TWAS hub - BCS1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0560	0.0320	9.1e-03	0.010	NA	0.042	NA	0.018	0.04300	NA	2.3e-04	NA	1.2e-02
2	GTEx	Breast Mammary Tissue	0.0530	0.0260	5.0e-03	0.029	NA	0.035	NA	0.024	0.01200	NA	6.8e-03	NA	2.0e-02
3	GTEx	Breast Mammary Tissue (Male)	0.0963	0.0548	2.0e-02	-0.010	NA	0.001	NA	-0.013	0.61000	NA	3.1e-01	NA	9.2e-01
4	GTEx	Breast Mammary Tissue (Female)	0.0595	0.0473	9.4e-02	0.027	NA	-0.010	NA	-0.009	0.05300	NA	8.8e-01	NA	7.1e-01
5	GTEx	Lung	0.0616	0.0391	8.7e-03	-0.003	NA	-0.002	NA	-0.004	0.60000	NA	4.8e-01	NA	8.6e-01
6	GTEx	Thyroid	0.0660	0.0370	4.2e-03	-0.003	NA	-0.004	NA	-0.003	0.64000	NA	9.8e-01	NA	6.6e-01
7	YFS	Blood	0.0270	0.0105	4.9e-06	0.011	0.023	0.020	0.023	0.023	0.00011	3.2e-08	3.3e-07	3.9e-08	4.7e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Height	12.0	231.2	400.0	20.0	16.0	18.2	13.9	12.8	16.5	-1.3
Blood Red Count	11.9	115.2	177.9	11.3	12.3	13.3	12.5	6.6	12.1	2.4
Comparative height size at age 10	10.8	59.3	112.4	10.6	7.5	8.3	6.3	7.8	8.5	-1.9
Standing height	10.3	101.9	187.7	13.7	10.8	11.8	9.0	8.4	10.7	-1.6
Blood Platelet Count	7.6	88.0	237.2	-15.4	-9.4	-10.0	-7.6	-5.3	-10.1	1.8
Impedance of leg (left)	6.5	31.6	54.3	4.6	6.9	7.4	6.8	0.8	6.6	2.6
Pulse wave reflection index	6.2	7.6	15.1	2.8	2.9	3.4	3.9	-0.0	3.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	6.2	12.9	29.6	5.4	4.1	4.0	3.8	2.2	2.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.2	7.3	11.4	-2.7	-3.0	-3.3	-3.2	-0.9	-3.4	-1.0
Mouth/teeth dental problems	6.1	9.4	18.7	3.4	3.1	4.3	3.2	0.1	3.5	1.9
Impedance of leg (right)	5.9	28.6	51.4	4.0	6.5	7.2	6.5	0.6	6.4	2.5
Body Mass Index (BMI) (2010)	5.8	7.9	16.1	-2.4	-4.0	-3.4	-3.5	-1.0	-2.7	-1.2
Sitting height	5.7	40.5	71.6	8.5	7.1	7.6	5.8	4.9	6.8	-0.7
Qualifications: A levels/AS levels or equivalent	5.7	12.6	20.6	3.8	4.4	4.5	4.1	1.2	3.9	1.1
Worry too long after embarrassment	5.1	8.6	14.8	2.3	2.8	3.8	2.8	1.3	3.4	3.3
Ever taken oral contraceptive pill	5.0	5.6	9.2	3.0	3.0	2.4	2.3	2.6	1.8	0.0
Qualifications: O levels/GCSEs or equivalent	4.6	7.4	13.0	3.1	3.5	3.6	2.7	0.9	3.0	-0.2
Body mass index (BMI)	4.3	18.2	37.7	-3.5	-6.1	-5.0	-5.1	-0.9	-4.7	-1.6
Forced vital capacity (FVC)	4.2	16.2	34.5	5.9	4.7	4.1	3.5	3.6	3.8	-1.1
Mouth/teeth dental problems: Dentures	4.2	7.2	11.1	-2.3	-2.9	-3.3	-3.0	0.3	-2.3	-3.3
Unable to work because of sickness or disability	4.2	5.4	9.9	-1.8	-2.8	-3.1	-3.1	0.4	-2.7	0.5
Medication: Bendroflumethiazide	4.1	6.3	11.1	-1.3	-3.3	-3.0	-2.4	0.6	-3.0	-2.6
Allergy or Eczema	4.0	10.6	19.4	-3.4	-4.4	-3.4	-2.7	-3.4	-3.3	-1.2
Eye problems/disorders: Diabetes related eye disease	4.0	4.3	5.1	-2.0	-2.1	-2.1	-2.2	-2.3	-2.2	1.8
Townsend deprivation index at recruitment	3.9	5.4	11.4	-3.4	-1.7	-2.6	-2.7	-0.6	-3.0	0.0
Trunk predicted mass	3.9	22.3	58.4	7.6	3.2	3.9	2.5	6.1	3.7	-4.0
Impedance of whole body	3.9	19.8	34.6	2.6	5.5	5.9	5.4	-0.1	5.3	3.2
BMI	3.8	22.0	40.7	-3.6	-6.4	-5.7	-5.4	-1.3	-5.6	-2.4
Trunk fat-free mass	3.8	21.8	57.9	7.6	3.1	3.8	2.4	6.0	3.7	-3.9
Qualifications: None of the above	3.7	7.9	15.2	-2.3	-3.3	-3.9	-3.3	1.1	-2.8	-1.9
Forced vital capacity (FVC), Best measure	3.6	13.3	28.6	5.3	4.0	3.6	3.0	3.7	3.3	-1.5
Hand grip strength (left)	3.4	9.0	26.1	5.1	3.5	2.7	2.6	2.1	2.4	-0.7
