[Hub]/) : Traits : Basal metabolic rate : ← →

chr4:305,291-2,437,290

Best TWAS P=3.86e-15 · Best GWAS P=5.95e-15 conditioned to 0.000151

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	NTR	Blood	CRIPAK	0.13	0.09	enet	31	0.15	1.5e-46	-3.81	-7.9	3.9e-15	0.00	1.00	0.00	TRUE
51	NTR	Blood	TACC3	0.05	0.03	lasso	9	0.04	2.7e-13	-6.10	7.2	6.8e-13	0.71	0.49	0.51	TRUE
31	GTEx	Muscle Skeletal	FGFRL1	0.14	0.08	lasso	4	0.06	3.7e-06	-7.39	6.8	1.4e-11	0.01	0.00	1.00	TRUE
29	GTEx	Lung	CRIPAK	0.61	0.22	enet	46	0.41	1.1e-33	-4.71	-7.3	3.4e-13	0.02	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	CRIPAK	0.50	0.11	enet	76	0.38	1.1e-28	-4.49	-7.2	4.3e-13	-0.08	1.00	0.00	FALSE
49	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	-4.76	-7.1	1.2e-12	0.08	1.00	0.00	FALSE
11	GTEx	Brain Hippocampus	CRIPAK	0.48	0.22	lasso	4	0.23	4.0e-06	-4.49	-7.1	1.6e-12	0.00	0.17	0.16	FALSE
45	METSIM	Adipose	CRIPAK	0.28	0.16	bslmm	335	0.25	2.7e-37	-4.15	-7.0	1.8e-12	-0.01	1.00	0.00	FALSE
50	NTR	Blood	SLBP	0.04	0.02	lasso	5	0.02	2.8e-08	-6.23	7.0	2.8e-12	0.82	0.03	0.97	FALSE
10	GTEx	Brain Cortex	CRIPAK	0.34	0.10	lasso	6	0.18	9.5e-06	-4.71	-6.9	6.0e-12	0.03	0.18	0.14	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CRIPAK	0.32	0.17	enet	29	0.26	2.7e-08	-4.08	-6.8	1.1e-11	0.01	0.53	0.04	FALSE
20	GTEx	Colon Transverse	TMEM129	0.23	0.05	lasso	4	0.03	1.8e-02	-6.12	6.5	5.7e-11	0.51	0.09	0.09	FALSE
55	YFS	Blood	CRIPAK	0.35	0.27	bslmm	301	0.33	6.0e-112	-4.49	-6.5	9.7e-11	-0.03	1.00	0.00	FALSE
35	GTEx	Ovary	CRIPAK	0.43	0.27	enet	19	0.32	9.0e-09	-4.71	-6.4	1.7e-10	0.03	0.46	0.07	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRIPAK	0.22	0.11	blup	28	0.14	5.6e-28	-4.49	-6.3	2.2e-10	0.01	0.00	0.96	FALSE
43	GTEx	Whole Blood	CRIPAK	0.38	0.17	lasso	9	0.28	3.4e-26	-4.49	-6.3	2.7e-10	0.02	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CRIPAK	0.31	0.15	enet	34	0.26	1.2e-31	-4.14	-6.3	2.9e-10	0.04	1.00	0.00	FALSE
37	GTEx	Pancreas	CRIPAK	0.34	0.13	lasso	6	0.27	1.0e-11	-4.49	-6.3	3.3e-10	0.01	0.83	0.01	FALSE
32	GTEx	Muscle Skeletal	CRIPAK	0.25	0.11	enet	32	0.18	7.6e-18	-4.71	-6.3	3.8e-10	0.03	1.00	0.00	FALSE
47	METSIM	Adipose	UVSSA	0.26	0.04	bslmm	366	0.12	9.0e-18	1.34	-6.2	6.2e-10	0.02	0.96	0.04	FALSE
15	GTEx	Brain Putamen basal ganglia	CRIPAK	0.30	0.00	enet	25	0.10	1.9e-03	-4.01	-6.2	6.3e-10	0.11	0.06	0.12	FALSE
4	GTEx	Adipose Visceral Omentum	CRIPAK	0.47	0.24	lasso	12	0.31	1.3e-16	-4.71	-6.1	1.2e-09	0.02	1.00	0.00	FALSE
56	YFS	Blood	SLBP	0.10	0.12	lasso	3	0.12	1.2e-35	-6.10	6.1	1.3e-09	0.60	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CRIPAK	0.28	0.16	blup	28	0.19	3.2e-21	-4.49	-6.0	1.9e-09	0.03	0.00	0.96	FALSE
