Best TWAS P=3.63e-16 · Best GWAS P=7.42e-30 conditioned to 6.34e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | BCS1L | 0.06 | 0.01 | enet | 9 | 0.04 | 2.3e-04 | -3.0 | 5.6 | 2.7e-08 | -0.04 | 0.07 | 0.24 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PNKD | 0.11 | 0.00 | enet | 31 | 0.00 | 2.3e-01 | -5.7 | 6.1 | 9.4e-10 | 0.06 | 0.01 | 0.92 | TRUE |
| 3 | GTEx | Pancreas | PNKD | 0.12 | 0.10 | lasso | 3 | 0.08 | 3.6e-04 | -5.7 | 5.3 | 1.4e-07 | 0.05 | 0.00 | 0.97 | FALSE |
| 4 | GTEx | Pituitary | PNKD | 0.29 | 0.23 | enet | 21 | 0.24 | 8.9e-07 | -5.7 | 5.6 | 2.2e-08 | 0.09 | 0.01 | 0.98 | FALSE |
| 5 | METSIM | Adipose | PNKD | 0.07 | 0.08 | lasso | 7 | 0.08 | 4.8e-12 | -5.7 | 5.6 | 2.6e-08 | 0.07 | 0.00 | 1.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | DIRC3 | 0.12 | 0.07 | bslmm | 697 | 0.08 | 2.7e-10 | -6.6 | 7.2 | 5.2e-13 | 0.00 | 1.00 | 0.00 | TRUE |
| 7 | YFS | Blood | PNKD | 0.08 | 0.07 | lasso | 6 | 0.09 | 2.9e-27 | -3.9 | 5.2 | 2.5e-07 | 0.05 | 0.04 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DIRC3 | 0.12 | 0.01 | blup | 275 | 0.02 | 3.3e-03 | -1.4 | 6.5 | 1.1e-10 | -0.51 | 0.05 | 0.52 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | DIRC3 | 0.08 | 0.06 | lasso | 5 | 0.07 | 2.7e-07 | -8.8 | 8.2 | 3.6e-16 | -0.56 | 0.98 | 0.01 | TRUE |