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chr4:16,922,182-18,507,692

Best TWAS P=1.75e-46 · Best GWAS P=2.25e-42 conditioned to 0.000385

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-12.9	14.3	1.8e-46	-0.81	0.05	0.78	TRUE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	9.3	13.3	3.5e-40	-0.64	0.08	0.80	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	9.0	12.7	5.0e-37	-0.65	0.14	0.79	FALSE
14	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	8.0	12.6	2.3e-36	-0.66	0.05	0.57	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-12.4	-12.4	4.3e-35	0.88	0.02	0.59	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-12.2	-12.0	5.3e-33	0.84	0.53	0.47	FALSE
6	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-12.2	11.9	1.4e-32	-0.76	0.04	0.59	FALSE
16	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	8.0	11.9	1.6e-32	-0.54	0.17	0.71	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	8.0	11.8	6.6e-32	-0.58	0.27	0.22	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-12.2	11.7	1.3e-31	-0.83	0.03	0.89	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-12.4	-11.0	5.0e-28	0.84	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	8.0	10.8	4.7e-27	-0.52	0.14	0.66	FALSE
4	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	9.3	10.4	2.3e-25	-0.36	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-11.1	-10.2	1.3e-24	0.76	0.03	0.47	FALSE
15	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	9.0	10.1	6.1e-24	-0.26	0.19	0.05	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	9.1	10.0	1.2e-23	-0.35	0.64	0.04	FALSE
20	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	9.3	9.3	2.0e-20	-0.25	0.84	0.04	FALSE
10	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	8.0	9.2	3.5e-20	-0.37	0.99	0.01	FALSE
2	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	8.0	9.2	4.3e-20	-0.35	0.29	0.46	FALSE
13	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	8.0	9.1	1.3e-19	-0.28	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	8.0	8.4	3.1e-17	-0.37	0.13	0.40	FALSE
11	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	8.0	8.2	2.0e-16	-0.38	0.07	0.33	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-12.4	-8.2	3.5e-16	0.68	0.02	0.82	FALSE
7	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	8.0	8.0	8.7e-16	-0.27	0.06	0.08	FALSE
1	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	8.0	7.8	4.6e-15	-0.24	1.00	0.00	FALSE
9	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	8.0	7.8	9.2e-15	-0.27	0.99	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	-4.8	-6.5	1.1e-10	0.26	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	-4.6	6.0	1.6e-09	-0.30	0.22	0.03	FALSE