Medication: Amlodipine	3.4	4.8	7.0	-2.5	-2.4	-2.6	-2.4	-0.9	-2.2	-1.8
Ulcerative Colitis	3.3	4.7	15.5	-3.5	-0.8	0.2	-0.7	-3.9	-0.6	1.9
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	28.3	5.3	3.7	3.1	2.6	2.9	2.8	-1.6
Comparative body size at age 10	3.3	9.1	17.9	-1.4	-3.5	-4.2	-3.5	0.8	-3.4	-2.7
Hand grip strength (right)	3.2	8.7	20.4	4.5	3.7	2.9	2.5	2.5	2.5	0.4
Pulse wave Arterial Stiffness index	3.2	3.7	7.9	0.7	1.6	2.6	2.8	-1.1	2.1	1.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	11.3	-2.3	-3.4	-3.0	-2.7	0.2	-2.3	-2.0
Long-standing illness, disability or infirmity	3.1	4.7	8.1	-2.8	-2.2	-2.4	-2.2	-1.1	-2.8	-0.3
Hypertension (Self-reported)	3.0	8.4	13.0	-2.7	-3.6	-3.4	-3.2	0.2	-3.1	-2.7
Arm fat percentage (left)	3.0	12.1	28.8	-3.3	-5.4	-3.8	-4.2	-1.1	-3.4	-0.7
Triglycerides	2.9	4.8	11.0	0.8	2.5	3.1	2.3	0.6	3.3	-0.2
Taking other prescription medications	2.9	4.5	8.4	-1.2	-2.9	-2.6	-2.5	-0.2	-2.4	-1.7
Allergy	2.9	6.7	11.2	3.3	2.6	2.4	1.9	3.3	2.9	-0.6
Arm fat percentage (right)	2.9	11.4	28.7	-3.1	-5.4	-3.5	-4.2	-1.1	-3.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	21.9	4.7	3.3	3.0	2.4	2.7	2.6	-2.0
Primary Biliary Cirrhosis	2.8	4.0	8.5	1.5	2.4	2.7	2.9	-1.3	1.7	-0.1
Chronotype (morning person)	2.8	6.5	11.2	1.8	3.3	3.4	3.2	-0.6	3.0	-0.3
Father’s age at death	2.8	3.7	6.7	-2.5	-2.3	-2.4	-2.6	-0.6	-1.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.0	-1.8	-2.2	-2.0	-2.1	-1.5	-1.6	1.0
Medication: Blood pressure	2.8	5.0	11.9	-1.2	-2.5	-2.2	-2.4	0.8	-1.9	-3.5
Hypothyroidism (self reported)	2.7	6.2	11.8	-2.4	-3.4	-2.9	-2.4	-0.3	-2.4	-2.4
Hayfever, allergic rhinitis or eczema	2.7	5.9	15.8	-2.7	-2.6	-2.0	-1.4	-4.0	-2.4	-0.4
Medication for cholesterol	2.7	4.1	6.8	2.3	2.4	2.4	1.9	-0.2	2.6	1.2
Medication: Co-codamol	2.6	3.0	5.4	-2.2	-1.8	-1.9	-2.3	-0.7	-1.7	0.8
Number of operations (self-reported)	2.6	3.9	6.7	0.4	-2.6	-2.2	-2.6	0.5	-2.2	-2.0
Mouth/teeth dental problems: Loose teeth	2.5	3.0	6.0	0.7	2.5	1.9	2.3	0.8	1.9	0.9
Arm predicted mass (right)	2.5	12.5	34.1	5.8	2.5	2.8	2.1	4.6	2.5	-2.9
High blood pressure	2.4	6.6	10.8	-2.0	-3.1	-2.8	-2.6	0.5	-2.7	-3.3
Alcohol usually taken with meals	2.4	3.8	8.4	2.9	1.2	2.5	1.5	0.8	2.5	1.3
Arm fat-free mass (right)	2.4	12.1	33.4	5.8	2.5	2.8	2.1	4.5	2.4	-2.6
Whole body fat-free mass	2.4	13.9	39.2	6.3	2.0	2.7	1.6	5.1	2.5	-3.5
Arm predicted mass (left)	2.4	12.0	33.1	5.8	2.0	2.7	1.7	4.7	2.3	-3.0
Systolic blood pressure, automated reading	2.3	6.5	12.5	-3.5	-3.1	-2.5	-2.7	-1.7	-2.7	-0.5
Medication: Ramipril	2.3	2.9	9.5	-3.1	-1.9	-1.2	-0.9	-1.5	-1.6	-0.1
Handedness (chirality/laterality): Left-handed	2.3	2.7	5.2	1.5	1.7	2.3	1.8	0.7	2.0	-0.9
Whole body water mass	2.3	13.3	37.8	6.2	1.9	2.5	1.4	5.0	2.3	-3.5
Arm fat-free mass (left)	2.2	11.3	31.2	5.6	2.0	2.7	1.7	4.5	2.2	-2.9
Alzheimer’s Disease (in father)	2.1	2.2	6.3	-0.6	-2.5	-1.5	-2.1	-0.3	-1.5	-0.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.1	-2.3	-1.8	-1.8	-1.4	-1.7	-1.7	-0.1
Time employed in main current job	2.1	2.4	4.4	0.2	-1.5	-1.7	-2.1	1.6	-1.7	-1.5
Medication: Omeprazole	2.1	2.5	4.8	0.9	2.1	2.2	1.7	0.3	1.8	1.0
Osteoarthritis (self-reported)	2.1	2.7	5.8	-0.9	-2.3	-1.8	-2.4	0.8	-1.6	-0.5
Number of self-reported non-cancer illnesses	2.1	3.6	8.2	-2.9	-1.8	-2.2	-1.5	-0.5	-2.3	-0.9
