TWAS hub - DIRC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1235	0.0313	2.2e-06	0.071	0.061	0.076	0.078	0.073	1.8e-09	2.8e-08	4.9e-10	2.7e-10	9.9e-10
2	TCGA	Breast Invasive Carcinoma	0.0262	0.0125	9.8e-04	0.013	0.012	0.009	NA	0.006	7.2e-04	1.4e-03	4.8e-03	NA	1.6e-02
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0854	0.0318	4.1e-06	0.098	0.048	0.089	NA	0.090	3.9e-11	3.6e-06	3.0e-10	NA	2.5e-10
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1215	0.0437	1.3e-03	0.011	0.018	0.012	NA	0.016	1.7e-02	3.3e-03	1.3e-02	NA	6.2e-03
5	TCGA	Thyroid Carcinoma	0.0780	0.0290	4.7e-05	0.063	0.053	0.045	NA	0.069	8.8e-07	6.1e-06	3.0e-05	NA	2.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Breast Cancer	15.8	38.1	69.6	-1.0	-5.4	-8.3	-4.7	8.3
Trunk fat-free mass	6.7	38.5	77.3	8.0	0.8	0.6	7.1	8.8
Trunk predicted mass	6.7	38.5	76.7	8.0	0.8	0.7	7.2	8.8
Whole body water mass	6.6	37.8	78.0	7.8	0.8	0.6	7.1	8.8
Whole body fat-free mass	6.5	37.4	76.2	7.7	0.9	0.7	7.0	8.7
Sitting height	6.4	45.2	110.2	8.0	-3.1	-2.2	6.1	10.5
Leg fat-free mass (right)	6.4	34.3	68.9	7.2	1.1	0.9	7.0	8.3
Leg predicted mass (right)	6.4	34.0	69.2	7.1	1.0	0.9	7.0	8.3
Migraine (self-reported)	6.2	7.7	13.5	2.2	2.8	3.7	3.5	0.5
Arm fat-free mass (left)	6.2	31.3	67.6	6.9	0.7	0.1	6.3	8.2
Arm predicted mass (left)	6.2	31.3	65.4	7.2	0.6	0.0	6.3	8.1
Arm predicted mass (right)	6.1	31.1	64.6	7.2	0.4	-0.0	6.3	8.0
Arm fat-free mass (right)	5.8	29.8	62.6	7.0	0.4	0.1	6.1	7.9
Basal metabolic rate	5.8	32.2	66.4	7.2	0.7	0.4	6.5	8.2
Leg predicted mass (left)	5.6	29.6	64.5	6.5	0.7	0.7	6.3	8.0
Leg fat-free mass (left)	5.5	29.4	64.6	6.5	0.7	0.7	6.2	8.0
Serious illness, injury or assault of a close relative in last 2 years	5.0	5.8	14.6	0.2	3.8	3.7	0.7	-0.6
Breast cancer (self-reported)	4.6	5.5	10.9	-0.2	2.8	3.3	0.4	-2.9
Height	4.5	85.8	201.6	12.5	-2.7	-1.0	7.9	14.2
Impedance of leg (right)	4.4	21.3	41.0	-3.9	-2.4	-2.1	-6.4	-6.3
Standing height	4.0	40.2	91.4	9.6	-0.3	0.4	6.0	8.6
Impedance of leg (left)	3.7	18.1	39.7	-3.2	-2.1	-2.0	-5.6	-6.3
Headache pain in last month	3.7	6.4	13.8	1.6	2.2	2.9	3.7	1.6
Birth weight	3.3	7.1	11.9	3.3	2.0	1.9	3.5	2.3
Impedance of whole body	3.3	16.6	36.0	-3.9	-1.1	-0.8	-5.5	-6.0
Weight	3.2	15.8	31.1	5.2	0.6	-0.1	4.5	5.6
Heel T-Score	3.1	25.0	68.7	-8.3	-5.6	-3.1	-3.8	-0.1
Comparative height size at age 10	3.1	16.9	43.6	6.6	0.4	0.2	4.4	4.7
Pain experienced in last month	3.0	5.0	7.4	-2.4	-1.6	-1.5	-2.6	-2.7
Waist Hip Ratio (WHR)	2.7	12.0	19.3	-2.6	-3.3	-3.4	-4.4	-3.4
Impedance of arm (left)	2.7	12.3	28.6	-3.5	-0.2	0.6	-4.5	-5.3
Birth weight of first child	2.7	4.9	16.3	4.0	1.3	0.8	1.6	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	16.5	4.1	-1.1	-1.0	2.4	1.8
Hand grip strength (left)	2.6	6.8	25.6	5.1	1.2	0.7	2.3	1.1