8	GTEx	Brain Cerebellum	CRIPAK	0.37	0.09	enet	24	0.31	8.8e-10	-4.21	-5.9	3.0e-09	-0.01	0.39	0.08	FALSE
40	GTEx	Thyroid	AC016773.1	0.11	0.07	enet	7	0.06	3.9e-05	-6.23	5.9	3.3e-09	0.52	0.67	0.04	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	CRIPAK	0.38	0.22	enet	12	0.25	5.4e-24	-4.49	-5.9	3.5e-09	0.01	0.00	0.96	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	CRIPAK	0.34	0.13	lasso	6	0.25	2.7e-07	-4.71	-5.9	3.6e-09	0.05	0.20	0.06	FALSE
25	GTEx	Esophagus Mucosa	CRIPAK	0.49	0.14	enet	28	0.40	6.8e-29	-4.71	-5.8	4.9e-09	0.00	0.98	0.02	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	AC016773.1	0.12	0.06	lasso	3	0.10	3.0e-12	-6.23	5.8	5.1e-09	0.52	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TACC3	0.09	0.08	enet	7	0.11	2.7e-05	-6.10	5.8	5.1e-09	0.52	0.13	0.21	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	CRIPAK	0.49	0.27	lasso	8	0.35	2.9e-12	-4.71	-5.8	6.1e-09	0.05	0.84	0.01	FALSE
16	GTEx	Breast Mammary Tissue	CRIPAK	0.42	0.12	enet	35	0.39	5.2e-21	-4.71	-5.8	6.4e-09	0.02	1.00	0.00	FALSE
9	GTEx	Brain Cortex	TACC3	0.26	0.13	lasso	4	0.17	1.7e-05	-6.12	5.8	6.7e-09	0.52	0.26	0.26	FALSE
5	GTEx	Artery Aorta	UVSSA	0.33	0.06	enet	30	0.28	7.2e-16	-4.76	-5.8	6.9e-09	0.01	0.22	0.77	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRIPAK	0.31	0.11	enet	10	0.18	1.5e-19	-4.49	-5.8	7.0e-09	-0.03	0.00	0.96	FALSE
44	GTEx	Whole Blood	AC016773.1	0.27	0.21	enet	8	0.22	1.2e-19	-6.12	5.8	7.3e-09	0.53	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CRIPAK	0.42	0.11	enet	42	0.34	9.0e-29	-4.16	-5.8	7.5e-09	0.04	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	UVSSA	0.46	0.05	lasso	11	0.24	1.1e-12	-4.76	-5.8	7.7e-09	0.01	0.81	0.08	FALSE
28	GTEx	Heart Atrial Appendage	CRIPAK	0.31	0.26	enet	23	0.33	2.1e-15	-4.71	-5.8	7.9e-09	0.03	1.00	0.00	FALSE
46	METSIM	Adipose	TMEM129	0.11	0.09	lasso	8	0.09	3.3e-13	-6.10	5.8	7.9e-09	0.57	1.00	0.00	FALSE
12	GTEx	Brain Hypothalamus	CRIPAK	0.22	0.00	lasso	5	0.01	2.1e-01	-4.76	-5.7	9.4e-09	0.02	0.06	0.08	FALSE
36	GTEx	Pancreas	TMEM129	0.20	0.19	lasso	3	0.14	1.5e-06	-6.12	5.7	9.5e-09	0.58	0.89	0.03	FALSE
21	GTEx	Colon Transverse	CRIPAK	0.33	0.10	enet	22	0.24	5.8e-12	-4.49	-5.7	1.2e-08	0.03	0.97	0.00	FALSE
6	GTEx	Artery Aorta	CRIPAK	0.31	0.20	enet	34	0.30	2.8e-17	-4.71	-5.7	1.3e-08	0.01	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	CRIPAK	0.38	0.16	blup	28	0.21	2.8e-12	-4.49	-5.7	1.4e-08	0.01	0.00	0.97	FALSE
19	GTEx	Colon Sigmoid	CRIPAK	0.40	0.21	lasso	7	0.30	4.7e-11	-4.99	-5.6	1.7e-08	0.06	0.72	0.02	FALSE