Vascular/heart problems diagnosed by doctor	2.1	5.8	13.4	1.6	2.8	2.4	2.5	-0.2	2.2	3.7
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	6.2	1.2	2.1	2.5	1.8	0.5	1.3	0.4
Major Depression (MDD)	2.0	2.4	3.9	-1.3	-1.9	-2.0	-1.7	0.6	-1.9	-0.9
Ovarian Cancer	2.0	2.6	5.0	-1.5	-1.7	-1.6	-0.9	-2.1	-2.2	-0.6
Noisy workplace	2.0	2.5	4.0	-1.6	-1.7	-1.4	-1.9	-2.0	-1.1	-1.0
Relative age of first facial hair	1.9	3.9	6.3	-2.1	-2.5	-2.2	-2.4	-1.3	-2.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.6	0.3	1.9	1.7	1.7	-0.1	1.9	1.1
Basal metabolic rate	1.9	10.7	30.9	5.6	1.4	2.3	1.1	4.5	2.1	-3.2
Ever depressed for a whole week	1.9	2.3	6.9	1.7	1.9	1.1	0.8	2.6	1.0	-0.1
Happiness	1.8	2.2	13.3	1.1	0.9	0.1	0.2	3.6	0.5	-0.1
Age at first live birth	1.8	3.2	4.9	0.7	1.6	2.0	2.2	-2.0	1.1	2.2
Breastfed as a baby	1.7	2.2	5.5	2.3	1.2	1.6	1.1	0.9	1.7	-0.9
Peak expiratory flow (PEF)	1.7	3.9	11.9	3.5	1.9	1.2	0.7	2.3	0.8	-1.9
Pulse wave peak to peak time	1.7	2.0	4.2	0.2	-0.6	-1.6	-2.0	1.6	-1.3	-1.5
Emphysema/chronic bronchitis	1.7	1.9	4.1	-2.0	-0.6	-0.2	-0.6	-1.8	-1.0	2.0
Age at last live birth	1.7	2.5	12.3	-0.1	0.8	0.9	0.9	-1.7	-0.0	3.5
Financial situation satisfaction	1.7	2.2	4.0	0.6	1.8	1.4	0.7	2.0	1.1	2.0
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.8	-0.7	-1.6	-1.5	-1.3	1.4	-1.2	-2.2
High cholesterol (Self-reported)	1.7	2.9	9.1	-3.0	1.0	0.9	1.2	-1.8	0.4	2.2
Cholesterol lowering medication	1.7	2.5	9.9	-3.1	-1.2	-0.9	-0.2	-1.8	-1.5	0.5
Age at First Birth	1.6	2.4	4.7	-0.4	-1.5	-1.7	-1.3	-0.7	-2.2	-2.1
Respiratory disease	1.6	3.5	11.6	-3.4	-1.8	-1.6	-1.4	-1.3	-1.7	0.6
Number of treatments/medications taken	1.6	2.9	6.6	-1.3	-2.6	-1.6	-1.5	-0.8	-1.6	-2.0
Medication: Levothyroxine sodium	1.6	2.8	4.8	-1.3	-2.2	-1.8	-1.8	0.8	-1.4	-1.9
Impedance of arm (right)	1.6	7.6	14.7	1.1	2.9	3.8	2.9	-0.2	3.8	2.5
Impedance of arm (left)	1.6	7.3	12.2	0.5	3.1	3.5	3.0	-0.6	3.4	3.0
Heart disease (mother)	1.6	1.9	9.9	0.4	-1.0	-0.5	-0.5	1.0	-0.8	-3.1
Illnesses of father: Heart disease	1.6	2.2	5.1	1.4	1.6	1.8	2.3	-0.3	1.4	0.8
Diabetes (father)	1.5	1.8	7.3	-2.7	-0.1	-0.7	-0.4	-0.3	-0.2	2.2
Serious illness, injury or assault to yourself	1.5	1.8	3.3	-1.8	-1.4	-1.5	-1.7	-0.3	-1.0	-1.1
Qualifications: College or University degree	1.5	4.9	7.9	2.8	1.9	2.8	2.8	0.1	2.3	1.2
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.4	1.0	1.7	1.5	1.6	0.6	1.9	0.4
Arm fat mass (left)	1.5	6.3	17.0	-1.3	-4.1	-2.6	-3.2	0.4	-2.5	-1.6
Average weekly champagne plus white wine intake	1.5	2.1	5.4	0.7	1.4	1.5	1.1	1.4	1.1	2.3
Wears glasses or contact lenses	1.5	1.8	4.8	-2.2	-1.0	-0.2	-1.0	-2.1	-0.2	1.0
Hearing aid user	1.5	1.7	3.4	0.0	-1.1	-1.6	-1.9	1.1	-1.6	0.9
Irritable Bowel Disease (IBD)	1.4	3.3	10.9	-3.3	-1.0	-0.8	-0.5	-2.3	-1.4	1.8
Neuroticism (2016)	1.4	2.1	4.7	1.7	1.8	1.3	2.2	0.5	1.3	-0.3
Heart attack	1.4	1.8	3.1	-0.4	1.5	1.3	1.8	0.4	1.6	-1.6
Depression (self-reported)	1.4	1.6	3.9	-0.1	2.0	0.8	1.7	0.9	0.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.5	-0.2	1.5	1.5	0.8	1.2	1.3	1.9
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.7	2.8	1.8	1.9	1.7	1.9	1.2	-0.4
Prostate Cancer	1.3	1.8	6.1	1.6	0.4	0.3	0.6	1.7	0.4	-2.5
Supplements: Zinc	1.3	1.4	3.9	-0.4	1.1	1.4	0.9	-0.6	1.3	2.0