Lung FVC	2.5	12.7	27.5	-0.6	-5.2	-3.2	-4.7	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.1	5.5	-2.4	0.6	1.9	1.0	2.2
Medication: Gliclazide	2.5	2.8	11.6	0.1	1.0	0.8	-0.9	-3.4
Supplements: Calcium	2.5	2.8	4.9	0.2	2.1	2.1	2.2	-0.3
Impedance of arm (right)	2.4	11.2	27.1	-3.1	-0.7	0.1	-4.3	-5.2
Neck or shoulder pain in last month	2.4	3.5	14.8	-0.5	-1.3	-0.7	0.3	3.8
Medication: Blood pressure	2.4	4.3	9.3	0.9	-2.7	-3.1	-1.4	-1.3
Number of operations (self-reported)	2.4	3.5	7.1	0.2	2.7	2.5	1.8	1.1
Forced vital capacity (FVC)	2.3	9.0	17.3	4.2	-3.7	-2.3	0.3	2.9
Forced expiratory volume in 1-second (FEV1)	2.3	7.6	16.0	3.5	-4.0	-2.2	-0.8	2.0
Medication: Ibuprofen	2.3	2.7	4.2	-1.9	1.0	2.0	0.9	2.0
Average weekly fortified wine intake	2.2	2.5	6.5	-2.5	-0.4	1.3	-0.5	2.0
Supplements: Glucosamine	2.2	2.8	9.8	3.1	0.4	0.7	1.7	0.9
Forced vital capacity (FVC), Best measure	2.2	8.2	15.3	3.8	-3.9	-2.4	0.2	2.3
Cholesterol lowering medication	2.2	3.2	5.3	-1.9	2.3	2.3	-1.0	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	7.4	0.3	2.7	1.8	1.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	16.5	3.0	-4.1	-2.2	-0.7	1.7
Eye problems/disorders: Cataract	2.1	2.5	8.0	-1.1	2.8	1.6	0.7	0.2
Alcohol drinker status: Previous	2.1	2.4	5.8	0.7	-2.4	-2.3	-0.1	0.3
Bipolar Disorder (2011)	2.0	1.9	5.5	2.3	-0.4	-0.5	1.6	1.1
Relative age voice broke	2.0	3.0	10.0	-0.9	-1.3	-1.5	-3.2	0.8
Medication: Cholesterol lowering	2.0	3.1	5.2	0.5	-2.0	-2.3	-2.3	-0.7
Major Depression (MDD)	1.9	2.4	4.7	0.4	2.2	1.1	1.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	14.5	-0.0	-3.8	-1.1	-1.8	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	9.7	-2.5	-3.1	-1.8	-0.7	1.1
Stomach or abdominal pain in last month	1.8	2.3	4.0	-1.1	2.0	1.8	-0.3	-1.7
Had other major operations	1.8	2.2	6.4	0.7	1.6	0.5	1.1	2.5
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	7.0	-0.1	2.1	2.6	1.3	1.5
Guilty feelings	1.8	2.7	8.1	1.1	1.5	2.9	1.2	-0.7
Coronary Artery Disease (CAD)	1.7	2.0	4.9	-1.2	1.7	2.2	1.0	0.2
Hip circumference	1.7	7.3	13.5	3.1	2.0	1.0	3.7	2.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.0	0.8	0.7	2.1	2.2	0.2
Bipolar Disorder (2018)	1.5	2.4	4.8	0.9	-2.2	-2.2	0.8	1.1
HbA1C	1.5	1.6	5.3	2.3	-0.1	-0.5	1.4	0.7
Hand grip strength (right)	1.5	4.0	14.9	3.9	0.8	0.8	1.6	1.1
Alcohol usually taken with meals	1.5	2.4	4.8	0.6	2.2	1.9	1.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	8.7	-2.1	-3.0	-1.8	-1.1	-0.5
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.1	0.1	-2.0	-1.6	-1.6	-0.8
Number of full brothers	1.5	1.9	3.6	-1.8	0.7	1.9	0.8	1.2
Basal cell carcinoma (self-reported)	1.5	1.8	6.5	1.3	0.0	-0.6	-0.6	-2.5
Current tobacco smoking	1.4	2.3	4.8	-2.2	-1.5	-0.7	-0.3	2.0
Asthma	1.4	2.7	3.8	1.9	1.8	0.5	1.9	-1.6
Illnesses of mother	1.4	1.8	3.8	-0.3	1.5	1.9	1.6	-0.2
