Hub : Genes

BCS1L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0560 0.0320 9.1e-03 0.010 NA 0.042 NA 0.018 0.04300 NA 2.3e-04 NA 1.2e-02
2 GTEx Breast Mammary Tissue 0.0530 0.0260 5.0e-03 0.029 NA 0.035 NA 0.024 0.01200 NA 6.8e-03 NA 2.0e-02
3 GTEx Breast Mammary Tissue (Male) 0.0963 0.0548 2.0e-02 -0.010 NA 0.001 NA -0.013 0.61000 NA 3.1e-01 NA 9.2e-01
4 GTEx Breast Mammary Tissue (Female) 0.0595 0.0473 9.4e-02 0.027 NA -0.010 NA -0.009 0.05300 NA 8.8e-01 NA 7.1e-01
5 GTEx Lung 0.0616 0.0391 8.7e-03 -0.003 NA -0.002 NA -0.004 0.60000 NA 4.8e-01 NA 8.6e-01
6 GTEx Thyroid 0.0660 0.0370 4.2e-03 -0.003 NA -0.004 NA -0.003 0.64000 NA 9.8e-01 NA 6.6e-01
7 YFS Blood 0.0270 0.0105 4.9e-06 0.011 0.023 0.020 0.023 0.023 0.00011 3.2e-08 3.3e-07 3.9e-08 4.7e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 1.5 -0.4 0.4 -0.1 0.0 1.2 -0.3 -0.7
Bipolar Disorder or Schizophrenia 0.2 0.5 1.4 -1.0 -0.1 -0.5 -0.5 0.1 -1.2 -0.6
Depressed Affect (Nagel 2018) 0.2 0.3 0.8 0.4 -0.2 -0.7 0.0 0.6 -0.9 -0.8
Depression (Nagel 2018) 0.3 0.4 0.8 -0.3 -0.8 -0.8 0.1 0.9 -0.8 -0.0
Intelligence (Savage-Jansen 2018) 0.5 1.7 3.4 1.8 1.4 1.6 1.3 0.8 0.7 -1.0
Neuroticism (Nagel 2018) 0.5 1.2 2.3 1.5 1.0 1.0 1.3 1.5 0.5 -0.2
Schizophrenia (2018) 0.4 0.7 1.7 -1.0 -0.4 -0.6 -0.6 -1.2 -1.3 -0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 -0.9 -0.2 0.2 0.2 -0.8 0.0 1.3
Worry (Nagel 2018) 0.9 1.8 3.6 1.8 1.2 1.4 1.6 1.9 0.6 -0.1
Alzheimer’s Disease (in mother) 0.8 0.9 1.5 0.4 0.8 1.2 0.6 1.0 1.2 1.2
Alzheimer’s Disease (in father) 2.1 2.2 6.3 -0.6 -2.5 -1.5 -2.1 -0.3 -1.5 -0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.9 -0.5 -1.4 -0.3 -1.2 0.2 0.0 0.6
Crohns Disease (2017) 1.1 2.4 8.6 -2.9 -1.2 -1.4 0.4 -1.3 -1.6 0.7
Irritable Bowel Disease (IBD) 1.4 3.3 10.9 -3.3 -1.0 -0.8 -0.5 -2.3 -1.4 1.8
Ulcerative Colitis (UC) 0.9 1.6 3.8 -1.9 -0.3 0.3 -0.7 -1.8 -0.7 1.8
Major Depression (MDD) 2.0 2.4 3.9 -1.3 -1.9 -2.0 -1.7 0.6 -1.9 -0.9
Reaction Time 0.2 0.4 1.1 -0.6 0.0 -0.6 0.1 -0.5 -1.0 0.7
Verbal and Numeric Reasoning (VNR) 1.3 3.2 7.7 2.8 1.8 1.9 1.7 1.9 1.2 -0.4
Breast Cancer 0.2 0.5 1.0 -1.0 -0.0 0.6 -0.2 0.9 1.0 0.5
Ovarian Cancer 2.0 2.6 5.0 -1.5 -1.7 -1.6 -0.9 -2.1 -2.2 -0.6
Prostate Cancer 1.3 1.8 6.1 1.6 0.4 0.3 0.6 1.7 0.4 -2.5
Age at First Birth 1.6 2.4 4.7 -0.4 -1.5 -1.7 -1.3 -0.7 -2.2 -2.1
Bipolar Disorder (2011) 0.5 0.5 1.9 -0.9 0.4 0.6 1.4 0.0 0.0 -0.1
Body Mass Index (BMI) (2010) 5.8 7.9 16.1 -2.4 -4.0 -3.4 -3.5 -1.0 -2.7 -1.2
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.3 0.2 0.2 0.4 0.3 0.0 -0.2
Crohns Disease (2012) 0.8 1.2 3.1 -1.8 -0.3 0.3 1.2 -1.7 0.0 1.1
Mean Putamen Volume 0.3 0.3 0.7 0.8 -0.0 0.5 0.5 0.6 0.0 -0.8
Fasting Glucose 0.3 0.3 0.8 -0.9 -0.5 -0.9 -0.5 -0.3 -0.5 0.0
HbA1C 0.4 0.5 1.5 0.5 -1.2 -0.7 -0.8 0.2 -0.2 -0.7
HDL Cholesterol 1.1 1.9 4.3 -0.2 -1.8 -1.6 -2.1 0.3 -1.7 -0.3
LDL Cholesterol 0.3 0.5 0.9 -0.1 0.5 0.9 -0.5 -0.8 0.9 0.6
Lupus 0.1 0.1 0.4 0.3 -0.1 0.2 0.4 -0.0 -0.4 -0.6
Neuroticism (2016) 1.4 2.1 4.7 1.7 1.8 1.3 2.2 0.5 1.3 -0.3
Primary Biliary Cirrhosis 2.8 4.0 8.5 1.5 2.4 2.7 2.9 -1.3 1.7 -0.1
Rheumatoid Arthritis 0.7 1.0 3.5 1.3 0.1 0.1 -0.4 1.9 -0.2 -1.1
Schizophrenia (2014) 0.2 0.4 1.3 -0.7 -0.4 -0.6 -0.4 -0.3 -1.2 -0.3