Medication: Atenolol	1.3	1.7	4.8	0.9	0.7	0.8	0.8	1.9	1.0	-2.2
Had menopause	1.3	1.6	5.4	-2.3	-1.1	-0.7	-1.1	-0.3	-0.2	1.7
Medication: Lansoprazole	1.3	1.4	5.3	1.3	0.3	0.9	0.2	1.1	1.1	-2.3
Arm fat mass (right)	1.3	5.5	15.8	-1.1	-4.0	-2.3	-2.9	0.4	-2.1	-1.7
Wheeze or whistling in the chest in last year	1.3	2.3	3.9	-2.0	-0.8	-1.9	-0.8	-1.8	-1.8	-0.5
Neck or shoulder pain in last month	1.3	1.9	4.8	-1.2	-1.8	-1.4	-1.1	-0.1	-2.2	-0.7
Osteoporosis (self-reported)	1.3	1.6	4.8	-0.1	-1.3	-1.4	-1.0	-0.5	-2.2	-1.1
Illnesses of father: High blood pressure	1.3	1.6	3.5	-1.9	-1.0	-1.7	-1.0	-1.1	-1.1	0.6
Alcohol drinker status: Never	1.3	1.5	6.4	1.5	0.5	0.0	0.4	1.3	0.4	-2.5
Supplements: Calcium	1.3	1.5	3.4	-1.0	-1.0	-0.7	-1.6	-1.9	-1.3	0.3
Blood White Count	1.2	9.0	24.2	4.1	0.1	1.2	0.5	4.4	0.7	-4.9
Hearing difficulty/problems with background noise	1.2	1.9	3.9	1.6	1.6	1.4	1.2	2.0	0.5	0.6
Diabetes (self-reported)	1.2	1.8	4.9	-1.9	-1.2	-0.9	-1.2	-0.8	-0.4	2.2
Fluid intelligence score	1.2	2.4	5.4	2.3	1.7	1.6	2.1	0.7	1.1	-0.3
Asthma	1.2	2.3	7.5	-2.7	-0.9	-0.9	-0.6	-1.7	-1.3	1.4
Medication: Seretide 50 evohaler	1.2	1.3	3.4	-1.3	-0.6	-1.5	-1.0	-0.3	-1.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	4.4	-2.1	-1.0	-0.9	-0.6	-1.8	-0.7	0.1
Medication: Blood pressure	1.2	2.2	4.6	-1.6	-2.1	-1.8	-1.2	-0.7	-1.8	-0.6
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.7	-0.6	1.4	1.2	1.6	0.5	1.6	-1.3
Heart disease (siblings)	1.2	1.4	3.3	0.1	-0.9	-0.6	-0.9	1.5	-1.5	-1.8
Crohns Disease (2017)	1.1	2.4	8.6	-2.9	-1.2	-1.4	0.4	-1.3	-1.6	0.7
HDL Cholesterol	1.1	1.9	4.3	-0.2	-1.8	-1.6	-2.1	0.3	-1.7	-0.3
Neuroticism	1.1	2.6	5.1	2.3	1.6	1.7	1.6	2.0	1.1	-0.1
Ever had hysterectomy (womb removed)	1.1	1.3	2.3	0.8	1.2	1.4	1.3	0.9	1.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.5	-0.7	-1.4	-1.6	-1.0	0.8	-1.9	-0.4
Neuroticism score	1.1	2.3	6.1	1.6	1.5	1.5	1.4	2.5	0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	0.4	0.7	1.5	1.2	-0.6	1.7	1.5
Medication: Paracetamol	1.1	1.7	7.6	2.8	0.3	1.0	1.0	0.8	0.7	-1.2
Leg fat percentage (right)	1.1	4.0	11.7	-1.9	-3.4	-1.7	-2.4	-0.7	-1.8	-0.3
Overall health rating	1.1	2.4	3.6	-1.2	-1.9	-1.9	-1.8	0.2	-1.8	-1.4
Leg fat-free mass (right)	1.1	5.8	17.7	4.2	0.3	0.9	0.1	3.7	0.9	-2.8
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	1.0	1.7	1.5	1.4	0.3	1.0	0.4
Leg predicted mass (right)	1.1	5.7	17.1	4.1	0.3	0.8	0.1	3.6	0.8	-2.8
Diastolic blood pressure, automated reading	1.1	3.4	13.0	2.4	0.6	1.2	1.4	0.4	1.1	-3.6
Myopia	1.1	1.6	6.7	-0.7	-1.2	-0.4	-1.1	-2.6	-0.9	0.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.8	-0.2	-1.4	-1.1	-1.7	0.9	-1.4	-0.1
Average weekly spirits intake	1.0	1.3	2.8	-1.2	-1.3	-1.1	-1.2	-0.4	-1.7	-0.2
Leg fat-free mass (left)	1.0	5.2	15.1	3.9	0.0	0.8	-0.0	3.5	0.8	-2.8
Relative age voice broke	1.0	1.6	3.4	-1.8	-0.5	-1.1	-0.5	-1.3	-1.7	1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.0	-1.1	-1.4	-1.1	-1.3	-0.1	-0.8	-0.7
Leg predicted mass (left)	1.0	5.3	15.4	3.9	0.1	0.9	0.0	3.5	0.8	-2.8
Hair/balding pattern: Pattern 3	1.0	1.5	3.7	1.4	1.6	1.0	1.2	-0.3	-0.1	1.9
Pulse rate, automated reading	1.0	3.1	6.0	0.5	1.7	2.4	2.4	-0.8	1.5	2.0
Had major operations	1.0	1.2	4.2	1.7	-0.9	0.3	-0.0	0.6	0.3	-2.0
Supplements: Vitamin C	1.0	1.1	2.4	0.7	-0.5	-0.4	-1.6	1.5	-0.4	-1.5