Breastfed as a baby	1.4	1.7	7.2	-2.7	0.3	0.9	0.1	0.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.8	-0.1	0.3	-1.1	-1.4	-2.2
Commuting to job workplace: Walk	1.4	1.5	2.6	-1.6	-1.1	1.1	-1.0	1.2
Medication for cholesterol	1.4	2.1	5.6	0.1	-2.4	-1.5	0.3	1.5
Osteoarthritis (self-reported)	1.4	1.8	7.4	-0.3	-0.6	-0.6	0.8	2.7
Fractured/broken bones in last 5 years	1.4	1.7	3.1	1.8	1.5	1.1	1.0	1.0
Had menopause	1.3	1.6	3.4	1.9	1.5	1.5	0.2	0.3
Number of children fathered	1.3	1.4	4.6	1.4	0.1	-0.2	2.1	-0.7
Family relationship satisfaction	1.3	1.5	3.6	0.5	-1.9	-1.3	-0.9	1.2
Asthma (self-reported)	1.3	2.6	4.5	1.5	1.9	0.6	2.1	-1.4
Medication: Aspirin	1.3	1.7	4.1	1.3	2.0	1.6	0.2	0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	1.4	1.2	0.2	-1.7	-1.4
Angina	1.2	1.6	2.3	1.5	-1.0	-1.4	-1.5	-0.4
Heart attack	1.2	1.6	2.7	1.3	1.3	0.4	-1.6	-1.3
Medication: Ramipril	1.2	1.6	7.0	-0.1	0.1	-0.3	-2.6	-0.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.4	-1.2	0.9	1.8	-1.2	-0.5
Number of self-reported non-cancer illnesses	1.2	2.1	5.1	2.3	1.3	0.9	1.5	-0.7
Fasting Glucose	1.1	1.3	2.2	0.3	1.5	1.1	1.4	-1.0
Rheumatoid Arthritis	1.1	1.5	6.1	2.5	1.1	0.2	-0.1	0.5
Blood White Count	1.1	7.9	19.8	0.8	-4.0	-4.5	-1.8	0.2
Nervous feelings	1.1	2.0	5.7	-0.0	-2.4	-1.6	-1.4	0.1
Pain all over the body in last month	1.1	1.2	3.7	0.8	-1.9	-0.9	-0.8	0.1
Medication for pain relief, constipation, heartburn	1.1	1.8	4.2	0.2	-2.0	-2.1	0.1	-1.0
Angina (self-reported)	1.1	1.4	2.0	1.4	-1.1	-1.4	-1.4	-0.3
Average weekly red wine intake	1.1	1.6	2.6	1.5	1.5	1.6	0.5	-0.8
Loneliness, isolation	1.1	1.6	2.6	1.3	-1.6	-1.4	0.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.2	0.7	1.0	1.0	1.8	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	6.4	-1.4	0.1	0.7	-2.5	-0.1
Smoking status: Current	1.1	1.8	4.1	-1.8	-1.1	-0.5	0.3	2.0
Average weekly beer plus cider intake	1.1	1.5	3.8	-2.0	-1.1	-1.4	-0.5	-0.7
Mean Putamen Volume	1.0	1.2	2.5	-0.7	1.6	1.3	-0.1	-1.1
Townsend deprivation index at recruitment	1.0	1.4	5.0	-2.2	0.8	1.0	-0.1	0.4
Taking other prescription medications	1.0	1.6	4.0	0.7	2.0	1.3	0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.1	-0.6	1.4	1.1	1.3	0.4
Qualifications: CSEs or equivalent	1.0	1.3	4.5	-1.0	-0.5	-2.1	0.1	0.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.7	-0.5	1.0	1.0	-0.9	-1.6
Medication: Levothyroxine sodium	1.0	1.7	3.1	1.7	0.7	0.1	1.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.7	0.5	1.2	1.9	1.1	-1.1
Wheeze or whistling in the chest in last year	1.0	1.7	3.7	1.3	1.9	0.8	1.3	-0.9
Had major operations	1.0	1.2	2.6	1.1	0.4	0.6	1.3	1.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	1.0	-1.7	-1.1	0.8	0.6
Medication: Paracetamol	1.0	1.5	4.0	0.0	0.8	1.5	1.0	2.0
Crohns Disease (2017)	0.9	2.0	4.4	1.5	-0.8	-1.5	2.1	0.6
Lung FEV1/FVC ratio	0.9	4.6	14.1	0.7	-3.8	-1.8	-2.2	0.9