Triglycerides 2.9 4.8 11.0 0.8 2.5 3.1 2.3 0.6 3.3 -0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.5 -0.5 0.3 0.5 0.5 0.2 0.0 0.7
Ulcerative Colitis 3.3 4.7 15.5 -3.5 -0.8 0.2 -0.7 -3.9 -0.6 1.9
Blood Eosinophil Count 0.5 4.1 10.4 3.2 1.1 2.8 1.6 0.3 2.5 0.6
Blood Platelet Count 7.6 88.0 237.2 -15.4 -9.4 -10.0 -7.6 -5.3 -10.1 1.8
Blood Red Count 11.9 115.2 177.9 11.3 12.3 13.3 12.5 6.6 12.1 2.4
Blood White Count 1.2 9.0 24.2 4.1 0.1 1.2 0.5 4.4 0.7 -4.9
Heel T-Score 0.3 2.5 6.5 -2.5 1.5 0.1 1.3 -2.5 0.7 0.3
BMI 3.8 22.0 40.7 -3.6 -6.4 -5.7 -5.4 -1.3 -5.6 -2.4
Height 12.0 231.2 400.0 20.0 16.0 18.2 13.9 12.8 16.5 -1.3
Waist Hip Ratio (WHR) 0.7 3.3 6.6 -0.0 2.4 2.6 2.5 0.8 1.8 -0.8
Systolic Blood Pressure 0.2 1.0 2.0 -1.4 -0.8 -0.5 -0.3 -1.4 -0.8 -1.3
Smoking Status 0.1 0.1 0.4 -0.2 0.2 -0.4 -0.2 -0.0 -0.6 -0.6
Allergy or Eczema 4.0 10.6 19.4 -3.4 -4.4 -3.4 -2.7 -3.4 -3.3 -1.2
Cardiovascular Disease 0.6 2.1 6.4 -1.4 -1.0 -1.2 -0.7 -0.8 -1.8 -2.5
Hypothyroidism (self reported) 2.7 6.2 11.8 -2.4 -3.4 -2.9 -2.4 -0.3 -2.4 -2.4
Respiratory disease 1.6 3.5 11.6 -3.4 -1.8 -1.6 -1.4 -1.3 -1.7 0.6
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.6 -0.5 -0.2 -0.1 -0.0 -0.3 0.8
Lung FEV1/FVC ratio 0.3 1.7 9.5 0.8 -0.5 -0.4 -0.3 -0.7 -0.8 -3.1
Lung FVC 0.9 4.7 11.1 -1.7 -2.4 -3.0 -3.3 0.3 -2.0 0.0
Neuroticism 1.1 2.6 5.1 2.3 1.6 1.7 1.6 2.0 1.1 -0.1
Chronotype (morning person) 2.8 6.5 11.2 1.8 3.3 3.4 3.2 -0.6 3.0 -0.3
Hair Pigment 0.0 1.0 2.5 -0.5 -1.4 -0.7 -1.0 1.6 0.2 0.8
Tanning 0.4 4.9 9.1 -2.8 -2.2 -3.0 -2.2 -0.8 -2.4 -1.0
Hand grip strength (left) 3.4 9.0 26.1 5.1 3.5 2.7 2.6 2.1 2.4 -0.7
Number of treatments/medications taken 1.6 2.9 6.6 -1.3 -2.6 -1.6 -1.5 -0.8 -1.6 -2.0
Average weekly spirits intake 1.0 1.3 2.8 -1.2 -1.3 -1.1 -1.2 -0.4 -1.7 -0.2
Sensitivity / hurt feelings 0.6 1.1 4.1 -0.0 0.9 0.9 0.9 2.0 0.9 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.0 0.6 0.0 0.2 -0.3 1.4 0.0 -0.5
Hearing difficulty/problems: Yes 0.4 0.6 1.6 0.8 0.1 -0.4 -0.4 1.3 -1.1 0.4
Relative age of first facial hair 1.9 3.9 6.3 -2.1 -2.5 -2.2 -2.4 -1.3 -2.0 -0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 4.2 0.9 -0.5 -0.4 -0.2 2.0 -0.6 -1.6
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.2 -1.8 -0.1 0.2 -0.7 0.5 0.2 1.2
Ever had hysterectomy (womb removed) 1.1 1.3 2.3 0.8 1.2 1.4 1.3 0.9 1.5 0.5
Systolic blood pressure, automated reading 2.3 6.5 12.5 -3.5 -3.1 -2.5 -2.7 -1.7 -2.7 -0.5
Eye problems/disorders: Diabetes related eye disease 4.0 4.3 5.1 -2.0 -2.1 -2.1 -2.2 -2.3 -2.2 1.8
Angina 0.4 0.5 2.5 -0.2 -0.3 0.3 -0.3 0.4 0.5 -1.6
Medication for hormone replacement therapy 0.6 0.7 1.5 -0.8 -0.7 -0.9 -1.2 1.0 -0.6 -0.4
Vitamin and mineral supplements 0.3 0.4 0.8 0.5 0.6 0.6 0.9 0.7 0.5 -0.5
Supplements: Zinc 1.3 1.4 3.9 -0.4 1.1 1.4 0.9 -0.6 1.3 2.0
Medication: Co-codamol 2.6 3.0 5.4 -2.2 -1.8 -1.9 -2.3 -0.7 -1.7 0.8
Medication: Metformin 0.8 1.1 3.0 -1.1 -1.0 -0.3 -0.5 -1.4 -0.7 1.7
Diabetes (father) 1.5 1.8 7.3 -2.7 -0.1 -0.7 -0.4 -0.3 -0.2 2.2
Diabetes (mother) 0.2 0.2 0.8 -0.9 -0.3 -0.7 0.5 0.2 -0.2 -0.1
Severe depression (siblings) 0.3 0.4 0.9 -0.3 0.8 0.2 0.8 0.4 -0.1 0.9
Pack years adult smoking proportion 0.2 0.4 1.7 -0.1 0.8 0.2 0.4 0.1 -0.0 1.3
