Best TWAS P=4.64e-17 · Best GWAS P=6.75e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IPO9 | 0.21 | 0.09 | enet | 36 | 0.13 | 2.3e-15 | 5.82 | 5.7 | 1.3e-08 | -0.32 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.94 | 6.6 | 4.0e-11 | -0.57 | 0.20 | 0.34 | FALSE |
| 3 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | -8.62 | 8.1 | 4.7e-16 | -0.99 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | -8.62 | 8.0 | 1.4e-15 | -0.98 | 0.01 | 0.99 | FALSE |
| 5 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -8.54 | 8.4 | 4.6e-17 | -0.97 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | 6.80 | 5.3 | 1.4e-07 | -0.56 | 0.04 | 0.16 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | -8.46 | 6.0 | 1.6e-09 | -0.86 | 0.01 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | -8.54 | 7.4 | 1.5e-13 | -0.90 | 0.01 | 0.88 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 6.80 | 7.6 | 3.7e-14 | -0.74 | 0.24 | 0.75 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | -8.40 | 7.6 | 2.4e-14 | -0.83 | 0.01 | 0.82 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LMOD1 | 0.08 | -0.01 | blup | 59 | 0.01 | 1.3e-01 | -0.13 | 5.9 | 3.4e-09 | -0.78 | 0.01 | 0.42 | FALSE |