Best TWAS P=1.3e-18 · Best GWAS P=1.03e-17 conditioned to 0.626
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | -7.8 | 8.5 | 2.8e-17 | -0.91 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | -7.8 | 8.8 | 1.3e-18 | -0.93 | 0.03 | 0.97 | TRUE |
| 3 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | -7.8 | 8.0 | 1.0e-15 | -0.86 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Aorta | VCL | 0.17 | 0.06 | lasso | 9 | 0.09 | 7.9e-06 | -4.0 | 5.3 | 1.2e-07 | -0.04 | 0.17 | 0.68 | TRUE |
| 5 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | -7.8 | 8.7 | 2.5e-18 | -0.86 | 0.18 | 0.82 | FALSE |
| 6 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | -7.8 | 8.4 | 4.5e-17 | -0.91 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Testis | ZNF503-AS2 | 0.16 | 0.02 | lasso | 4 | 0.06 | 1.3e-03 | -6.7 | -6.2 | 6.1e-10 | 0.55 | 0.08 | 0.44 | FALSE |
| 8 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | -7.3 | 8.4 | 3.1e-17 | -0.86 | 0.10 | 0.90 | FALSE |
| 9 | METSIM | Adipose | C10orf11 | 0.11 | 0.10 | enet | 14 | 0.10 | 1.1e-14 | -7.3 | 7.2 | 5.3e-13 | -0.83 | 0.40 | 0.60 | FALSE |