Impedance of leg (right) 5.9 28.6 51.4 4.0 6.5 7.2 6.5 0.6 6.4 2.5
Leg fat-free mass (left) 1.0 5.2 15.1 3.9 0.0 0.8 -0.0 3.5 0.8 -2.8
Trunk fat percentage 0.4 1.7 7.0 -0.7 -2.6 -0.8 -1.7 -0.2 -0.7 -0.4
Hand grip strength (right) 3.2 8.7 20.4 4.5 3.7 2.9 2.5 2.5 2.5 0.4
Townsend deprivation index at recruitment 3.9 5.4 11.4 -3.4 -1.7 -2.6 -2.7 -0.6 -3.0 0.0
Current tobacco smoking 0.4 0.7 1.7 -1.3 -0.2 -0.9 -1.0 -0.3 -1.0 -0.2
Average weekly fortified wine intake 0.4 0.5 1.5 -0.7 -0.8 -0.7 -0.4 0.2 -0.2 1.2
Maternal smoking around birth 0.7 1.1 3.9 1.5 0.1 -0.3 -0.0 1.0 -0.3 -2.0
Fed-up feelings 0.2 0.4 1.0 -0.8 -0.0 -0.4 -0.3 0.5 -1.0 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.5 -0.7 -1.4 -1.6 -1.0 0.8 -1.9 -0.4
Relative age voice broke 1.0 1.6 3.4 -1.8 -0.5 -1.1 -0.5 -1.3 -1.7 1.0
Taking other prescription medications 2.9 4.5 8.4 -1.2 -2.9 -2.6 -2.5 -0.2 -2.4 -1.7
Age when periods started (menarche) 0.1 0.2 0.8 -0.9 0.1 0.1 0.1 -0.5 -0.5 0.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 0.0 -0.2 -0.3 -0.1 0.9 -0.3 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.5 -0.6 1.6 0.6 0.7 0.5 0.8 0.5
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 2.0 -1.1 -1.4 -1.1 -1.3 -0.1 -0.8 -0.7
Qualifications: CSEs or equivalent 0.2 0.3 1.1 -0.5 -0.2 -0.2 -0.4 -0.8 -0.3 1.1
Serious illness, injury or assault to yourself 1.5 1.8 3.3 -1.8 -1.4 -1.5 -1.7 -0.3 -1.0 -1.1
High blood pressure 2.4 6.6 10.8 -2.0 -3.1 -2.8 -2.6 0.5 -2.7 -3.3
Hayfever, allergic rhinitis or eczema 2.7 5.9 15.8 -2.7 -2.6 -2.0 -1.4 -4.0 -2.4 -0.4
Multivitamins +/- minerals 0.5 0.6 3.4 -0.5 0.2 0.2 0.5 -0.4 0.5 1.8
Stomach or abdominal pain in last month 0.6 0.7 2.9 -1.7 -0.9 -0.6 -0.4 -0.7 -0.5 -0.1
Supplements: Glucosamine 0.1 0.1 0.3 0.3 -0.2 -0.1 -0.0 0.0 0.2 -0.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 3.1 -1.8 -0.5 -0.6 -0.2 0.1 -0.7 0.5
Medication: Atenolol 1.3 1.7 4.8 0.9 0.7 0.8 0.8 1.9 1.0 -2.2
Medication: Levothyroxine sodium 1.6 2.8 4.8 -1.3 -2.2 -1.8 -1.8 0.8 -1.4 -1.9
Sitting height 5.7 40.5 71.6 8.5 7.1 7.6 5.8 4.9 6.8 -0.7
Chronic bronchitis/emphysema (father) 0.6 0.7 2.0 -0.4 -0.9 -0.6 -1.4 0.3 -0.7 -0.8
High blood pressure (mother) 0.8 1.1 2.5 -0.5 -1.6 -1.0 -1.4 -0.9 -0.5 -1.0
Body mass index (BMI) 4.3 18.2 37.7 -3.5 -6.1 -5.0 -5.1 -0.9 -4.7 -1.6
Impedance of leg (left) 6.5 31.6 54.3 4.6 6.9 7.4 6.8 0.8 6.6 2.6
Leg predicted mass (left) 1.0 5.3 15.4 3.9 0.1 0.9 0.0 3.5 0.8 -2.8
Trunk fat mass 0.3 1.4 3.4 1.2 -1.9 0.1 -1.1 1.3 0.1 -1.5
Waist circumference 0.6 2.4 5.3 -0.2 -2.3 -1.0 -2.2 1.2 -1.1 -1.6
Number of incorrect matches in round 0.4 0.7 3.4 -1.1 0.3 0.5 0.3 0.3 -0.1 1.8
Past tobacco smoking 0.0 0.1 0.3 -0.2 -0.0 -0.0 0.3 -0.5 0.2 -0.1
Alcohol usually taken with meals 2.4 3.8 8.4 2.9 1.2 2.5 1.5 0.8 2.5 1.3
Nervous feelings 0.2 0.3 1.3 0.3 -0.1 0.1 0.6 1.1 -0.6 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.3 0.9 0.8 1.0 1.5 0.6 -0.1 -0.0
Hearing difficulty/problems with background noise 1.2 1.9 3.9 1.6 1.6 1.4 1.2 2.0 0.5 0.6
Hair/balding pattern: Pattern 2 0.7 0.9 4.1 -2.0 -0.7 0.1 -0.1 -0.3 0.4 1.0
Had menopause 1.3 1.6 5.4 -2.3 -1.1 -0.7 -1.1 -0.3 -0.2 1.7
Had other major operations 0.7 0.9 1.9 0.9 -1.4 -0.6 -1.2 -0.7 -0.9 0.0
