Best TWAS P=8.82e-10 · Best GWAS P=2.56e-14 conditioned to 3.15e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HN1L | 0.08 | 0.01 | blup | 487 | 0.04 | 2.4e-05 | -3.64 | 5.8 | 7.6e-09 | 0.02 | 0.33 | 0.43 | FALSE |
| 2 | GTEx | Artery Tibial | LA16c-316G12.2 | 0.13 | 0.05 | enet | 18 | 0.06 | 1.1e-05 | -6.65 | -5.9 | 3.1e-09 | -0.05 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Hippocampus | CLUAP1 | 0.37 | 0.10 | lasso | 5 | 0.09 | 4.9e-03 | -4.13 | -5.3 | 1.3e-07 | 0.02 | 0.17 | 0.06 | FALSE |
| 4 | GTEx | Esophagus Mucosa | BRICD5 | 0.17 | 0.06 | enet | 9 | 0.11 | 1.3e-07 | 5.05 | 5.3 | 1.1e-07 | -0.06 | 0.54 | 0.39 | FALSE |
| 5 | GTEx | Esophagus Muscularis | LA16c-361A3.3 | 0.12 | 0.04 | enet | 7 | 0.05 | 5.1e-04 | -4.45 | -5.5 | 5.0e-08 | -0.08 | 0.29 | 0.57 | FALSE |
| 6 | GTEx | Thyroid | MLST8 | 0.10 | 0.06 | lasso | 5 | 0.06 | 2.2e-05 | 5.05 | -5.3 | 8.7e-08 | 0.04 | 0.50 | 0.41 | FALSE |
| 7 | METSIM | Adipose | TMEM204 | 0.08 | 0.01 | blup | 498 | 0.02 | 2.5e-04 | -4.84 | -5.1 | 2.9e-07 | -0.08 | 0.02 | 0.98 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | IFT140 | 0.11 | 0.02 | bslmm | 498 | 0.07 | 5.9e-09 | -0.93 | 5.1 | 3.1e-07 | 0.01 | 0.19 | 0.81 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | 7.48 | 6.1 | 9.1e-10 | 0.86 | 0.00 | 1.00 | TRUE |
| 10 | YFS | Blood | CRAMP1L | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.6e-04 | -4.64 | -5.8 | 5.9e-09 | -0.05 | 0.70 | 0.26 | FALSE |
| 11 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | 5.05 | -5.8 | 8.5e-09 | -0.02 | 0.03 | 0.97 | TRUE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NLRC3 | 0.05 | 0.01 | blup | 39 | 0.02 | 9.8e-03 | -4.66 | 5.1 | 3.0e-07 | -0.09 | 0.02 | 0.52 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM204 | 0.02 | 0.01 | blup | 64 | 0.01 | 4.4e-03 | -3.63 | -5.2 | 1.7e-07 | -0.04 | 0.08 | 0.44 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MAPK8IP3 | 0.18 | 0.06 | blup | 77 | 0.10 | 8.7e-06 | -4.45 | -5.7 | 1.0e-08 | -0.13 | 0.10 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NLRC3 | 0.07 | 0.02 | blup | 39 | 0.01 | 7.4e-02 | 4.26 | 5.5 | 3.6e-08 | -0.12 | 0.01 | 0.64 | TRUE |
| 16 | The Cancer Genome Atlas | Esophageal Carcinoma | CRAMP1L | 0.11 | 0.08 | blup | 60 | 0.07 | 2.2e-03 | -4.96 | -6.1 | 8.8e-10 | -0.07 | 0.02 | 0.84 | TRUE |
| 17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MLST8 | 0.09 | 0.05 | blup | 38 | 0.04 | 8.7e-03 | 5.27 | -5.5 | 3.1e-08 | 0.04 | 0.00 | 0.94 | FALSE |
| 18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | NLRC3 | 0.32 | 0.08 | enet | 10 | 0.23 | 3.3e-06 | -3.76 | 5.3 | 1.4e-07 | -0.14 | 0.01 | 0.69 | FALSE |