Best TWAS P=9.87e-22 · Best GWAS P=2.52e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BTBD7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.8e-04 | 6.5 | -6.6 | 4.6e-11 | -0.05 | 0.57 | 0.39 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | 6.8 | -6.3 | 2.8e-10 | -0.02 | 0.08 | 0.90 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | 8.1 | -8.2 | 2.1e-16 | 0.00 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -9.5 | 9.6 | 9.9e-22 | -1.00 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | 7.9 | 7.8 | 4.7e-15 | -0.02 | 0.05 | 0.88 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | -7.8 | 7.7 | 1.9e-14 | -0.47 | 0.04 | 0.83 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | C14orf159 | 0.18 | 0.10 | lasso | 4 | 0.06 | 1.6e-03 | 4.7 | 5.3 | 1.1e-07 | -0.03 | 0.12 | 0.68 | FALSE |
| 8 | GTEx | Heart Left Ventricle | RPS6KA5 | 0.13 | 0.00 | enet | 38 | 0.02 | 2.2e-02 | 5.0 | 6.2 | 5.7e-10 | -0.06 | 0.03 | 0.74 | FALSE |
| 9 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | 6.6 | -7.8 | 9.0e-15 | 0.03 | 0.09 | 0.32 | FALSE |
| 10 | GTEx | Testis | BTBD7 | 0.19 | 0.00 | enet | 45 | 0.01 | 9.5e-02 | 6.0 | -5.3 | 9.3e-08 | -0.03 | 0.14 | 0.62 | FALSE |
| 11 | METSIM | Adipose | C14orf159 | 0.04 | 0.00 | blup | 464 | 0.01 | 4.0e-03 | 5.3 | -6.3 | 2.9e-10 | 0.01 | 0.06 | 0.80 | FALSE |
| 12 | NTR | Blood | BTBD7 | 0.02 | 0.03 | lasso | 2 | 0.02 | 6.1e-08 | 6.5 | -6.7 | 2.8e-11 | -0.03 | 0.66 | 0.34 | TRUE |
| 13 | YFS | Blood | RPS6KA5 | 0.11 | 0.03 | enet | 59 | 0.07 | 4.0e-21 | 5.0 | 5.4 | 7.9e-08 | -0.03 | 0.78 | 0.22 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | 3.5 | 6.7 | 2.9e-11 | -0.12 | 0.03 | 0.04 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BTBD7 | 0.02 | 0.01 | blup | 72 | 0.02 | 6.8e-03 | 7.2 | -6.8 | 1.1e-11 | 0.01 | 0.01 | 0.91 | TRUE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | 6.8 | -6.6 | 3.9e-11 | -0.04 | 0.04 | 0.54 | FALSE |