Diabetes diagnosed by doctor	1.0	1.6	3.3	-1.8	-1.1	-0.8	-0.9	-1.3	-0.7	1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.1	-1.8	-0.9	-1.4	-0.3	-1.4	-1.4	0.9
Asthma (self-reported)	1.0	2.1	6.8	-2.6	-0.9	-1.1	-0.9	-1.3	-1.2	1.3
Leg fat percentage (left)	1.0	3.8	10.8	-1.6	-3.3	-1.8	-2.5	-0.4	-1.8	-0.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.9	1.0	1.1	1.0	0.6	1.7	1.3	-0.2
Worry (Nagel 2018)	0.9	1.8	3.6	1.8	1.2	1.4	1.6	1.9	0.6	-0.1
Ulcerative Colitis (UC)	0.9	1.6	3.8	-1.9	-0.3	0.3	-0.7	-1.8	-0.7	1.8
Lung FVC	0.9	4.7	11.1	-1.7	-2.4	-3.0	-3.3	0.3	-2.0	0.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.2	0.9	-0.5	-0.4	-0.2	2.0	-0.6	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.7	0.4	2.4	0.8	1.9	1.4	1.4	-0.8
Exposure to tobacco smoke at home	0.9	1.0	3.4	-0.5	-0.8	-1.4	-1.0	0.1	-1.8	0.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.0	-1.0	-0.5	-1.2	-0.7	-1.7	-1.1	-0.6
Migraine (self-reported)	0.9	1.1	2.7	1.0	1.6	1.0	1.5	0.8	0.7	-0.2
Average weekly red wine intake	0.9	1.4	7.3	2.7	-0.3	0.4	-0.5	0.5	-0.2	-1.3
Mother’s age at death	0.9	1.1	2.8	-0.6	-1.5	-1.1	-1.7	0.3	-0.7	-0.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.5	0.4	0.8	1.2	0.6	1.0	1.2	1.2
Crohns Disease (2012)	0.8	1.2	3.1	-1.8	-0.3	0.3	1.2	-1.7	0.0	1.1
Medication: Metformin	0.8	1.1	3.0	-1.1	-1.0	-0.3	-0.5	-1.4	-0.7	1.7
High blood pressure (mother)	0.8	1.1	2.5	-0.5	-1.6	-1.0	-1.4	-0.9	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.6	1.3	0.8	0.1	0.3	1.9	0.5	-0.8
Medication: Simvastatin	0.8	1.1	3.6	-1.9	-0.4	0.1	0.3	-1.9	-0.7	-0.0
Tense / ‘highly strung’	0.8	1.4	4.1	2.0	0.8	1.2	1.1	1.4	0.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.7	1.4	1.1	0.6	1.4	0.0	0.8	1.6
Gout (self-reported)	0.8	1.1	2.2	-1.5	-0.9	-1.0	-0.4	-1.2	-0.5	-1.3
Body fat percentage	0.8	3.2	10.8	-1.5	-3.3	-1.4	-2.2	-0.6	-1.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.9	-1.1	-0.2	-0.9	-0.7	1.7	-1.1	-0.9
Number of full sisters	0.8	1.0	2.1	-1.5	-0.6	-1.3	-0.9	0.3	-1.4	-0.1
Knee pain experienced in last month	0.8	1.2	2.6	0.1	-1.3	-1.0	-1.6	-0.9	-0.8	-1.4
Loneliness, isolation	0.8	1.1	4.2	-0.0	-0.7	-1.5	-1.0	0.0	-2.0	-0.0
Rheumatoid Arthritis	0.7	1.0	3.5	1.3	0.1	0.1	-0.4	1.9	-0.2	-1.1
Waist Hip Ratio (WHR)	0.7	3.3	6.6	-0.0	2.4	2.6	2.5	0.8	1.8	-0.8
Maternal smoking around birth	0.7	1.1	3.9	1.5	0.1	-0.3	-0.0	1.0	-0.3	-2.0
Hair/balding pattern: Pattern 2	0.7	0.9	4.1	-2.0	-0.7	0.1	-0.1	-0.3	0.4	1.0
Had other major operations	0.7	0.9	1.9	0.9	-1.4	-0.6	-1.2	-0.7	-0.9	0.0
Illnesses of siblings	0.7	0.9	2.0	-0.9	-0.2	-1.4	-0.1	-1.4	-0.6	1.2
Weight	0.7	3.3	8.8	2.8	-0.9	0.6	-0.7	3.0	0.4	-2.2
Alcohol intake versus 10 years previously	0.7	1.0	4.0	-1.3	-0.4	-0.8	-0.3	-2.0	-0.8	0.2
Worrier / anxious feelings	0.7	1.4	2.9	1.1	1.0	1.3	1.4	1.7	0.8	-0.4
Prospective memory result	0.7	0.9	2.5	-1.6	-0.1	-0.2	0.2	-1.1	-0.2	1.5
Illnesses of mother	0.7	0.9	2.3	0.9	0.9	0.9	0.8	0.1	0.6	1.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	-0.7	-0.9	-0.8	-0.6	-1.5	-1.4	0.3
Eye problems/disorders: None of the above	0.7	0.9	2.7	1.7	0.6	0.9	0.2	1.0	0.7	0.7
Leg fat mass (right)	0.7	2.6	8.6	-0.1	-2.9	-1.1	-2.0	0.7	-1.2	-1.6
