Best TWAS P=1.28e-10 · Best GWAS P=3.72e-09 conditioned to 0.00175
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HINT1 | 0.10 | 0.07 | enet | 16 | 0.06 | 8.8e-06 | 5.5 | 6.4 | 1.3e-10 | 0.49 | 0.06 | 0.93 | TRUE |
| 2 | GTEx | Artery Aorta | HINT1 | 0.07 | 0.07 | enet | 8 | 0.06 | 4.7e-04 | 5.5 | 6.2 | 5.8e-10 | 0.75 | 0.06 | 0.68 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | HINT1 | 0.10 | 0.06 | lasso | 2 | 0.05 | 2.1e-04 | 5.4 | 5.8 | 8.7e-09 | 0.57 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Artery Tibial | HINT1 | 0.11 | 0.04 | enet | 18 | 0.06 | 1.0e-05 | 5.4 | 5.5 | 4.4e-08 | 0.55 | 0.05 | 0.91 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | HINT1 | 0.07 | 0.04 | lasso | 2 | 0.01 | 1.8e-02 | 5.4 | 5.4 | 7.7e-08 | 0.57 | 0.00 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | LYRM7 | 0.03 | 0.01 | enet | 10 | 0.02 | 7.5e-04 | 3.8 | -5.2 | 1.9e-07 | -0.74 | 0.01 | 0.64 | FALSE |