Best TWAS P=2.05e-09 · Best GWAS P=4.36e-09 conditioned to 0.0396
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | -5.6 | -5.4 | 6.8e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | RP4-773A18.4 | 0.10 | 0.03 | enet | 16 | 0.04 | 2.6e-04 | -5.6 | 5.4 | 5.5e-08 | 0.04 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Brain Cortex | WNT2B | 0.36 | 0.19 | lasso | 5 | 0.23 | 5.5e-07 | -5.3 | -5.2 | 1.9e-07 | 0.91 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | WNT2B | 0.29 | 0.28 | lasso | 3 | 0.29 | 2.6e-08 | -5.7 | -5.2 | 2.0e-07 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | SLC16A1 | 0.12 | 0.00 | lasso | 5 | 0.04 | 5.0e-03 | -5.3 | 6.0 | 2.1e-09 | -0.81 | 0.02 | 0.87 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | -5.3 | -5.4 | 5.4e-08 | 0.92 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MOV10 | 0.03 | 0.00 | lasso | 9 | 0.00 | 9.9e-02 | -5.8 | -5.2 | 2.0e-07 | 0.65 | 0.01 | 0.80 | FALSE |