Leg pain on walking	0.7	0.9	2.3	-1.0	-1.1	-0.8	-1.5	-0.2	-1.0	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.7	-0.4	1.6	0.9	1.0	-0.8	-0.1	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.3	0.6	-0.2	-0.4	0.1	1.8	-0.3	-1.2
Friendships satisfaction	0.7	0.8	1.7	-0.0	1.3	0.5	1.0	1.0	0.1	1.3
Leg fat mass (left)	0.7	2.8	8.7	0.1	-3.0	-1.3	-2.1	0.8	-1.2	-1.7
Cardiovascular Disease	0.6	2.1	6.4	-1.4	-1.0	-1.2	-0.7	-0.8	-1.8	-2.5
Sensitivity / hurt feelings	0.6	1.1	4.1	-0.0	0.9	0.9	0.9	2.0	0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.2	-1.8	-0.1	0.2	-0.7	0.5	0.2	1.2
Medication for hormone replacement therapy	0.6	0.7	1.5	-0.8	-0.7	-0.9	-1.2	1.0	-0.6	-0.4
Stomach or abdominal pain in last month	0.6	0.7	2.9	-1.7	-0.9	-0.6	-0.4	-0.7	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	-1.8	-0.5	-0.6	-0.2	0.1	-0.7	0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-0.4	-0.9	-0.6	-1.4	0.3	-0.7	-0.8
Waist circumference	0.6	2.4	5.3	-0.2	-2.3	-1.0	-2.2	1.2	-1.1	-1.6
Hip circumference	0.6	2.5	4.6	1.6	-2.0	-0.4	-2.1	1.5	-0.2	-1.8
Falls in the last year	0.6	0.8	2.2	-1.1	-0.6	-0.6	-0.5	-1.5	-0.8	0.9
Length of working week for main job	0.6	0.6	2.2	-0.3	-0.7	-0.8	-0.7	0.2	-0.6	-1.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.8	0.0	-1.1	0.1	0.2	-1.3	1.4
Blood clot in the leg (DVT)	0.6	0.7	3.2	0.9	-0.5	-0.6	-0.4	0.2	-0.6	-1.8
High blood pressure (siblings)	0.6	0.9	1.6	1.1	0.4	1.1	0.3	1.3	0.7	-1.1
Exposure to tobacco smoke outside home	0.6	0.8	1.7	0.7	-1.3	-0.7	-1.0	-0.3	-0.1	-1.3
Number of children fathered	0.6	0.6	2.5	0.2	-0.5	-0.5	0.1	1.2	-0.1	-1.6
Medication: Allopurinol	0.6	0.9	3.0	-1.7	-1.0	-0.7	-0.5	-0.8	-0.7	0.2
Suffer from ‘nerves’	0.6	0.9	3.1	0.8	0.4	0.1	1.2	1.8	-1.0	-0.2
Family relationship satisfaction	0.6	0.8	2.8	-0.1	0.9	0.7	0.3	1.7	0.8	0.6
Qualifications: nursing, teaching	0.6	0.9	2.0	1.1	1.0	0.8	1.4	-0.2	0.8	1.0
Guilty feelings	0.6	0.9	3.2	0.8	0.7	1.1	0.3	1.8	-0.1	-0.7
Medication: Paracetamol	0.6	0.9	4.3	2.1	-0.1	0.7	0.7	0.6	0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.5	1.7	3.4	1.8	1.4	1.6	1.3	0.8	0.7	-1.0
Neuroticism (Nagel 2018)	0.5	1.2	2.3	1.5	1.0	1.0	1.3	1.5	0.5	-0.2
Bipolar Disorder (2011)	0.5	0.5	1.9	-0.9	0.4	0.6	1.4	0.0	0.0	-0.1
Blood Eosinophil Count	0.5	4.1	10.4	3.2	1.1	2.8	1.6	0.3	2.5	0.6
Multivitamins +/- minerals	0.5	0.6	3.4	-0.5	0.2	0.2	0.5	-0.4	0.5	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.3	0.9	0.8	1.0	1.5	0.6	-0.1	-0.0
Number of full brothers	0.5	0.7	2.7	0.1	0.5	0.3	1.1	-0.4	0.5	-1.6
Medication: Ibuprofen	0.5	0.7	2.3	-0.1	-0.2	0.7	0.4	-0.7	1.0	1.5
Whole body fat mass	0.5	1.9	6.6	0.3	-2.6	-0.7	-1.7	0.8	-0.7	-1.5
Alcohol intake frequency.	0.5	1.2	3.6	-0.1	-0.9	-1.4	-0.9	0.2	-1.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.4	-0.8	0.0	0.6	0.5	-1.5	0.4	0.1
Commuting to job workplace: Walk	0.5	0.6	2.6	-0.5	0.2	0.4	-0.7	-0.8	0.1	1.6
Eye problems/disorders: Cataract	0.5	0.5	2.1	0.2	-0.7	-0.9	-0.4	0.2	-0.5	-1.4
Breast cancer (self-reported)	0.5	0.6	2.4	0.6	0.4	0.8	-0.2	1.6	0.3	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-0.5	1.3	0.8	0.9	-0.4	0.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	3.1	1.0	-0.4	-0.5	-0.3	0.2	-0.4	-1.8
Schizophrenia (2018)	0.4	0.7	1.7	-1.0	-0.4	-0.6	-0.6	-1.2	-1.3	-0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	-0.9	-0.2	0.2	0.2	-0.8	0.0	1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.5	-1.4	-0.3	-1.2	0.2	0.0	0.6