27	GTEx	Esophagus Muscularis	CRIPAK	0.38	0.14	enet	34	0.30	2.6e-18	-4.71	-5.6	1.7e-08	0.05	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM129	0.20	0.21	lasso	5	0.24	3.5e-23	-3.78	5.6	1.7e-08	0.49	1.00	0.00	FALSE
34	GTEx	Ovary	UVSSA	0.33	0.10	enet	12	0.32	1.5e-08	-4.76	-5.6	1.9e-08	0.02	0.11	0.07	FALSE
42	GTEx	Whole Blood	TACC3	0.11	0.05	enet	7	0.06	2.8e-06	-3.55	5.5	2.8e-08	0.59	0.94	0.03	FALSE
30	GTEx	Lung	RP11-20I20.4	0.07	0.00	lasso	3	0.01	6.0e-02	-4.99	-5.5	2.9e-08	0.03	0.14	0.03	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRIPAK	0.21	0.10	enet	9	0.15	1.3e-16	-4.49	-5.5	3.0e-08	0.00	0.00	0.94	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	CRIPAK	0.31	0.23	lasso	12	0.40	6.4e-55	-4.15	-5.5	3.5e-08	0.01	1.00	0.00	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	CRIPAK	0.33	0.20	lasso	5	0.30	1.4e-11	-4.71	-5.5	3.6e-08	0.02	0.99	0.00	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1530	0.13	0.01	blup	48	0.03	4.9e-07	-4.21	-5.5	4.6e-08	-0.05	0.01	0.90	FALSE
7	GTEx	Brain Caudate basal ganglia	CRIPAK	0.27	0.00	lasso	2	0.02	9.3e-02	-4.76	-5.5	5.2e-08	0.01	0.06	0.06	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	UVSSA	0.24	0.00	enet	33	0.04	2.8e-02	0.62	-5.4	6.2e-08	-0.10	0.07	0.06	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CRIPAK	0.36	0.09	enet	40	0.35	8.7e-30	-4.16	-5.4	6.2e-08	0.03	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	CRIPAK	0.37	0.07	lasso	2	0.12	1.2e-03	-4.49	-5.4	6.4e-08	0.03	0.00	0.31	FALSE
39	GTEx	Thyroid	TMEM129	0.44	0.31	lasso	7	0.34	1.2e-26	-3.83	5.4	7.7e-08	0.46	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	FAM53A	0.05	0.03	blup	56	0.04	1.8e-04	3.71	5.4	8.0e-08	0.79	0.01	0.95	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	UVSSA	0.30	0.00	enet	23	0.08	1.1e-03	-4.71	-5.3	9.6e-08	0.09	0.28	0.04	FALSE
26	GTEx	Esophagus Muscularis	UVSSA	0.35	0.03	enet	33	0.16	3.5e-10	-4.71	-5.3	1.1e-07	0.03	0.93	0.01	FALSE
22	GTEx	Colon Transverse	RP11-20I20.4	0.17	0.05	lasso	3	0.05	2.3e-03	-4.99	-5.3	1.2e-07	0.01	0.43	0.02	FALSE
41	GTEx	Uterus	CRIPAK	0.52	0.34	lasso	3	0.33	1.7e-07	-4.76	-5.3	1.4e-07	0.01	0.23	0.06	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CRIPAK	0.13	0.06	blup	29	0.08	1.2e-04	-4.49	-5.3	1.4e-07	0.01	0.00	0.65	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	UVSSA	0.31	0.05	blup	350	0.23	7.1e-29	1.34	-5.3	1.5e-07	-0.05	0.59	0.41	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	CRIPAK	0.20	0.10	lasso	5	0.15	2.2e-09	-4.71	-5.2	2.2e-07	0.07	0.00	0.97	FALSE
64	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRIPAK	0.41	0.10	lasso	4	0.08	5.2e-04	-4.49	-5.1	2.7e-07	0.02	0.00	0.70	FALSE