Best TWAS P=3.92e-17 · Best GWAS P=1.52e-13 conditioned to 0.053
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 5.7 | -5.7 | 1.0e-08 | -0.08 | 0.22 | 0.06 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -5.6 | -7.6 | 2.8e-14 | 0.00 | 0.13 | 0.06 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -6.7 | -8.4 | 3.9e-17 | -0.71 | 0.09 | 0.28 | TRUE |
| 4 | GTEx | Colon Sigmoid | CTD-3076O17.1 | 0.25 | 0.15 | lasso | 5 | 0.09 | 3.5e-04 | -6.6 | -5.3 | 1.4e-07 | -0.57 | 0.11 | 0.54 | FALSE |
| 5 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -6.7 | -5.8 | 7.9e-09 | -0.59 | 0.14 | 0.86 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -2.0 | -5.3 | 1.1e-07 | -0.38 | 0.10 | 0.18 | FALSE |
| 7 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -6.7 | -6.5 | 6.0e-11 | -0.57 | 0.14 | 0.86 | FALSE |
| 8 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -6.6 | -7.5 | 7.0e-14 | -0.58 | 0.13 | 0.76 | FALSE |
| 9 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -6.5 | -6.5 | 9.0e-11 | -0.62 | 0.21 | 0.79 | FALSE |
| 10 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -6.5 | -7.0 | 3.0e-12 | -0.66 | 0.18 | 0.80 | FALSE |