HbA1C	0.4	0.5	1.5	0.5	-1.2	-0.7	-0.8	0.2	-0.2	-0.7
Tanning	0.4	4.9	9.1	-2.8	-2.2	-3.0	-2.2	-0.8	-2.4	-1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.8	0.1	-0.4	-0.4	1.3	-1.1	0.4
Angina	0.4	0.5	2.5	-0.2	-0.3	0.3	-0.3	0.4	0.5	-1.6
Trunk fat percentage	0.4	1.7	7.0	-0.7	-2.6	-0.8	-1.7	-0.2	-0.7	-0.4
Current tobacco smoking	0.4	0.7	1.7	-1.3	-0.2	-0.9	-1.0	-0.3	-1.0	-0.2
Average weekly fortified wine intake	0.4	0.5	1.5	-0.7	-0.8	-0.7	-0.4	0.2	-0.2	1.2
Number of incorrect matches in round	0.4	0.7	3.4	-1.1	0.3	0.5	0.3	0.3	-0.1	1.8
Pain all over the body in last month	0.4	0.4	1.2	-0.3	0.2	-0.3	0.4	1.0	-0.3	-1.1
Medication: Cholesterol lowering	0.4	0.7	1.4	-1.2	0.7	1.1	0.8	-0.6	0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	3.3	-0.3	0.3	0.4	0.4	1.8	0.1	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.5	0.3	0.8	0.3	1.2	-0.4	0.1	-0.7
Birth weight	0.4	0.8	4.6	0.8	0.3	0.1	0.1	2.1	-0.0	-0.4
Mean time to correctly identify matches	0.4	0.7	1.9	-1.4	-0.5	-0.9	-0.5	-0.5	-1.0	0.5
Chest pain or discomfort	0.4	0.5	1.6	0.0	0.6	0.6	1.1	-0.3	-0.1	-1.2
Medication: Aspirin	0.4	0.5	1.4	-0.6	-0.5	-0.5	-0.5	-0.2	-0.9	-1.2
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.7	-0.7	0.1	-0.8	0.9	0.0	-1.2
Ever had bowel cancer screening	0.4	0.5	2.3	-1.5	-0.6	-0.5	-0.2	-0.6	-0.5	0.1
Back pain experienced in last month	0.4	0.6	1.3	-0.9	-1.1	-0.6	-0.1	-1.1	-0.6	-0.2
Smoking status: Current	0.4	0.6	2.0	-1.4	-0.0	-0.7	-0.6	-0.8	-0.9	0.1
Commuting to job workplace: Public transport	0.4	0.5	1.2	0.1	0.7	1.1	0.3	-0.2	1.1	0.8
Medication: Atorvastatin	0.4	0.5	1.0	-0.5	0.9	0.5	1.0	0.3	0.8	-0.4
Depression (Nagel 2018)	0.3	0.4	0.8	-0.3	-0.8	-0.8	0.1	0.9	-0.8	-0.0
Mean Putamen Volume	0.3	0.3	0.7	0.8	-0.0	0.5	0.5	0.6	0.0	-0.8
Fasting Glucose	0.3	0.3	0.8	-0.9	-0.5	-0.9	-0.5	-0.3	-0.5	0.0
LDL Cholesterol	0.3	0.5	0.9	-0.1	0.5	0.9	-0.5	-0.8	0.9	0.6
Heel T-Score	0.3	2.5	6.5	-2.5	1.5	0.1	1.3	-2.5	0.7	0.3
Lung FEV1/FVC ratio	0.3	1.7	9.5	0.8	-0.5	-0.4	-0.3	-0.7	-0.8	-3.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	0.6	0.0	0.2	-0.3	1.4	0.0	-0.5
Vitamin and mineral supplements	0.3	0.4	0.8	0.5	0.6	0.6	0.9	0.7	0.5	-0.5
Severe depression (siblings)	0.3	0.4	0.9	-0.3	0.8	0.2	0.8	0.4	-0.1	0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.0	-0.2	-0.3	-0.1	0.9	-0.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.5	-0.6	1.6	0.6	0.7	0.5	0.8	0.5
Trunk fat mass	0.3	1.4	3.4	1.2	-1.9	0.1	-1.1	1.3	0.1	-1.5
Number of live births	0.3	0.4	1.0	-0.6	-0.1	-0.3	-0.7	-1.0	-0.8	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.5	0.9	-1.6	0.2	-0.2	-0.2	-1.5	0.1
Birth weight of first child	0.3	0.5	1.8	1.4	0.2	-0.0	0.6	0.4	0.2	-1.2
Loud music exposure frequency	0.3	0.3	0.7	0.1	0.2	0.3	-0.3	0.9	0.8	-0.7
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.2	-0.8	-0.3	-0.8	-0.6	-0.7	-0.2
Angina (self-reported)	0.3	0.4	2.0	-0.3	-0.3	0.3	-0.2	0.2	0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	0.3	0.7	0.7	0.5	0.4	1.2	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	-0.3	0.6	0.4	0.5	0.1	0.3	1.1
Medication: Lisinopril	0.3	0.4	1.0	1.0	0.6	0.9	0.3	-0.1	0.7	0.1
