Best TWAS P=1.3e-10 · Best GWAS P=3.98e-11 conditioned to 0.0311
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | WDR20 | 0.14 | 0.18 | lasso | 3 | 0.18 | 9.0e-21 | -5.8 | -5.6 | 1.9e-08 | 0.90 | 0.27 | 0.73 | FALSE |
2 | GTEx | Adipose Subcutaneous | MARK3 | 0.12 | 0.05 | lasso | 3 | 0.06 | 2.5e-05 | 5.4 | 5.6 | 1.9e-08 | 0.05 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adipose Visceral Omentum | KLC1 | 0.06 | 0.02 | lasso | 2 | 0.00 | 2.2e-01 | 5.1 | -5.4 | 5.9e-08 | 0.01 | 0.08 | 0.46 | FALSE |
4 | GTEx | Artery Aorta | KLC1 | 0.10 | 0.14 | lasso | 3 | 0.14 | 6.1e-08 | 5.1 | -5.3 | 1.3e-07 | 0.03 | 0.06 | 0.94 | FALSE |
5 | GTEx | Artery Tibial | TRMT61A | 0.07 | 0.07 | lasso | 3 | 0.06 | 2.4e-05 | 5.2 | 5.5 | 2.9e-08 | 0.05 | 0.02 | 0.98 | FALSE |
6 | GTEx | Brain Cerebellum | ZNF839 | 0.22 | 0.04 | lasso | 4 | 0.07 | 5.2e-03 | -4.1 | -5.3 | 1.2e-07 | 0.54 | 0.09 | 0.26 | FALSE |
7 | GTEx | Breast Mammary Tissue | MARK3 | 0.12 | 0.11 | lasso | 2 | 0.08 | 3.9e-05 | 5.4 | 5.5 | 5.1e-08 | 0.02 | 0.01 | 0.98 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | MARK3 | 0.08 | 0.00 | enet | 9 | -0.01 | 7.2e-01 | 5.4 | 5.8 | 5.4e-09 | 0.03 | 0.02 | 0.47 | TRUE |
9 | GTEx | Cells Transformed fibroblasts | APOPT1 | 0.14 | 0.12 | lasso | 3 | 0.10 | 6.4e-08 | 5.0 | 5.2 | 2.0e-07 | -0.02 | 0.08 | 0.91 | FALSE |
10 | GTEx | Esophagus Muscularis | MOK | 0.13 | 0.02 | lasso | 5 | 0.01 | 4.1e-02 | -6.1 | 5.3 | 9.9e-08 | -0.76 | 0.04 | 0.73 | FALSE |
11 | GTEx | Lung | MARK3 | 0.06 | 0.02 | lasso | 3 | 0.01 | 6.6e-02 | 5.4 | 5.7 | 1.1e-08 | 0.03 | 0.02 | 0.96 | FALSE |
12 | GTEx | Lung | CKB | 0.07 | 0.01 | lasso | 2 | 0.01 | 3.4e-02 | 5.1 | 5.7 | 1.0e-08 | 0.02 | 0.02 | 0.93 | FALSE |
13 | GTEx | Pituitary | MARK3 | 0.21 | 0.27 | enet | 8 | 0.25 | 4.9e-07 | 5.4 | 5.6 | 1.9e-08 | 0.02 | 0.01 | 0.98 | FALSE |
14 | GTEx | Prostate | MARK3 | 0.18 | 0.22 | enet | 11 | 0.20 | 8.0e-06 | 5.5 | 5.3 | 1.2e-07 | 0.02 | 0.01 | 0.97 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | MARK3 | 0.16 | 0.10 | lasso | 3 | 0.10 | 6.7e-06 | 5.4 | 5.7 | 1.3e-08 | 0.02 | 0.01 | 0.99 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | MARK3 | 0.10 | 0.09 | enet | 13 | 0.08 | 7.5e-07 | 5.4 | 5.3 | 1.5e-07 | 0.03 | 0.01 | 0.99 | FALSE |
17 | GTEx | Stomach | MARK3 | 0.10 | 0.09 | lasso | 2 | 0.04 | 4.5e-03 | 5.4 | 5.4 | 8.3e-08 | 0.03 | 0.01 | 0.96 | FALSE |
18 | GTEx | Stomach | TRMT61A | 0.12 | 0.11 | lasso | 5 | 0.08 | 1.2e-04 | 5.4 | 5.5 | 5.0e-08 | 0.02 | 0.01 | 0.98 | FALSE |
19 | GTEx | Thyroid | ZNF839 | 0.10 | 0.08 | enet | 9 | 0.13 | 5.6e-10 | -5.7 | -5.7 | 1.2e-08 | 0.64 | 0.67 | 0.32 | FALSE |
20 | GTEx | Thyroid | MARK3 | 0.38 | 0.48 | lasso | 4 | 0.48 | 2.8e-41 | 5.4 | 5.4 | 5.6e-08 | 0.02 | 0.01 | 0.99 | FALSE |
21 | METSIM | Adipose | WDR20 | 0.03 | 0.04 | lasso | 8 | 0.04 | 1.6e-06 | -6.4 | 6.4 | 1.3e-10 | -0.92 | 0.03 | 0.97 | TRUE |
22 | YFS | Blood | KLC1 | 0.01 | 0.01 | blup | 389 | 0.01 | 1.0e-03 | 4.6 | -5.6 | 1.7e-08 | -0.02 | 0.08 | 0.79 | FALSE |
23 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAGE | 0.08 | 0.09 | blup | 60 | 0.09 | 7.3e-06 | -6.2 | 5.7 | 1.2e-08 | -0.82 | 0.02 | 0.97 | FALSE |
24 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAGE | 0.04 | 0.01 | blup | 60 | 0.03 | 2.5e-04 | -6.2 | 5.8 | 8.6e-09 | -0.75 | 0.02 | 0.98 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TRMT61A | 0.02 | 0.00 | blup | 34 | 0.01 | 6.2e-02 | -3.4 | 5.3 | 1.4e-07 | 0.05 | 0.01 | 0.70 | FALSE |
26 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BAG5 | 0.08 | 0.09 | lasso | 2 | 0.08 | 3.7e-04 | 5.4 | 5.4 | 6.3e-08 | 0.03 | 0.00 | 0.96 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf153 | 0.09 | 0.08 | blup | 38 | 0.09 | 6.2e-10 | 5.0 | 5.3 | 9.5e-08 | -0.02 | 0.02 | 0.98 | FALSE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MARK3 | 0.07 | 0.06 | enet | 7 | 0.08 | 1.0e-08 | 4.9 | 5.5 | 4.2e-08 | 0.05 | 0.03 | 0.97 | FALSE |
29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT61A | 0.03 | 0.01 | blup | 32 | 0.01 | 1.4e-02 | 5.2 | 5.2 | 2.2e-07 | 0.03 | 0.00 | 0.64 | FALSE |
30 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAGE | 0.09 | 0.00 | blup | 58 | 0.03 | 3.0e-02 | -3.5 | 5.1 | 3.0e-07 | -0.76 | 0.02 | 0.64 | FALSE |
31 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | 4.9 | 5.3 | 9.9e-08 | -0.01 | 0.01 | 0.58 | FALSE |