Number of treatments/medications taken	0.9	1.5	4.9	0.7	2.2	1.3	0.1	-0.8
Sensitivity / hurt feelings	0.9	1.6	3.1	0.7	-1.2	-1.8	0.7	-1.5
Supplements: Zinc	0.9	1.0	1.6	0.9	0.7	1.1	-1.0	-1.3
Hearing difficulty/problems with background noise	0.9	1.4	4.9	-0.1	2.2	1.4	0.4	-0.2
Illnesses of siblings	0.9	1.2	3.4	-0.4	-1.5	-0.1	-0.4	1.9
Hair/balding pattern: Pattern 4	0.9	2.1	4.2	-1.9	-0.7	-1.4	-2.0	0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.3	1.8	0.6	0.1	1.6	1.6
Medication: Allopurinol	0.9	1.2	3.9	-0.2	-0.8	-2.0	-0.3	-1.1
Leg pain on walking	0.9	1.1	3.0	-1.5	-0.4	0.3	0.3	1.7
Illnesses of father: None of the above (group 1)	0.9	1.1	3.6	0.8	-0.9	-0.2	1.9	0.4
Commuting to job workplace: Cycle	0.9	1.1	2.1	-1.4	0.5	1.4	0.6	-1.0
Alzheimer’s Disease (in mother)	0.8	0.9	3.9	-2.0	-0.3	0.4	0.4	-0.5
Ovarian Cancer	0.8	1.1	2.0	-1.2	1.4	0.0	1.1	0.8
HDL Cholesterol	0.8	1.3	2.9	-0.1	0.9	1.7	1.4	-0.8
Hearing difficulty/problems: Yes	0.8	1.2	2.9	-1.1	1.7	1.4	0.2	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	-0.3	1.1	0.3	1.7	0.5
Diabetes (mother)	0.8	1.0	1.6	1.0	-1.0	-1.1	0.3	1.2
Severe depression (siblings)	0.8	0.9	2.0	0.7	0.3	0.7	1.1	1.4
Father’s age at death	0.8	1.1	2.9	-1.1	0.9	1.7	0.7	-0.0
Medication: Paracetamol	0.8	1.3	2.8	-0.3	1.0	1.7	0.6	1.5
High blood pressure (siblings)	0.8	1.2	4.4	0.7	0.6	-0.7	-0.1	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.4	-0.1	-1.9	-1.0	-0.8	-0.1
Pulse wave peak to peak time	0.8	1.0	3.1	1.8	-0.5	0.1	-0.7	1.0
Shortness of breath walking on level ground	0.8	0.9	2.0	0.2	1.4	1.1	0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.9	-1.2	0.8	1.4	-0.1	0.8
Medication: Aspirin	0.8	1.1	2.4	1.2	1.6	1.0	-0.4	0.5
Supplements: Vitamin C	0.8	0.9	2.4	1.6	0.2	-0.6	1.0	0.8
Mineral and other dietary supplements	0.8	1.1	3.8	-1.9	-0.8	-0.4	-0.6	0.7
Wears glasses or contact lenses	0.8	0.9	2.0	-0.1	1.0	1.2	1.4	0.2
Ever taken oral contraceptive pill	0.8	0.9	1.7	-0.2	-1.2	-1.1	-1.3	-0.5
Mother’s age at death	0.8	1.0	2.9	1.2	0.1	-0.2	0.8	1.7
Medication: Lisinopril	0.8	1.1	4.0	0.3	-0.3	0.2	1.1	-2.0
Ever depressed for a whole week	0.8	1.0	3.8	-1.9	0.9	0.5	-0.2	-0.1
Body Mass Index (BMI) (2010)	0.7	0.9	2.1	-0.9	-1.5	-0.8	-0.2	1.0
Hypothyroidism (self reported)	0.7	1.6	3.2	1.8	0.8	-0.1	1.2	1.6
Respiratory disease	0.7	1.5	3.5	0.9	1.3	0.1	1.9	-1.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	1.4	0.5	0.5	1.0	1.0
Trunk fat mass	0.7	3.0	6.2	2.5	0.1	-0.6	1.8	2.3
Qualifications: None of the above	0.7	1.5	3.2	-1.1	-1.0	-1.8	-1.3	0.7
Mouth/teeth dental problems	0.7	1.0	2.0	0.3	0.9	0.8	1.4	1.2
Worrier / anxious feelings	0.7	1.3	2.3	0.9	-0.9	-1.5	-1.0	-1.2
Medication: Lansoprazole	0.7	0.8	2.7	0.1	-0.5	-0.8	-1.6	-0.8
Prospective memory result	0.7	0.8	1.8	-0.4	-0.8	-1.0	-1.4	0.7
Arm fat mass (right)	0.7	2.9	6.4	1.9	0.5	-0.1	2.1	2.5