Forced vital capacity (FVC) 4.2 16.2 34.5 5.9 4.7 4.1 3.5 3.6 3.8 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 5.7 0.4 2.4 0.8 1.9 1.4 1.4 -0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.6 1.3 0.8 0.1 0.3 1.9 0.5 -0.8
Qualifications: None of the above 3.7 7.9 15.2 -2.3 -3.3 -3.9 -3.3 1.1 -2.8 -1.9
Financial difficulties in last 2 years 0.1 0.2 0.5 0.4 0.3 0.6 -0.3 0.7 0.4 0.1
Mouth/teeth dental problems 6.1 9.4 18.7 3.4 3.1 4.3 3.2 0.1 3.5 1.9
Heart attack 1.4 1.8 3.1 -0.4 1.5 1.3 1.8 0.4 1.6 -1.6
Allergy 2.9 6.7 11.2 3.3 2.6 2.4 1.9 3.3 2.9 -0.6
Pain all over the body in last month 0.4 0.4 1.2 -0.3 0.2 -0.3 0.4 1.0 -0.3 -1.1
Diabetes (self-reported) 1.2 1.8 4.9 -1.9 -1.2 -0.9 -1.2 -0.8 -0.4 2.2
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 5.1 -2.3 -1.8 -1.8 -1.4 -1.7 -1.7 -0.1
Medication: Ramipril 2.3 2.9 9.5 -3.1 -1.9 -1.2 -0.9 -1.5 -1.6 -0.1
Medication: Simvastatin 0.8 1.1 3.6 -1.9 -0.4 0.1 0.3 -1.9 -0.7 -0.0
Fluid intelligence score 1.2 2.4 5.4 2.3 1.7 1.6 2.1 0.7 1.1 -0.3
Illnesses of siblings 0.7 0.9 2.0 -0.9 -0.2 -1.4 -0.1 -1.4 -0.6 1.2
Neuroticism score 1.1 2.3 6.1 1.6 1.5 1.5 1.4 2.5 0.6 0.5
Weight 0.7 3.3 8.8 2.8 -0.9 0.6 -0.7 3.0 0.4 -2.2
Impedance of arm (right) 1.6 7.6 14.7 1.1 2.9 3.8 2.9 -0.2 3.8 2.5
Arm fat percentage (right) 2.9 11.4 28.7 -3.1 -5.4 -3.5 -4.2 -1.1 -3.1 -0.8
Trunk fat-free mass 3.8 21.8 57.9 7.6 3.1 3.8 2.4 6.0 3.7 -3.9
Hip circumference 0.6 2.5 4.6 1.6 -2.0 -0.4 -2.1 1.5 -0.2 -1.8
Time employed in main current job 2.1 2.4 4.4 0.2 -1.5 -1.7 -2.1 1.6 -1.7 -1.5
Alcohol intake versus 10 years previously 0.7 1.0 4.0 -1.3 -0.4 -0.8 -0.3 -2.0 -0.8 0.2
Father’s age at death 2.8 3.7 6.7 -2.5 -2.3 -2.4 -2.6 -0.6 -1.3 0.6
Worrier / anxious feelings 0.7 1.4 2.9 1.1 1.0 1.3 1.4 1.7 0.8 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 0.5 0.3 0.2 0.7 0.4 -0.1 -0.5
Falls in the last year 0.6 0.8 2.2 -1.1 -0.6 -0.6 -0.5 -1.5 -0.8 0.9
Hair/balding pattern: Pattern 3 1.0 1.5 3.7 1.4 1.6 1.0 1.2 -0.3 -0.1 1.9
Number of live births 0.3 0.4 1.0 -0.6 -0.1 -0.3 -0.7 -1.0 -0.8 0.6
Forced expiratory volume in 1-second (FEV1) 3.3 11.1 28.3 5.3 3.7 3.1 2.6 2.9 2.8 -1.6
Pulse rate 0.2 0.4 1.2 -0.8 0.3 0.4 -0.1 -0.6 -0.3 1.1
Happiness 1.8 2.2 13.3 1.1 0.9 0.1 0.2 3.6 0.5 -0.1
Noisy workplace 2.0 2.5 4.0 -1.6 -1.7 -1.4 -1.9 -2.0 -1.1 -1.0
Qualifications: A levels/AS levels or equivalent 5.7 12.6 20.6 3.8 4.4 4.5 4.1 1.2 3.9 1.1
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.2 5.0 -1.8 -2.2 -2.0 -2.1 -1.5 -1.6 1.0
Mouth/teeth dental problems: Dentures 4.2 7.2 11.1 -2.3 -2.9 -3.3 -3.0 0.3 -2.3 -3.3
Asthma 1.2 2.3 7.5 -2.7 -0.9 -0.9 -0.6 -1.7 -1.3 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.8 0.4 0.7 1.5 1.2 -0.6 1.7 1.5
Medication: Cholesterol lowering 0.4 0.7 1.4 -1.2 0.7 1.1 0.8 -0.6 0.7 -0.1
Depression (self-reported) 1.4 1.6 3.9 -0.1 2.0 0.8 1.7 0.9 0.5 1.7
Medication: Lansoprazole 1.3 1.4 5.3 1.3 0.3 0.9 0.2 1.1 1.1 -2.3
Prospective memory result 0.7 0.9 2.5 -1.6 -0.1 -0.2 0.2 -1.1 -0.2 1.5
Lung cancer (father) 0.2 0.3 0.6 -0.6 -0.5 -0.8 0.2 -0.1 -0.6 -0.7
Illnesses of mother 0.7 0.9 2.3 0.9 0.9 0.9 0.8 0.1 0.6 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.9 9.3 21.9 4.7 3.3 3.0 2.4 2.7 2.6 -2.0
