TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Impedance of whole body
:
←
→
chr10:71,736,472-73,345,380
Best TWAS P=6.58e-17 · Best GWAS P=4.87e-22 conditioned to 0.989
71.8M
72M
72.2M
72.4M
72.6M
72.8M
73M
73.2M
73.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
ADAMTS14
0.38
0.35
bslmm
710
0.47
3.9e-67
9.6
8.4
6.6e-17
0.87
0.00
1.00
TRUE
2
GTEx
Artery Tibial
PCBD1
0.19
0.01
lasso
6
0.01
3.0e-02
-5.5
5.4
6.1e-08
0.44
0.11
0.17
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADAMTS14
0.28
0.24
bslmm
733
0.35
7.9e-44
-3.5
7.8
5.8e-15
0.81
0.03
0.97
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ADAMTS14
0.05
0.03
enet
17
0.03
3.4e-07
-3.8
6.4
1.5e-10
0.72
0.10
0.90
FALSE
5
The Cancer Genome Atlas
Brain Lower Grade Glioma
ADAMTS14
0.08
0.04
blup
165
0.05
1.8e-06
-3.5
5.1
2.8e-07
0.69
0.02
0.98
FALSE