Average weekly beer plus cider intake	0.3	0.4	1.2	-0.0	-0.6	-0.9	-0.3	0.2	-0.4	-1.1
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.2	0.8	0.5	0.9	-0.3	0.6	0.6
Pack years of smoking	0.3	0.4	1.2	0.2	0.9	0.5	0.5	0.7	0.2	1.1
Bipolar Disorder (2018)	0.2	0.3	1.5	-0.4	0.4	-0.1	0.0	1.2	-0.3	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-1.0	-0.1	-0.5	-0.5	0.1	-1.2	-0.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	0.4	-0.2	-0.7	0.0	0.6	-0.9	-0.8
Reaction Time	0.2	0.4	1.1	-0.6	0.0	-0.6	0.1	-0.5	-1.0	0.7
Breast Cancer	0.2	0.5	1.0	-1.0	-0.0	0.6	-0.2	0.9	1.0	0.5
Schizophrenia (2014)	0.2	0.4	1.3	-0.7	-0.4	-0.6	-0.4	-0.3	-1.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.5	0.3	0.5	0.5	0.2	0.0	0.7
Systolic Blood Pressure	0.2	1.0	2.0	-1.4	-0.8	-0.5	-0.3	-1.4	-0.8	-1.3
Diabetes (mother)	0.2	0.2	0.8	-0.9	-0.3	-0.7	0.5	0.2	-0.2	-0.1
Pack years adult smoking proportion	0.2	0.4	1.7	-0.1	0.8	0.2	0.4	0.1	-0.0	1.3
Fed-up feelings	0.2	0.4	1.0	-0.8	-0.0	-0.4	-0.3	0.5	-1.0	0.8
Qualifications: CSEs or equivalent	0.2	0.3	1.1	-0.5	-0.2	-0.2	-0.4	-0.8	-0.3	1.1
Nervous feelings	0.2	0.3	1.3	0.3	-0.1	0.1	0.6	1.1	-0.6	0.5
Pulse rate	0.2	0.4	1.2	-0.8	0.3	0.4	-0.1	-0.6	-0.3	1.1
Lung cancer (father)	0.2	0.3	0.6	-0.6	-0.5	-0.8	0.2	-0.1	-0.6	-0.7
Headache pain in last month	0.2	0.3	1.2	1.1	0.3	0.3	0.7	-0.5	0.1	-0.0
Glaucoma (self-reported)	0.2	0.3	1.4	-0.4	1.2	0.2	0.4	0.0	-0.2	-0.3
Health satisfaction	0.2	0.3	1.1	-0.3	0.4	0.4	0.2	0.9	0.1	1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	-1.0	0.2	-0.6	-0.3	0.1	-0.4	1.0
Medication: Aspirin	0.2	0.3	1.2	-0.2	-0.2	-0.2	-0.4	0.1	-0.7	-1.1
Medication: Gliclazide	0.2	0.2	0.9	0.1	-0.2	0.1	0.0	-0.5	-0.1	1.0
Miserableness	0.2	0.4	1.4	0.8	-0.3	-0.1	-0.5	1.2	-0.5	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.9	-0.0	0.4	0.4	0.2	-0.0	0.6	0.9
Risk taking	0.2	0.2	0.7	-0.5	-0.0	-0.1	0.2	0.6	-0.9	-0.4
Age started oral contraceptive pill	0.2	0.3	1.8	-1.3	0.1	0.0	0.2	0.5	0.0	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.3	0.2	0.2	0.4	0.3	0.0	-0.2
Lupus	0.1	0.1	0.4	0.3	-0.1	0.2	0.4	-0.0	-0.4	-0.6
Smoking Status	0.1	0.1	0.4	-0.2	0.2	-0.4	-0.2	-0.0	-0.6	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.6	-0.5	-0.2	-0.1	-0.0	-0.3	0.8
Age when periods started (menarche)	0.1	0.2	0.8	-0.9	0.1	0.1	0.1	-0.5	-0.5	0.1
Supplements: Glucosamine	0.1	0.1	0.3	0.3	-0.2	-0.1	-0.0	0.0	0.2	-0.5
Financial difficulties in last 2 years	0.1	0.2	0.5	0.4	0.3	0.6	-0.3	0.7	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.5	0.3	0.2	0.7	0.4	-0.1	-0.5
Smoking status: Previous	0.1	0.2	0.4	-0.2	-0.5	-0.5	-0.4	0.6	-0.6	-0.0
Mood swings	0.1	0.2	0.7	0.5	0.8	0.2	0.8	-0.1	-0.0	-0.2
Mineral and other dietary supplements	0.1	0.2	0.8	-0.0	-0.1	-0.1	0.1	0.9	-0.2	-0.5
Irritability	0.1	0.3	1.0	1.0	0.2	0.3	0.6	0.1	-0.2	0.4
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.6	-0.3	0.2	-0.4	-0.3	0.5	0.2
Pain experienced in last month	0.1	0.1	0.6	0.2	0.3	-0.2	-0.1	0.8	-0.2	0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	0.4	0.4	-0.2	0.0	0.5	0.1	-0.2
Hair Pigment	0.0	1.0	2.5	-0.5	-1.4	-0.7	-1.0	1.6	0.2	0.8
Past tobacco smoking	0.0	0.1	0.3	-0.2	-0.0	-0.0	0.3	-0.5	0.2	-0.1
Ever smoked	0.0	0.1	0.2	-0.1	0.2	0.1	-0.2	0.1	-0.4	0.5

Hub : Genes

BCS1L

Models

Trait associations