[Hub]/) : Traits : Impedance of whole body : ← →

chr10:101,975,269-106,371,784

Best TWAS P=1.21e-17 · Best GWAS P=1.46e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	-8.5	-8.6	1.2e-17	0.96	0.00	0.99	TRUE
20	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	5.3	7.2	6.3e-13	-0.01	0.07	0.10	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-6.2	-6.1	9.8e-10	0.04	0.03	0.97	TRUE
16	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-6.0	-6.1	1.4e-09	0.05	0.18	0.60	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM180	0.06	0.03	lasso	5	0.03	3.7e-04	-5.3	-5.9	2.8e-09	0.07	0.00	0.99	TRUE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-4.5	5.5	4.7e-08	-0.02	0.30	0.68	TRUE
28	GTEx	Thyroid	RP11-18I14.10	0.14	0.03	enet	24	0.07	3.5e-06	-2.7	-5.3	1.1e-07	0.08	0.53	0.14	TRUE
11	GTEx	Breast Mammary Tissue	SFXN2	0.11	0.00	enet	12	0.03	1.3e-02	-2.5	5.3	1.3e-07	-0.06	0.14	0.30	TRUE
27	GTEx	Thyroid	OBFC1	0.09	0.00	enet	15	0.01	1.1e-01	3.8	-5.2	1.8e-07	0.08	0.05	0.47	TRUE
19	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	-8.5	-8.5	1.6e-17	1.00	0.00	1.00	FALSE
6	GTEx	Artery Tibial	RP11-179B2.2	0.11	0.09	lasso	4	0.08	8.8e-07	-8.5	-8.5	2.7e-17	0.96	0.00	1.00	FALSE
18	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	-8.5	-8.5	2.8e-17	0.98	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	-8.5	-8.2	3.3e-16	0.99	0.00	0.99	FALSE
5	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	-8.5	-8.1	5.0e-16	0.98	0.00	0.99	FALSE
10	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	-8.5	-8.1	5.4e-16	0.98	0.01	0.97	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL43	0.07	0.02	blup	52	0.00	1.7e-01	-8.1	8.1	6.1e-16	-0.80	0.01	0.84	FALSE
21	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	-8.5	-8.1	7.9e-16	0.99	0.00	1.00	FALSE
12	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	-8.5	-7.6	3.8e-14	0.96	0.01	0.99	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RP11-179B2.2	0.16	-0.01	enet	4	-0.01	7.1e-01	7.4	-7.5	8.5e-14	0.77	0.03	0.47	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	RP11-179B2.2	0.27	0.15	enet	36	0.15	2.0e-08	-8.5	-7.3	4.0e-13	0.75	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-179B2.2	0.15	0.08	lasso	6	0.08	3.2e-07	-6.2	-7.2	5.2e-13	0.90	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	2.8	7.1	1.0e-12	-0.09	0.06	0.48	FALSE
23	GTEx	Nerve Tibial	RP11-179B2.2	0.15	0.08	lasso	2	0.12	6.4e-09	-8.5	-6.9	4.9e-12	0.88	0.01	0.99	FALSE
29	GTEx	Thyroid	RP11-179B2.2	0.18	0.12	lasso	7	0.11	8.3e-09	-6.2	-6.8	1.3e-11	0.91	0.04	0.96	FALSE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM178A	0.14	0.08	lasso	2	0.08	5.9e-04	7.3	6.6	3.9e-11	-0.54	0.07	0.13	FALSE
26	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-6.1	6.2	7.5e-10	-0.04	0.04	0.94	FALSE
4	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-5.2	6.0	1.5e-09	-0.09	0.02	0.96	FALSE
15	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-6.3	-6.0	2.0e-09	0.08	0.04	0.54	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEMA4G	0.04	0.01	blup	52	0.02	1.2e-03	-5.9	-5.9	2.7e-09	0.83	0.01	0.81	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA4G	0.03	0.01	blup	52	0.01	4.2e-02	-8.5	-5.9	3.8e-09	0.83	0.00	0.90	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RP11-179B2.2	0.12	0.09	lasso	2	0.08	1.7e-07	-5.9	-5.8	5.8e-09	0.86	0.05	0.95	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	-5.2	5.8	6.4e-09	-0.06	0.90	0.10	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	-5.2	5.6	1.7e-08	-0.08	0.01	0.61	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	-5.4	5.6	2.1e-08	-0.08	0.02	0.75	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	SEMA4G	0.07	0.08	blup	52	0.08	5.1e-08	3.7	-5.5	4.4e-08	0.75	0.04	0.96	FALSE
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-6.3	-5.5	4.6e-08	0.07	0.04	0.90	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-6.1	-5.4	5.7e-08	0.02	0.04	0.45	FALSE
22	GTEx	Muscle Skeletal	TMEM180	0.05	0.01	lasso	6	0.01	8.3e-02	-3.8	-5.4	7.0e-08	0.07	0.04	0.68	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL43	0.03	0.02	blup	52	0.03	3.0e-04	3.7	5.3	9.7e-08	-0.68	0.09	0.53	FALSE
9	GTEx	Brain Frontal Cortex BA9	NFKB2	0.27	0.00	lasso	5	0.00	3.3e-01	-3.9	-5.3	1.1e-07	0.05	0.05	0.21	FALSE
17	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	-5.2	5.2	2.2e-07	-0.09	0.06	0.75	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACTR1A	0.04	0.01	blup	51	0.02	7.1e-04	-2.6	-5.1	2.9e-07	0.08	0.03	0.33	FALSE