Pulse wave Arterial Stiffness index 3.2 3.7 7.9 0.7 1.6 2.6 2.8 -1.1 2.1 1.6
Impedance of arm (left) 1.6 7.3 12.2 0.5 3.1 3.5 3.0 -0.6 3.4 3.0
Arm fat mass (right) 1.3 5.5 15.8 -1.1 -4.0 -2.3 -2.9 0.4 -2.1 -1.7
Trunk predicted mass 3.9 22.3 58.4 7.6 3.2 3.9 2.5 6.1 3.7 -4.0
Standing height 10.3 101.9 187.7 13.7 10.8 11.8 9.0 8.4 10.7 -1.6
Length of working week for main job 0.6 0.6 2.2 -0.3 -0.7 -0.8 -0.7 0.2 -0.6 -1.5
Exposure to tobacco smoke at home 0.9 1.0 3.4 -0.5 -0.8 -1.4 -1.0 0.1 -1.8 0.1
Breastfed as a baby 1.7 2.2 5.5 2.3 1.2 1.6 1.1 0.9 1.7 -0.9
Tense / ‘highly strung’ 0.8 1.4 4.1 2.0 0.8 1.2 1.1 1.4 0.2 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 3.3 -0.3 0.3 0.4 0.4 1.8 0.1 0.1
Hair/balding pattern: Pattern 4 0.3 0.8 2.5 0.9 -1.6 0.2 -0.2 -0.2 -1.5 0.1
Birth weight of first child 0.3 0.5 1.8 1.4 0.2 -0.0 0.6 0.4 0.2 -1.2
Peak expiratory flow (PEF) 1.7 3.9 11.9 3.5 1.9 1.2 0.7 2.3 0.8 -1.9
Pulse wave reflection index 6.2 7.6 15.1 2.8 2.9 3.4 3.9 -0.0 3.1 0.9
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.5 0.3 0.8 0.3 1.2 -0.4 0.1 -0.7
Loud music exposure frequency 0.3 0.3 0.7 0.1 0.2 0.3 -0.3 0.9 0.8 -0.7
Qualifications: O levels/GCSEs or equivalent 4.6 7.4 13.0 3.1 3.5 3.6 2.7 0.9 3.0 -0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -0.8 0.0 -1.1 0.1 0.2 -1.3 1.4
Blood clot in the leg (DVT) 0.6 0.7 3.2 0.9 -0.5 -0.6 -0.4 0.2 -0.6 -1.8
Medication: Paracetamol 1.1 1.7 7.6 2.8 0.3 1.0 1.0 0.8 0.7 -1.2
Headache pain in last month 0.2 0.3 1.2 1.1 0.3 0.3 0.7 -0.5 0.1 -0.0
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.7 1.4 1.1 0.6 1.4 0.0 0.8 1.6
Glaucoma (self-reported) 0.2 0.3 1.4 -0.4 1.2 0.2 0.4 0.0 -0.2 -0.3
Gout (self-reported) 0.8 1.1 2.2 -1.5 -0.9 -1.0 -0.4 -1.2 -0.5 -1.3
Hypothyroidism/myxoedema (self-reported) 3.1 6.1 11.3 -2.3 -3.4 -3.0 -2.7 0.2 -2.3 -2.0
Medication: Amlodipine 3.4 4.8 7.0 -2.5 -2.4 -2.6 -2.4 -0.9 -2.2 -1.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.2 -0.7 -0.9 -0.8 -0.6 -1.5 -1.4 0.3
Birth weight 0.4 0.8 4.6 0.8 0.3 0.1 0.1 2.1 -0.0 -0.4
Chronic bronchitis/emphysema (mother) 0.9 1.1 3.0 -1.0 -0.5 -1.2 -0.7 -1.7 -1.1 -0.6
High blood pressure (siblings) 0.6 0.9 1.6 1.1 0.4 1.1 0.3 1.3 0.7 -1.1
Forced vital capacity (FVC), Best measure 3.6 13.3 28.6 5.3 4.0 3.6 3.0 3.7 3.3 -1.5
Body fat percentage 0.8 3.2 10.8 -1.5 -3.3 -1.4 -2.2 -0.6 -1.4 -0.4
Leg fat percentage (right) 1.1 4.0 11.7 -1.9 -3.4 -1.7 -2.4 -0.7 -1.8 -0.3
Arm fat-free mass (right) 2.4 12.1 33.4 5.8 2.5 2.8 2.1 4.5 2.4 -2.6
Exposure to tobacco smoke outside home 0.6 0.8 1.7 0.7 -1.3 -0.7 -1.0 -0.3 -0.1 -1.3
Comparative body size at age 10 3.3 9.1 17.9 -1.4 -3.5 -4.2 -3.5 0.8 -3.4 -2.7
Number of full brothers 0.5 0.7 2.7 0.1 0.5 0.3 1.1 -0.4 0.5 -1.6
Worry too long after embarrassment 5.1 8.6 14.8 2.3 2.8 3.8 2.8 1.3 3.4 3.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.9 -1.1 -0.2 -0.9 -0.7 1.7 -1.1 -0.9
Wheeze or whistling in the chest in last year 1.3 2.3 3.9 -2.0 -0.8 -1.9 -0.8 -1.8 -1.8 -0.5
Number of children fathered 0.6 0.6 2.5 0.2 -0.5 -0.5 0.1 1.2 -0.1 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.5 -0.2 1.5 1.5 0.8 1.2 1.3 1.9
Age at first live birth 1.8 3.2 4.9 0.7 1.6 2.0 2.2 -2.0 1.1 2.2
