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chr3:51,860,817-53,860,103

Best TWAS P=9.57e-11 · Best GWAS P=2.01e-09 conditioned to 0.856

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
44	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RFT1	0.29	0.15	blup	45	0.15	6.5e-05	5.0	6.5	9.6e-11	0.85	0.01	0.87	TRUE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	SPCS1	0.11	0.00	blup	41	0.01	9.9e-03	-3.3	6.0	1.7e-09	0.36	0.00	0.23	TRUE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RFT1	0.31	0.07	blup	45	0.19	1.8e-09	3.5	6.4	1.3e-10	0.86	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	RFT1	0.13	0.05	blup	45	0.10	6.9e-08	5.6	6.4	2.0e-10	0.85	0.01	0.99	FALSE
3	GTEx	Prostate	RFT1	0.39	0.18	enet	17	0.24	1.1e-06	3.9	6.2	7.1e-10	0.68	0.10	0.84	FALSE
39	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RFT1	0.29	0.04	blup	45	0.11	8.2e-04	5.2	6.1	9.2e-10	0.79	0.01	0.85	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM110	0.20	0.06	blup	59	0.10	1.2e-10	5.8	5.9	3.1e-09	0.83	0.00	1.00	FALSE
5	GTEx	Stomach	RFT1	0.23	0.03	enet	19	0.06	6.3e-04	3.9	5.9	3.7e-09	0.75	0.07	0.86	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RFT1	0.07	0.03	enet	7	0.06	1.2e-07	5.0	5.9	3.8e-09	0.75	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM110	0.20	0.01	lasso	2	0.09	3.2e-04	5.8	5.9	4.2e-09	0.97	0.00	0.90	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM110	0.20	0.13	blup	59	0.15	3.0e-10	5.8	5.9	4.3e-09	0.82	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	RFT1	0.10	0.05	enet	12	0.05	1.0e-03	5.6	5.9	4.6e-09	0.87	0.01	0.94	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	RFT1	0.16	0.12	enet	16	0.14	1.7e-08	5.5	5.8	6.2e-09	0.90	0.00	0.99	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFT1	0.10	0.08	enet	11	0.15	2.3e-29	5.2	5.8	6.4e-09	0.80	0.03	0.97	FALSE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RFT1	0.14	0.08	enet	12	0.15	5.5e-08	5.5	5.8	9.1e-09	0.78	0.01	0.98	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM110	0.19	0.13	blup	59	0.13	4.2e-11	4.9	5.7	1.1e-08	0.84	0.06	0.94	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	RFT1	0.14	0.11	blup	45	0.11	1.9e-12	5.2	5.7	1.2e-08	0.92	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFT1	0.21	0.10	lasso	6	0.23	1.9e-15	5.4	5.7	1.2e-08	0.82	0.01	0.99	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RFT1	0.18	0.10	lasso	7	0.10	1.8e-08	5.5	5.7	1.6e-08	0.97	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPCS1	0.15	0.03	lasso	3	0.04	4.3e-05	5.2	5.7	1.6e-08	0.58	0.00	0.92	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMEM110	0.12	0.07	blup	59	0.12	7.5e-08	5.7	5.6	1.8e-08	0.73	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM110	0.19	0.12	blup	59	0.13	1.6e-09	5.0	5.6	2.0e-08	0.79	0.13	0.86	FALSE
42	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RFT1	0.39	0.22	lasso	4	0.25	3.1e-09	5.3	5.6	2.0e-08	0.94	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RFT1	0.24	0.12	lasso	5	0.20	1.3e-11	5.2	5.6	2.3e-08	0.81	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFMBT1	0.17	0.08	lasso	2	0.06	5.5e-04	5.6	5.6	2.3e-08	0.97	0.01	0.94	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	3.6	5.5	3.0e-08	0.67	0.74	0.24	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM110	0.27	0.10	blup	59	0.14	3.0e-15	5.0	5.5	3.8e-08	0.84	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	RFT1	0.18	0.09	blup	45	0.09	4.8e-10	5.5	5.5	3.8e-08	0.93	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM110	0.24	0.09	blup	59	0.14	1.4e-07	4.9	5.5	3.9e-08	0.76	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM110	0.36	0.05	blup	59	0.08	3.4e-04	5.2	5.5	5.0e-08	0.77	0.02	0.68	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM110	0.13	0.09	lasso	3	0.10	5.9e-20	5.2	5.4	7.4e-08	0.82	0.14	0.86	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM110	0.21	0.10	lasso	4	0.08	2.3e-05	4.9	5.4	7.6e-08	0.78	0.06	0.94	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM110	0.19	0.10	lasso	5	0.11	2.1e-12	5.2	5.4	7.7e-08	0.71	0.12	0.88	FALSE
2	GTEx	Pancreas	RFT1	0.32	0.13	lasso	4	0.17	1.3e-07	6.0	5.4	7.8e-08	0.93	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RFT1	0.14	0.10	lasso	4	0.12	8.4e-14	3.9	5.3	8.6e-08	0.62	0.85	0.12	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM110	0.29	0.16	lasso	6	0.17	1.8e-18	5.1	5.3	9.7e-08	0.78	0.13	0.86	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	GNL3	0.07	0.06	lasso	4	0.06	4.5e-04	3.9	5.3	1.4e-07	0.73	0.05	0.82	FALSE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RFT1	0.41	0.17	enet	12	0.16	2.4e-07	3.9	5.3	1.4e-07	0.66	0.32	0.65	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	NISCH	0.06	0.05	lasso	4	0.04	7.5e-06	5.4	5.3	1.5e-07	0.54	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NT5DC2	0.11	0.05	enet	22	0.04	5.0e-06	3.4	-5.2	1.7e-07	-0.47	0.29	0.65	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM110	0.26	0.09	lasso	4	0.09	1.6e-04	5.0	5.2	1.7e-07	0.74	0.08	0.82	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM110	0.16	0.13	lasso	3	0.12	2.1e-14	5.2	5.2	2.5e-07	0.76	0.12	0.88	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLT8D1	0.22	0.08	lasso	1	0.07	8.5e-09	5.2	5.2	2.6e-07	0.54	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GLT8D1	0.20	0.05	lasso	1	0.04	1.0e-03	5.2	5.2	2.6e-07	0.54	0.00	0.94	FALSE