Eye problems/disorders: None of the above	0.7	0.8	1.6	0.7	-1.3	-0.7	-0.1	1.1
Emphysema/chronic bronchitis	0.7	0.8	1.2	1.0	-0.3	-1.0	0.7	1.1
Heart disease (mother)	0.7	0.8	1.7	1.3	0.7	0.0	-0.9	-1.1
Whole body fat mass	0.7	2.7	5.4	2.2	0.1	-0.4	1.9	2.3
Knee pain experienced in last month	0.7	1.1	3.0	0.3	0.8	0.9	0.9	1.7
Illnesses of father: Heart disease	0.7	0.9	2.7	-0.2	-0.1	-0.7	-1.6	-1.2
Arm fat mass (left)	0.7	2.7	6.4	1.7	0.6	0.0	2.0	2.5
Financial situation satisfaction	0.7	0.8	1.2	-0.5	-0.9	-1.1	-1.1	-0.8
Medication: Blood pressure	0.7	1.4	3.3	-0.9	1.8	0.7	-0.6	-1.4
High cholesterol (Self-reported)	0.7	1.3	4.0	-2.0	-0.7	0.4	-1.1	-0.7
Age started oral contraceptive pill	0.7	0.9	2.8	-0.6	0.8	0.7	-0.2	-1.7
Depression (Nagel 2018)	0.6	0.9	2.1	-0.2	1.0	1.5	0.3	-1.2
Alzheimer’s Disease (in father)	0.6	0.6	1.3	-0.4	0.5	1.1	1.0	-0.7
Triglycerides	0.6	0.9	1.6	-0.8	-1.2	-0.6	-0.8	1.2
Relative age of first facial hair	0.6	1.2	2.7	-1.0	-0.3	-0.5	-1.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	-1.1	-1.0	-0.2	-0.1	1.0
Allergy	0.6	1.3	3.6	-1.9	-0.7	-0.2	-0.8	1.4
Falls in the last year	0.6	0.9	2.0	-0.6	-0.7	-1.2	-1.4	0.3
Pulse rate	0.6	1.1	3.7	-0.9	-1.9	-0.4	-0.4	0.6
Lung cancer (father)	0.6	0.7	2.2	0.4	-0.0	0.5	1.5	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	-0.8	1.3	0.2	1.1	0.4
Pulse rate, automated reading	0.6	1.8	4.2	-1.7	-2.1	-1.1	0.5	0.8
Suffer from ‘nerves’	0.6	0.9	3.6	-0.2	0.2	0.8	-0.3	-1.9
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-0.8	0.6	-0.1	-0.7	1.4
Smoking status: Previous	0.6	0.9	2.6	1.6	0.5	-0.0	0.8	-0.9
Hearing aid user	0.6	0.7	1.4	-0.8	-0.7	-0.9	-1.2	-0.0
Illnesses of father: High blood pressure	0.6	0.8	1.4	-1.0	0.4	0.3	-1.2	-1.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.9	-0.8	0.7	1.4	1.5	1.7
Pack years of smoking	0.6	0.9	1.8	-0.4	-0.5	-1.3	-0.8	1.3
Leg fat mass (left)	0.6	2.5	5.1	2.2	0.2	-0.6	1.8	1.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-1.2	-0.7	0.5	1.1	-0.4
Ulcerative Colitis (UC)	0.5	1.0	3.1	0.8	0.7	1.8	0.5	-0.8
Crohns Disease (2012)	0.5	0.8	2.9	0.8	0.4	-0.4	1.7	-0.3
Schizophrenia (2014)	0.5	1.2	3.1	-0.3	1.4	0.4	1.8	0.7
Blood Platelet Count	0.5	5.7	15.1	3.9	-2.4	-2.5	-1.1	-0.5
Systolic Blood Pressure	0.5	2.4	5.9	0.5	-0.2	-2.4	-2.1	-1.2
Average weekly spirits intake	0.5	0.6	1.9	1.0	-0.1	0.1	0.3	1.4
Pack years adult smoking proportion	0.5	0.8	1.6	-0.8	-0.3	-1.0	-0.9	1.3
Maternal smoking around birth	0.5	0.8	2.5	-0.5	-1.0	-0.2	-0.3	1.6
Age when periods started (menarche)	0.5	1.1	2.0	0.5	0.7	1.4	1.2	1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.4	-0.8	-0.4	-1.3	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	2.4	-1.5	0.8	0.4	0.2	0.0
Medication: Simvastatin	0.5	0.7	1.7	-0.9	-0.4	0.0	-0.8	-1.3
Mouth/teeth dental problems: Dentures	0.5	0.8	2.5	-0.0	-0.8	-1.6	0.9	-0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-1.2	0.5	0.0	1.0	-0.4