Pulse wave peak to peak time 1.7 2.0 4.2 0.2 -0.6 -1.6 -2.0 1.6 -1.3 -1.5
Health satisfaction 0.2 0.3 1.1 -0.3 0.4 0.4 0.2 0.9 0.1 1.1
Shortness of breath walking on level ground 0.3 0.3 0.7 -0.2 -0.8 -0.3 -0.8 -0.6 -0.7 -0.2
Qualifications: College or University degree 1.5 4.9 7.9 2.8 1.9 2.8 2.8 0.1 2.3 1.2
Eye problems/disorders: None of the above 0.7 0.9 2.7 1.7 0.6 0.9 0.2 1.0 0.7 0.7
Mouth/teeth dental problems: Loose teeth 2.5 3.0 6.0 0.7 2.5 1.9 2.3 0.8 1.9 0.9
Emphysema/chronic bronchitis 1.7 1.9 4.1 -2.0 -0.6 -0.2 -0.6 -1.8 -1.0 2.0
Medication for pain relief, constipation, heartburn 0.2 0.4 1.0 -1.0 0.2 -0.6 -0.3 0.1 -0.4 1.0
Neck or shoulder pain in last month 1.3 1.9 4.8 -1.2 -1.8 -1.4 -1.1 -0.1 -2.2 -0.7
Medication: Blood pressure 2.8 5.0 11.9 -1.2 -2.5 -2.2 -2.4 0.8 -1.9 -3.5
Angina (self-reported) 0.3 0.4 2.0 -0.3 -0.3 0.3 -0.2 0.2 0.6 -1.4
Migraine (self-reported) 0.9 1.1 2.7 1.0 1.6 1.0 1.5 0.8 0.7 -0.2
Medication: Ibuprofen 0.5 0.7 2.3 -0.1 -0.2 0.7 0.4 -0.7 1.0 1.5
Medication: Allopurinol 0.6 0.9 3.0 -1.7 -1.0 -0.7 -0.5 -0.8 -0.7 0.2
Medication: Omeprazole 2.1 2.5 4.8 0.9 2.1 2.2 1.7 0.3 1.8 1.0
Medication: Seretide 50 evohaler 1.2 1.3 3.4 -1.3 -0.6 -1.5 -1.0 -0.3 -1.8 0.9
Mean time to correctly identify matches 0.4 0.7 1.9 -1.4 -0.5 -0.9 -0.5 -0.5 -1.0 0.5
Heart disease (mother) 1.6 1.9 9.9 0.4 -1.0 -0.5 -0.5 1.0 -0.8 -3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 4.4 -2.1 -1.0 -0.9 -0.6 -1.8 -0.7 0.1
Whole body fat mass 0.5 1.9 6.6 0.3 -2.6 -0.7 -1.7 0.8 -0.7 -1.5
Leg fat mass (right) 0.7 2.6 8.6 -0.1 -2.9 -1.1 -2.0 0.7 -1.2 -1.6
Arm predicted mass (right) 2.5 12.5 34.1 5.8 2.5 2.8 2.1 4.6 2.5 -2.9
Pulse rate, automated reading 1.0 3.1 6.0 0.5 1.7 2.4 2.4 -0.8 1.5 2.0
Alcohol intake frequency. 0.5 1.2 3.6 -0.1 -0.9 -1.4 -0.9 0.2 -1.2 -1.9
Comparative height size at age 10 10.8 59.3 112.4 10.6 7.5 8.3 6.3 7.8 8.5 -1.9
Number of full sisters 0.8 1.0 2.1 -1.5 -0.6 -1.3 -0.9 0.3 -1.4 -0.1
Suffer from ‘nerves’ 0.6 0.9 3.1 0.8 0.4 0.1 1.2 1.8 -1.0 -0.2
Overall health rating 1.1 2.4 3.6 -1.2 -1.9 -1.9 -1.8 0.2 -1.8 -1.4
Chest pain or discomfort 0.4 0.5 1.6 0.0 0.6 0.6 1.1 -0.3 -0.1 -1.2
Had major operations 1.0 1.2 4.2 1.7 -0.9 0.3 -0.0 0.6 0.3 -2.0
Age at last live birth 1.7 2.5 12.3 -0.1 0.8 0.9 0.9 -1.7 -0.0 3.5
Family relationship satisfaction 0.6 0.8 2.8 -0.1 0.9 0.7 0.3 1.7 0.8 0.6
Leg pain on walking 0.7 0.9 2.3 -1.0 -1.1 -0.8 -1.5 -0.2 -1.0 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.7 -0.4 1.6 0.9 1.0 -0.8 -0.1 -0.7
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.3 0.6 -0.2 -0.4 0.1 1.8 -0.3 -1.2
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.4 1.0 1.7 1.5 1.6 0.6 1.9 0.4
Medication: Aspirin 0.4 0.5 1.4 -0.6 -0.5 -0.5 -0.5 -0.2 -0.9 -1.2
Supplements: Vitamin C 1.0 1.1 2.4 0.7 -0.5 -0.4 -1.6 1.5 -0.4 -1.5
Knee pain experienced in last month 0.8 1.2 2.6 0.1 -1.3 -1.0 -1.6 -0.9 -0.8 -1.4
Hypertension (Self-reported) 3.0 8.4 13.0 -2.7 -3.6 -3.4 -3.2 0.2 -3.1 -2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.4 -0.8 0.0 0.6 0.5 -1.5 0.4 0.1
Illnesses of father: Heart disease 1.6 2.2 5.1 1.4 1.6 1.8 2.3 -0.3 1.4 0.8
Illnesses of siblings: Diabetes 0.4 0.5 1.3 -0.7 -0.7 0.1 -0.8 0.9 0.0 -1.2
