Best TWAS P=9.86e-15 · Best GWAS P=2.75e-16 conditioned to 7.15e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Skin Sun Exposed Lower leg | R3HCC1L | 0.10 | 0.05 | enet | 14 | 0.05 | 3.4e-05 | -6.6 | 7.7 | 9.9e-15 | 0.68 | 0.11 | 0.89 | TRUE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOXL4 | 0.08 | 0.00 | blup | 51 | 0.02 | 9.4e-03 | 5.2 | 7.3 | 2.4e-13 | 0.62 | 0.01 | 0.45 | FALSE |
| 2 | GTEx | Nerve Tibial | R3HCC1L | 0.06 | 0.07 | enet | 8 | 0.05 | 1.1e-04 | 6.3 | 7.1 | 1.5e-12 | 0.87 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Testis | LOXL4 | 0.48 | 0.47 | enet | 8 | 0.46 | 1.0e-22 | -7.0 | 7.0 | 1.9e-12 | 0.48 | 0.90 | 0.10 | FALSE |
| 1 | GTEx | Esophagus Muscularis | LOXL4 | 0.16 | 0.16 | lasso | 3 | 0.15 | 2.4e-09 | -6.9 | 7.0 | 2.3e-12 | 0.49 | 0.90 | 0.10 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOXL4 | 0.09 | 0.05 | enet | 12 | 0.05 | 3.0e-06 | -5.8 | 6.9 | 5.2e-12 | 0.42 | 0.57 | 0.27 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | R3HCC1L | 0.03 | 0.04 | lasso | 3 | 0.02 | 1.1e-03 | -6.8 | 6.6 | 3.0e-11 | 0.46 | 0.69 | 0.14 | FALSE |
| 3 | GTEx | Pancreas | HPS1 | 0.19 | 0.00 | enet | 18 | 0.03 | 2.2e-02 | 1.9 | 5.3 | 1.2e-07 | 0.34 | 0.06 | 0.47 | FALSE |