TWAS
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Models
Genes
Traits
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Traits
:
Basal metabolic rate
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chr2:207,696,167-209,182,548
Best TWAS P=6.77e-10 · Best GWAS P=2.46e-09 conditioned to 0.000866
207.8M
208M
208.2M
208.4M
208.6M
208.8M
209M
209.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells Transformed fibroblasts
CREB1
0.15
0.00
enet
7
0.00
2.8e-01
-4.6
-6.2
6.8e-10
-0.50
0.13
0.44
TRUE
1
GTEx
Adipose Subcutaneous
METTL21A
0.10
0.02
lasso
4
0.02
1.6e-02
-4.6
5.5
4.8e-08
0.32
0.21
0.12
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
FAM119A
0.04
0.02
blup
51
0.03
1.0e-06
-4.5
5.2
1.9e-07
0.64
0.03
0.95
FALSE