Smoking status: Previous 0.1 0.2 0.4 -0.2 -0.5 -0.5 -0.4 0.6 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 6.2 12.9 29.6 5.4 4.1 4.0 3.8 2.2 2.8 -0.9
Whole body fat-free mass 2.4 13.9 39.2 6.3 2.0 2.7 1.6 5.1 2.5 -3.5
Leg fat-free mass (right) 1.1 5.8 17.7 4.2 0.3 0.9 0.1 3.7 0.9 -2.8
Arm fat percentage (left) 3.0 12.1 28.8 -3.3 -5.4 -3.8 -4.2 -1.1 -3.4 -0.7
Average weekly red wine intake 0.9 1.4 7.3 2.7 -0.3 0.4 -0.5 0.5 -0.2 -1.3
Handedness (chirality/laterality): Left-handed 2.3 2.7 5.2 1.5 1.7 2.3 1.8 0.7 2.0 -0.9
Mood swings 0.1 0.2 0.7 0.5 0.8 0.2 0.8 -0.1 -0.0 -0.2
Loneliness, isolation 0.8 1.1 4.2 -0.0 -0.7 -1.5 -1.0 0.0 -2.0 -0.0
Long-standing illness, disability or infirmity 3.1 4.7 8.1 -2.8 -2.2 -2.4 -2.2 -1.1 -2.8 -0.3
Ever had bowel cancer screening 0.4 0.5 2.3 -1.5 -0.6 -0.5 -0.2 -0.6 -0.5 0.1
Diabetes diagnosed by doctor 1.0 1.6 3.3 -1.8 -1.1 -0.8 -0.9 -1.3 -0.7 1.8
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 3.6 0.3 1.9 1.7 1.7 -0.1 1.9 1.1
Friendships satisfaction 0.7 0.8 1.7 -0.0 1.3 0.5 1.0 1.0 0.1 1.3
Qualifications: nursing, teaching 0.6 0.9 2.0 1.1 1.0 0.8 1.4 -0.2 0.8 1.0
Commuting to job workplace: Walk 0.5 0.6 2.6 -0.5 0.2 0.4 -0.7 -0.8 0.1 1.6
Eye problems/disorders: Cataract 0.5 0.5 2.1 0.2 -0.7 -0.9 -0.4 0.2 -0.5 -1.4
Mouth/teeth dental problems: Mouth ulcers 1.0 1.5 3.1 -1.8 -0.9 -1.4 -0.3 -1.4 -1.4 0.9
Medication for cholesterol 2.7 4.1 6.8 2.3 2.4 2.4 1.9 -0.2 2.6 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 6.2 7.3 11.4 -2.7 -3.0 -3.3 -3.2 -0.9 -3.4 -1.0
Back pain experienced in last month 0.4 0.6 1.3 -0.9 -1.1 -0.6 -0.1 -1.1 -0.6 -0.2
Mineral and other dietary supplements 0.1 0.2 0.8 -0.0 -0.1 -0.1 0.1 0.9 -0.2 -0.5
Breast cancer (self-reported) 0.5 0.6 2.4 0.6 0.4 0.8 -0.2 1.6 0.3 -0.2
Asthma (self-reported) 1.0 2.1 6.8 -2.6 -0.9 -1.1 -0.9 -1.3 -1.2 1.3
Osteoporosis (self-reported) 1.3 1.6 4.8 -0.1 -1.3 -1.4 -1.0 -0.5 -2.2 -1.1
Osteoarthritis (self-reported) 2.1 2.7 5.8 -0.9 -2.3 -1.8 -2.4 0.8 -1.6 -0.5
Medication: Aspirin 0.2 0.3 1.2 -0.2 -0.2 -0.2 -0.4 0.1 -0.7 -1.1
Medication: Gliclazide 0.2 0.2 0.9 0.1 -0.2 0.1 0.0 -0.5 -0.1 1.0
Illnesses of father: None of the above (group 1) 1.1 1.4 2.9 1.0 1.7 1.5 1.4 0.3 1.0 0.4
Smoking status: Current 0.4 0.6 2.0 -1.4 -0.0 -0.7 -0.6 -0.8 -0.9 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.4 0.3 0.7 0.7 0.5 0.4 1.2 -1.0
Whole body water mass 2.3 13.3 37.8 6.2 1.9 2.5 1.4 5.0 2.3 -3.5
Leg predicted mass (right) 1.1 5.7 17.1 4.1 0.3 0.8 0.1 3.6 0.8 -2.8
Arm fat mass (left) 1.5 6.3 17.0 -1.3 -4.1 -2.6 -3.2 0.4 -2.5 -1.6
Number of self-reported non-cancer illnesses 2.1 3.6 8.2 -2.9 -1.8 -2.2 -1.5 -0.5 -2.3 -0.9
Average weekly champagne plus white wine intake 1.5 2.1 5.4 0.7 1.4 1.5 1.1 1.4 1.1 2.3
Miserableness 0.2 0.4 1.4 0.8 -0.3 -0.1 -0.5 1.2 -0.5 -0.6
Guilty feelings 0.6 0.9 3.2 0.8 0.7 1.1 0.3 1.8 -0.1 -0.7
Wears glasses or contact lenses 1.5 1.8 4.8 -2.2 -1.0 -0.2 -1.0 -2.1 -0.2 1.0
Ever taken oral contraceptive pill 5.0 5.6 9.2 3.0 3.0 2.4 2.3 2.6 1.8 0.0
Hearing aid user 1.5 1.7 3.4 0.0 -1.1 -1.6 -1.9 1.1 -1.6 0.9
Mother’s age at death 0.9 1.1 2.8 -0.6 -1.5 -1.1 -1.7 0.3 -0.7 -0.5
Financial situation satisfaction 1.7 2.2 4.0 0.6 1.8 1.4 0.7 2.0 1.1 2.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.1 -0.3 0.6 0.4 0.5 0.1 0.3 1.1