Peak expiratory flow (PEF)	0.5	1.1	2.3	-0.1	-1.3	-0.6	-1.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.0	1.2	0.8	0.9	0.2
Age at first live birth	0.5	0.9	2.0	0.9	-0.5	-0.7	-1.4	-1.1
Leg fat mass (right)	0.5	1.8	3.5	1.8	-0.0	-0.8	1.4	1.9
Friendships satisfaction	0.5	0.6	1.9	-0.6	-0.5	-0.6	-1.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.7	1.6	0.4	-0.5	0.1	-0.0
Alcohol drinker status: Never	0.5	0.7	1.8	-0.0	0.9	0.8	-1.3	-0.1
Unable to work because of sickness or disability	0.5	0.6	2.0	-0.5	-0.9	0.2	0.4	1.4
Heart disease (siblings)	0.5	0.7	1.5	-1.2	0.0	-0.9	-0.2	-0.9
Bipolar Disorder or Schizophrenia	0.4	0.9	3.0	0.4	-0.7	-0.6	1.7	0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.6	0.9	-0.4	0.9	1.1	-1.2
Schizophrenia (2018)	0.4	0.9	2.4	-0.2	0.9	1.0	1.6	0.3
Schizophrenia vs Biploar Disorder	0.4	0.6	1.5	-0.2	1.1	1.2	0.3	0.1
Worry (Nagel 2018)	0.4	0.8	2.1	0.7	-0.7	1.0	-0.2	-1.5
Irritable Bowel Disease (IBD)	0.4	1.0	2.9	1.4	0.3	0.3	1.7	0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.2	0.1	0.7	0.5	0.9	1.8
Ulcerative Colitis	0.4	0.5	1.4	-0.9	0.4	1.2	-0.6	-0.0
Blood Eosinophil Count	0.4	2.8	5.9	0.6	2.4	1.8	2.0	0.6
Smoking Status	0.4	0.9	2.6	-0.8	-0.8	-0.6	-0.3	1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.2	-0.2	-1.0	-0.9	-1.1	-0.9
Neuroticism	0.4	0.9	1.9	1.1	-0.3	0.8	0.8	-1.4
Vitamin and mineral supplements	0.4	0.6	2.0	-1.4	0.1	0.7	0.1	-0.7
Medication: Co-codamol	0.4	0.4	0.9	-0.7	0.9	0.6	0.5	0.5
Diabetes (father)	0.4	0.5	1.4	-1.2	0.4	0.8	-0.5	0.1
High blood pressure	0.4	1.1	3.2	0.5	-0.3	-1.1	-1.0	-1.8
High blood pressure (mother)	0.4	0.5	1.4	-0.4	-0.4	-0.6	-1.2	-0.7
Body mass index (BMI)	0.4	1.7	4.0	1.0	0.7	-0.2	2.0	1.8
Financial difficulties in last 2 years	0.4	0.5	1.6	-1.3	0.2	-0.5	-0.3	0.8
Neuroticism score	0.4	0.8	1.8	1.3	-1.1	-0.3	0.8	-0.4
Time employed in main current job	0.4	0.4	0.9	-0.3	-0.5	-1.0	-0.8	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.3	-0.0	1.1	0.1	-0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	-0.4	0.7	1.0	0.7	-1.2
Hair/balding pattern: Pattern 3	0.4	0.7	2.2	0.0	-0.2	0.5	1.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	0.2	0.7	1.7	-1.1	-0.0
Length of working week for main job	0.4	0.4	1.0	0.2	-1.0	-0.7	0.4	0.5
Tense / ‘highly strung’	0.4	0.7	1.9	1.4	-1.0	-0.4	-0.4	0.5
Blood clot in the leg (DVT)	0.4	0.5	1.1	0.2	1.0	1.0	0.5	0.6
Glaucoma (self-reported)	0.4	0.5	2.0	-0.2	1.4	0.3	0.7	0.2
Medication: Amlodipine	0.4	0.6	1.7	0.9	0.2	-1.3	0.1	-0.6
Comparative body size at age 10	0.4	1.0	2.5	-0.2	-1.6	-1.2	0.7	-0.8
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.2	-0.1	-0.5	-0.9	-1.2
Alcohol intake frequency.	0.4	0.8	1.3	-0.9	-0.4	-0.9	-1.0	-1.1
Hypertension (Self-reported)	0.4	1.0	3.3	0.7	-0.0	-0.9	-0.7	-1.8
