.3	1.4e-07	-0.72	0.17	0.81	FALSE