Commuting to job workplace: Public transport 0.4 0.5 1.2 0.1 0.7 1.1 0.3 -0.2 1.1 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 1.7 -0.5 1.3 0.8 0.9 -0.4 0.7 -0.0
Medication: Blood pressure 1.2 2.2 4.6 -1.6 -2.1 -1.8 -1.2 -0.7 -1.8 -0.6
Pain type(s) experienced in last month: Hip pain 1.7 2.2 4.8 -0.7 -1.6 -1.5 -1.3 1.4 -1.2 -2.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.9 -0.0 0.4 0.4 0.2 -0.0 0.6 0.9
High cholesterol (Self-reported) 1.7 2.9 9.1 -3.0 1.0 0.9 1.2 -1.8 0.4 2.2
Medication: Bendroflumethiazide 4.1 6.3 11.1 -1.3 -3.3 -3.0 -2.4 0.6 -3.0 -2.6
Medication: Paracetamol 0.6 0.9 4.3 2.1 -0.1 0.7 0.7 0.6 0.3 -0.6
Medication: Lisinopril 0.3 0.4 1.0 1.0 0.6 0.9 0.3 -0.1 0.7 0.1
Medication: Atorvastatin 0.4 0.5 1.0 -0.5 0.9 0.5 1.0 0.3 0.8 -0.4
Illnesses of father: High blood pressure 1.3 1.6 3.5 -1.9 -1.0 -1.7 -1.0 -1.1 -1.1 0.6
Alcohol drinker status: Never 1.3 1.5 6.4 1.5 0.5 0.0 0.4 1.3 0.4 -2.5
Ever smoked 0.0 0.1 0.2 -0.1 0.2 0.1 -0.2 0.1 -0.4 0.5
Basal metabolic rate 1.9 10.7 30.9 5.6 1.4 2.3 1.1 4.5 2.1 -3.2
Leg fat percentage (left) 1.0 3.8 10.8 -1.6 -3.3 -1.8 -2.5 -0.4 -1.8 -0.4
Arm fat-free mass (left) 2.2 11.3 31.2 5.6 2.0 2.7 1.7 4.5 2.2 -2.9
Number of operations (self-reported) 2.6 3.9 6.7 0.4 -2.6 -2.2 -2.6 0.5 -2.2 -2.0
Average weekly beer plus cider intake 0.3 0.4 1.2 -0.0 -0.6 -0.9 -0.3 0.2 -0.4 -1.1
Irritability 0.1 0.3 1.0 1.0 0.2 0.3 0.6 0.1 -0.2 0.4
Risk taking 0.2 0.2 0.7 -0.5 -0.0 -0.1 0.2 0.6 -0.9 -0.4
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.9 1.0 1.1 1.0 0.6 1.7 1.3 -0.2
Fractured/broken bones in last 5 years 0.1 0.2 0.3 -0.6 -0.3 0.2 -0.4 -0.3 0.5 0.2
Age started oral contraceptive pill 0.2 0.3 1.8 -1.3 0.1 0.0 0.2 0.5 0.0 0.2
Diastolic blood pressure, automated reading 1.1 3.4 13.0 2.4 0.6 1.2 1.4 0.4 1.1 -3.6
Ever depressed for a whole week 1.9 2.3 6.9 1.7 1.9 1.1 0.8 2.6 1.0 -0.1
Unable to work because of sickness or disability 4.2 5.4 9.9 -1.8 -2.8 -3.1 -3.1 0.4 -2.7 0.5
Commuting to job workplace: Cycle 0.3 0.4 0.7 0.2 0.8 0.5 0.9 -0.3 0.6 0.6
Myopia 1.1 1.6 6.7 -0.7 -1.2 -0.4 -1.1 -2.6 -0.9 0.6
Vascular/heart problems diagnosed by doctor 2.1 5.8 13.4 1.6 2.8 2.4 2.5 -0.2 2.2 3.7
Cholesterol lowering medication 1.7 2.5 9.9 -3.1 -1.2 -0.9 -0.2 -1.8 -1.5 0.5
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 6.2 1.2 2.1 2.5 1.8 0.5 1.3 0.4
Pain experienced in last month 0.1 0.1 0.6 0.2 0.3 -0.2 -0.1 0.8 -0.2 0.2
Supplements: Calcium 1.3 1.5 3.4 -1.0 -1.0 -0.7 -1.6 -1.9 -1.3 0.3
Basal cell carcinoma (self-reported) 1.1 1.3 2.8 -0.2 -1.4 -1.1 -1.7 0.9 -1.4 -0.1
Heart attack/myocardial infarction (self-reported) 1.2 1.6 2.7 -0.6 1.4 1.2 1.6 0.5 1.6 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 3.1 1.0 -0.4 -0.5 -0.3 0.2 -0.4 -1.8
Heart disease (siblings) 1.2 1.4 3.3 0.1 -0.9 -0.6 -0.9 1.5 -1.5 -1.8
Alcohol drinker status: Previous 0.1 0.1 0.3 0.4 0.4 -0.2 0.0 0.5 0.1 -0.2
Pack years of smoking 0.3 0.4 1.2 0.2 0.9 0.5 0.5 0.7 0.2 1.1
Impedance of whole body 3.9 19.8 34.6 2.6 5.5 5.9 5.4 -0.1 5.3 3.2
Leg fat mass (left) 0.7 2.8 8.7 0.1 -3.0 -1.3 -2.1 0.8 -1.2 -1.7
Arm predicted mass (left) 2.4 12.0 33.1 5.8 2.0 2.7 1.7 4.7 2.3 -3.0