Best TWAS P=1.26e-11 · Best GWAS P=5.38e-17 conditioned to 0.0283
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | WARS2 | 0.51 | 0.32 | enet | 34 | 0.44 | 1.6e-12 | 5.0 | -5.2 | 1.8e-07 | 0.76 | 0.06 | 0.94 | FALSE |
2 | GTEx | Brain Frontal Cortex BA9 | WARS2 | 0.59 | 0.35 | lasso | 9 | 0.35 | 3.8e-10 | 5.0 | -5.3 | 1.2e-07 | 0.78 | 0.12 | 0.85 | FALSE |
3 | GTEx | Brain Hypothalamus | WARS2 | 0.28 | 0.15 | enet | 13 | 0.25 | 1.1e-06 | 2.3 | -5.7 | 1.5e-08 | 0.84 | 0.02 | 0.96 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | WARS2 | 0.40 | 0.18 | enet | 10 | 0.23 | 9.2e-07 | 5.0 | -5.8 | 8.4e-09 | 0.79 | 0.01 | 0.96 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | WARS2 | 0.36 | 0.12 | enet | 9 | 0.29 | 5.0e-11 | 5.0 | -5.2 | 2.1e-07 | 0.77 | 0.08 | 0.92 | FALSE |
6 | GTEx | Pancreas | WARS2 | 0.33 | 0.14 | lasso | 8 | 0.28 | 3.8e-12 | 2.5 | -5.3 | 1.4e-07 | 0.78 | 0.09 | 0.91 | FALSE |
7 | GTEx | Testis | WARS2 | 0.25 | 0.17 | lasso | 3 | 0.17 | 4.3e-08 | 4.8 | 5.6 | 2.3e-08 | -0.46 | 0.83 | 0.08 | TRUE |
8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | WARS2 | 0.12 | 0.04 | blup | 73 | 0.06 | 5.6e-04 | 2.3 | -5.3 | 1.3e-07 | 0.76 | 0.04 | 0.88 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBX15 | 0.07 | 0.02 | blup | 92 | 0.05 | 2.2e-06 | 6.2 | 6.8 | 1.3e-11 | -0.67 | 0.11 | 0.88 | TRUE |
10 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | WARS2 | 0.30 | 0.12 | blup | 73 | 0.29 | 2.3e-08 | 5.0 | -5.4 | 6.4e-08 | 0.82 | 0.02 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | WARS2 | 0.27 | 0.15 | blup | 73 | 0.22 | 6.3e-16 | 5.0 | -5.5 | 3.9e-08 | 0.77 | 0.02 | 0.98 | FALSE |