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.6	-0.2	-0.9	1.2	-0.1
Miserableness	0.4	0.7	2.2	0.6	-0.7	-0.1	1.5	0.7
Medication: Bendroflumethiazide	0.4	0.6	1.0	-0.7	1.0	0.9	0.1	-1.0
Medication: Atorvastatin	0.4	0.5	1.6	-0.9	0.1	-0.4	-1.3	-0.0
Risk taking	0.4	0.6	1.4	-0.2	1.0	0.8	1.2	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-1.1	0.4	0.5	-0.9	-0.0
Depressed Affect (Nagel 2018)	0.3	0.5	1.8	0.6	0.1	0.7	1.3	-0.2
Lupus	0.3	0.5	2.3	-0.0	0.5	-0.1	0.3	-1.5
Neuroticism (2016)	0.3	0.4	1.3	1.2	0.6	0.4	-0.4	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	0.8	-0.1	-0.7	0.5	-0.4
Blood Red Count	0.3	2.9	4.8	-1.9	-2.2	-1.3	-2.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.1	-0.4	-0.6	0.6	-0.7
Medication for hormone replacement therapy	0.3	0.4	1.4	1.2	0.0	0.4	0.5	-0.4
Fed-up feelings	0.3	0.6	2.4	0.2	0.8	-0.2	1.6	0.3
Medication: Atenolol	0.3	0.4	1.6	-0.0	1.3	-0.0	-0.5	-0.3
Waist circumference	0.3	1.0	1.9	1.4	0.3	-0.7	1.4	0.8
Number of incorrect matches in round	0.3	0.5	1.4	0.9	-1.2	-0.1	0.2	-0.4
Past tobacco smoking	0.3	0.6	1.4	-1.2	-0.0	0.4	-1.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.7	0.5	0.9	0.7	0.2
Fluid intelligence score	0.3	0.5	1.3	-0.2	1.1	0.8	0.0	0.8
Number of live births	0.3	0.4	1.0	0.3	-0.0	-0.9	-1.0	0.2
Noisy workplace	0.3	0.3	0.8	-0.4	0.1	-0.8	0.1	0.9
Depression (self-reported)	0.3	0.4	1.0	-1.0	-0.0	0.5	0.8	-0.2
Pulse wave reflection index	0.3	0.4	1.1	-0.7	0.6	0.2	0.2	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.6	0.6	-0.6	-0.5	-0.8
Loud music exposure frequency	0.3	0.4	0.6	-0.7	-0.5	0.7	-0.8	0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.1	1.1	-0.6	-0.0	-0.0	0.6
Qualifications: College or University degree	0.3	0.9	4.0	0.3	0.7	2.0	0.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	1.1	-0.1	-0.4	-0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.4	-0.9	-0.8	-0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.6	0.2	-0.1	0.6	-0.0	1.3
Qualifications: nursing, teaching	0.3	0.5	0.9	-0.6	-0.9	0.7	0.5	0.7
Back pain experienced in last month	0.3	0.4	0.7	0.3	0.5	0.8	0.8	-0.5
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.4	0.9	0.5	0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	1.0	0.0	-1.0	-0.3	-0.1
Ever smoked	0.3	0.5	1.0	0.6	0.3	0.0	1.0	-1.0
Irritability	0.3	0.5	1.0	-0.4	0.3	-0.6	0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-1.0	-0.3	-0.1	-0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.0	0.7	0.7	0.4	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	0.9	0.0	0.2	1.1	1.1
Age at First Birth	0.2	0.3	0.6	0.5	0.2	-0.6	-0.7	-0.7
LDL Cholesterol	0.2	0.3	0.5	-0.6	0.5	-0.7	-0.2	-0.4
Primary Biliary Cirrhosis	0.2	0.3	1.5	1.2	0.0	-0.5	0.1	0.1
BMI	0.2	1.3	2.7	1.2	0.8	-0.3	1.6	1.3
Allergy or Eczema	0.2	0.6	2.0	1.0	0.1	0.4	1.4	0.0
Cardiovascular Disease	0.2	0.6	2.0	-0.2	0.6	-0.1	-0.6	-1.4
Chronotype (morning person)	0.2	0.4	1.1	-0.1	0.0	-0.7	0.5	-1.1
Hair Pigment	0.2	5.8	20.2	4.5	-0.6	-0.8	2.1	1.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.7	-0.1	-0.1	-0.1	-0.9
Systolic blood pressure, automated reading	0.2	0.7	2.9	0.2	-0.4	-1.7	-0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	0.4	0.1	0.2	1.0	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	1.2	0.0	0.5	0.7	-0.3
Multivitamins +/- minerals	0.2	0.2	0.5	0.6	0.1	0.2	0.7	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.6	-0.4	-0.6	0.2	0.8
Diabetes (self-reported)	0.2	0.3	1.0	-0.5	0.1	-0.0	-0.6	-1.0
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.1	-0.8	-0.5	-0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.7	0.5	1.0	0.1	-0.1
Gout (self-reported)	0.2	0.3	0.7	-0.4	0.3	-0.1	-0.9	-0.7
Leg fat percentage (right)	0.2	0.7	2.1	-0.6	0.1	-0.8	-0.7	-1.5
Worry too long after embarrassment	0.2	0.3	0.7	0.7	-0.4	0.0	0.9	-0.3
Health satisfaction	0.2	0.3	0.6	0.6	-0.1	-0.5	-0.8	-0.3
Number of full sisters	0.2	0.2	0.6	-0.4	-0.2	0.4	0.8	-0.1
Chest pain or discomfort	0.2	0.3	0.6	0.7	-0.7	-0.3	-0.3	-0.4
Age at last live birth	0.2	0.3	1.2	0.4	-0.3	-0.2	-1.1	-0.2
Mood swings	0.2	0.4	0.9	0.7	0.3	-0.4	0.5	0.9
Ever had bowel cancer screening	0.2	0.2	0.7	-0.3	0.0	-0.2	-0.8	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.1	0.2	0.5	0.0	-0.9
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.1	-0.1	-0.6	-0.2	1.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.2	0.5	0.8	-0.7	0.2
Leg fat percentage (left)	0.2	0.5	2.1	0.0	0.4	-0.7	0.1	-1.5
Diastolic blood pressure, automated reading	0.2	0.6	1.7	-0.1	1.3	0.7	-0.1	-1.0
Reaction Time	0.1	0.2	0.6	-0.3	-0.6	-0.0	-0.8	-0.3
Prostate Cancer	0.1	0.2	0.4	0.2	-0.4	0.2	-0.7	-0.6
Tanning	0.1	1.4	3.0	0.4	-1.7	-1.0	-1.4	1.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.5	0.4	0.7	0.3	-0.1
Medication: Metformin	0.1	0.1	0.2	-0.3	0.5	0.1	0.1	-0.2
Happiness	0.1	0.2	0.3	-0.4	-0.5	-0.2	-0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.4	0.1	0.9	-0.2	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.3	0.6	0.3	0.1	-0.2
Medication: Omeprazole	0.1	0.2	0.6	-0.8	0.2	-0.3	-0.3	0.1
Mean time to correctly identify matches	0.1	0.2	0.6	0.5	0.2	0.5	-0.0	-0.8
Overall health rating	0.1	0.2	0.4	0.1	0.6	-0.3	0.5	-0.7
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	-0.5	-0.6	-0.1	-0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.5	0.2	-0.5	0.0	0.4
Myopia	0.1	0.2	0.5	-0.0	-0.1	0.1	-0.7	0.5
Trunk fat percentage	0.0	0.2	0.8	0.3	0.0	-0.9	-0.2	-0.2
Arm fat percentage (right)	0.0	0.1	0.2	-0.4	0.4	0.0	0.3	-0.2
Body fat percentage	0.0	0.2	0.4	-0.0	0.1	-0.7	-0.3	-0.7
Arm fat percentage (left)	0.0	0.2	0.4	-0.4	0.6	0.2	0.2	-0.4

Hub : Genes

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Trait associations